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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "Vol 20, No 1 (2004)" : 10 Documents clear
EFEK EKSTRAK DAUN CIPLUKAN (Physalis minima L) TERHADAP RELAKSASI OTOT POLOS TERPISAH TRAKEA MARMUT (Cavia porcellus) Priyantoro, Sigit Tri Yus; Sudjari, Sudjari; Karyono, Setyawati S.
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.636 KB) | DOI: 10.21776/ub.jkb.2004.020.01.7

Abstract

Physalis minima L’s leaf contains atropin and skopolamin which possess anti cholinergic effect. Cholinergic agent has constriction effect to the smooth muscle of respiratory tract. In asthma bronchiale there is an airway constriction. This experiment was to observe the effect of Physalis minima L’s ethanol extract on the relaxation of the guinea pig’s trachea’s smooth muscle which was induced with histamin by the method of in vitro. Isolated trachea of 5 male guinea pig’s was used as samples in this experiment. Transducer, amplifier and mac lab computer were used to create  the trachea’s contraction–relaxation curve. The independent variabel was Physalis minima L’s leaf ethanol extract dosage andthe dependent variabel was the trachea’s contraction. 4 dosage of Physalis minima L’s leaf ethanol extract were used (1 control, 3 comparable dosage), the dosage of 0.5 % Physalis minima L’s leaf extract showed significant relaxation of trachea (anova, p<0.05). There was a positive corelation between theincreasing dosage of Physalis minima L’s leaf ethanol extract and the relaxation of trachea (regression, r = 0.770, p< 0.05). The conclusion of this study is that the Physalis minima L’s leaf ethanol extract has positive effect in relaxing isolated trachea of guinea pig’s induced by histamin and there is a positive correlation between increasing dosageof Physalis minima L’s leaf ethanol extract and the relaxation of isolated trachea. Keywords:trachea smooth muscle’s relaxation, histamine, Physalis minima L’s leaf ethanol extract.
PENGARUH DEFISIENSI FOLAT TERHADAP FERTILITAS INDUK DAN KUALITAS JANIN TIKUS E.S., Moch. Istiadjid
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (479.777 KB) | DOI: 10.21776/ub.jkb.2004.020.01.2

Abstract

This experimental study was performed to reveals the association of folic acid deficiency with the rat’s fertility and also with life quality of baby’s rat. The level of folic acid deficiency were divided into two groups, consisted of severe and mild, based on the intake of folic acid, those were given to each groups that consist  of ten mature Sprague-Dawley rats. Other were givennormal folic acid as a control. Sixteen weeks after dietary suplly, rat’s  blood were evaluated to measure the contain of folic acid in the serum and erythrocyte and then the rats were forced mating. Baby rats were born with histerostomy. Rat’s fertility were evaluated by measured the number of delivered baby’s rat in 21th, 42th and 63th gestation or delivered days at each group. The quality of baby’s rats were evaluated by measured the body weight of each baby  and examined of any kind of congenital anomaly, such as spina bifida, encephalocele or anencephaly. The data analysis suggested the positive impact of maternal folic acid level in erythrocyte and maternal serum with the level of maternal fertilityand life quality of the baby,s, especially its body weight. Thus, the deficiency of folic acid will cause maternal infertility, lowered body weight of the baby’s rats and may be also congenital anomaly. Key words:Folic acid deficiency, infertility, low body weight, congenital anomaly.
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINETERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei Mulyastuti, Yuanita; Widijanti, Anik; Ali, Mulyohadi; Iskandar, Agustin; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.731 KB) | DOI: 10.21776/ub.jkb.2004.020.01.8

