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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 54, No. 2" : 13 Documents clear
Risk Factors of Children Behavior in Schistosomythical Transfer in Two Villages of Lindu Regency, Sigi District, Central Sulawesi in 2017 Sulistiyawati, Tri; Utomo, Budi; Soeharto, Soeharto
Folia Medica Indonesiana Vol. 54, No. 2
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Abstract

Children of primary school are particularly vulnerable to schistosomiasis because 60-70% of them with age of 5-14 years do a lot of activity outside home. The impact of schistosomiasis in children are the lack of concentration in learning, anemia, and impaired growth. This study aimed to describe the behavior of children aged 7-12 years in Puro'o and Tomado Villages in preventing the transmission of schistosomiasis and to determine the correlation between age, sex behavior community in the prevention of schistosomiasis. The study was conducted in Tomado and Puro'o villages for 3 months from March to June 2016. This was a cross sectional study. The samples in this study were children aged 7-12 years, selected by stratified multistage random cluster sampling which was done in three phases: the first phase was the villages, the second phase was the primary school in the village, and the third stage was household selected by proportional random sampling. Data were collected through interview using a structured questionnaire and the observation was analyzed using chi-square test. Respondents who had less knowledge, mostly behave defecate/urinate (80%) in latrine/WC, handwashing behavior with soap after defecating/urinating (50%), wearing footwear outside the home (86.5%), and playing in the rice fields, marshes and lakes (67.3%). Analysis of the relationship between knowledge and child's behavior showed no significant relationship (p=0.114). As a conclusion, children aged 7-12 years in Tomado and Puro'o villages mostly had less supportive behavior in preventing the transmission of schistosomiasis and had moderate or less reliable knowledge.
Purple Rosella (Hibiscus sabdariffa Linn.) Petal Extract Prevents Hepatocyte Degeneration in Wistar Rats Exposed to Cigarette Smoke Ulilalbab, Arya; Wiratmadi, Bambang; Adriani, Merryana
Folia Medica Indonesiana Vol. 54, No. 2
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Currently, the number of smokers in Indonesia is still high. Cigarette smoke contains free radicals. This study aimed to analyze the effects of purple rosella petal extract on the prevention of hepatocyte degeneration in Wistar rats exposed to cigarette smoke. Twenty male rats were divided into four groups: negative control, positive control, treatment group receiving 270 mg/kg BW purple rosella petal extract, and treatment group receiving 540 mg/kg BW purple rosella calyx extract. Negative control was only given with standard feed. Positive control was given with standard feed and exposed to 2 cigarettes a day. Treatment groups were fed with standard feed and administered with rosella extract in the morning then exposed to 2 cigarettes every day. This study was conducted for 28 days. At the end of the study, hepatocyte degeneration was observed in liver histopathology stained with hematoxilin eosin. The administration of purple rosella petal extracts in the doses of 540 mg/kgBW and 270 mg/kgBW significantly (p<0.05) prevented hepatocyte degeneration. Purple rosella petal extract is able to prevent hepatocyte degeneration in Wistar rats exposed to cigarette smoke.
Effect of Cancer Related Fatigue tTo the Level of Independence of Cancer Patients and Caregiver Stress Level Werdani, Yesiana Dwi Wahyu
Folia Medica Indonesiana Vol. 54, No. 2
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Chemotherapy/radiation in cancer patients causes cancer-related fatigue (CRF). It affects the level of independence of patients' activity of daily living (ADL). Thus, the responsibility of caregivers will be higher and it impacts on caregiver stress level. The aim of this study was to prove the effects of CRF on independence level of cancer patients and caregivers' stress level. This study used analytical associative design. The population was cancer patients and caregivers in Yayasan Kanker Indonesia in East Java. The number of samples were 30 cancer patients and 30 caregivers, taken by total sampling method. The assessment was based on instrument brief fatigue questionnaire, activity of daily living based on Katz, and caregiver stress on self assessment questionnaire. The effects of CRF on the level of independence were indicated by p=0.000, and the levels of independence of the caregiver stress level were indicated by p=0.000. As a conclusion, the failure of muscle function due to CRF can affect the independence of patient's ADL fulfilling, so caregiver should take much time to treat patient and it affects on the increased stress level of caregiver.
