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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI

ISSN : 23026391 EISSN : 27211924 DOI : https://doi.org/10.53366/jimki

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 326 Documents

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Potensi Injeksi Intra-artikular Sel Punca Mesenkimal sebagai Terapi Osteoartritis Lutut:: Tinjauan Sistematis Mengenai Efektivitas dan Profil Keamanan Vincentius Mario Yusuf; Ivena Leonita; Aurielle Annalicia Setiawan; Muhammad Yusuf
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.483

Background: Osteoarthritis (OA) is a chronic multifactorial disease (inflammatory, mechanical, and metabolic) that is most often found in knee joints. Current OA therapy mostly uses NSAIDs as symptomatic treatment, with severe side-effects in long-term use. Therefore, a new causative therapy is needed that can minimize side effects and also has high efficacy. Mesenchymal stem cells (MSC) have promising potential for further research as a novel therapy for OA. Methods: This systematic review was conducted by including validated studies extracted from PubMed, Cochrane, ScienceDirect, dan ProQuest databases, using the keywords “knee osteoarthritis” and “mesenchymal stem cells” with a publication range of 2011-2021. RCT studies examining the use of intra-articular injection of MSC for knee OA were included. Outcome measures used were Visual Analog Scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), MRI results (WORMS, cartilage volume, cartilage defect size), and side effects. Discussion: MSC can improve clinical assessment of OA, as seen from the significantly improved WOMAC and VAS scores and also radiological improvement, as seen from the improved WORMS scores, cartilage defects and volume. MSCs have anti-inflammatory and immunomodulatory potential, and are able to stimulate cartilage-like cells, which can assist in the recovery and prevention of further development of OA. Adverse effects are generally mild and self-limiting, therefore safe for human use. Conclusion: Intra-articular injection of MSC is potentially effective as a method of knee OA therapy with minimal side effects.

TOCILIZUMAB AS MONOCLONAL ANTIBODY THERAPY IN OVERCOMING ACUTE RESPIRATORY DISTRESS SYNDROME IN COVID-19 PATIENTS Muhammad Thifan Satyagraha; Graceanne Sheridan; Vito Etenio Ade Laryan; Gibran Chandra Syarif Hidayatullah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.488

Acute respiratory distress syndrome (ARDS) as a clinical manifestation of severe pneumonia is a major cause of death for patients with coronavirus disease 2019 (COVID-19) who are treated in intensive care units (ICU). ARDS is triggered by cytokine storm. Cytokine storm is characterized by an increased in proinflammatory cytokines such as IL-6, IL-1?, and IL-1?. Thus, IL-6 and IL-1 cytokine inhibitors in the form of monoclonal antibodies are needed to overcome this. This review of the scientific literature aims to identify the effect of monoclonal antibody therapy, which is focusing on the inhibitors of cytokines IL-6 (tocilizumab) and IL-1 (anakira) in patients with severe pneumonia caused by severe acute respiratory coronavirus-2 (SARS-CoV-2) ) with clinical manifestations in the form of ARDS. The design used in the form of scientific literature review. Articles were collected via Google Scholar search engine through several data sources (Pubmed, Sciencedirect, Nature, Proquest, and Springer Link). Inclusion criteria used were literature sources published between 2011 – 2020 in the form of research articles, systematic reviews, annual reports, and/or books. Meanwhile, the exclusion criterion used was literature sources under 2011. Based on article search results, tocilizumab can efficiently improve clinical status and reduce the mortality rate of COVID-19 patients with ARDS. Even so, tocilizumab can increase the risk of infection and the evidence obtained by the authors was not enough to support the administration of tocilizumab outside of clinical trials. Thus, the safety and side effects of monoclonal antibodies need to be further investigated.

Tingkat Pengetahuan dan Sikap Mahasiswa FK USU tentang Pentingnya Vaksinasi COVID-19 Caroline, Chyntia
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.509

Background. In the beginning of 2020, earth have been shocked by new pneumonia virus pandemic that start from Wuhan, Tiongkok. The virus have been rapidly spread and the disease is called Coronavirus disease 2019 (COVID-19). This research is conducted to survey student’s knowledge and attitude about the importance of COVID-19 vaccination. Purpose. This research of this study is to describe FK USU student’s knowledge about the importance of COVID-19 vaccine. Methods. Observational research without intervention or experiment with cross sectional design. Data will be collected by quesionaire. The number of sample that needed for this study are 88 sample and will be randomized using Simple Random Sampling method. Result. From this study, there are 50% of FK USU students with good knowledge, 40.4% with sufficient level of knowledge and 9.6% with low knowledge. Based on attitude level, there are 95.7% students with good level of attitude, 4.3% with sufficient level of attitude, while there are none of them with low level of attitude. Conclusion. Most of the USU’s Medical Student have good level of both knowledge and attitude towards COVID-19 Vaccine.

