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Frontiers on Healthcare Research
Published by RSUP Dr M Djamil Padang
ISSN : 30327725     EISSN : -     DOI : https://doi.org/10.63918/fhr.v2.n2
Core Subject : Health,
Health Professions Public Health
The principal aim of Frontiers on Healthcare Research is to catalyze advancements in healthcare research that directly inform and improve the efficacy of health system operations, enrich patient experiences, and guarantee fairness in health service access
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 44 Documents
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Xenotransplantation in Healthcare: A Literature Review of Clinical Advances, Immunological Barriers, and Ethical Challenges Thongwichian, Phonchai; Sari, Melsi Pita
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p82-91.2025

Abstract

Background: The global shortage of donor organs remains a critical challenge in healthcare, driving the search for alternative strategies to reduce waiting list mortality. Xenotransplantation the transplantation of organs, tissues, or cells across species—has emerged as a promising solution. Advances in genetic engineering, immunological modulation, and tissue preservation have accelerated progress, yet clinical translation remains constrained by unresolved biological and ethical barriers.Objectives: This review aimed to systematically evaluate the current evidence on xenotransplantation, focusing on its safety, efficacy, immunological challenges, and societal implications, in order to assess its readiness for integration into clinical practice.Methods: A literature review was conducted in this study. PubMed and Scopus were searched for publications between January 2020 and August 2025. Eligible studies included clinical reports, preclinical experiments, mechanistic investigations, and survey-based studies addressing xenotransplantation. Data were extracted on study design, xenograft type, intervention details, and reported outcomes. Due to heterogeneity, results were synthesized narratively.Results: Twenty studies were included. Clinical reports demonstrated that genetically engineered pig organs could function in humans for several weeks, though rejection, coagulation dysregulation, and viral reactivation remain obstacles. Preclinical models in nonhuman primates and rodents confirmed prolonged graft survival with multigene donor modifications and costimulation blockade. Cellular approaches, including porcine islets and ovarian tissue grafts, showed promise in metabolic and reproductive medicine. Surveys revealed moderate public support but persistent concerns regarding safety and ethics.Conclusion: Xenotransplantation has progressed from experimental proof-of-concept to early clinical application. While advances in genetic editing, immunosuppression, and graft preservation are encouraging, clinical translation will require overcoming immunological and infectious barriers, alongside addressing societal and ethical considerations, to ensure safe and sustainable implementation in healthcare.
Epidemiology and Clinical Patterns of Leprosy: A Retrospective Study at Dr. M. Djamil General Hospital, Padang, Indonesia Ariani, Tutty; Triani , Aisha; Aulia , Salsabila Syafna
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p35-44.2025

Abstract

Background: Indonesia ranks third globally in the number of leprosy cases, following Brazil and India. Despite this, leprosy remains a neglected disease. Monitoring its epidemiology through retrospective studies is essential to inform effective disease control programs. Methods: This retrospective descriptive study reviewed medical records of leprosy patients who visited Dr. M. Djamil General Hospital, Padang, between 2021 and mid-2024. Data were extracted from patients’ electronic medical records. Results: A total of 92 patients were confirmed with leprosy during the study period. The incidence increased from 13 patients in 2021 to 22 in 2022, and 40 in 2023, with 17 additional cases identified by mid-2024. Of these, 70 (76.1%) were multibacillary cases and 22 (23.9%) were paucibacillary cases. Male patients predominated, with a mean age of 35 years (range: 7–79 years). Leprosy reactions occurred in 44 patients (47.8%), consisting of 20 (45.5%) reversal reactions and 24 (54.5%) erythema nodosum leprosum (ENL). Most cases originated from Pesisir Selatan Regency and Pariaman City, both recognized as high-endemic areas in West Sumatra Province. Conclusion: The incidence of leprosy is rising annually, with multibacillary cases predominating. Male patients are more frequently affected, and nearly half experience leprosy reactions, with ENL more common than reversal reactions. Strengthened disease control strategies are urgently needed to detect and reduce new cases in endemic regions. Study limitations include reliance on retrospective medical record data and a single tertiary hospital setting.
Assessment of Functional Outcome of Intertrochanteric Fractures Treated by PFN A2 in Elderly Patients in a Tertiary Care Hospital Thimmaiah, Sreenivas; TP, Avinash; B, Padmini Kumari
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p10-17.2025

Abstract

Background: The Proximal Femoral Nail Antirotation (PFNA2) surgical implant has been developed as an efficient internal fixation device for treating intertrochanteric fractures. This study aims to evaluate the functional outcomes of geriatric patients with intertrochanteric fractures treated with the PFNA2, focusing on pain alleviation and hip function recovery. Materials and Methods: This was a single-center, observational, prospective study conducted at a tertiary care hospital. A total of 100 patients with intertrochanteric fractures were included. Patients treated with PFNA2 were followed up for 6 months. The functional outcomes were measured using the Visual Analogue Scale (VAS) for pain and the Harris Hip Score (HHS) for hip function. Results: The average age of the 100 patients was 66.47 ± 6.66 years. The majority of patients in this study had A2-type fractures, as classified by the AO/OTA system. Both the VAS for pain and the HHS for hip function showed significant improvement between the pre-operative and 6-month post-operative assessments. Conclusion: The Proximal Femoral Nail A2 is an excellent treatment option for elderly patients with intertrochanteric fractures, providing significant improvements in pain relief and functional outcomes.
Perceptions of Patient-Centered Care at Dr. M. Djamil General Hospital Dorisnita, Dorisnita; alfitri, alfitri; Yauma, Fithratil
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p58-65.2025

Abstract

Background: Patient-Centered Care (PCC) is a key component of health services that emphasizes respect for patient dignity, provision of information, active participation, and collaboration in decision-making. Dr. M. Djamil General Hospital needs to evaluate the implementation of PCC from the patient’s perspective to identify service gaps and improve care quality. This study aimed to assess the implementation of PCC across four main dimensions: dignity, information provision, patient participation, and collaboration. Methods: This study employed a descriptive quantitative design with a cross-sectional approach, involving 353 inpatients selected through stratified random sampling. Data were collected from January to June 2024 using a structured questionnaire adapted from Harvey Picker’s PCC framework. Each dimension was measured with a Likert scale and analyzed descriptively. Results: Implementation of PCC was rated highly in terms of dignity by physicians (94.94%) and nurses (96.32%). Information provision received positive perceptions for physicians (75.92%) and nurses (77.34%), but lower for dietitians (57.79%) and pharmacists (57.79%). The participation dimension was rated lower for physicians (58.36%), dietitians (54.67%), and pharmacists (66.01%), while nurses received a comparatively better score (56.66%). Collaboration was perceived positively for physicians (54.96%) and nurses (58.07%). Conclusion: The implementation of PCC showed favorable results in dignity, information, and collaboration, while patient participation remained suboptimal. Strengthening effective communication and enhancing active involvement of all healthcare professionals, including pharmacists and dietitians, were essential to improve the quality of patient-centered care.

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