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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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MODERN APPROACHES TO THE PROBLEM OF CHRONIC ALCOHOLISM Rustam Baxtiyarovich, Alkarov; Anvar Uzokboyevich, Turgunboyev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1190

Abstract

Objective: The aim of this study is to investigate the long-term effects of ethanol intoxication on various body organs and systems, particularly focusing on the progression from minimal vascular damage to multi-organ pathology, as well as the development of specific clinical and psychopathological symptoms associated with alcoholism. Methods: This research employs a comprehensive review and analysis of existing studies on alcohol disease, examining its impact on microcirculation, organ morphology, and functional alterations caused by repeated ethanol exposure. Additionally, clinical data on the psychopathological symptoms exhibited by individuals with alcohol-related diseases are analyzed. Results: The findings highlight that chronic ethanol intoxication leads to significant morphological and functional changes in body organs, particularly affecting the vascular system and microcirculation. Over time, these alterations progress into multi-organ pathology, with clinical manifestations that include various psychopathological symptoms. Novelty: This study provides new insights into the specific mechanisms by which long-term ethanol exposure induces multi-organ pathology and psychopathological disorders. It emphasizes the gradual progression of alcohol disease, contributing to a deeper understanding of its pathophysiology and potential clinical interventions.
IMPLANTATION AND RESTORATION OF TEETH: ERRORS AND COMPLICATIONS AFTER IMPLANTATION Nasiba Asrorovna, Xolboeva; Xidirnazar Beknazar Oʻgʻli, Buriev; Nurali Fazliddin Oʻgʻli, Bobojonov
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1191

Abstract

Objective: This study is to evaluate the body’s response to temperature changes following dental implant surgery, specifically focusing on the natural increase in temperature post-surgery. Methods: Used involve observing patients after implant insertion, where a small incision is made in the gum to access the bone, and the implant is screwed into the jaw. This process disrupts bone tissue integrity, leading to a temporary rise in body temperature. Results: The results indicate that a temperature increase up to 38 degrees Celsius is normal within the first 2-3 days after surgery due to the body's natural response to microsurgical interventions in the oral cavity. Notably, implants are made from hypoallergenic materials, thus preventing allergic reactions. Novelty: Its exploration of the diverse patient responses to temperature changes, emphasizing that individual tolerance varies, with some patients feeling unwell even at 37 degrees Celsius. For managing elevated temperatures, the use of antipyretic drugs like Paracetamol or Ibuprofen is recommended. This research contributes to understanding postoperative reactions and patient care in dental implant procedures.
THE EFFECTIVENESS OF COLLABORATIVE LEARNING IN DEVELOPING COMMUNICATION SKILLS IN ESL Zebo Xakimjon Kizi, Botirova; Zebona Xayrulla Kizi, Sayfiddinova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1192

Abstract

Objective: This study explores the effectiveness of collaborative learning in enhancing communication skills among English as a Second Language (ESL) learners. The focus is on understanding how this instructional approach contributes to the development of linguistic and interpersonal abilities. Methods: The research involves a review of theoretical frameworks and empirical studies on collaborative learning. It emphasizes the implementation of small-group activities aimed at achieving shared goals, analyzing their impact on active communication, language proficiency, and social interactions in ESL contexts. Results: Findings indicate that collaborative learning significantly improves speaking and listening skills, boosts learners' confidence, and facilitates peer-to-peer learning. Additionally, it promotes a supportive environment that enhances both linguistic and social competencies. Novelty: By synthesizing theoretical insights and empirical evidence, this study highlights the underexplored potential of collaborative learning as a transformative tool in ESL education. It offers actionable recommendations for incorporating these strategies into instructional practices, making a meaningful contribution to the field.
IMPROVEMENT OF METHODS OF CONSERVATIVE THERAPY OF EXUDATIVE OTITIS MEDIA IN CHILDREN Erkinovich, Shadiev Anvar; O’g’li, Akramov Shamsiddin Abdisamat; Alisherovich, Normuradov Nodirzhon
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1194

