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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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RISK FACTORS FOR THE DEVELOPMENT OF RENAL PATHOLOGY, CARDIOVASCULAR AND CEREBROVASCULAR SYSTEMS Malikaxon Mirxamzayevna, Mamurova; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1202

Abstract

Objective: This study aims to identify and analyze common risk factors contributing to the development of renal pathology, cardiovascular diseases, and cerebrovascular disorders, highlighting the interconnected pathophysiological mechanisms among these systems. Method: A comprehensive literature review and comparative analysis were conducted to examine the overlapping pathogenetic pathways and shared risk factors across renal, cardiovascular, and cerebrovascular conditions. The study synthesized data from peer-reviewed articles, clinical studies, and epidemiological reports to identify key mechanisms influencing disease progression. Results: The analysis revealed that risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, and chronic inflammation are common to all three systems, contributing to endothelial dysfunction, atherosclerosis, and impaired vascular regulation. These shared mechanisms underscore the parallel progression of pathology within the brain, heart, and kidneys, increasing the susceptibility to comorbid conditions. Novelty: This study provides new insights into the integrated pathophysiological processes linking renal, cardiovascular, and cerebrovascular diseases, emphasizing the need for holistic prevention strategies and multidisciplinary management approaches to address these interrelated health risks effectively.
MODERN METHODS OF DIAGNOSING AND TREATING NEUROLOGICAL CHANGES OBSERVED IN ALCOHOLISM Shuxrat Toshtemirovich, Niyozov; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1203

Abstract

Objective: This study aims to explore modern methods of diagnosing and treating neurological changes associated with alcoholism, with a focus on understanding the pathological mechanisms underlying alcohol dependence and its impact on the nervous system. Method: A systematic review of recent clinical studies, diagnostic criteria from DSM-5, and neuroimaging techniques was conducted to evaluate current diagnostic tools and therapeutic approaches. The analysis included neuropsychological assessments, biomarker identification, and pharmacological interventions targeting alcohol-induced neurological impairments. Results: Findings indicate that advanced neuroimaging techniques, such as MRI and PET scans, along with neurocognitive testing, are effective in detecting alcohol-related neurological damage. Pharmacological treatments, including the use of naltrexone, acamprosate, and disulfiram, combined with cognitive-behavioral therapy, show significant efficacy in managing alcohol cravings and mitigating neurological deterioration. Novelty: This study highlights the integration of neuroimaging biomarkers with personalized pharmacological and behavioral interventions as a novel approach for improving diagnostic accuracy and treatment outcomes in patients with alcohol-related neurological changes.
CLINICAL AND DYNAMIC CHARACTERISTICS IN THE COMORBID COURSE OF ALCOHOL DEPENDENCE AND AFFECTIVE DISORDERS Vitaly Sergeevich, Sedenkov; Shoxrux Xabibullayevich, Sultanov; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1204

Abstract

Objective: This study aims to investigate the clinical and dynamic characteristics of the comorbid course of alcohol dependence and affective disorders, focusing on the relationship between harmful alcohol consumption and mental health conditions such as anxiety, depression, self-harm, and suicidal behavior. Method: An evidence-based review was conducted, analyzing data from clinical studies, epidemiological reports, and psychiatric assessments to explore the associations between alcohol dependence and affective disorders. The review included comparative analyses of patient histories, diagnostic criteria, and treatment outcomes. Results: The findings indicate a strong correlation between harmful alcohol use and the prevalence of affective disorders, with alcohol dependence significantly increasing the risk of anxiety, depressive symptoms, and suicidal tendencies. However, the causal pathways underlying these associations remain complex and multifactorial, influenced by genetic, neurobiological, and psychosocial factors. Novelty: This study highlights the critical need for integrated treatment models that address both alcohol dependence and co-occurring affective disorders, offering new insights into the development of comprehensive therapeutic strategies aimed at improving mental health outcomes in individuals with dual diagnoses.
CHARACTERISTIC FEATURES OF THE COMORBID COURSE OF ALCOHOLISM AND SCHIZOAFFECTIVE DISORDERS Vitaly Sergeevich, Sedenkov; Shoxrux Xabibullayevich, Sultanov; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1205