PENGARUH POSISI DUDUK TERHADAP KELUHAN LOW BACK PAIN PADA MAHASISWA UNIVERSITAS YARSI ANGKATAN 2018 Milenia, Natasyia
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.510

Background: Lectures in Indonesia during the COVID-19 pandemic are generally held online, as well as at YARSI University. Sitting for a long time in online lectures requires students to be in a static or even uncomfortable sitting position. Sitting either upright or bent over a period of more than 30 minutes can cause muscle disorders so many individuals experience complaints of low back pain (LBP). It is felt as pain or muscle stiffness under the lower angle of the 12th costae and above the lower gluteal folds (inferior gluteal), with or without pain radiating from the lower back to the legs. The purpose of this study was to determine whether there was a relationship between sitting posture and the incidence of low back pain in YARSI University students class of 2018 from the Faculty of Medicine, Faculty of Law, and Faculty of Information Technology. Methods: The research design used was quantitative analytic with a cross sectional research design. The sample was determined using the simple random sampling method. The collection instrument used in this study was the Oswestry Disability Index (ODI) questionnaire. The researcher analyzed the univariate and bivariate data variables by using the chi-square test. Results: Based on bivariate chi square analysis, the p value of sitting position with complaints of LBP was 0.741 (p>0.05), meaning that there was no significant relationship between sitting position and complaints of LBP. Conclusions: There is no relationship between sitting position and complaints of low back pain on class of 2018 YARSI University students of Faculty of Medicine, Faculty of Law, and Faculty of Information Technology.

PENGARUH PANDEMI COVID-19 DAN PEMBATASAN SOSIAL TERHADAP PASIEN Rakasiwi, Muhammad Ilham Dhiya
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.512

Background:

INFEKSI KUSTA PASCA INFEKSI COVID-19 : ANCAMAN PENYAKIT TROPIS TERABAIKAN PASCA PANDEMI BAGI INDONESIA Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Anggraini, Yuni Eka
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.513

Background: Leprosy is still a health problem in Indonesia and as the third world largest contributor the number of cases ranging from 8% world’s cases. Leprosy has various challenges in Indonesia, such as negative stigma, public reluctance to seek medical treatment and comply with medication and the pandemic. Pandemic COVID-19 seems to cover up leprosy cases in Indonesia. A Population-based study in Brazil showed that the impact of pandemic as increasing the diagnosis of multibacillary leprosy. Correlation studies COVID-19 and Leprosy is still unknown. No article identified about leprosy and COVID-19 related in Indonesia. Researchers are trying to explore more about leprosy infection and COVID-19 mechanisms that may occur and also probable condition that would happen in Indonesia. Methods: This literature review sourced from Pubmed, Science Direct and Google Scholar according to the inclusion criteria and evaluated and studied. Discussion: Patient would had Lymphopenia after COVID-19. This supports growth of leprosy in the patient’s body as the patient contact with other leprosy patient. The growth will be progressive due to decreased immunity in COVID-19 patients that would persist for a certain period of time. Increasing severity of COVID-19, the greater the susceptibility of the patient to be infected with leprosy. This allows for a sudden spike in leprosy cases after the pandemic. Solution that can be carried out by the government, such as education to eradicate stigma, to serological examination of IgM PGL-1 are needed to find leprosy case as early as possible, especially in patients with sublclinical phase. Finding cases of leprosy as early as possible is needed so that it can be treated before the occurrence of disability in the patient. Conclusion: Infection of COVID-19 would make patient more susceptible for leprosy infection to growth progressively hence increasing case of leprosy after the pandemic if the case is not found as early as possible especially in subclinical phase of Leprosy infection.

POTENSI PENGGUNAAN SMARTWATCH SEBAGAI ALAT PEMBERI UMPAN BALIK RESUSITASI JANTUNG PARU: SEBUAH KAJIAN SISTEMATIS Dirjayanto, Valerie Josephine; Soloan, Garry; Duindrahajeng, Bernadine Gracia
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.514

Introduction: Cardiac arrest is the first cause of mortality, causing 50% of all cardiovascular deaths. Previous studies have documented the potency of electronic devices such as smartwatch in increasing the quality of cardiopulmonary resuscitation (CPR). Thus, this review is made in order to evaluate the utility of smartwatches in increasing the quality of various CPR parameters. Methods: This review follows PRISMA guidelines, searching for studies from databases such as PubMed, Cochrane, Science Direct, Wiley Online Library, Scopus, and Google Scholar that evaluate the utility of smartwatches in increasing parameters of CPR quality, including depth or frequency, in adults and pediatric population. Quality of studies are assessed with Revised Cochrane Risk of Bias Tool for Randomized Trials (RoB) 2.0. Results and Discussion: Smartwatches are proven effective in guiding CPR both during in-hospital cardiac arrest (IHCA) and more so in out-of-hospital cardiac arrest (OHCA). Smartwatch can increase both the accuracy of frequency and depth of chest compressions significantly. In pediatric population, regardless of expertise of helper, smartwatches can help in achieving high quality CPR. Feedback feature from smartwatches can prevent over- and underventilation. With increase of confidence of helper in reducing patient injury, smartwatch is also potential for maintaining CPR quality, resulting in better patient survival. Conclusion: This review shows the effectiveness of smartwatches as CPR feedback devices that can increase quality, both in terms of depth and frequency. Further clinical studies are encouraged with greater samples to strengthen evidence.