Increased HIF-1alpha And VEGF Expression Found in Various T Stages of Clear Cell Renal Cell Carcinoma Octavianda, Yohana; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 54, No. 2
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There is an increase in renal cell carcinoma in males aged over fifty years with smoking risk factors. Clear cell renal cell carcinoma is the most common malignant tumor found in the kidneys that have an aggressive nature. This carcinoma is classified according to TNM into T1, T2, T3 and T4 stages. The higher the T stage, the worse the prognosis of the patient, as it involves the role of the HIF-1a transcription factor accumulated under hypoxic condition due to inactivation of VHL, thus activating VEGF. So far, clear cell renal cell carcinoma frequently found in smoking males of fifth decade of age or older has not been explained.. An observational analytic study was conducted on the sample of paraffin blocks of patients with clear cell renal cell carcinoma in 2010-2016. T1, T2, T3, and T4 stages of 9 samples, 12 samples, 12 samples and 6 samples, respectively, were collected in Anatomic Pathology Laboratory, Dr. Soetomo Hospital, Surabaya. Detection of HIF-1a and VEGF expression was performed using immunohisto-chemical immunity with HIF-1a and VEGF antibodies. The results were analyzed statistically by Kruskal-Wallis and Mann-Whitney methods. The correlation between HIF-1a and VEGF in T stages was analyzed using Spearman method. There was a difference of HIF-1a expression between stage T1 with T2, T1 with T3, T1 with T4 (p=0.041, p=0.000, and p=0.002), stage T2 with T3 and stage T2 with T4 (p=0.001, and p=0.013). There was a difference in VEGF expression in stage T1 with T2, T1 with T3, T1 with T4 (p=0.007, p=0.000, and p=0.002), and stage T2 with T3 (p=0,001). There was a correlation between HIF-1a and VEGF expressions with all T stages (rs=0.624 with p 0.000). As a conclusion, the higher the stage of T, the higher the expression of HIF-1a and VEGF. The higher the levels of HIF-1a and VEGF, the worse the prognosis of clear cell renal carcinoma. HIF-1a and VEGF play a role in the pathogenesis of clear cell renal cell carcinoma. Thus, HIF-1a and VEGF can be developed as prognostic markers. Increased Hif-1aAnd Vegf Expression Found In Various T Stages Of Clear Cell Renal Cell Carcinoma
Case Report: Diagnosis and Treatment of Psychosomatic Gastritis at a Primary Health Clinic in West Surabaya, Indonesia Roosihermiatie, Betty; Isfandari, Siti; Fauzia, Yurika
Folia Medica Indonesiana Vol. 54, No. 2
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Abstract

Indonesia is highly populated of a total 238,452,952 people with 274,396 gastritis cases. However, psychosomatic gastritis was just reported by very few patients. Because of the common gastritis cases in Indonesia and with the act of Healthcare and Social Security Agency or BPJS, so primary health cares should diagnose and manage the cases. This study aimed to determine the diagnosis and management of psychosomatic gastritis at a primary health clinic in West of Surabaya. It was a case study. It was a case on a woman aged 45 years old. She was high school graduate, married and had a child. She experienced reflux gastritis and psychiatric condition of depression and anxienty disorders. She was treated by psychiatrist at the first time and self-medicated for the gastritis. After stopping visiting the psychiatrist, she had problems of gastritis in four months. Then, she was referred to internist and examined Ultra Sonography of abdominal organs with normal result. There was a conventional method to determine psychosomatic gastritis that consicting of life styles, psychologic factor, social factor, and behavior assessment. This patient was a local migrant who struggled to gain a better life in the city, had a trigger for his father's death, had a relatively low socioeconomic state and lived in a monthly boarding house, and was a part-time worker. First-line care should establish a psychosomatic diagnosis of gastritis and treat psychological disorders together with their somatic abnormalities. Thus, the first level of health services must provide holistic services consisting of physical, psychological and social aspects.
