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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Articles 18 Documents
Search results for , issue "Vol. 58, No. 1" : 18 Documents clear
Skill Improvement for Public Health Center Staffs in the Management of Toxic and Hazardous Materials Djuari, Lilik; Dewanti, Linda; Sulistiawati, Sulistiawati; Mahendra, Arya Ivan; Fahruddin, Ahmad Cholifa
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • There was an increase in the accumulation of B3 waste in health centers during the COVID-19 pandemic. • The knowledge and skills level of health center staff in medical THM waste management before and after medical THM waste management training were determined. • Medical THM waste management training was increasing the knowledge and skills level of health center staff. Abstract: The generation of medical toxic and hazardous material (THM) waste at public health centers tends to increase during the Covid-19 pandemic. Only 6.89% of the health centers have medical waste management practices that meet the standards. Medical waste management practices not in accordance with the procedures can be a source of infection, even though only 56% of health workers have good knowledge and attitudes in solid medical waste management. For this reason, it is necessary to increase the skills of health center staff in managing medical THM waste during the Covid-19 pandemic. The purpose of this study was to determine the level of knowledge and skills of health center staff in medical THM waste management before and after medical THM waste management training. The training participants were 20 health center staffs who filled out a pretest questionnaire to measure their level of knowledge and skills prior to the training. The training materials include THM waste, medical THM waste, medical THM waste management and medical THM Temporary Storage. After the training, a post-test was conducted to measure the knowledge and skills scores of the trainees. The results of this study indicated that there was a significant difference in knowledge before and after training (p < 0.05). The average knowledge score before training was 6.2 (sufficient knowledge) and after training 8.15 (good knowledge). There was a significant difference in skill scores before and after training (p <0.05). The average skill before training was 6.3 (adequate) and after training 8.65 (good). In conclusion, there was an increase in the skills of health center staff in managing medical THM waste during covid-19 pandemic after participating in medical THM waste management training by the Community Service Team, Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Prostate-Specific Antigen and Time to PSA Nadir as Prognostic Significance in Castration-Resistant Prostate Cancer Pranata, Firmantya Hadi; Djatisoesanto, Wahjoe; Soebadi, Doddy M.
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Assessing the survival rate in castration-resistant prostate cancer was descriptived. • PSA level between survivor and non survivor was significant but not for PSA nadir level, TTN and TTC. • Initial PSA level can predict survival prognosis rate of castration-resistant prostate cancer patients. Abstract: High mortality rates was often found in castration-resistant prostate cancer (CRPC). Our aim on this research was to assess the PSA level and time to PSA nadir as a prognostic tool for survival in CRPC patients. Several factors are considered to be useful as prognostic marker in CRPC patients. This study was a descriptive study assessing the survival rate in castration-resistant prostate cancer. Evaluation data included sex, age, initial PSA level, final PSA level, time to PSA nadir (TTN), time to CRPC progression (TTC), and survival status. A total of 24 patients with CRPC were evaluated in this study. There was significant difference found of initial PSA level between survivor (445.7 + 165.6 ng/mL) and non-survivor (200.7 + 144.9 ng/mL). There were no significant differences were also found in PSA nadir level, TTN and TTC between survivor and non-survivor groups. This study revealed that there was association between initial PSA level on survival rate of CRPC patients. Initial PSA level could be used to predict survival prognosis in CRPC patients.
The Role of Dermoscopy in Diagnosis of Benign Skin Neoplasms Purnamasari, Indah; Sari, Maylita
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Dermoscopy is a practical, non-invasive and accurate method for reducing the number of unnecessary excision of benign skin neoplasms. • Knowledge about vascular pattern and description setting can lead to a prompt benign skin neoplasm diagnosis. Abstract: Benign skin neoplasms are commonly found in the population. It has a well-differentiated and slow growth nature. The patients often come seeking treatment when the tumor has developed into malignancy. This usual delay in diagnosis and therapy frequently happens because early-stage mass has not generated any complaints by the patients. Detection and monitoring of benign skin neoplasms can be carried out earlier and more effectively if the clinician or dermatologist has the knowledge of distinguishing benign from malignant lesions. The histopathological examination can help to establish the diagnosis, but this method is invasive and requires an extended amount of time. Dermoscopy is a practical, non-invasive and accurate method for early detection of skin disorder which reduces the number of unnecessary excisions of benign skin neoplasms. Knowledge of the vascular pattern and arrangement description, combined with the additional dermoscopic feature can lead to the prompt diagnosis of benign skin neoplasms.