Abstract

Objective: To evaluate the clinical efficacy of antihistamines, antileukotrienes, and topical intranasal glucocorticosteroids in the complex therapy of exudative otitis media associated with allergic rhinitis. Methods: Patients with exudative otitis media and concurrent allergic rhinitis were treated with a combination of antihistamines, antileukotrienes, and topical intranasal glucocorticosteroids. Clinical outcomes were assessed through auditory evaluations, symptom severity scores, and quality of life measurements. Results: The therapeutic regimen demonstrated significant clinical efficacy. Patients experienced restored hearing, substantial symptom reduction, and notable improvements in overall quality of life s. Novelty: This study highlights the synergistic potential of combining antihistamines, antileukotrienes, and intranasal glucocorticosteroids, providing a comprehensive approach to managing exudative otitis media in the context of allergic rhinitis
IMPROVING THE EFFECTIVENESS OF TREATING ORAL CHANGES CAUSED BY PSYCHOTROPIC DRUGS Kaxxorovna, Rakhmonova Bakhora
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1195

Abstract

Objective: This study aimed to evaluate the effects of systemic hormone replacement therapy (HRT) on clinical and laboratory parameters of the oral cavity and salivary glands in women with surgically induced menopause. Methods: Seventy women aged 45 to 53 years with surgically induced menopause were examined. Thirty-four of these women received treatment to maintain dental health according to the traditional scheme, while thirty-six were additionally prescribed systemic HRT with transdermal gel “Estrogen” containing estradiol. A comparison group consisted of 34 premenopausal women. Hormonal status, dental condition indicators, and the properties and composition of mixed saliva were assessed. Cytological and microbiological studies of smears from the oral mucosa were conducted. Dynamic monitoring was performed preoperatively and at 3, 6, and 12 months post-surgery. Results: Women with surgically induced menopause, treated according to the traditional regimen, showed worsening clinical and laboratory indicators, including saliva quantity and quality, with signs of xerostomia, changes in the microbial landscape, and oral mucosal epithelium alterations. In contrast, women receiving HRT in addition to traditional treatment exhibited significantly less deterioration in these parameters. Novelty: This study reveals the positive effect of systemic hormone replacement therapy with transdermal estradiol on oral cavity health in women with surgically induced menopause, highlighting its role in mitigating adverse changes in the salivary glands and oral mucosa during early menopause.
FEATURES OF THE COURSE AND TREATMENT OF GLOMERULONEPHRITIS IN CHILDREN Batirovna, Ibragimova Yulduz
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1196

Abstract

Objective: Glomerulonephritis in children represents a significant medical condition characterized by acute or chronic inflammation of the renal glomeruli, stemming from an infectious-allergic etiology. Understanding its clinical manifestations and establishing precise diagnostic and therapeutic approaches are vital for effective management. Methods: Diagnosis of glomerulonephritis in children involves a combination of medical history analysis, evaluation of clinical symptoms, laboratory testing, ultrasound imaging, and kidney puncture biopsy. Treatment in the acute phase integrates bed rest, a regulated diet, and pharmacological interventions, including antibiotics, corticosteroids, anticoagulants, diuretics, hypotensive agents, and immunosuppressive drugs. Results: The acute form is identified by a triad of symptoms: urinary syndrome (oliguria, anuria, hematuria, proteinuria), edema, and hypertension. Chronic forms may exhibit the predominance of one syndrome or present a latent course. Timely diagnosis and appropriate treatment improve the prognosis, reduce complications, and support recovery. Novelty: This study highlights the critical role of a multifaceted diagnostic approach combining clinical, laboratory, and imaging techniques. Additionally, it underscores the comprehensive pharmacological management strategies tailored to the acute and chronic manifestations of glomerulonephritis in children.
CHANGES IN THE ORAL MUCOSA AFTER ORTHODONTIC CONSTRUCTIONS Asrorovna, Kholboyeva Nasiba; Qizi, Usanova Sarvinoz Ilkhom; Bakhodirovna, Sharipova Bonu
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1197

