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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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IMPACT OF INFECTION BY H. PYLORI ON GASTRIC PARIETAL CELL PHYSIOLOGY: REVIEW Bakheet NZ, Noor Zuhair
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 10 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i10.1407

Abstract

Objective: This review aims to highlight the strategies used by Helicobacter pylori to influence the physiology of gastric parietal cells, affecting gastric acid secretion, epithelial elasticity, and the development of various gastric diseases. Method: The study reviews existing literature on Helicobacter pylori infection and its impact on gastric parietal cells, including mechanisms of colonization, inflammatory response, and physiological effects on the stomach and duodenum. Results: Helicobacter pylori infection can significantly affect parietal cells, which are essential for gastric acid production. Upon Helicobacter pylori infection, inflammatory cells replace normal glandular cells, leading to hypo- or hyperchloremia, based on the colonization site in the stomach. Chronic colonization of the gastric lumen promotes hyperacidity and duodenal ulcers, while hypoacidity resulting from long-term Helicobacter pylori infection of the gastric corpuscle and fundus increases the risk of gastric cancer and may damage these cells, gastric atrophy, and other complications. Novelty: In summary, Helicobacter pylori infection has a complex and multifaceted effect on the physiology of gastric parietal cells, affecting acid secretion, epithelial cell elasticity, and the development of various gastric diseases.
LITERATURE REVIEW: PHYSIOTHERAPY MANAGEMENT IN THE CASE OF PLANTAR FASCIITIS Anjasmara, Bagas
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 9 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i9.1408

Abstract

Objective: This study aims to review and summarize secondary data related to the management of plantar fasciitis injuries through a physiotherapy approach. Method: This study uses a literature review method, by collecting and analyzing scientific journals relevant to the topic of plantar fasciitis. Data sources were obtained from several academic databases such as Google Scholar, ScienceDirect, and PubMed. Results: From the review of several journals, it is known that patients with plantar fasciitis injuries can be given several physiotherapy interventions in the form of modalities and physical exercise tailored to the clinical symptoms experienced. Novelty: Based on the literature review, physiotherapy interventions such as Extracorporeal Shockwave Therapy (ESWT), ultrasound therapy, stretching exercises, and Active Release Technique (ART) are proven effective in reducing pain and improving the range of motion (ROM) in people with plantar fasciitis.
IMMUNOLOGICAL INVESTIGATION OF TORQUE TENO VIRUS AMONG BLOOD DONORS IN MOSUL CITY, IRAQ Anwer, Noor Sabah; Al-Taii, Hiyam Adil; Al-Taie , Anmar A.
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 10 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i10.1413

Abstract

Objective: This study aimed to detect Torque Teno virus antigens using the ELISA technique and to evaluate the immune status by measuring the levels of inflammatory cytokines, namely Tumor Necrosis Factor (TNF) and Interleukin-10 (IL-10). Method: This study was conducted on 150 blood samples collected from blood donors at the main blood bank in Mosul, Iraq. The study used an enzyme-linked immunosorbent assay (ELISA) to detect viral antigens. The immune response was assessed by measuring the levels of tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10).  Results: the ELISA test results revealed a low prevalence of TTV antigen (9.33%), with the highest rates recorded among the oldest age group (34–41 years) at 4.67%. Novelty: The results revealed the presence of immune regulatory dysfunction in this group of patients, as they exhibited signs of both immune activation and suppression simultaneously. This underscores the importance of continuous immunological monitoring for this category of patients.
GENES RESPONSIBLE FOR HEAVY METAL BIOACCUMULATION IN FUNGI ASPERGILLUS Badr, Sanaa Qasem
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 10 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i10.1417

