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Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions
Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK covers the disciplines of medicine, pharmacy, and health with several types of articles, namely: 1. Research 2. Literature review 3. Case report 4. Evidence-based case report (EBCR), systematic review 5. Other scientific articles Based on the SK Kemendikbudristek Nomor 152/E/KPT/2023, CDK has obtained Rank 4 (SINTA 4) for Scientific Journals.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,276 Documents
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Pendekatan Diagnosis Ensefalomielitis Diseminata Akut: Tinjauan Pustaka Felicia -
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1311

Abstract

Acute disseminated encephalomyelitis (ADEM) is an acute neurological disorder characterized by demyelination of the central nervous system (CNS). It can affect individuals of all ages, more commonly observed in boys with prior viral or bacterial infections and immunizations. ADEM typically presents with an acute and monophasic course of polyfocal neurological deficits. There are no specific symptoms in ADEM, clinical manifestations are based on the site of demyelination. Diagnosis relies on exclusion criteria as there is no definitive marker for diagnosing ADEM.
Perbandingan Efek Samping ARNI vs ACEi/ARB pada Terapi Gagal Jantung: Analisis Anjar Nuryanto; Riana Suwarni
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1314

Abstract

Introduction: Pharmacological treatment of heart failure continues to develop. Newer drugs such as ARNI (angiotensin receptor neprilysin inhibitor) have become standard for heart failure treatment. This systematic review aims to compare the side efects of ARNI with those of previous standard heart failure therapy. Methods: This research uses PRISMA rules to analyze articles from PubMed and Cochrane. Results: A total of 2,741 articles, excluding duplicates, were selected for title and abstract screening. Twelve articles met the requirements for thorough screening. Of the 12 articles, 4 articles were selected for systematic review analysis. There were 6,553 samples, 2,580 in the ARNI group and 2,390 in the ACEI/ARB group. ARNI was better in reducing the risk of decreased eGFR (RR: 0.51; 0.34-0.78) and the incidence of hyperkalemia (RR: 0.87; 0.76-0.99) but the risk of symptomatic hypotension was greater in the ARNI group (RR: 1.47; 1.23-1.70). Conclusion: The risk of hypotension as well as a reduced risk of cardiovascular death and rehospitalization was higher in the ARNI group, while the risk of decreased eGFR and hyperkalemia was higher in the ACEi/ARB group.
Tata Laksana Refluks Gastroesofageal pada Anak: Tinjauan Pustaka Agus Indra Yudhistira Diva Putra; Luh Putu Winansari Ratih; Veronica Lily Limantara; Anira Rema Aurelya; Komang Sutama Arta; Erick Kusuma Tandiono
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.1318

Abstract

Gastroesophageal reflux is common in adult population but mostly underdiagnosed in pediatric population. Diagnosis of gastroesophageal reflux in children is difficult and may masquerade as other gastrointestinal disease. This review discusses the management of gastroesophageal reflux in children especially in primary health care center to facilitate initial treatment and referral as needed.
Pengaruh Status Refraksi terhadap Stereopsis Dekat pada Anak Usia Sekolah: Hasil Penelitian I Nyoman Surya Ari Wahyudi; Lely Retno Wulandari; Nanda Wahyu Anandita; Anny Sulistiyowati
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1322

Abstract

Introduction: This study aims to evaluate the effect of refractive status on near stereopsis function among school-age children. Methods: A population-based cross-sectional study in 13 orphanages in Malang city with 334 respondents. Visual acuity (VA) and inter-eye line difference were measured using LogMAR of LVRC chart. Refractive status was determined using spherical equivalent (SE) of autorefractometer, classified into emmetropia, myopia and hypermetropia (low, moderate, and high). Near stereopsis was measured using TNO and Butterfly test in arcsecond and completion time also calculated. Data were analyzed using Kruskal-Wallis and Spearman test. Results: There were significant differences of refractive status and inter-eye line difference to both TNO and butterfly score and time (p<0.05). The group with more severe refractive status and more inter-eye line difference in VA have lower stereopsis score and longer completion time. There were no differences between the age group to both TNO and butterfly score and time (p>0.05). There was a positive correlation between TNO and butterfly test (p<0.05, r= 0.365). Conclusion: There is a significant difference of refractive status and inter-eye line difference on near stereopsis function in school-aged children. Stereopsis test may be beneficial for screening of refractive disorder.
Penerapan Model Prediktif untuk Hasil Meningitis Tuberkulosis: Analisis Perbandingan Pendekatan Pohon Keputusan dan Regresi Logistik Ferrdy Pratama Wijaya; Arthur H.P. Mawuntu; Sarah Muharomah; Melke J. Tumboimbela; F.L. Fredrik G. Langi
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.1324

