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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 21, No 1 (2005)" : 8 Documents clear
PROTEIN FIMBRIA 16 kDa BAKTERI ACINETOBACTER BAUMANNIIDARI URIN PENDERITA INFEKSI SALURAN KEMIH BERPERAN SEBAGAI PROTEIN HEMAGLUTININ DAN ADHESIN Noorhamdani, Noorhamdani
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1030.429 KB) | DOI: 10.21776/ub.jkb.2005.021.01.8

Abstract

Acinetobacter baumannii (Acb) is an opportunistic and nosocomial pathogen that ussualy found in clinical specimen from patients with intensive care. The pathogenic mechanism of this bacteria are not fully elucidated especially potential activity of its protein as hemaglutinin and adhesion molecul. The aim of this study is to evaluate the  role of 16 kDa fimbriae protein from urnary tract infection (UTI) patient as hemaglutinin and adhesion molecule. Usingexplorative design this study was started by isolation Acb bacteria from urine of patient that had been determine as UTI clinically and laboratory. After identification this bacteria by microbact system hemaglutination test and isolation  of its fimbriae fraction, 12.5% SDS-PAGE had been used to isolated fimbriae protein, following assay in vitro to adhesion test..The study showed that the 16 kDa fimbriae protein of Acb bacteria was a hemaglutinin protein that could agglutinate 0.5% mice erythrocytes (1/32), and human blood group O erythrocytes (1/8). Hemaglutination test were negative onerythrocytes from rat, guinea pig, sheep, and human blood group A, B. The 16 kDa fimbriae protein (AF16) was also adhesion protein that had been revealed by its activity to adherenceto receptor of mice enterocytes. The increasing dose of AF16 molecules will decrease the amount of Acb bacteria to adherence to enterocytes (p<0.05). The fimbriae of Acb is maybe classified P type. Key words:Acinetobacter baumannii, fimbriae, hemaglutinin protein, adhesion protein
PERUBAHAN KADAR SITOKIN DAN MOLEKUL AGREGASI PADA BERBAGAI TINGKAT TROMBOSITOPENIA PADA DEMAM BERDARAH DENGUE Djunaedi, Djoni
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.882 KB) | DOI: 10.21776/ub.jkb.2005.021.01.3

Abstract

The uncovering of the changes in the concentration of aggregation molecules (vWF, PGI2) and cytokines (TNFα, IL-1β, IL-6) in different levels of thrombocytopenia in DHF patients can be used as the basis in predicting the occurrence of thrombocytopenia. A prospective-observational studywas undertaken utilizing a 3-day sequentially drawn vein blood of inclusive DHF patients. The TNFα, IL-1β and IL-6 test was conducted utilizing the quantikine high sensitivity human cytokine immunoassay, and the vWF and PGI2test was conducted utilizing the ELISA procedure.  The multivariate and discriminant analyses tests on the deltas between day 1 and 2 observations, and between day 2 and 3 observations of the 6 variables showed Wilks’ Lambda =0.638 with p=0.008 and platelets and vWF as the most powerful discriminating variable (70.5.%). The findings of this study indicated that in DHF patients (1) the changing of the concentration of TNFα, IL-1βand IL-6 cytokines do not play a significant role  in the mechanism of platelets aggregation, (2) platelets count decreases in a condition in which vWF facilitated platelets aggregation, (3) the changing of a positive contribution of vWF causes a determination of the process of platelets aggregation, and (4) a positive changing of vWF’s concentration can be used as a prognostic indicator of a negative changing of platelets count.. Key words: Dengue Hemorrhogic Fever, thrombocytopenia, vWF
SKOR KEBOCORAN VASKULER SEBAGAI PREDIKTOR AWAL SYOK PADA DEMAM BERDARAH DENGUE Setiati, Tatty Ermin; Retnaningsih, Anastasia; Supriatna, Mohmad; Soemantri, Agustinus
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.547 KB) | DOI: 10.21776/ub.jkb.2005.021.01.4

Abstract

The prediction of shock in Dengue Hemorrhagic Fever is difficult to made, hence, is difficult to detect  shock as early as possible. This results in delayed management and ultimately can cause death. Serum levels of protein, albumin, hematocrit, and PEI which are markers of vascular leakage hoped to be able to be used as predictor of  shock in DHF. The aim of this study was to develop a scoring system, the Vascular Leakage Score (VLS) that could be used as the predictor of shock and to define the probability ofshock from each total score. This was a cross-sectional, observational analytic study, in RSDK, Semarang from 2001-2003. The samples were 138 children with DHF, aged 3-14 years old, divided into 52 cases of DHF without shock, and 76 cases of Dengue Shock Syndrome. Serum levels of protein, albumin, PEI, and hematocrit were obtained at admission. Then, a classification was made upon the four parameters mentioned above, based on the ROC curve analysis from the previous studies, and based on the WHO’s criteria. To develop a formula for VLS, we gave points-weight for each parameter to calculate the β-coefficient, then continued with calculation of DSS probability based on total combination of the four categories above, using a logistic-regression analysis of multivariate.
HUBUNGAN KADAR SENG SERUM DENGAN TINGGI BADAN ANAK SEKOLAH DASAR PENDERITA GAKY Setijowati, Nanik
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.892 KB) | DOI: 10.21776/ub.jkb.2005.021.01.5

Abstract

The incidence goiter starts to the extend in Urban area. Not all Elementary School children with goiterexperience of pursued growth. This indicates that besides low iodine content, there are other elements which also influence growth. This research intends to study the relationship between zinc the level of serum and height on elementary school children (8 – 12 year) in endemic goitre areas, in Malang Municipality. Data ware collected with cross-sectional study from August to December 2000. Blood and urine sample of twenty  children of each group were examined for zinc serumand iodine urine concentration. Information about diet pattern, socio-economical condition were obtained by structured questionairre for mother and children.This research used Independent T-test, Person Correlation test, and Multiple Regression for statistics analysis. The result showed that: (1). There were significant relationships between energy (r= 0.364, p = 0.012); protein (r = 0.481, p = 0.001) and zinc intake (r =0.491, p = 0.001) with height; (2). There were significant difference in energy (p = 0.014), carbohydrate (p = 0.042), lipid( p = 0.014), protein (p = 0.003), and zinc intake(p = 0.004) between the two groups examined. The conclusion was that lower height for age was possibly ascribed to lack of energy, protein, iodine and zinc intake. Key words:zinc serum, iodine urine, height for age, and goiter
PERANAN MAKROFAG PADA PROLIFERASI, DIFERENSIASI DAN APOPTOSIS PADA PROSES HEMATOPOISIS (PENELITIAN PADA LIMPA JANIN TIKUS DAN ASPIRAT SUMSUM TULANG MANUSIA) Widjajanto, Edi
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1346.822 KB) | DOI: 10.21776/ub.jkb.2005.021.01.6

Abstract

Macrophage stimulates growth of surrounding cells by various cytokines and growth factors synthesized  and eliminate apoptotic cells by its phagocytes activity. This study was to evaluate the evidence of macrophage as regulator cells during haematopoiesis. Haematopoietic activity assessed microscopically by proportion of various haematopoietic blood cells to total nucleated blood cells on imprint preparation of fetal ratus (Wistar) spleen and human marrow aspirate, after Wright’s stain coloration. Fetal ratus spleen and human marrow aspirate were used to evaluate macrophage as a stimulator cell and suppressor cell respectively. During prenatal period, the proportion of macrophage increased at 14thdays (1.3 ± 0.9%), 16thdays (7.6 ± 1.8 %), 18thdays (12.9 ± 2.8 %) and 20thdays prenatal gestation periods (14.1 ± 3.1%). Thismacrophage increment was associated with the increase of other blood cells, except the proportion of lymphoid cell which decreased. During postnatal period the macrophage proportion decreased (11.0 ± 1.7 %), and other bloodcells proportion continuously increased except lymphoid cells which decreased. Many haematopoietic islands representing active haematopoietic process were found at 14thdays of fetal rat spleen. Macrophage in human hypocellular marrow (n = 9) increased and it exceed other blood cells proportion (29 %, p < 0.001) and contained phagocytosed apoptotic bodies. This study concludes that high macrophage regulates  haematopoiesis when it was proportionally low and regulate haematopoiesis when it was proportionally high. Keywords:Macrophage, Apoptosis, Haematopoiesis
SINYAL TRANSDUKSI DARI BROMELAIN SEBAGAI ANTIINFLAMASI PADA UDEMA TELAPAK KAKI TIKUS YANG DISEBABKAN OLEH KARAGEN Sudjarwo, Sri Agus
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2005.021.01.1