Effects of Red Fruit (Pandanus conoideus Lam) Oil on Malondialdehyde Level and Spermatozoa Quality in Mice (Mus musculus) Exposed to Monosodium Glutamate Agustina, Widayati; Widjiati, Widjiati; Hayati, Alfiah
Folia Medica Indonesiana Vol. 54, No. 2
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This study aimed to determine the effects of red fruit (Pandanus conoideus Lam) oil on MDA levels and spermatozoa quality in mice (Mus musculus) exposed to MSG. The quality includes motility, viability, concentration, and morphology of spermatozoa. This experimental study used randomized post-test only control group design. The subjects of this study were 25 mice (Mus musculus), divided into 5 groups (5 mice per group). K- group received distilled water for 35 days. K+ group received 4 mg/g BW MSG for 21 days. P1, P2, and P3 treatment groups received 4 mg/g BW MSG for 21 days and 0.02; 0.04; 0.08 ml/g BW red fruit oil, respectively, from day 22 to 35. The results showed that mean spermatozoa morphology in K-, K+, P1, P2, P3 groups were as follows: 0.86; 0.56; 0.67; 0.61; and 0.87 (%). The spermatozoa concentrations were sequentially as follows: 21; 10; 15; 32,8,19 (107 cells/ml). The spermatozoa's vitalities were as follows: 0,64; 0,14; 0,24; P2: 0.36; 0.68 (%). MDA levels were respectively: 0.29; 0.60; 0.35; 0.23; and 0.19 (nm). As a conclusion, testicular MDA levels in mice exposed to MSG and given with red fruit oil were lower than those in mice exposed to MSG without receiving red fruit oil. The quality of spermatozoa in mice exposed to MSG and receiving red fruit oil was higher than that of mice exposed to MSG without being given with red fruit oil.
Epiphyseal Closure Time of Radius and Ulna Bones of the Proximal Section Lio, Tiara Mayang Pratiwi; Koesbardiati, Toetik; Yudianto, Achmad; Setiawati, Rosy
Folia Medica Indonesiana Vol. 54, No. 2
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Accurate determination of age is important in the legal process; when a person's age is unknown or must be authenticated, a forensic age identification method must be applied. One of such methods is to assess the epiphyseal closure on the bone through radiological examination. The main problem associated with the use of this method is the relevance of the reference population provided because epiphyseal closure is influenced by genetics and nutrition. This method needs data to represent each population. Radiological examination of elbow bones of 30 male patients aged 11-30 years and 18 female patients aged 14-28 years in Dr. Soetomo Hospital, Surabaya from January to April 2016 was carried out to determine the time of epiphyseal closure of the radius and ulna distal section. This was cross-sectional descriptive study. In conclusion, epiphyseal closure of proximal radius and ulna is complete at age 16 in males and 14 in females.
Early Warning Systems (E-Wars) Design for Early Detection of Stroke Incidence Erawantini, Feby; Karimah, Rinda Nurul
Folia Medica Indonesiana Vol. 54, No. 2
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Stroke is a neurological disease whose occurrence increases from year to year and causes disability and death worldwide. Stroke is caused by many factors or multicausal. This was a qualitative study conducted for one year with system design using prototype method. The prototype method began with the identification of needs, mapping, and then inference mechanism. Identification of needs was based on the literature review and discussion. The literature review from 15 sources consisting of journal articles, books and proceedings was done by comparing, contrasting, criticizing, synthesizing and summarizing. Stroke risk factor discussion were carried out with neurologists. The results of the review and literature discussion found identification of factors that cause stroke, which consisted of hypertension, high blood glucose, cholesterol, heart disease, behavioral factors, such as smoking behavior and alcoholism, stress and other causes. The risk factors of stroke were then mapped in the form of mobile application prototype through inference mechanism. The output in this study was early warning systems (E-WARS) prototype for early detection of stroke occurrence. The prototype results were expected to be used in operations into mobile applications that were beneficial to the public, in particular for self-control and personal risk factors for stroke. It was intended for early screening and early detection of the risk of stroke.
