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Mochamad Nashrullah
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Kavling Banar, Pilang, Sidoarjo, Jawa Timur
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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PATHOGENESIS OF DIABETIC POLYNEUROPATHY AND MODERN SOLUTIONS FOR CLINICAL DIAGNOSIS Dilmurod Do‘stmamat Oʻgʻli, Nematullayev; Umid Arzikulovich, Qodirov; Sokhiba Ziyadulloyevna, Khakimova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1177

Abstract

Objective: Diabetic polyneuropathy encompasses a spectrum of symptoms signaling damage to nerve fibers and impaired functionality, primarily driven by prolonged hyperglycemia. Methods: This condition arises due to metabolic dysfunction in the body, often linked to decompensated diabetes mellitus, leading to progressive nerve cell deterioration. Results: : Patients exhibit reduced limb sensitivity, which, in severe cases, may escalate to complete sensory loss. Novelty: The study underscores the intricate relationship between sustained hyperglycemia and the gradual degeneration of nerve cells, highlighting the critical need for targeted interventions to prevent or mitigate nerve damage in diabetic patients.
THE EFFECT OF PSIDIUM GUAJAVA LEAVES EXTRACTS AND THEIR EFFECTIVE COMPOUND AGAINST LEISHMANIA INFANTUM A. Taha, Sahar
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1180

Abstract

Objective: This study aims to evaluate the anti-leishmanial activity of aqueous and alcoholic extracts of Psidium guajava L. against Leishmania infantum. Additionally, it involves screening the phenolic and flavonoid compounds in the extracts using High-Performance Liquid Chromatography (HPLC). Methods: Standardized methods were employed to prepare aqueous and alcoholic extracts of Psidium guajava L. In vitro assays tested the inhibitory effect of these extracts on the growth of Leishmania infantum promastigotes, with the IC50 values determined. HPLC analysis identified flavonoids and phenolic compounds in the alcoholic extract. Data analysis explored the correlation between compound concentration and anti-leishmanial activity. Results: : The aqueous and alcoholic extracts exhibited significant inhibitory effects on Leishmania infantum promastigote growth. The IC50 value for the aqueous extract was 0.25 mg/mL, while the alcoholic extract showed a slightly higher potency with an IC50 of 0.23 mg/mL. HPLC analysis confirmed the presence of phenolic and flavonoid compounds in the alcoholic extract, which are likely responsible for the observed anti-leishmanial activity. Novelty: This study demonstrates the anti-leishmanial potential of Psidium guajava L., highlighting its aqueous and alcoholic extracts as promising candidates for further investigation. The identification of specific phenolic and flavonoid compounds provides insights into the bioactive components contributing to the inhibitory effects.
HISTOMORPHOLOGY OF KIDNEY OF EXPERIMENTAL ANIMALS AFTER MELOXICAM ADMINISTRATION Kh. Ibraheem Al. Jubory, Raghad
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1181

Abstract

Objective: This study investigates the deleterious effects of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically meloxicam, on renal tissue in albino rats. Methods: Sixteen Sprague Dawley albino rats were divided into two groups: Group A received normal saline, while Group B was administered meloxicam at a dose of 15 mg/kg/day via a feeding tube for 14 days. On day 15, all animals were sacrificed, and their kidneys were extracted, preserved, and sectioned. The kidney samples were stained with silver methenamine, PAS, and H&E, and renal histology was examined under a light microscope to assess changes in the renal tubules. Results: The study found that meloxicam caused significant damage to the distal and proximal convoluted tubules in Group B rats. Notable histological changes included tubule dilatation, epithelial flattening, rupture of the brush border in proximal tubules, and thickening of the basement membrane surrounding the tubular epithelium. Novelty: This research highlights the nephrotoxic effects of meloxicam, a commonly used NSAID, providing new insights into its potential harmful impact on renal health, which has not been widely emphasized in previous studies on its adverse effects.
MIDWIFERY CARE CONTINUITY OF CARE FOR MRS. M, 31 YEARS OLD, G1P0A0, 33/34 WEEKS GESTATION, SINGLE LIVE FETUS WITH BREECH PRESENTATION + GRADE 2 OBESITY + CPD + DISABILITY (SPEECH IMPAIRMENT) AT RSIA PURA RAHARJA SURABAYA CITY Permatasari, Ikke; Yuliatin, Nur Linda; Ningse, Tri Muliati
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1182