Abstract

Objective: Heavy metal contamination, particularly with cadmium (Cd²⁺), lead (Pb²⁺), and arsenic (As³⁺/As⁵⁺), represents a critical environmental and health concern due to their toxicity and persistence. Microorganisms such as Aspergillus species have demonstrated significant potential for bioremediation, primarily through complex genetic and biochemical mechanisms. This study synthesizes existing literature to examine the molecular basis of heavy metal tolerance and bioaccumulation in Aspergillus. Method: This study synthesizes existing literature to examine the molecular basis of heavy metal tolerance and bioaccumulation in Aspergillus. Results: The findings highlight multiple defense strategies, including cadmium detoxification via glutathione biosynthesis genes (GSH1, GSH2), phytochelatin synthase (PCS), and vacuolar sequestration mediated by CDF transporters (CrpA, ZRC1, COT1). Lead bioaccumulation involves structural binding to cell wall polymers such as chitin, glucans, and melanin, complemented by transporter genes (CrpA, YCF1, ABC transporters) and intracellular chelation through glutathione and metallothioneins. Arsenic tolerance relies on aquaglyceroporin channels (Fps1), efflux transporters (Acr3), and arsenate reductase (ArsC), which enable reduction and detoxification, alongside phytochelatin-mediated sequestration. Across all metals, oxidative stress is mitigated by antioxidant defense genes, including SOD, CAT, and TRX, while Yap1-like transcription factors coordinate regulatory responses. Novelty: The integration of adsorption, chelation, transport, and oxidative stress defense establishes Aspergillus as a versatile and resilient organism capable of surviving in heavy metal-polluted environments. These findings underscore the potential application of Aspergillus in bioremediation strategies targeting multi-metal contamination.
TYPES OF EXTRACELLULAR ENZYMES SECRETED BY FUNGI Badr, Sanaa Qasem
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 11 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i11.1418

Abstract

Objective: This study aims to review the diversity and significance of extracellular enzymes secreted by fungi, with a focus on their ecological functions and industrial applications. Method: A literature-based analysis was conducted, summarizing the main categories of fungal enzymes, including cellulases, ligninases, proteases, lipases, and pectinases, as well as their associated roles in both natural and applied contexts. Results: The findings highlight that fungal extracellular enzymes play essential roles in breaking down complex organic materials, thereby facilitating nutrient cycling, decomposition, and ecosystem balance. Industrially, these enzymes are widely applied in biofuel production, bioremediation, food processing, pharmaceuticals, and textiles, demonstrating their versatility and economic value. Novelty: This review integrates ecological and industrial perspectives, emphasizing the dual importance of fungal enzymes as natural mediators of biodegradation and as key biocatalysts driving sustainable innovations in biotechnology and environmental management.
REVIEW OF ISOLATION OF FUNGI FROM SHRIMPS Badr, Sanaa Qasem
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 11 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i11.1419

Abstract

Objective: This study aims to review the current knowledge on the isolation of fungi from shrimps, focusing on their ecological roles, pathogenic potential, and biotechnological applications. Method: A systematic review of previous studies was conducted, highlighting both direct isolation techniques, such as surface sterilization, agar plate, and dilution methods, and indirect approaches, including molecular identification and metagenomics. Results: The findings reveal a wide diversity of fungal genera, such as Aspergillus, Penicillium, Fusarium, Candida, and Cryptococcus, associated with shrimps, with implications for food safety, aquaculture health, and nutrient cycling in marine ecosystems. Several fungi were also identified as potential producers of bioactive compounds with antimicrobial and anticancer properties. Novelty: This review synthesizes traditional and modern approaches to fungal isolation in shrimp, bridging ecological insights with biotechnological potential, while emphasizing the urgent need for further research to address ecological risks and harness the benefits of marine-derived fungi in aquaculture and biotechnology.
EXPLORING IRAQI NURSES’ KNOWLEDGE TOWARD INFECTION CONTROL IN BURNING CENTER Kadhim, Jihad Jawad
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 10 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i10.1420

