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Frontiers on Healthcare Research
Published by RSUP Dr M Djamil Padang
ISSN : 30327725     EISSN : -     DOI : https://doi.org/10.63918/fhr.v2.n2
Core Subject : Health,
Health Professions Public Health
The principal aim of Frontiers on Healthcare Research is to catalyze advancements in healthcare research that directly inform and improve the efficacy of health system operations, enrich patient experiences, and guarantee fairness in health service access
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 44 Documents
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The Effectiveness of a 4-Week Physical Exercise Program in Patients with Pulmonary Arterial Hypertension: A Pilot Study in Sumatra Kiki Krevani, Citra; Azzuhdi, Muhammad Zakiy; Soegistiono, Feiky Herfandi; Maulina, Putri
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p46-54.2024

Abstract

Background: Pulmonary Arterial Hypertension (PAH) is known to induce a decline in functional capacity, attributed to mechanisms such as right ventricular dysfunction, chronotropic incompetence, ventilation abnormalities, and skeletal muscle dysfunction. Despite the recommendation of physical exercise programs, a standardized and easily implementable regimen for PAH patients is currently lacking. This study aims to investigate the influence of physical exercise on the 6-minute walking distance (6MWD), functional capacity, and pulmonary vascular resistance (PVR) in individuals with PAH. Methods: This study employed a non-randomized clinical trial design involving adult patients with Pulmonary Arterial Hypertension (PAH), who were divided into intervention and control groups. Baseline characteristics, differences in 6-Minute Walking Distance (6MWD), peak VO2, and Pulmonary Vascular Resistance (PVR) before and after a four-week period (20 sessions, five times a week) of physical exercise were documented. The Shapiro-Wilk normality test was conducted before analyzing numerical data, followed by independent t-tests or Mann-Whitney tests to assess intergroup differences. Results: The study included 32 PAH patients, with 16 subjects in each group. Baseline characteristics revealed a distribution of 22 females (68.75%) and 10 males (31.25%), with an age range of 18-55 years. Statistical analysis indicated no significant differences in baseline characteristics, hemodynamic data, and echocardiography between the two groups. However, there were significant differences between the control and intervention groups in terms of Δ6MWD (17.07 ± 48.30 (95% CI: -10.82 – 44.96) vs. 115.36 ± 54.69 meters (95% CI: 83.78 – 146.94), p-value < 0.001), ΔVO2 peak (159.42 ± 209.32 (95% CI: -92 – 707) vs. 14.5 ± 60.4 (95% CI: -77 – 148), p-value < 0.05), and ΔPVR (-1.36±0.67 (95% CI: -0.33-(-2.85)) vs. -0.34±0.30 (95% CI: -0.39-(0.63)), p-value < 0.05). Conclusion: A four-week physical exercise program improved 6MWD, functional capacity, and PVR in patients with PAH.
Histological Comparison of Lyophilized Amniotic Membrane, Tulle Gras Dressing and Topical Gentamicin on Acute Partial Thickness Wound : In Vivo Study Raymond, Benni; Fadila, Srigunda Arisya; Rahmadian, Rizki; Tofrizal, Tofrizal
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p1-7.2024

Abstract

Background: Partial thickness wounds refer to the damage that extends from the epidermis to the upper layers of dermis. This study aims to compare the histological regrowth of acute partial thickness wounds following application of lyophilized amniotic membrane, tulle grass dressing and topical gentamicin. This study aims to establish a standard approach for treating partial thickness wound. Methods: Three groups of Mus Musculus mice were used in our experimental study. Similar to harvesting split thickness skin grafts, partial thickness wounds are performed. The wound was then treated with lyophilized amniotic membrane, tulle grass dressing and topical gentamicin. Using the Scoring System for Histological Assessment of Wound Healing, the wound is histopathologically examined at day 14. In this study, One way Anova was used for statistical analysis. Results: Application of lyophilized amniotic membrane showed different histological characteristic of healing from other method, with p=0.001 it showed significance epidermal growth compared to topical gentamicin. Whereas dermal thickness were also better, accompanied by lower dermal collagen density. Amniotic membrane has a large source of stem cells and contains several growth factors which is important in the physiological process of wound healing and tissue regeneration. Conclusions: Characteristic of skin healing using lyophilized amniotic membrane showed rapid epidermal growth and gave impression of less fibrosis tissue, so that would be potential for better wound treatment especially for prevention of scar.
Forensic Medical Findings in Child Sexual Violence: A Case Report Septiawan, Dedi Andika; Arviandi, Rizki; Lubis, Adriansyah
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p30-34.2024