Abstract

Objective: This study aims to provide Continuity of Care (COC) midwifery services for pregnant, laboring, postpartum women, newborns, and family planning clients, ensuring comprehensive and sustainable care, particularly for cases with complex conditions. Method: A descriptive case study approach was employed, utilizing primary and secondary data collected through interviews, observations, examinations, and documentation reviews, analyzed according to midwifery care management. The case involved Mrs. M, a 31-year-old primigravida at 33/34 weeks of gestation with a breech presentation, grade 2 obesity, cephalopelvic disproportion (CPD), and speech impairment, conducted at RSIA Pura Raharja, Surabaya, starting December 9, 2024. Results: The implementation of COC midwifery care facilitated continuous monitoring and comprehensive management of Mrs. M's condition, improving maternal and fetal health outcomes while fostering trust and satisfaction in healthcare services. Novelty: This study highlights the integration of evidence-based midwifery care tailored for pregnant women with disabilities, emphasizing the role of COC in enhancing maternal and neonatal health while contributing to the reduction of maternal and infant mortality rates.
MIDWIFERY CARE CONTINUITY OF CARE (COC) MRS. B, 39 YEARS OLD, G4 P2012, 37/38 WEEKS OF GESTATION + IUFD NOTOPURO REGIONAL GENERAL HOSPITAL, SIDOARJO Agustini, Dwi; Makhina; Yusmayanti, Vilda
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1183

Abstract

Objective: This study aims to analyze the implementation of Continuity of Care (COC) midwifery care for Mrs. B, a 39-year-old woman (G4 P2012) at 37/38 weeks of gestation with Intrauterine Fetal Death (IUFD) at Notopuro Regional General Hospital, Sidoarjo. The study emphasizes holistic care addressing physical, psychological, social, and spiritual needs. Method: A descriptive case study approach was employed to provide an in-depth analysis of Mrs. B's condition. Data were collected through interviews, direct observations, and medical record reviews. The focus of care included pregnancy management, delivery, postpartum care, and psychosocial support. Results: The COC approach effectively facilitated comprehensive care for Mrs. B, integrating medical management of IUFD and psychosocial support to address emotional distress due to fetal loss and abandonment by her spouse. This care model promoted physical recovery and emotional resilience, contributing to Mrs. B's readiness for future reproductive health planning. Novelty: This study highlights the critical role of COC in managing IUFD cases by integrating continuous, patient-centered care that extends beyond physical treatment to encompass psychosocial recovery. The findings underscore the importance of personalized support systems for high-risk pregnancies to improve maternal health outcomes holistically.
CLINICAL COURSE OF ALCOHOLIC POLYNEUROPATHY AND ALCOHOLIC MYOPATHY OBSERVED IN ALCOHOLISM Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1185

Abstract

Objective: This article aims to explore the most prevalent neurological manifestations associated with alcoholism, including dysmetabolic encephalopathy, central pontine myelinolysis, demyelination of the corpus callosum, alcoholic polyneuropathy, and alcoholic myopathy. Methods: The study examines the potential therapeutic role of drugs containing succinate, focusing on their application in pathogenetic treatment approaches to address these neurological conditions. Results: Key findings indicate that succinate-containing drugs may offer significant benefits in mitigating the pathological effects of alcoholism on the nervous system by targeting specific mechanisms underlying these disorders. Novelty: The article provides novel insights into the therapeutic potential of succinate-based treatments, presenting an alternative strategy for addressing complex neurological disorders linked to chronic alcohol consumption.
CLINICAL PICTURES OF COGNITIVE DYSFUNCTIONS OBSERVED IN ALCOHOLISM Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1186