Abstract

Background: Tuberculous meningitis remains one of the most severe complications of tuberculosis infection. This study evaluated critical factors influencing mortality among tuberculous meningitis (TBM) patients and compared the predictive efficacies of logistic regression and decision tree models. Methods: A retrospective cohort analysis using medical records from 65 TBM patients at R.D. Kandou Hospital from January 2018 to July 2021. Patient outcomes were assessed with the Glasgow outcome scale (GOS), and the mortality risk was calculated. Key predictors of mortality identified by both multivariate logistic regression and the decision tree were compared using the receiving operating characteristic (ROC) curve. Result: Multivariate logistic regression analysis identified SGOT levels at admission (aOR: 1.06; CI95% 1.02-1.09; p=0.001), length of stay (aOR: 0.81; CI95% 0.71-0.92; p=0.002), and positive nuchal rigidity (aOR: 41.78; CI95% 3.41-512.27; p=0.004) as significant predictors of mortality. Decision tree analysis highlighted the British Medical Research Council (BMRC) stage, temperature, and potassium levels below 4.3 as critical predictors. Both models showed comparable predictive performance on the ROC curve, with no significant difference (0.85 vs. 0.95; p = 0.074). Conclusion: These results suggest that decision tree analysis is a viable alternative to logistic regression for predicting mortality in TBM patients, providing complementary insights into outcome-related factors. Further research is needed to refine these predictive models.
Penatalaksanaan Awal Takikardia Supraventrikular Paroksismal dengan Depresi Segmen ST pada Pengaturan Perawatan Primer: Laporan Kasus Kevin Fernando Suhardi; Franky Kurniawan; Lusiani
Cermin Dunia Kedokteran Vol 52 No 6 (2025): Kesehatan Jiwa
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i6.1327

Abstract

Introduction: Supraventricular tachycardia (SVT) is a common cardiac emergency that can be life-threatening. Symptoms may include palpitations, chest pain, and difficulty breathing. Case: A 50-year-old male with sudden palpitations since one hour ago, accompanied by chest pain and breathing difficulty. A 12-lead ECG revealed an SVT rhythm with ST-segment depression in leads II, III, aVF, and V2-V6. After initial interventions, which included carotid massage, Valsalva maneuver, and oral bisoprolol, the rhythm converted to sinus rhythm within an hour. ST-segment depression may occur during SVT, which warrants evaluation for ischemic etiology. Conclusion: The report focuses on the initial management of SVT in a primary care setting with constraints on equipment and referral facilities. It's important to note that changes in the ST segment in SVT do not always indicate myocardial infarction, and further examination is necessary to confirm the diagnosis.
Mengoptimalkan Standar Mutu di Pharma 4.0 dengan Menerapkan Perilaku Mutu untuk Keunggulan di Era Digital: Tinjauan Pustaka Steffen Thomas; Rusli Ananta
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1329

Abstract

The pharmaceutical industry is undergoing a significant transformation with the emergence of the Pharma 4.0 concept, driven by technological advancements such as the internet of things (IoT), artificial intelligence (AI), and robotic production systems (continuous manufacturing). One crucial aspect of this transformation is the need for strong data integrity (DI) to ensure the data reliability and security related to pharmaceutical product quality. In the era of Pharma 4.0, performance data from the pharmaceutical industry can be integrated to support real-time decision-making, the presence of DI is crucial to protect consumers and comply with industry regulations. The ALCOA+ principle is used to ensure the integrity of data throughout its lifecycle, including identification, sustainability, and availability of data. Quality behavior is needed to enhance self-awareness in the 4.0 transformation, especially with the increasing focus on cybersecurity and the rising number of data integrity cases, particularly in implementing the ALCOA+ principle. Quality behavior becomes crucial in addressing the challenges and opportunities presented by the Pharma 4.0 transformation and in maintaining data integrity in pharmaceutical industry.
Konsentrasi Fenolik Total dan Aktivitas Antioksidan dari Ekstrak Metanol Daun Kari (Murraya koenigii L.): Hasil Penelitian Ardhita Felicia Tanuhariono; David Limanan; Frans Ferdinal; Eny Yulianti
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1333