Abstract

Objective: This study aims to investigate the characteristic features of the comorbid course of alcoholism and schizoaffective disorders, focusing on the interplay between neurobiological mechanisms and clinical outcomes in patients with dual diagnoses. Method: A comprehensive review of clinical data and neurobiological studies was conducted, analyzing treatment approaches and the convergence of pathophysiological processes in patients with co-occurring alcohol dependence and schizoaffective disorders. Particular attention was given to the role of the dynorphin kappa-opioid system as a modulator of mesocorticolimbic dopaminergic system activity, which is implicated in both mental disorders and substance addiction. Results: The findings indicate that comorbid patients exhibit more severe clinical symptoms, poorer prognoses, and reduced treatment efficacy compared to individuals with singular diagnoses. The dysregulation of the dynorphin kappa-opioid system contributes to the exacerbation of both psychotic and addictive symptoms, complicating therapeutic interventions. Novelty: This study highlights the critical role of the dynorphin kappa-opioid system as a universal modulator in the pathogenesis of schizoaffective disorders and alcoholism, emphasizing the need for integrated treatment strategies that target both neurobiological and clinical dimensions of comorbidity.
THE ORIGIN, DIAGNOSIS AND MODERN CLINICAL DIAGNOSTIC METHODS OF MYOCARDIAL INFARCTION Lenura Madjidovna, Appazova; Dil'shod Firdavsovna, Shaymatova; Oyjamol Narzullayevna, Uzoqova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1206

Abstract

Objective: This study aims to explore the origin, diagnosis, and modern clinical diagnostic methods of myocardial infarction, a critical condition caused by the disruption of blood supply to the heart muscle. Method: A comprehensive review of current literature and clinical guidelines was conducted, focusing on the pathophysiological mechanisms, diagnostic criteria, and advancements in diagnostic technologies. The study analyzed data from clinical trials, imaging techniques, and biomarker evaluations to assess the effectiveness of contemporary diagnostic approaches. Results: The findings indicate that myocardial infarction predominantly results from coronary artery occlusion, leading to ischemia and necrosis of the myocardial tissue. Diagnostic advancements include high-sensitivity cardiac troponin assays, electrocardiography (ECG), echocardiography, and coronary angiography, which have significantly improved early detection and risk stratification. Additionally, non-invasive imaging modalities such as cardiac MRI and CT angiography enhance diagnostic accuracy. Novelty: This study highlights the integration of novel biomarkers with advanced imaging techniques as a transformative approach in the early diagnosis and management of myocardial infarction, offering new insights into improving patient outcomes through rapid and precise clinical assessment.
MODERN APPROACHES TO THE DEVELOPMENT AND USE OF BIOCOMPATIBLE IMPLANTS: MATERIALS, TECHNOLOGIES AND PROSPECTS Farkhodjon Khusenovich, Mamatkulov
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1207

Abstract

Objective: This study aims to evaluate the osseointegration potential of stainless steel implants manufactured using additive technologies for tibial prosthetics in rabbits, focusing on mechanical stability and bone-implant integration. Method: The experimental study was conducted on six chinchilla rabbits aged 6–8 months. Under general anesthesia, each rabbit underwent leg amputation followed by the implantation of a screw-type stainless steel implant produced through additive manufacturing. The implants were stabilized using the Ilizarov apparatus for six weeks. Clinical assessments, radiological imaging, and histological analyses were performed to evaluate the extent of osseointegration. Results: The findings demonstrate that the screw-type implant structure successfully osseointegrated into the tubular bone, with significant new bone tissue formation observed on the implant surface after 12 weeks. This bone-implant integration formed a stable bone-implant block capable of withstanding mechanical stress, confirming the implant's mechanical stability within the bone. Novelty: This study highlights the promising potential of additive manufacturing technologies in producing biocompatible implants with enhanced osseointegration capabilities, paving the way for more effective and durable orthopedic prosthetics.
ASSESSMENT OF THE QUALITY OF LIFE OF PATIENTS WITH DIFFUSE TOXIC GOITER AGAINST THE BACKGROUND OF DRUG THERAPY AND SURGICAL TREATMENT D.A, Urunbayeva; D.T, Umarova; A.E, Bashirova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1208

Abstract

Objective: This study aims to evaluate the quality of life in patients with diffuse toxic goiter (DTG) undergoing drug therapy and surgical treatment. It also seeks to identify key predictors of complications associated with DTG. Methods: The study involved patients diagnosed with DTG, assessing the prevalence of subclinical and manifest thyrotoxicosis. The analysis focused on the impact of disease duration on complications such as thyrotoxic heart disease, endocrine ophthalmopathy, and toxic hepatitis. Additionally, the quality of life was compared between patients receiving thyroidectomy and those undergoing drug therapy with thyreostatics. Results: Findings indicate that DTG is more prevalent in women than men. Among the patients, subclinical thyrotoxicosis accounted for 66.7%, while manifest thyrotoxicosis was 33.3%. Disease duration was a critical factor in the progression of complications. Patients who underwent timely thyroidectomy exhibited better quality of life outcomes. Physical functioning improved by 23%, while emotional functioning, mental health, and social functioning increased by 40.7%, 22.5%, and 30.7%, respectively, compared to those receiving drug therapy. Novelty: This study highlights the significant role of thyroidectomy in improving the quality of life for DTG patients compared to drug therapy. It also emphasizes the predictive value of disease duration in the development of DTG-related complications, contributing to better clinical decision-making.
RATIONAL THERAPY OF HYPERACID GASTRITIS IN PREGNANT WOMEN Z.M, Usmonova; Oʻgʻli, Rizayev Eldor Sayfulla
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1212

Abstract

Objective: The objective of this study is to investigate the causes, diagnostic methods, and treatment strategies for gastritis with high acidity, focusing on its clinical manifestation, diagnosis, and management. Methods: This study uses clinical and instrumental methods for diagnosing gastritis with high acidity, including FEGDS with a pH meter of gastric juice, biopsy of the mucosa, and Helicobacter pylori infection testing. Various treatment approaches, such as dietary modifications, antacids, proton pump inhibitors, gastroprotectors, and antibacterial therapy, are also explored. Results: The results highlight the effectiveness of combining diet modifications, antacids, proton pump inhibitors, and gastroprotectors in managing symptoms of gastritis with high acidity. Additionally, the study emphasizes the importance of detecting and treating Helicobacter pylori infection to prevent further complications. Novelty: This study presents a comprehensive approach to the diagnosis and treatment of gastritis with high acidity, integrating clinical findings with effective management techniques, including the role of sanatorium-resort treatment and physiotherapy during remission periods.
MODERN SOLUTIONS FOR THE USE OF ANTICOAGULANTS IN MYOCARDIAL INFARCTION AND ARRHYTHMIAS H.N, Turayev; Kholmurodovich, Khurramov Bobir
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1213

Abstract

Objective: This study aims to explore the causes, symptoms, diagnostic methods, and treatment strategies for acute myocardial infarction (AMI), focusing on the role of coronary artery obstruction in its development and the available therapeutic options. Methods: Diagnosis of AMI is based on electrocardiography (ECG) and biomarker analysis. Treatment protocols include the administration of antiplatelet agents, anticoagulants, nitrates, beta-blockers, statins, and various reperfusion therapies. The study also examines the use of fibrinolytic drugs, percutaneous interventions, and coronary artery bypass grafting (CABG) in different types of AMI. Results: Acute myocardial infarction presents with symptoms such as shortness of breath, nausea, chest discomfort, and sweating. Diagnosis is confirmed through ECG readings and biomarker testing. Effective treatment varies based on the severity and type of AMI, with reperfusion therapy being critical for ST-segment elevation myocardial infarction (STEMI), while non-ST-segment elevation myocardial infarction (NSTEMI) may require percutaneous intervention or CABG. Novelty: This study contributes to understanding the nuanced diagnostic and therapeutic approaches to AMI, particularly in differentiating treatment strategies for STEMI and NSTEMI, highlighting the importance of timely and appropriate interventions for improving patient outcomes.
CLINICAL-NEUROPHYSIOLOGICAL AND MORPHOLOGICAL STUDIES OF CHILDREN WITH CONSEQUENCES OF HYPOXIC Saidovich, Ergashev Suxrob; Mirxamzayevna, Mamurova Mavludaxon; Temirpulotovich, Turayev Bobir
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1214

Abstract

Objective: The problem of perinatal brain injury of hypoxic-ischemic genesis remains a critical issue, with a focus on its high mortality rates, significant disability, and impact on neuropsychic and somatic development in children. These injuries lead to difficulties in social adaptation, diagnosis, and treatment. Methods: The study aims to explore current therapeutic measures applied to children with perinatal hypoxic-ischemic damage to the central nervous system (CNS), evaluating their effectiveness in addressing these challenges. Various medical and social factors are examined to understand the limitations in the treatment of such conditions. Results: It is found that the existing therapeutic interventions for children suffering from perinatal hypoxic-ischemic CNS damage are not always sufficiently effective. The analysis highlights the need for better approaches to diagnosis, treatment, and overall care to improve the quality of life and development for affected children. Novelty: This study contributes new insights into the current state of perinatal brain injury treatment and diagnosis, emphasizing the importance of developing more effective therapeutic strategies to combat the long-term effects of hypoxic-ischemic damage in children. The findings suggest areas for further research to address these challenges comprehensively.

Page 30 of 38 | Total Record : 372

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