Abstract

Objective: To explore the complications of the nervous system associated with alcoholism and address the gaps in understanding the pathogenesis and effects of ethanol on neural and muscular systems. Methods: A comprehensive review of historical and recent studies on alcoholic lesions of the nervous system was conducted. This involved examining the extent of damage caused by ethanol exposure across various nervous system components and muscles, as well as analyzing the diverse pathogenetic mechanisms underlying these toxic effects. Results: Findings indicate that ethanol exposure results in widespread damage to nearly all parts of the nervous system and muscular structures. The toxic effects are attributed to a variety of pathogenetic mechanisms, which collectively contribute to the complex clinical manifestations of alcohol-induced neurological disorders. Novelty: This study underscores the multifaceted impact of ethanol toxicity, emphasizing the need for a deeper understanding of its pathogenetic mechanisms. It highlights areas where current knowledge is insufficient, paving the way for future research to better address and manage alcohol-related neurological complications.
PHARMACOEPIDEMIOLOGICAL BASIS FOR THE USE OF ANTIBACTERIAL DRUGS FOR COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN OF DIFFERENT AGES IN A MODERN INTERPRETATION Shakhlo Salokhitdinovna, Kodirova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1187

Abstract

Objective: This study addresses the urgent issue of rational antibiotic therapy for pneumonia, focusing on improving the effectiveness of treatment and minimizing negative consequences. Despite the availability of various antibacterial agents, pneumonia incidence and complications continue to rise. Methods: The study examines two main trends in antibiotic selection for pneumonia: 1) the use of selective drugs to ensure a rational and cost-effective approach, minimizing disruption to the patient's saprophytic flora, and reducing the risk of superinfection and immunosuppressive effects; 2) empirical prescription of broad-spectrum antibiotics. Results: Findings highlight the effectiveness of selective antibiotics in reducing adverse outcomes, while broad-spectrum antibiotics are commonly used in empirical treatments. However, overuse of broad-spectrum agents may lead to resistance and other complications. Novelty: The research emphasizes the importance of rational antibiotic selection, advocating for selective drugs over broad-spectrum antibiotics to reduce the risk of resistance, improve patient outcomes, and avoid unnecessary side effects. This approach proposes a more targeted and economical method of managing pneumonia, offering a potential solution to the rising incidence and worsening consequences.
DIAGNOSTIC EXAMINATION AND APPROACHES IN ADOLESCENTS WITH A HIGH RISK OF ALCOHOLISM Dilnoza Hamidullayevna, Xushvaktova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1188

Abstract

Objective: The aim of this study is to explore the efforts of public health professionals, including scientists, narcologist-practitioners, and teachers, in addressing the issues of alcoholism and drug addiction. This includes promoting medical and legal knowledge, as well as providing preventive and therapeutic measures. Methods: The study investigates the methods employed in the prevention of alcoholism and drug addiction, including public lectures, visual propaganda (posters, booklets, etc.), and media campaigns. It also explores the role of a specialized drug service that offers medical-preventive, medical-social, and medico-legal support to individuals affected by addiction. Results: The findings reveal that these methods contribute to raising awareness about addiction and its consequences. The media, both traditional and digital, plays a significant role in reaching a broader audience, while the drug service provides essential assistance in managing and treating addiction cases. Novelty: This study highlights the integrated approach involving education, public campaigns, and specialized medical services in addressing the complex issue of addiction. It emphasizes the importance of both preventive and therapeutic interventions in tackling alcoholism and drug dependency.
CLINICAL MANIFESTATIONS OF NEUROLOGICAL DISORDERS OBSERVED IN ALCOHOLISM Dilnoza Hamidullayevna, Xushvaktova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1189

Abstract

Objective: This study aims to explore the neurological characteristics in patients with alcohol dependence, emphasizing the impact of alcohol abuse on their social adaptation. Methods: A comprehensive analysis was conducted, focusing on patients with alcohol dependence, including detailed neurological assessments and behavioral observations. Data collection involved patient histories, clinical examinations, and standardized tests for neurological dysfunction. Results: The findings highlight a significant relationship between alcohol abuse and neurological impairments, including cognitive deficits, motor dysfunction, and mental health disturbances. These impairments are linked to the disruption of social functioning, contributing to challenges in social adaptation for these individuals. Novelty: This research presents a unique perspective on the neurological manifestations of alcohol dependence, focusing on the combined effect of ethanol's pharmacological activity and its influence on the nervous system. The study also sheds light on the broader societal implications, particularly regarding social adaptation challenges faced by patients.

Page 28 of 38 | Total Record : 372

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