Abstract

Objective: The study aimed to assess knowledge level among nurses regarding infection control in burn units and to find out the relationship between nurses’ knowledge and their sociodemographic data. Method: A descriptive cross-sectional study was conducted from November 1st, 2023, until April 1st, 2024, involving a non-probability purposeful sample of 70 nurses working at the Burns Center in Najaf and Al-Sadr Teaching Hospital. Result: The findings indicated that the majority of nurses demonstrated a good knowledge level regarding infection control, with nurses’ educational level and the availability of protocols showing a statistically significant relationship with their knowledge. Novelty: This study highlights the critical role of nurses’ educational background and institutional support in shaping infection control practices in burn units, emphasizing the need for continuing education, larger-scale research across wider regions, and the use of mass media by the Ministry of Health to strengthen infection control knowledge among nursing staff.
MUCORMYCOSIS (BLACK FUNGUS): INTERPLAY BETWEEN IMMUNOSUPPRESSION, DIABETES MELLITUS, AND GENETIC SUSCEPTIBILITY: A REVIEW Al-Rhman, Rand Manaf Abd; Mahmood, Marwa Shaker; Turky, Hala Ali
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 10 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i10.1421

Abstract

Objective: Moulds called mucormycetes are the source of the uncommon but dangerous fungal infection known as mucormycosis, or zygomycosis. Method: Immunocompromised people, such as those with untreated diabetes, haematologic malignancies, and immunological dysregulation brought on by COVID-19, are the main victims. Results: Rapid progression, angioinvasion, tissue necrosis, and a high death rate if left untreated are the disease's hallmarks. Novelty: This study highlights the emerging association of mucormycosis with COVID-19-induced immunological dysregulation, emphasizing its significance in recent patient populations and the urgent need for clinical awareness.
EFFECT OF ADDING DIFFERENT LEVELS OF FLAXSEED OIL TO DIETS ON EJACULATE VOLUME AND SPERM CONCENTRATION IN SEMEN IN OSTRICHES Ali, Nashwan Majeed
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 11 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i11.1422

Abstract

Objective: This study aimed to investigate the impact of dietary supplementation with flaxseed oil on the morphological characteristics of semen in male ostriches. Method: The experiment was conducted at the Babylon Reserve for Ostrich, Falcon, and Deer Breeding, Babylon Province, Iraq, using 27 sexually mature ostriches divided into three treatment groups with three replicates each, organized under a family-based system (two females and one male per replicate). Birds were housed in specialized pens, with males separated from females from the beginning of the trial, and all were provided a standardized diet containing 17.34% crude protein and 2740.56 kcal/kg metabolizable energy. Treatments included a control diet and diets supplemented with 1% or 2% flaxseed oil. Semen traits assessed included ejaculate volume, sperm concentration, and packed sperm volume. Results: Supplementation with flaxseed oil at both inclusion levels led to statistically significant and highly significant improvements in most evaluated semen parameters compared with the control. Novelty: These findings provide new evidence that flaxseed oil, as a rich source of Omega-3 fatty acids, can enhance reproductive performance in male ostriches, offering a natural nutritional strategy to improve fertility and productivity in ostrich farming systems.
EFFECT OF ADDING DIFFERENT LEVELS OF RAW POWDERED MULBERRY AND ARTICHOKE LEAVES, AND THEIR COMBINATION, ON LIVER ENZYMES AND CERTAIN OXIDATIVE STRESS MARKERS IN LAYING HENS EXPOSED TO HEAT STRESS Ali, Nashwan Majeed
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 11 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i11.1423

Abstract

Objective: This study aimed to investigate the biological effects of dietary supplementation with mulberry and artichoke leaves on mitigating the negative impacts of heat stress in laying hens. Method: A total of 144 Lohmann Brown laying hens were randomly assigned to six dietary treatments (24 hens per treatment, three replicates of eight hens each). The treatments consisted of a basal diet supplemented with artichoke leaf powder, mulberry leaf powder, or their combination at inclusion levels of 0, 1, 1.5, 1, 1.5, and 1.5+1.5 g/kg of feed, respectively. The trial lasted four months, during which blood samples were collected biweekly from each replicate, and monthly averages were analyzed to evaluate liver enzyme activities (AST, ALT, ALP) and oxidative stress markers (MDA, SOD). Results: The findings revealed that dietary supplementation with mulberry and artichoke leaves, individually or in combination, significantly alleviated the adverse effects of heat stress, as reflected by improved oxidative status and more favorable liver enzyme activity. Novelty: This study highlights the functional potential of natural plant-based additives, such as mulberry and artichoke leaves, as sustainable nutritional strategies to enhance resilience and maintain performance of laying hens under heat stress conditions.

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