Abstract

Introduction: Curry leaves (Murraya koenigii L.) are plants that naturally grow in the Indian subcontinent, except at the peak of the Himalayan mountains, which in their development have spread widely to various corners of the world. Traditionally, curry leaves have been used by people as medicine. However, it is now known that this plant contains carbazole alkaloid compounds and polyphenols that have antioxidant activity. This is very useful for controlling free radical levels in the human body so that they remain within reasonable limits. This is very useful for controlling the levels of free radicals in the human body to stay within reasonable limits. Free radicals are produced by normal cell metabolism which has recently been associated with the pathophysiology of various diseases. Methods: This in vitro research was to determine phenolic content and antioxidant potential in methanol extract of curry leaves. Total phenolic content testing used the Folin-Ciocalteu method and expressed by Gallic Acid Equivalent (GAE). Total antioxidant capacity testing used the DPPH method and Trolox as a comparison solution. Results: The total antioxidant capacity is expressed in the form of IC50. The total phenolic content of curry leaf methanol extract was 4007.78 μg/mL or equivalent to 133.59 mg GAE/g DW and the total antioxidant capacity of curry leaf methanol extract was 37.418 μg/mL. Conclusion: The total phenolic content of curry leaf methanol extract is high (>5 mg GAE/g). Correspondingly, the total antioxidant capacity of curry leaf methanol extract is also classified as very strong (<150 µg/mL).
Efek Anti-hiperkolesterolemik Ekstrak Etanol Daun Cnidosculus aconitifolius terhadap Pembentukan Lesi Aterosklerosis Arteri Koroner pada Tikus Wistar Jantan yang Diberi Diet Aterogenik (Rattus norvegicus): Hasil Penelitian Ni Ketut Rake Putri Saraswati; Ida Sri Iswari; I Wayan Juli Sumadi
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1336

Abstract

Introduction: Foods high in cholesterol increase the production of free radicals and inflammation, and may also trigger the formation of atherosclerotic lesions. Cnidosculus aconitifolius or tree spinach leaves were known to have antioxidant and anti-inflammatory activities. This study was to determine the effect of Cnidosculus aconitifolius on blood cholesterol level and coronary artery atherosclerotic lesions formation using a rat model. Methods: A randomized post-test-only control group of 30 male Wistar rats (Rattus norvegicus), aged 2-3 months, randomly divided into 3 groups: standard control was given regular food; negative control was given an atherogenic diet; and the treatment group was given an atherogenic diet + Cnidosculus aconitifolius leaf ethanol extracts. The treatment lasted 44 days. Data was analyzed with OneWay ANOVA and Kruskal-Wallis test. Results: The total cholesterol and LDL levels were significantly lower in the treatment group compared to the control group (p<0.001). A decrease of atherosclerotic lesion scores in the treatment group compared to the control (p=0.010) was also observed. Conclusion: Cnidosculus aconitifolius leaf ethanol extracts have an anti-hypercholesterolemic effect, hence the potential to prevent the formation of atherosclerotic lesions in the coronary arteries of hypercholesterolemic Wistar rats.
Gagal Jantung akibat Kardiomiopati Alkoholik pada Pria Muda: Laporan Kasus Rizky Darmawan
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1341

Abstract

Latar belakang: Kardiomiopati alkoholik (alcoholic cardiomyopathy/ACM) merupakan tipe kardiomiopati akibat konsumsi alkohol berlebihan. Diagnosis ditegakkan berdasarkan riwayat konsumsi alkohol, klinis, dan pemeriksaan penunjang. Kasus: Laki-laki, berusia 29 tahun, mengeluh sesak napas saat berjalan kaki, berbaring, hingga terbangun di malam hari. Pasien mengonsumsi “arak Flores” 4 botol/hari sejak 14 tahun terakhir. Pemeriksaan tekanan darah 124/93, nadi 101 x/menit, laju napas 24 x/menit, murmur sistolik apeks dan parasternal kiri, ronki pada kedua basal paru, dan edema kedua tungkai. Elektrokardiografi menunjukkan RAD, RAE, LBBB, dan LVH. Foto toraks menunjukkan kardiomegali dan efusi pleura minimal. Pemeriksaan laboratorium SGOT 986,2 U/L, SGPT 448,3 U/L, dan ketidakseimbangan elektrolit. Hasil TTE menunjukkan hipokinetik global, dilatasi semua ruang jantung, penurunan fungsi sistolik LV berat (EF 21,6%), TR berat, dan MR sedang-berat. Hasil angiografi menunjukkan tidak terdapat stenosis di semua arteri koroner. Hasil MRI serupa dengan TTE dan tanpa late gadolinium enhancement (LGE). Terapi sesuai guided-directed medical therapies (GDMT). Simpulan: ACM merupakan kardiomiopati dengan temuan objektif yang sangat bervariasi. Anamnesis terkait riwayat konsumsi alkohol perlu ditanyakan dan kemungkinan penyebab lainnya harus disingkirkan.

Page 96 of 128 | Total Record : 1276

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