Abstract

Objective: The aim of this study is to address the challenges associated with prosthetics, particularly complete removable dentures, which require specific conditions for fixation in the oral cavity. It also aims to explore the design considerations and post-treatment care to improve patient adaptation and the longevity of the prosthetic devices. Methods: The study focuses on the evaluation of various factors considered by orthopedic dentists when designing removable dentures. These factors include the condition of the temporomandibular joint (TMJ), the elasticity of mucous membranes, the presence of scars or cords, the degree of bone tissue atrophy, and the shape of the palate. After the prosthesis is delivered, patients are instructed on its use, as well as on specific speech exercises to aid in adaptation. Results: The findings highlight the importance of assessing the patient's oral condition before prosthetic design. Proper care and adaptation exercises post-prosthetic fitting significantly enhance the patient’s ability to adjust to the dentures, thus improving both comfort and effectiveness. Novelty: This study provides insights into the complexities of designing complete removable dentures and emphasizes the critical role of personalized care and speech training to facilitate faster adaptation and extend the lifespan of dentures.
OPTIMIZING THE TREATMENT OF PATIENTS WITH ACUTE SENSORINEURAL PAIN Takhsinovna, Nasretdinova Makhzuna; Alisherovich , Normuradov Nadirjon; Nazarovna, Normirova Nargiza
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1199

Abstract

Objective: This study aims to evaluate the outcomes of treating patients with acute neurosensory hearing loss across different age groups. The research emphasizes the restoration of hearing as a complex, multi-level process, focusing on the highest level responsible for ensuring proper sensory-motor correction of functional activities. Methods: Hearing restoration was examined using advanced methods, including posturography, which provided insights into sensory-motor adjustments. The study involved patients from varied age demographics, ensuring a comprehensive analysis of age-related differences in treatment responses. Results: The findings demonstrate significant improvements in hearing restoration across all age groups. Posturography proved instrumental in facilitating sensory-motor corrections, highlighting its efficacy as part of a structured rehabilitation process. Age-specific variations in recovery patterns were also observed, providing valuable data for tailoring treatment protocols. Novelty: This research introduces a novel approach by integrating posturography into the treatment framework for acute neurosensory hearing loss. The study underscores the importance of addressing sensory-motor functions as a critical element of hearing restoration, particularly in a multi-level rehabilitation context.
THE ROLE OF ENDOTHELIAL DYSFUNCTION IN THE DEVELOPMENT OF HEMOSTATIC DISTURBANCES IN RHEUMATOID ARTHRITIS AND IMPROVING TREATMENT STRATEGIES Baxtiyorovna, Musayeva Nargiza
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1200

Abstract

Objective: This article investigates the role of endothelial dysfunction in the development of hemostatic disturbances and cardiovascular complications in rheumatoid arthritis (RA) patients. It aims to understand how RA-induced inflammation leads to endothelial dysfunction, increasing oxidative stress, and disrupting the blood clotting system, which heightens the risk of thrombosis and cardiovascular diseases. Methods: The study reviews existing literature and current treatment strategies, including biological therapies, anticoagulants, and anti-inflammatory agents, to explore their impact on reducing endothelial dysfunction and improving cardiovascular outcomes in RA patients. Results: The findings demonstrate that endothelial dysfunction, as a result of RA-induced inflammation, contributes to oxidative stress and disturbances in the blood clotting system. These factors collectively elevate the risk of thrombosis and cardiovascular diseases in RA patients, which are leading causes of morbidity and mortality. Novelty: This article highlights emerging therapeutic approaches that may provide better management of endothelial dysfunction and hemostatic disturbances in RA, offering new potential strategies for improving patient outcomes beyond current treatment options.
DIRECT EFFECT OF COMORBID MENTAL DISORDERS ON THE CLINICAL COURSE OF ALCOHOLISM Akmal Axmadjonovich, Gaybiyev; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1201

Abstract

Objective: This study aims to investigate the direct effect of comorbid mental disorders on the clinical course of alcoholism, emphasizing the complexities involved in diagnosis, treatment, and rehabilitation. Method: A comprehensive analysis was conducted through a cross-sectional study involving patients diagnosed with alcohol use disorder (AUD) and co-occurring mental health conditions. Data were collected using standardized psychiatric assessments and clinical evaluations from both narcology and psychiatry specialists. Results: The findings reveal that the presence of comorbid mental disorders significantly exacerbates the severity and chronicity of alcoholism, leading to poorer treatment outcomes, increased relapse rates, and heightened resistance to standard therapeutic interventions. Patients with dual diagnoses exhibited more complex clinical profiles, necessitating integrated and multidisciplinary treatment approaches. Novelty: This study highlights the critical need for dual-specialist involvement in the management of AUD with comorbid mental disorders, offering new insights into integrated treatment frameworks that can enhance clinical outcomes and reduce the burden of relapse.

Page 29 of 38 | Total Record : 372

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