The Edge Provided by Prostratin Utilization in Reversing Latency and Eradicating Human Immunodeficiency Virus: The Application of Medicinal Plant Extract to Overcome Latency and Eradicate Human Immunodeficiency Virus Completely Aurelie, Nadine
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.520

Background: For decades, HIV has caused severe impact toward society by generating vulnerable population. Even though this condition can be kept stabile with antiretroviral usage, other issues including toxicity and resistance emerge due to long term utilization. Therefore, researchers have taken new approach to eradicate HIV infection, which is through shock and kill pace using latency reversal agent. One of the promising candidates is prostratin, compound obtained from medicinal plant extract. Discussion: Aside of reactivating latent HIV-infected cell, prostratin can also prepare related immune system function to combat and eliminate HIV infection, enhancing success chance to obtain full recovery. Combination alongside with other pharmacotherapy agents can further escalate synergist effectivity in shock and kill approach, thus maximizing eradication of HIV infection completely. Conclusion: Therefore, based on the discussion that has been explained above, it can be sum up that prostratin has several advantages compared to other latency reversal agents. Thus, prostratin application might bring one step closer for mankind to annihilate HIV infection completely.

Vaksin HPV sebagai Strategi Pencegahan Kanker Serviks di Indonesia Suryoadji, Kemal Akbar; Ridwan, Alifaturrasyid Syafaatullah; Kusuma, Fitriyadi
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.521

Cervical cancer is the third most common cancer in women in the world and the second most common in women in Indonesia. Cervical cancer accounts for 7.5% of cancer deaths in the world and most of them come from developing countries including Indonesia. The cause of cervical cancer is high-risk HPV and can actually be prevented through high-risk HPV vaccines that are available throughout the world, including Indonesia. Discussion: The HPV vaccine has been shown to be effective in preventing cervical cancer, which is known to reduce the incidence by up to 90%. Various preparations of the HPV vaccine have been shown to be safe to give to patients. Conditions in Indonesia currently make the HPV vaccine a mandatory vaccine given as part of the school children's immunization month program as an effort to prevent cervical cancer for the community in the future. Conclusion: The HPV vaccine has effectiveness and side effects that are safe to be given to the public at large. The policy in Indonesia to require the provision of the HPV vaccine in the schoolchildren's immunization month program is the right step to prevent cervical cancer.

Potensi CtpF pada Mycobacterium tuberculosis dalam Pengembangan CtpF-Inhibitor sebagai Inovasi Terapi Target Mutakhir pada Pengobatan TB MDR/XDR Rahmatika, Alfi; Mufaiduddin, Muhammad; Innelya, Innelya
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.523

Background: Tuberculosis (TB) is one of the major causes of death in the world with the number of cases reaching millions every year. TB is caused by Mycobacterium tuberculosis. The occurrence of mutations in M. tuberculosis that cause resistance to anti-tuberculosis drugs has become a health crisis in TB treatment. Drug resistance in TB consists of MDR TB and XDR TB. The incidence of MDR/XDR TB has increased rapidly in the world with total MDR TB cases reaching more than 480 thousand each year and 9% of those develop into XDR TB. Therefore, it is requisite to develop new therapeutic targets to reduce the prevalence of MDR/XDR TB. CtpF in M. Tuberculosis is the latest innovative therapeutic target in making a new anti-tuberculosis drug because it plays important role in M. tuberculosis homeostasis. Method: This study was made using a non-systematic review method with four sources of publication and several keywords. Overall, 88 pieces of literature that meet the inclusion criteria were used. Results and Discussion: CtpF is a type of P-type ATPase that transports Ca2+ ions and plays important role in responding to intraphagosomal stress conditions that are important for bacterial survival. Inhibition of CtpF can pull down Ca2+ homeostasis in M. tuberculosis so that it is unable to carry out various biomolecular processes and lose defense mechanisms against stress conditions. In addition, CtpF also has a very low mutation ability. This makes CtpF a druggable target for designing new anti-tuberculosis therapy that is not susceptible to resistance. Conclusion: CtpF-inhibitor candidates have the potential to be developed as the latest target therapy in the treatment of MDR / XDR TB.

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Contact Name Norbertus Marcell Prayogi

Contact Email editor.jimki.bapin@gmail.com

Phone +6281372545321

Journal Mail Official editor@jimki.bapin.or.id

Editorial Address Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

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Contact Name
Norbertus Marcell Prayogi

Contact Email
editor.jimki.bapin@gmail.com

Phone
+6281372545321

Journal Mail Official
editor@jimki.bapin.or.id

Editorial Address
Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA