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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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EVALUATION OF THE EFFECT OF FLAVONOIDS ISOLATED FROM SILYBUM MARIANUM ON LYMPHOCYTES OF ADULT FEMALE RATS AND THEIR FETUSES (MTT ASSAY) Saleh, Ahmed Hamad
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 12 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i12.1507

Abstract

Objective: This study aimed to evaluate the effects of flavonoids isolated from Silybum marianum (milk thistle) on the lymphocytes of adult female rats and their fetuses, focusing on cytotoxicity and compound characterization. Method: Fresh leaves collected from Sulaymaniyah, Iraq, in January 2025 were subjected to flavonoid extraction and analyzed using High Performance Liquid Chromatography (HPLC) and Fourier Transform Infrared Spectroscopy (FT-IR) to identify phenolic compounds. Lymphocytes were isolated from rat blood samples via density gradient sedimentation, and MTT assays were performed to assess cell viability at different extract concentrations (25, 50, and 100 μg/ml). Results: HPLC analysis identified several flavonoids, with 4-hydroxyl benzoic acid (282.5 ppm) and catechol (233.1 ppm) being the most abundant. Cytotoxicity tests showed high lymphocyte viability for both adult females (92.34–81.35%) and fetuses (91.92–81.7%), with IC₅₀ values of 324.9 μg/ml and 347.3 μg/ml, respectively. Novelty: The study demonstrates that S. marianum leaf extracts are rich in bioactive flavonoids with low cytotoxic effects on lymphocytes, suggesting potential for safe therapeutic use in antioxidant or protective applications.
THOROUGH BIOINFORMATICS EXAMINATION REVEALS NOC4L AS A PROGNOSTIC INDICATOR IN LUNG ADENOCARCINOMA A-Zaalan , Ayoob Radhi
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 12 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i12.1498

Abstract

Objective: This study systematically investigates the prognostic significance of nucleolar complex-associated protein 4 homolog (NOC4L) in lung adenocarcinoma (LUAD) and explores its associations with clinicopathological parameters, immune microenvironment components, and molecular pathways. Method: A bioinformatics-based approach was applied using publicly available databases including Kaplan–Meier Plotter, GEPIA2, UALCAN, and TIMER2.0. Survival analyses encompassed overall survival (OS), disease-free survival (DFS), first progression survival (FPS), and post-progression survival (PPS). Correlations with tumor stage, nodal metastasis, histological subtypes, tumor-infiltrating immune cells, and p53 pathway genes were evaluated. Results: High NOC4L expression was consistently associated with poor prognosis across all survival indicators and correlated with advanced tumor stage, nodal metastasis, and aggressive histological forms. Elevated NOC4L expression showed positive correlations with immunosuppressive cells such as myeloid-derived suppressor cells and cancer-associated fibroblasts, and negative correlations with cytotoxic CD8⁺ T cells. Novelty: This study identifies NOC4L as a potential prognostic biomarker in LUAD, linking its overexpression to immune suppression and tumor aggressiveness, thereby suggesting its role in cancer progression and its potential as a therapeutic target.
SALINITY AGRICULTURAL PROBLEM IN AGRICULTURAL LANDS Fattah, Mahdi Fahmi; Nawkhas, Burhan Nareeman
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1584

Abstract

Objective: This study aims to address the increasing challenge of soil salinity as a critical barrier to sustainable agricultural production, emphasizing the essential roles of soil and water quality in maintaining productivity. Method: The research employs a descriptive and analytical approach, examining the causes of soil salinization in dry and semi-arid regions by differentiating between natural and human-induced factors, including improper irrigation practices, poor drainage, and excessive fertilizer use. Results: The findings indicate that the persistent use of low-quality irrigation water due to water scarcity and pollution accelerates salinity accumulation in agricultural soils, leading to a significant decline in soil fertility and crop yield. The study highlights that effective mitigation requires leaching techniques, improved irrigation management, and the cultivation of salt-tolerant crops. Novelty: This article provides an integrative perspective that combines ecological and agronomic factors, offering practical strategies to rehabilitate saline soils and promote sustainable agriculture, especially in regions facing increasing water stress due to climate change.
THE RELATIONSHIP BETWEEN GUT MICROBIOME ALTERATIONS AND HEPATOCELLULAR CARCINOMA DEVELOPMENT IN CHRONIC HEPATITIS B PATIENTS: A CLINICAL AND MICROBIOLOGICAL STUDY FROM IRAQ Obeed, Ameer Najy
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 12 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i12.1587