Abstract

Background: Sexual violence is physical or psychological violence in sexual ways or by targeting sexuality. It includes sexual slavery, sexual torture, public sexual humiliation, sexual harassment, and rape. In Indonesia, the incidence of child sexual violence has increased. Based on KPAI data, 2019, there were 190 child victims of sexual violence. It increased to 419 victims in 2020. In North Sumatra Province, the PPPA Service states showed sexual violence is the most common type of violence with 609 cases of sexual violence against women and children. This case report aims to provide the role of forensic medical examination in case of sexual violence against a minor. Case report: In this case, the victim was a 14-year-old girl who admitted that she had been sexually violence by a person she had only met twice. The victim had bruises on the neck, chest, and breasts. She also had fresh lacerations on her hymen. The vaginal smear examination revealed spermatozoa were found. These findings were consistent with signs of sexual intercourse. Conclusion: The victim had suffered blunt force to the genitals that was consistent with signs of sexual intercourse as a sexual violence.
Histopathological Description of Invasive Breast Carcinoma Patients at Dr.M.Djamil Hospital 2019-2020 Azzahra Saidah Ramadhani; Yenita; Yaunin, Yaslinda
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p54-63.2024

Abstract

Background: Breast carcinoma is a type of malignancy originating from the epithelium cells of the breast. There are several risk factors that are often associated with this disease, such as : genetics, age, gender, obesity, hormonal, etc. The aim of this study is to describe the histopathological description of invasive breast carcinoma patients based on age and body mass index at Dr. M. Djamil Padang hospital in 2019-2020. Methods: This research is descriptive observational using secondary data from the results of histopathological examination and medical records in May 2022-June 2022. The data were analyzed using univariate analysis. Results: The results showed that the majority of patients were in the group of age between 46 to 55 years old (33.1%), obesity (33.8%), Invasive Carcinoma of No Special Type (54, 9%), and grade III (69%). Most patients with Invasive Carcinoma of No Special Type are in the group of age between 46 to 55 years old (28,2%) with obesity (35,9%). Patients with grade III mostly in the group of age between 46 to 55 years old (39,8%) with obesity (35,7%). Conclusion: The conclusion of this study is that the majority of invasive breast carcinoma patients are Invasive Carcinoma of No Special Type, grade III, in the group of age between 46 to 55 years old age, with obesity
Clinical Severity of COVID-19 among Pediatric in Tertiary Level Hospital, West Sumatra Yani, Finny Fitry; Izzah, Amirah Zatil; Alkamdani, Riki; Widoyo, Ratno
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p8-16.2024