Abstract

The signal transduction of bromelain as antiinflamatory in carragenan-induced rat paw edema were investigated. Sprague Dawley Rats were divided into the control groups which were given saline, and bromelain groups which received doses of 10, 20 and 40 mg/kg bromelain (peroral) respectively. This was followed by the administration of 1 % caragenin through the intraplantar route 30 min after administration  bromelain or saline. After the carrageenan injection paw volume, prostaglandin (PGE2) production and cyclooxigenase (COX)-1 and COX-2 expression was measured. The bromelain in doses of 10, 20 and 40 mg/kg showed 11.3; 45.1 and  56.3 % inhibition of paw edema respectively at the  end of three hours. The increase in Prostaglandin (PGE2) levels after carrageenan injection was significantly prevented by preadministration of the bromelain at 20 and 40 mg/kg but not bromelain at 10 mg/kg. Bromelain a dose-dependent inhibited both COX-1and COX-2 activity in carrageenin-induced inflammation. Bromelain inhibited COX-2  than COX-1 stronger activity. These results suggest that antiinflammatory effect of bromelain is due to its ability to inhibit PGE2production could be mediated by inhibition mainly on COX-2 than COX-1 activity. Keywords: Bromelain, Cyclooxigenase, Prostaglandin
HUBUNGAN KADAR GULA DARAH SAAT MASUK RUMAH SAKIT DENGANCARDIAC EVENTS PADA PENDERITA INFARK MIOKARD AKUT DI RS DR SARDJITO YOGYAKARTA Irawan, Bambang; Suharno, Suharno; Rochmah, Wasilah
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.196 KB) | DOI: 10.21776/ub.jkb.2005.021.01.7

Abstract

Hyperglycaemia is common in patients with acute myocardial infarction with and without diabetes mellitus. There is a positive relationship between hyperglycaemia at thetime of event and highly incidence of mortality and morbidity after acute myocardial infarction. Consequently, understanding the possible mechanisms through which hyperglycaemia worsens the prognosis of acute myocardial infarction, as well as effectiveness of its control during acute myocardial infarction, seems to be a great relevance. This study to investigate wether a relationship exists between blood glucose level on admission and cardiac events in non diabetic patients after an acute myocardial infarction. Method,  a cohort prospective observational study was done on acute myocardial infarction’s patients who were hospitalized in ICCU DR Sardjito’s hospital from March 2002 until October 2004. Subject who met inclusion and exclusion criteria were divided into 2 groups, the group in which blood glucose level onadmission was ≤ 140 mg/dl and the group with bloodglucose on admission was > 140 mg/dl. Cardiac events as well as mortality, cardiac failure, reinfarction and cardiogenic shock were observed for 6 months. There were 95 subjects, 93 males and 2 females.
KEMAMPUAN SEL LIMPA NORMAL MENCEGAH TERJADINYA PENYAKIT AUTOIMMUNE PADA MENCIT IL-2Rβ ββ β -/- Rifa’i, Muhaimin
Jurnal Kedokteran Brawijaya Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.37 KB) | DOI: 10.21776/ub.jkb.2005.021.01.2

Abstract

Adoptive transfer is a potentially curative treatment for both inherited and acquired diseases of hematopoietic compartment and organ failure. The aim of this experiment was to know the potency of normal unfractionated spleen cells to prevent pathological autoimmunity in IL-2Rβ-/-mice. Here, we show that the normal unfractionatedspleen cells have a capacity to prevent autoimmune diseases when adoptively transferred to IL-2Rβ-/- mice. Intravenously, and adoptively transferred of normal unfractionated spleen cells (107) to IL-2Rβ-/-mice (3 wks) gave an evidence on preventing the lethal phenotype due to autoimmune disease in IL-2Rβ-/-mice. The donor cells have a capacity to reverse the status of recipient cells from memory to naïve type. In addition, donorcells also have a capacity to regulate the development of granulocyte cells into normal level of homeostasis. These findings suggest that normal unfractionated spleen cells  could in the future be used in clinical settings to cure autoimmune diseases. Keywords :autoimmune, spleen cells, IL-2Rβ-/-, mice

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