Abstract

Objective: To investigate the relationship between gut microbiome composition and the development of HCC in Iraqi patients with chronic HBV infection. Method: A cross-sectional case-control study was conducted involving 150 participants divided into three groups: HBV with HCC (n=60), HBV without HCC (n=60), and healthy controls (n=30). Clinical, biochemical, and microbiome data (16S rRNA sequencing of fecal samples) were collected. Statistical analyses included ANOVA, chi-square, and Pearson correlation.  Results:  Patients with HCC exhibited significant dysbiosis, characterized by decreased microbial diversity (Shannon index: 2.8 ± 0.4) compared to HBV-only (3.6 ± 0.5) and controls (4.1 ± 0.3), p<0.001. Increased abundance of Bacteroides fragilis and Enterobacteriaceae correlated with higher AFP levels (r=0.63, p<0.001).  Novelty: Gut microbiome alterations are associated with HCC development in chronic HBV patients. These findings suggest potential microbiome-based biomarkers for early detection and therapeutic strategies.
GENETIC MUTATIONS IN INFLUENZA VIRUS AND THEIR IMPACT ON ANTIVIRAL TREATMENTS: A THEORETICAL ANALYSIS Obeed, Ameer Najy; Aziz, Zainab Nadhum; Al-Waeli, Jaafar Hamid Jaafar
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1589

Abstract

Objective: This study synthesizes recent evidence (2020–2025) to evaluate key influenza virus mutations associated with resistance to neuraminidase inhibitors (oseltamivir, zanamivir) and cap-dependent endonuclease inhibitors (baloxavir), and to assess their implications for antiviral efficacy. Method: A structured literature analysis was conducted by integrating global surveillance reports and peer-reviewed studies, summarizing mutation frequencies and resistance patterns, supported by descriptive statistical tabulation and simulated trend visualization. Results: The findings indicate that canonical neuraminidase resistance mutations such as H275Y, R292K, and N295S remain rare, generally occurring at <1% prevalence across most surveillance datasets, although localized increases in PA-I38 substitutions associated with reduced baloxavir susceptibility have emerged in specific regions. The theoretical impact assessment suggests that resistance-linked mutations primarily reduce clinical effectiveness in post-treatment isolates and in severe or immunocompromised cases. Novelty: This work provides an updated synthesis of post-pandemic influenza antiviral resistance trends and highlights the growing relevance of PA-I38 variants, underscoring the need for continuous genomic surveillance and the development of next-generation antiviral strategies that target highly conserved viral functions.
METABOLIC REMODELING AFTER BARIATRIC SURGERY IN IRAQ: BIOMARKER-LINKED OUTCOMES STRATIFIED BY NAFLD SEVERITY AND METABOLIC SYNDROME AT 3 YEARS Melek, Hassan Khalil
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1590

Abstract

Objective: To complete 3 year prospective assessment of clinical and molecular outcomes after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in Iraqi patients, respectively, with the express links between the weight loss curves, comorbidity improvement, and the serial profiling of the major metabolic biomarkers. Method: The present study was a multicenter prospective cohort study carried out between January 2020 and December 2023 in the Al-Zahraa and Al-Karama Teaching Hospitals in Wasit, Iraq. The number of patients (RYGB: n=120; SG: n=120) followed in the 36 months was 240. Primary outcomes: percent excess weight loss (%EWL), type 2 diabetes mellitus (T2DM; HbA1c <6.5% off medication) remission and improvement of non-alcoholic fatty liver disease (NAFLD) (improvement in CAP score at least 30% by FibroScan). Secondary outcomes: postoperative complications (Clavien-Dindo classification) and preoperative and 12 and 36 months serial quantification of biomarkers: leptin, total ghrelin, adiponectin, active GLP-1, HOMA-IR, and QUICKI. Statistical methods were done in SPSS v28 and R v4.3 with multivariate logistic regression and Pearson correlation. Results:  RYGB showed much better percent EWL (77.1% +12.8 vs. 68.3% +14.5; p=0.004), T2DM remission (81.2 vs. 67.5; p=0.025), and NAFLD improvement (85.0 vs. 71.7; p=0.015) at 36 months. Biomarker examination showed that RYGB led to much more pronounced leptin (': -34.5 vs. -27.6 ng/mL; p=0.005) and adiponectin (': +5.5 vs. +3.4 0g/mL; p=0.003) and active GLP-1 (': +17.8 vs. +9.1 pmol/L; p<0.001) decreases. The remission of T2DM was independently predicted by preoperative adiponectin >5 μg/mL (OR 2.9, 95% CI 1.366.1; p=0.007). RYGB offered more absolute metabolic benefit to patients with baseline MetS + (n=165). Patients who have severe NAFLD (CAP ≥310 dB/m) had a much greater improvement using RYGB compared to SG (62.9% vs. 40.5%; p=0.04). An index of composite adiponectin/HOMA-IR above 0.75 was a predictor of 90% remission following RYGB (AUC 0.86). Significant complications (Clavien-Dindo ≥III) were equal (RYGB 8.3% vs. SG 5.8%; p=0.45). Novelty: This is the inaugural Iraqi investigation to correlate length of surgical results with sequence serially of biomarkers to propose, albeit the constraints of its observational design, a platform of biomarker-managed, customized metabolic surgery in the area.
THE PSYCHOLOGICAL DISTRESS AMONG PATIENTS WITH CORONAVIRUS AFTER RECOVERING Fatlawi, Duaa
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1595

Abstract

Objective: The Psychological Distress among Patients with Coronavirus after Recovering. Due to that public health emergencies resulting from COVID-19 are negatively impacting the mental health of the population affected by COVID pandemic. Method: A descriptive – analytic study Online sample that selected from Al Najaf Governorate from January 15th2021 through July 1st2021. Participants were invited to complete the GHQ-28 scale during the quarantine period. Results: A total of n = 199 surveys completed by patients with coronavirus. (53.77 %) of them have moderate levels according to the total score of 28-GH scale. And no significant relationship between demographic data and total 28-GH assessment. Novelty: The COVID-19 quarantine was associated with stresses and significant increases in symptoms of depression, anxiety, and stress in patients with coronavirus. The patients require increased access to mental health services to meet this increase in COVID-19-related psychological distress.
HOST-PARASITE GENOMIC INTERACTIONS IN LEISHMANIASIS: EMERGING DIAGNOSTIC BIOMARKERS AND PREDICTIVE GENE SIGNATURES Abbas, Zainab Khamees; Al Alouci, Muntaha Maddah; Mohsein , Osama A
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1598

Abstract

Objective: This review aims to explore the genetic underpinnings of Leishmaniasis, focusing on host-parasite genomic interactions and their implications for diagnostics, treatment, and control. Method: The study synthesizes recent advancements in host-parasite genomics, highlighting genetic polymorphisms in the host's immune response and parasite-mediated virulence determinants, identified through high-throughput sequencing and multi-omics analyses. Results: Key findings include the identification of genetic markers associated with immune responses and disease severity, as well as parasite traits influencing tissue tropism and survival. Co-regulated gene networks have been revealed, underscoring the dynamic interplay between host immunity and parasite adaptability. Novelty: The review identifies the potential for genomic biomarkers to differentiate asymptomatic carriers from active cases, predict treatment failure, and enable personalized treatment strategies. Furthermore, it discusses the prospects of genomic insights in developing targeted vaccines and enhancing control programs for leishmaniasis. This work contributes to precision medicine and the future control of leishmaniasis through the application of genomic biomarkers.
RESPIRATORY ADENOVIRUS INFECTIONS IN IRAQ (2020–2025): EPIDEMIOLOGICAL AND MOLECULAR OVERVIEW Obeed, Ameer Najy; Wetwet, Nadhema Bahaa; Kareem, Baneen Maan
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1599

Abstract

Objective: This study provides an updated assessment of respiratory adenovirus infections in Iraq from 2020 to 2025 by examining national trends in incidence, demographic distribution, and circulating viral strains. Method: Data were collected from multiple medical centers and health institutions across Iraq, and patient samples were analyzed using molecular diagnostic techniques, including PCR-based detection and genotyping, to identify prevalent adenovirus types. Epidemiological indicators were evaluated to determine infection patterns among different age groups. Results: The findings reveal a gradual increase in reported respiratory adenovirus cases over the study period, with the highest incidence occurring among young children and older adults. Molecular analysis identified human adenovirus types 3, 7, and 14 as the most frequently detected variants, reflecting their continued circulation and clinical relevance. Novelty: This research provides one of the most recent national overviews of adenovirus activity in Iraq, integrating multicenter epidemiological data with molecular characterization to highlight emerging trends and strain distribution, underscoring the need for strengthened surveillance and expanded diagnostic capacity.
PREVALENCE OF ENTEROBIUS VERMICULARIS (PINWORM) AMONG PRIMARY SCHOOL BOYS IN SELECTED VILLAGES OF MISAN GOVERNORATE, SOUTHERN IRAQ Abul-Doanej, Hasan Azaati Ibadi
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1600

Abstract

Objective: This study aimed to determine the prevalence of Enterobius vermicularis (pinworm) infection among male primary school pupils in selected rural villages in Misan Governorate, Iraq, and to examine age-related infection patterns as well as the health and environmental factors contributing to its transmission. Method: A total of 384 schoolchildren aged 7–13 years were surveyed between 25 February and 30 April 2025. Stool samples were collected and examined using the wet-mount normal saline technique to detect intestinal parasites, with a specific focus on E. vermicularis. Results: Parasitological analysis identified 43 infections (11.2%), including 26 cases of E. vermicularis (6.77%), 8 cases of Entamoeba histolytica (2.08%), and 9 cases of Giardia lamblia (2.34%), with no mixed infections recorded. The highest prevalence of E. vermicularis occurred among 7-year-olds (42.9%), while the lowest (3%) appeared in the 11–12 age groups. Infection rates decreased progressively with age, except for a slight increase at age 13 (9%), with differences statistically significant (P ≤ 0.05). Novelty: This study provides updated epidemiological evidence from understudied rural communities in Misan Governorate, emphasizing the continuing public health burden of enterobiasis and the need for targeted hygiene-focused interventions.

Page 37 of 38 | Total Record : 372

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