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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 23, No 2 (2007)" : 6 Documents clear
PENINGKATAN KUALITAS SPERMATOZOA PADA PROSES PEMISAHAN SPERMATOZOA DENGAN SENTRIFUGASI GRADIEN DENSITAS PERCOLL MELALUI PEMBERIAN FOSFOLIPID Rumende, Rooije R.H.; Kalim, Handono; Widodo, M Aris; Djati, Moch Sasmito
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (947.856 KB) | DOI: 10.21776/ub.jkb.2007.023.02.3

Abstract

The separation of X and Y spermatozoa can be conducted by using Percoll Gradient Density Centrifugation(SGDP) method. It is, easy, valid, cheap and applicable method for developing made-insemination. Although it  has often been applied in sexing the spermatozoa, it was reported  that the method had often caused damages on the spermatozoa membranes and resulted in decreasing of the spermatozoa quality. The damages of spermatozoa after SGDP  process were specifically caused by (I) the loss of seminalplasma, (II) the increase of free radicals, and (III) the collision or friction among the spermatozoa. Among the three causal factors above, the third or the physical factor is claimed to be the most important one. It was assumed that the first and the second factors can be overcome if the third one is avoided. The spermatozoa membranes consist of lipids, protein, carbohydrate, and some substances at a low rate. Thegeneral objectives of this research was to identify the influence of the phospholipids PC (Phosphatidylcholin)to spermatozoa in order to avoid the damages of the spermatozoa in the process of SGDP.
RESISTENSI OBAT MALARIA: MEKANISME DAN PERAN OBAT KOMBINASI OBAT ANTIMALARIA UNTUK MENCEGAH Simamora, Dorta; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1046.929 KB) | DOI: 10.21776/ub.jkb.2007.023.02.4

Abstract

Multi drug resistance (MDR) of malariae parasite iscaused by decreasing ability of some antimalarial  drugs examples chloroquine, mefloquine, antifolate and atovaquone  to Plasmodium. Resistance to artemisin has not beenfound yet. Antimalaria drug resistance happened because some factors especially : genetic factor (gene mutation)  of the Plasmodium. Mechanism pathway of resistance differsin location, because the different target drug action. Resistance migh be reduce by using combination therapy. Key words: resistance, Plasmodium falciparum, antimalaria combination
PENGARUH PEMBERIAN PASTA TOMAT TERHADAP JUMLAH SEL BUSA PADA ARKUS AORTAAORTA ARCUS TUNICA INTIMA RATTUS NOVERGICUS STRAIN WISTAR TIKUS DENGAN YANG DIBERI DIET ATEROGENIK Handayani, Dian; Prijadi, Bambang
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1628.232 KB) | DOI: 10.21776/ub.jkb.2007.023.02.5

Abstract

In Indonesia, the prevalence of coronary heart disease (CHD) was increased. It currently became the main cause of mortality. Unhealthy dietary pattern as the most determinant of atherosclerosis through the increasingof plasma LDL, will be worsen by the presence of free radical such as reactive oxygen species (ROS) that led to accumulation of atherosclerosis plaques. The negative effects of free radicals can be inhibited by antioxidant. Lycopene is a strong antioxidant that able to neutralize free radicals,  especially oxygen derived free radicals. This studyaimed to assess the effect of tomato paste containing lycopne to total  foam cells. Lycopene has the role to prevent artericoronaria related to atherosclerosis. The most lycopene source is tomatoproducts. This study was a laboratory-experimental study with randomized control group – post-test design. Twentyrandomly selected rats, divided into 5  treatment groups, group P1 (normal diet treatment), P2 (atherogenic diet treatmen)t, P3 (atherogenic diet and addition 0.01 g/days oftomato pasta treatment, P4 (atherogenic diet and addition 0.02 g/days of tomato pasta treatment,),
IDENTIIFKASI PROTEIN IMUNOGENIK CHLAMYDIA PNEUMONIAE TERHADAP SERUM PENDERITA INFARK MIOARD AKUT Murwani, Sri; Hidayati, Dwi Yuni Nur
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.466 KB) | DOI: 10.21776/ub.jkb.2007.023.02.6

Abstract

Chlamydia pneumoniae is human respiratory tract pathogen and recently investigated as pathogen causingatherosclerosis and acute myocardial infarction (AMI). This research was carrier out to detect proteinpattern of C. pneumoniae, and to study it relation to AMI throughdetection of immunogenic protein. Design research  was laboratory observational and analyzed descriptively. The subject was C. pneumoniae. Protein pattern the bacteria was detected by electrophoresis method, and to detect the immunogenic protein was done immunoblotting. Serum was obtained from AMI patients in Saiful Anwar and Lavallette hospitals.  The result showed, protein pattern C. pneumoniae wasprotein with molecular weight 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44,  34 kDa. Non immunogenic proteins were 97, 91, 23, 19, 9, 5 and 4 kDa. Protein 61 kDa react to all of patient’s serum. It was concluded, C. pneumoniae have protein fractions 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, and 4kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44, 34 kDa, and 61 kDa was the  immunodominant protein. The result proved C. pneumoniae as causative agent of atherosclerosis and acute myocardial infarction, in Indonesia particularly. Key words:C. pneumoniae, immunogenic, AMI
PENGEMBANGAN DIAGNOSIS TUBERKULOSIS PADA HEWAN KESAYANGAN ANJING MENGGUNAKAN ANTIGEN SPESIFIK Mycobacterium tuberculosisESAT-6 DAN CFP-10 Tjahajati, Ida; Asmara, Widya; Soebono, Hardyanto
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1627.133 KB) | DOI: 10.21776/ub.jkb.2007.023.02.1

Abstract

Early diagnosis is one of the important methods to  control tuberculosis because this disease is zoonotic which easily spread through the air. Early detection of tuberculosis in dog is also very important since dog as petanimal have a potency to transfer the disease to human or other animals. The discovery of two specific M.tuberculosisantigens, ESAT06 and CFP-10, provide the opportunity to developa specific diagnostic kit for tuberculosis by using ELISA based on the secretion of IFN-γ. The development of a tuberculosis diagnostic kit based on this molecular biology and immunological method would provide a good alternative method to detect tuberculosis specially, accurately as early as possible. The result of this experiment would provide contribution for the development of health science and technology, especially in the eradication of tuberculosis. Keywords: diagnosis, tuberculosis, ESAT-6, CFP-10, interferon-gamma.
EFEK ANTIMIKROBA DARI EKSTRAK BIJI DAN DAUN MIMBA (Azadirachta indica A. Juss.) TERHADAP PERTUMBUHAN Malassezia globosa Hastuti, Utami Sri
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2007.023.02.2

Abstract

Neem (Azadirachta indica A. Juss.) is a sort of a useful plant especially for health. Antimicrobial compounds in seed and leaf of neem especially are: azadirachtin, fenol, quinon, alkaloid, nimbin, nimbidin and gedunin. Malassezia globosa is a pathogenic yeast that cause dandruff on head skin.  This research is done on behalf to know: 1) the inhibition of neem seed extract to the growth of M. globosa in vitro;2) the difference of the effect of neem seed extract concentration to the growth inhibition of M. globosa in vitro; 3) the  inhibition of neem leaf extract to the growth of M.globosa; 4) the difference of the effect of leaf neem extract concentration to the growth inhibition of M. globosa in  vitro. Neem seed and neem leaf extract made in some sort of concentration, i.e: 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%. The growth inhibition of M. globosa was measured by  measuring the inhibition zone diameter of the yeastgrowth on Sabouroud’s Dextrosa Agar.

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