Positivity of ExoU Gene of Type III Secretion System and Fluoroquinolone Resistance of Psedomonas aeruginosa from Sputum of Nosocomial Pneumonia Patients in Sanglah Hospital, Bali Saputra, I Wayan Agus Gede Manik; Mertaniasih, Ni Made; Fatmawati, Ni Nengah Dwi
Folia Medica Indonesiana Vol. 54, No. 2
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Pseudomonas aeruginosa is one of the Gram-negative rods bacteria that frequently cause nosocomial pneumonia. One of the main virulent effector proteins on Type III secretion system (TTSS) of P. aeruginosa is Exoenzyme U ( ExoU). ExoU works as a phospholipase A2 activity and exhibits lung tissue injury effect in pneumonia. As an antibiotic that has activity against P. aeruginosa, fluoroquinolone resistance has increased as many as three fold since the last decade. Infections caused by P. aeruginosa that are fluoroquinolone resistant and positive for ExoU gene show worse clinical outcome. The aim of this study was to determine the positivity of ExoU gene TTSS and fluoroquinolone resistance of P. aeruginosa that isolated from sputum of nosocomial pneumonia patients in Sanglah Hospital, Bali. P. aeruginosa isolated from sputum of patient that diagnosed as nosocomial pneumonia, isolates had been identified phenotypically by Vitek2 Compact system (bioMérieux, Inc., Marcy-l'Etoile - France), and then continued by genotypic detection by PCR. The susceptibility testing of P. aeruginosa isolates to Ciprofloxacin were conducted by Vitek2 Compact, whereas ExoU genes were detected by PCR. Fifty-three P. aeruginosa isolates were identified in this study, in which 35 isolates (66.1%) had ExoU gene and 22 isolates (41.5%) were resistant to Ciprofloxacin. Based on nosocomial pneumonia type, the highest proportion of isolates genotipically ExoU+ and phenotypically Ciprofloxacin were on VAP group accounted for 57.1% and 54.5%, respectively. Chi-square analysis showed significant correlation between Ciprofloxacin resistance and ExoU gene (p=0.001). As a conclusion, the positivity of ExoU+ isolates were more likely found in Ciprofloxacin resistant group.
Effects of Sambiloto Ethanol Extract on Fatty Liver, SGOT/SGPT Levels and Lipid Profile of Wistar Strain White Rat (Rattus norvegicus) Exposed to High-Fat Diet Jong, FX Himawan Haryanto; Gunawan, Ari; Santoso, Mochamad Wirono Aman; Anjani, Susilowati; Tirthaningsih, Ni Wayan; Basori, Ahmad
Folia Medica Indonesiana Vol. 54, No. 2
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The aim of this study was to analyze the effects of ethanol extract of sambiloto (Andrographis paniculata) on fatty liver percentage, serum glutamic oxaloacetic transaminase (SGOT) level and lipid profile of wistar strain white rat exposed to high fat diet. The study used randomized post test only control group design. Total sample was 50 male wistar strain rats (Rattus norvegicus) divided randomly into 5 groups (randomization). The normality test used was Kolmogorov Smirnov test (a=0.05). The homogeneity test used was Levene test (a=0.05). The comparative test was done using Anova test (analysis of variance) (a=0.05) or Brown-Forsythe test (a=0.05). The correlation test was done using Pearson test (a=0.05). The administration of sambiloto ethanol extract with doses of 100, 200 and 400 milligrams (mg)/kilogram (kg) body weight (BW) decreased the percentage of fatty liver (r=-0.950), SGOT (r=-0.964)/SGPT (r=(R=-0.973)/LDL (low-density lipoprotein) (r=-0.960) and increased HDL (high-density lipoprotein) levels (r=-0.923)=0.956) in white rats exposed to a high-fat diet. In conclusion, increased dose of ethanol extract of sambiloto can decrease the percentage of fatty liver, SGOT/SGPT and total cholesterol/TG/LDL and increase HDL level of white rats exposed to high fat diet.

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