Abstract

Background: COVID-19 clinical signs can be different for each pediatric patient. This study aims to systematically evaluate the clinical, laboratory examination, severity of COVID-19 infection of pediatric patients in RSUP Dr. M. Djamil General Hospital. Methods: This is a cohort retrospective study. Data were extracted from the medical records of pediatric patient who received COVID-19 medical treatment between September 2020 to June 2021. The data were presented as frequency, percentage and adjusted odd ratio (aOR). Bivariate and multivariate analysis was done to identify the association. Results: The results showed that from a total sample of 93 patients, the majority of these patients were male (60,2%) and fell within the age groups of 1-5 years (30,1%) and 11-15 years (31,2%). Most pediatric patients presented with a mild severity level of COVID-19. Clinical characteristics, such as consciousness (p=0.014), neurologic deficits (p=0.035), and thoracic abnormalities (p=0.040), showed a significant association with the severity level of COVID-19. There are no significant association between laboratory results and the severity level of COVID-19. Admission to PICU was identified as a protective factor against the mortality of COVID-19 (aOR=0.02) and abdominal abnormalities were identified as a contributing factor to mortality among pediatric COVID-19 cases (aOR=14.44). Conclusions: Clinical characteristics including consciousness, neurologic deficits, and thoracic abnormalities were associated with the severity level of COVID-19. PICU admission and abdominal abnormalities were associated with mortality among pediatric COVID-19 patients.
Characteristics of Type 2 Diabetes Mellitus Patients With Diabetic Ketoacidosis: A Study in A National Referral Hospital in Indonesia Fuada, Afifah Annis; Aprilia, Dinda; Putri, Biomechy Oktomalio
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p17-23.2024

Abstract

Background: Diabetic ketoacidosis (DKA) is one of the acute complication of diabetes mellitus (DM) with high mortality and morbidity rates. Research data regarding the characteristics of patients with type 2 diabetes mellitus (T2DM) with and without DKA are not yet widely available. Therefore, further research is needed to minimize the annual morbidity and mortality rate and prevent complications at the earliest possible moment. This study was carried out to determine the differences in the characteristics of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January 2018 to 31stDecember 2020. Methods: This study used a comparative analytic study with a cross-sectional approach using the medical records of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January to 31st December 2020 with total sampling. Data analysis calculated by chi-square test, unpaired T-test, and Mann-Whitney test. Results: Most of T2DM patients with DKA were aged ≥ 40 years (62.1%), female (65.5%), secondary level of education (72.4%), DM diagnosis duration was ≤ 5 years (75.9%), had infection precipitating factors (65.5%), on insulin (58.6%), Body Mass Index (BMI) in overweight-obese criteria (55%), fasting blood glucose (FBG) < 250 mg/dl (62.1%), and post-prandial glucose (PPG) 250-600 mg/dl (51.7%). This study found that the association of age, DM diagnosis duration, precipitating factors, medication use, and PPG with DKA in T2DM patients (p<0.05). Conclusion: This study confirmed significant differences in age, DM diagnosis duration, precipitation factors, type of antidiabetic therapy, and PPG between T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang.
Nutritional Status and Cognitive Development in Children Aged 2-5: A Narrative Review Ismail, Fauziah; Fasrini, Ulya Uti; Harmen, Anggia Perdana
Frontiers on Healthcare Research Vol. 2 No. 1 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n1.p44-52.2025

Abstract

Background: Meeting the nutritional needs of children is crucial for optimal growth and development. Children aged 2-5 years are in the preoperational stage, characterized by egocentric and intuitive thinking. Nutritional deficiencies can negatively impact their development, including cognitive abilities and learning capacity. Research worldwide has extensively studied the relationship between nutritional status and children's development, emphasizing the importance of proper nutrition for motor, speech, and behavioral skills essential for learning. This narrative review presents the results of relevant research from various countries on the relationship between nutritional status and the development of children aged 2-5 years in terms of motor skills, speech, and behavior. Methods: This review is a narrative review of relevant articles from the last decade, focusing on the discussion of the cognitive development process of children and its relationship to nutritional status. Results: Several studies have linked nutritional status with overall development, while some have specifically focused on motor or cognitive development. Although most results indicate a relationship between nutritional status and the development of children aged 2-5 years, the observed developmental levels and achievements are not entirely conclusive. Child development is also influenced by external factors. Conclusion: A total of 11 articles from 18 articles stated that there was a significant relationship between nutritional status and children’s cognitive development.
Characteristics of Tuberculous Spondylitis Patients at Dr. M. Djamil Padang Hospital 2018-2020 Athiyyah, Salsa Naudzul; Sahputra, Roni Eka; Reza, Mohamad
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p64-69.2024