Abstract

Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area which is endemic to malaria, about 15 million new case ofmalaria occurred every year. In malaria immune response forms free radical which assist to eliminate the cause of disease but  also destroys endothelial cells at various organ. This oxidative damage plays an important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of Choroquine combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination of Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infected by Plasmodium berghei. Measurement of the degree ofparasitemia was done everyday and the amount of the platelet as one of the nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups, group of chloroquine(0,05 mg/gr), group of N-Acetylcysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combination group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consistedof infected mice without treatment as control group.
DETEKSI BAKTERI Klebsiella pneumoniaePADA SPUTUM DENGAN METODE IMUNOSITOKIMIA MENGGUNAKAN ANTI OUTER MEMBRANE PROTEIN BERAT MOLEKUL 40 KDA Klebsiella pneumoniaeSEBAGAI ANTIBODI Susilo, Joko; Sartono, Teguh R.; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (537.411 KB) | DOI: 10.21776/ub.jkb.2004.020.01.3

Abstract

Klebsiella pneumoniae (K. pneumoniae) is a normal flora in human Gastro Intestinal Tract. This strain of K.pneumoniae are implicated the gram negative bacteria that can cause pneumoniabeside urinary tract infection and nosocomial infection. Until now, to identify this bacteria there are seveval methods had been used included staining and culture, Elisa, histologic and serologic that need a long time. The goal of this research is to detect K. pneumoniae with immunocytochemistry methode using antibody of K.pneumoniae and OMP K.pneumoniae as spesific antigen. The design of this reseach was explorative descriptive. The method content of K.pneumoniae isolation, specific antigen of OMP K.pneumoniae isolation, producing antibody anti OMP K.pneumoniae, and detection this bacteria on sputum with immunocytochemistry methode respectivelly. For diagnostic test sensitivity and specificity. Analysis has been used. The result showed that molecular weight of OMP K.pneumoniae was 40 kDa, antibody of OMP K.pneumoniae couldidentify the OMP K.pneumoniae as antigen and could detect K.pneumoniae on sputum by using Western Blotting and immunocytochemistry. Sensitivity and specificity of this diagnostic testwas 90 %, 95 % consequently. Key words: Klebsiella pneumoniae, Outer Membrane Protein, Immunocytochemistry
PERBEDAAN PENGARUH PENDIDIKAN SEKS METODE SIMULASI DAN DISKUSI KELOMPOK TERHADAP SIKAPREMAJA PADA UPAYA PENCEGAHAN PERILAKU SEKS MENYIMPANG Kumboyono, Kumboyono; M, Hanafi,; E. P, Lestari,
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.273 KB) | DOI: 10.21776/ub.jkb.2004.020.01.9

Abstract

Sex education is a process to express message that one of the purpose is to create adolescense positive attitude avoiding incorrect sex behavior. The method used to create adolescensepositive attitude in order to avoid the incorrect  sex behavior are group discussion method, demonstration, playing role or simulation method. The purpose of this study was to  find out the differences between the influence of giving sex education with simulation method and group discussion of adolescense attitude changes to avoid incorrect sex behavior, and to find out a method that give the biggest score of attitude changes amongthem. The design of this study was quasi experimental pretest posttest design. While the way to collect samples using multi stage random sampling technique with the number of 90 samples divided into 30 groups of  control, 30 groups using simulation method of treatment and 30 groups using discussion group method of treatment. The result from showed that there was difference between score of pretest attitude and score of posttest attitude in the group of simulation treatment (t-test p = 0.644) and the discussion group of treatment (t-test p = 0.000), but there was no difference between score of pretest attitude and score of posttest in control group (t-test p = 0.000)  α = 0.05. Another finding that there was difference attitude among control group, group of simulation treatment, and group of discussion treatment (anova p = 0.000)  α = 0.05.
PERAN LABORATORIUM DALAM DIAGNOSIS DAN PENATALAKSANAAN KASUS KASUS PENYAKIT TROPIK DAN INFEKSI Sardjono, Teguh Wahju; Ismanoe, Gatoet; Widjayanto, Edi
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.874 KB) | DOI: 10.21776/ub.jkb.2004.020.01.4

Abstract

Infectious disease is still a health problem in theworld, especially in tropical and developing countries, including Indonesia. The diagnosis of tropical disease cases mostly are still based on the main of clinical symptoms, that is fever. Among 900 fever patients, 21% of the disease were diagnosed by clinical examinations, 35% by laboratory tests and 40% were diagnosed as fever of unknown origin (FUO). One forth of the FUO patients were definitively diagnosed after specific laboratory tests, but the use of the specific tests in daily practice were relatively rare. The tests ordered by physicians to the Department of Central Clinical Laboratory Dr. Saiful Anwar Hospital Malang, are mostly hematology and blood chemical tests (59.54% and 21.52%). Specific tests for microbiology and parasitology were only 3.15% and 0.46% respectively. Fever patients who not definitively diagnosed, often received unnecessary treatments or medications (over-treatment), those are actually dangerous to them. To improve the quality of clinical management, the traditional laboratory service should be changed tobe the interactive laboratory service. It needs a  role, understanding and good collaboration between clinical practitioners who know the basic sciences and the pre/para-clinical scientists who interest to the clinical phenomenon. The aim of the change is to get the more scientific, ethical and professional medical services. Key words:Laboratory medicine, diagnosis,management, infectious disease
GAMBARAN BAKTERIOLOGIS TANGAN PERAWAT Zuhriyah, Lilik
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (106.96 KB) | DOI: 10.21776/ub.jkb.2004.020.01.10

Abstract

Hand hygiene of health-care workers become an important thing since hands of health-care personnel arethe most frequent vehicles for nosocomial ifections. However, adherence of hand washing has been poor. This study was to obtain bacteriological descriptions of nurses’s hand. The study was conducted in Surgical  and Medical Intensive Care Services using A Cross Sectional Survey. Populationwere all of nurses in ICU and CVC room. Purposive Sampling was carried to obtain samples of  20 nurses. Measurement was carried on January 2004. Bacteriological descriptions of nurses’s hand was measured by swabbing ofright side after hand washing. Examination by hand swab with positive result were found in 20% of nurses. Species of bacteria which were found from nurses’s hand were Staphilococcus epidermidis and Enterobacter aerogenes. It can be concluded that species of bacteria found from had swabbing are non pathogenic bacteria. Efforts to improve of all health workers for hand hygiene appropriate with procedures are still needed. Focusing on had washing practice among nurses and others health workers are needed for the following research. Keywords: bacteriological, nurses’s hand
HUBUNGAN PENINGKATAN TEKANAN INTRAVESIKA URINARIA DENGAN PERDARAHAN INTRAPERITONEAL AKIBAT TRAUMA TUMPUL ABDOMEN Soemarko, M.
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.159 KB) | DOI: 10.21776/ub.jkb.2004.020.01.5

Abstract

The diagnosis of intraperitoneal hemorrhage must bequickly with a high accuracy, before an acute exploratory laparotomy. This study was conducted to find out if intravesical pressure measurement should be as an alternative indicator of diagnostic peritoneal lavage in predicting intraperitoneal hemorrhage that indicating an acute exploratory laparotomy. Using an Explorative, Cross Sectional Design. Results of the exploratory laparotomy were used as  a standard of determining the accuracy of Diagnostic Peritoneal Lavage and intravesical pressure measurement in predicting theindication for the exploratory laparotomy. 18 of 24 patients has positive results of diagnostic peritoneal lavage, but an active intraperitoneal hemorrhage only found in 15 patients, witha positive predictive value 83,33 %, negative predictive value 100%. The results of intravesical pressure measurement in the same patients predicted 17 patients has positive results, with slight a higher positive predictive value (88,24 %), negative predictive value  100%. The conclusion is the measurement of intravesical pressure is an alternative procedure of Diagnostic Peritonel lavage for predicting intraperitoneal hemorrhage. Key words:Blunt Trauma Abdomen; Intravesical Pressure Measurement; Diagnostic Peritoneal Lavage; Exploratory Laparotomy; Intraperitoneal Hemorrhage.
UJI EFEKTIFITAS DEKOK BUNGA BELIMBING WULUH (Averrhoa bilimbi) SEBAGAI ANTIMIKROBA TERHADAP BAKTERI Salmonella Typhi SECARA IN VITRO Ardananurdin, Alhamfaib; Winarsih, Sri; Widayat, Mahono
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.007 KB) | DOI: 10.21776/ub.jkb.2004.020.01.6

Abstract

Salmonella typhi is causative agent of typhoid fever and its still a main health problem in Indonesia.Pickle fruit flower had been recognized by Indonesian society that have usefulness to cure various diseases. Pickle fruit flower contain active substance of saponin, polifenol and flavonoids. The experimentallaboratoric aim was to know the efficacy of picklefruit flower decoct as an antimicrobial agent to Salmonella typhi in vitro byusing tube dilution method and continued by streaking on Bismuth Sulfite Agar. The concentration of pickle fruit flower decoct were 0%; 5%; 7.5%; 10%; 12.5%; and 15% and the sample of Salmonella typhi were 4 isolates derived from different patients. The concentration of Salmonella typhi was 104cell/ml. The result from the experiment was MIC at 10% and MBC at 12,5% concentration. The statistic analysis showed that pickle fruit flower decoct can reduce Salmonella typhi growth in vitro significantly (Anova, p=0.000) and there was a correlation between increasing concentration of pickle fruit flower with the reduced amount of colonies (correlation, R=-0.795). From this study we can conclude that pickle fruit flower decoct has an antimicrobial effect to Salmonella typhi fondly of MIC and MBC at 10% and 12.5% respectively. Key word:The pickle fruit flower, Salmonella typhi, MinimalInhibition Concentration (MIC), Minimal Bactericidal Concentration (MBC).
ANALISIS URUTAN NUKLEOTIDA DAN EKSPRESI DARI MUSCLE A-KINASE ANCHORING PROTEIN (mAKAP) MENUNJUKKAN KEMUNGKINAN FUNGSI mAKAP PADA DIFERENSIASI KARDIMIOSIT: PERBANDINGAN EKSPRESI mAKAP PADA JANTUNG MDX DAN KONTROL Rohman, Mohammad Saifur
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.174 KB) | DOI: 10.21776/ub.jkb.2004.020.01.1

Abstract

Muscle A-Kinase Anchoring Protein (mAKAP) is an A-kinase anchoring protein (AKAP) which targets cAMP-dependent protein kinase(PKA) to the nuclear envelope. mAKAP not only binds to PKA, but also to the ryanodine receptor (RyR2) and the rolipram-inhibitedcAMP-specific phosphodiesterase (PDE4D3). Amino acid sequence analysis revealed that mAKAP possesses LXCXE andFYDYSYL, the consensus-binding domain of pRB and CBP/p300, respectively. pRB and CBP/p300 are known as a key componentsin cardiomyocyte differentiation processes. Northern blot analysis revealed that mAKAP was expressed in a 13 day old rat heart andits expression increased by 15 days of age when cardiomyocytes reveal a terminal differentiation phenotype. In culturedcardiomyocytes mAKAP was expressed in differentiated but not undifferentiated. Accordingly, mAKAP may play a role in the terminaldifferentiation process through pRB-CBP/p300 functions. Furthermore, we observed mAKAP expression in old mdx heart, a mousemodel of Duchenne muscular dystrophy, compared to control mice. In the control heart, mAKAP transcripts were detected at 6-, 20-,64- and 76-weeks of age. However, mAKAP expression significantly appeared only in 64- and 76-week old mdx hearts. DelayedmAKAP expression in mdx may contribute to impaired function of pRB, CBP/p300, cAMP and Ca2+ complex.Key words: mAKAP, domain architecture, terminal differentiation, pRB, CBP/p300, mdx.

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