Abstract

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which has long been known and still one of the top 10 causes of death in the world. Tuberculosis spondylitis is one of the most common extrapulmonary tuberculosis. This study aims to describe the characteristics of patients diagnosed with tuberculous spondylitis at RSUP Dr. M. Djamil Padang in 2018 – 2020. Methods: This study is an observational descriptive study with a retrospective approach using medical record data from patients diagnosed with tuberculosis spondylitis at RSUP Dr. M. Djamil Padang 2018 - 2020. The sampling method used total sampling technique. Results: The results of this study show that tuberculous spondylitis is mostly in the age group 17 – 25 years (25%), the ratio between male and female gender is 1:1, patients come from outside Padang (78.8%), occupation most were housewives (27.5%), and most had no family history of tuberculosis (80%). Local pain is the most common clinical manifestation experienced by as many as 70 people. The lesion location is most often in the thoracic region (45%). Conclusion: Tuberculous spondylitis is most common in the age group 17 – 25 years, comes from outside the field, is a housewife, and has no family history of tuberculosis. Men and women have the same number of cases. Local pain is the most common clinical manifestation and the thoracic lesion is the most frequently found location.
Effects of Iodine Solution on Histopathologic Features of Lead Acetate-Induced Rat Hepar Prillia, Khalilah; Julizar; Miftah
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p24-29.2024

Abstract

Background: Lead is a heavy metal that can be found in the environment. Lead can be naturally occurring or produced from human activities. Lead entering the body can cause oxidative stress which can then cause cell damage. Iodine in the body can act as an antioxidant which then prevents oxidative stress. Methods: This study is an experimental study on 18 Rattus novergicus rats conducted for 19 days. Rats were divided into three groups: negative, positive control group, and treatment group. On the 20th day the rats were killed then the hepatic organs were taken and preparations were made. The preparations were assessed using Knodell’s Score. Data were analyzed using Kruskal-Wallis and then followed by Mann-Whitney Test. Results: The negative control group showed that the dominant is in the form of normal hepatocytes whilst the positive control group hepatic cells experienced cell damage in the form of inflammation, degeneration, and necrosis. In the treatment group, damage to hepatic cells was lower than the positive control group. Conclusion: There is an effect of iodine solution administration in preventing damage to rat hepatic cells induced by lead acetate.
Characteristics of Cancer Patients Enrolled for Radiotherapy in Andalas University Hospital Hanggara, Muhammad Azzel; Hanum, Fathiya Juwita; Adrial
Frontiers on Healthcare Research Vol. 2 No. 1 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n1.p15-23.2025

Abstract

Background: Cancer remains a significant global health burden, with radiotherapy being a crucial treatment modality. However, data on the characteristics of cancer patients undergoing radiotherapy in West Sumatra is limited. This study aims to analyze the demographic and clinical characteristics of patients receiving radiotherapy at Andalas University Hospital. Methods: A retrospective descriptive study was conducted on 510 cancer patients who underwent radiotherapy between 2019 and 2020. Data were collected from medical records, including demographics, cancer types, staging, and treatment history. Results: Breast cancer (42.5%) was the most common malignancy, with a higher prevalence in female patients (72.5%), particularly in the 45–64 age group. Stage IV (26.1%) was the most frequently recorded staging, though nearly 50% of cases lacked staging data, highlighting documentation gaps. The majority of patients were from West Sumatra (78.6%), with a significant number referred from other provinces, emphasizing Andalas University Hospital’s role as a regional referral center for radiotherapy. Conclusion: The findings underscore the high prevalence of late-stage cancer diagnoses and incomplete medical records, necessitating enhanced cancer registration systems and early detection programs. Strengthening data management and accessibility is crucial for improving cancer care and treatment outcomes in West Sumatra.

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