Rare Diagnosis of a Proliferating Pilar Tumor in a Facial Hairline Cryst Imran, Farrah-Hani; Imami, Nabilah Hasna; Wen, Adzim Poh Yuen
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Sebaceous cyst or epidermoid cyst is a benign capsulated tumour on the scalp region, face, neck, and trunk that subepidermal nodule filled with keratin. • Proliferating Pilar Tumours (PPT) are rare tumours was found in hair follicle. • Sebaceous cyst diagnose on facial hairline tumour turned out to be a rare Proliferating Pilar Tumour (PPT). Abstract: Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the scrotum, genitalia, fingers, and buccal mucosa. Proliferating Pilar Tumors (PPT) are rare tumors. It is derived from the external root sheath of the hair follicle. These tumors are like irregular subcutaneous nodules and often appear on the scalp. This case report was about a 59 years old woman who came to the hospital following excision of a frontal lump elsewhere, with a sebaceous cyst as the initial diagnosis. From the histopathologic examination, grossly there was a whitish and greyish lump with a soft outer surface. Microscopically, there were malignancy signs with areas with keratinization. The tumor formed a solid pattern of enlarged cells with moderate to marked nuclear pleomorphism with vesicular nuclei, prominent nucleoli, and abundant pale eosinophilic to clear cytoplasm. There was also much free keratinous debris noted and numerous foci of calcification identified within the tumor. Mitotic figures with abnormal forms were frequently seen. The final diagnosis after the histopathological examination was Proliferating Pilar Tumour with focal malignancies. In conclusion, facial hairline tumor differentially diagnosed as a sebaceous cyst turned out to be a rare Proliferating Pilar Tumor (PPT). Following histopathological confirmation, the patient was referred for further management by a specialist team.
Acute Diarrhea Patients among Children Under Five Hospitalized in a Tertiary Hospital in East Java, Indonesia Adiba, Asmahan Farah; Soedarmo, Subijanto Marto; Sulistiawati, Sulistiawati; Athiyyah, Alpha Fardah
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • The characteristics of acute diarrhea patients among chidren in Tertiary Hospital In East Java was evaluated. • The highest incidence of diarrhea was found in the 0-24 months age group, good nutritional status, male sex, and hospitalized in less than 5 days. • Mild-moderate dehydration, intravenous rehydration treated, anemia, hyponatremia, and metabolic acidosis were mostly founded. Abstract: Diarrhea is the second leading cause of morbidity and mortality in children under five years of age in Indonesia after pneumonia. In 2017, diarrhea became an outbreak in 12 provinces. Diarrhea in under-fives can cause several complications and can cause death if it is not treated properly. This study aimed to evaluate the characteristics of acute diarrhea patients in under-fives hospitalized in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia for six months. This study was a descriptive study with retrospective approach which evaluated all acute diarrhea patients hospitalized from July to December 2019. Patients' data were taken from medical records and presented descriptively. Of the total 125 patients, most acute diarrhea patients were male (60%) aged 0 to 24 months (83.2%), had good nutritional status (58.4%), and hospitalized for less than 5 days (60.8%). The most degree of dehydration was mild-moderate dehydration (83.2%), mostly treated with intravenous rehydration (96.8%), the most common comorbidity was anemia (13.4%), and the most electrolyte disorder was hyponatremia (41%), while acid-base disorder was mostly metabolic acidosis (75%).
The AKT Pathway and Satellite Cell Activation in Skeletal Muscle Mass Regulation Sofiyanti, Santi; Goenawan, Hanna; Lesmana, Ronny; Tarawan, Vita Murniati
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • AKT or protein kinase B increase protein synthesis and control the degradation of proteins. • Satellite cells was provided remarkable ability to regenerate skeletal muscle. • Stimulation of protein synthesis is effective therapy to maintain muscle mass, prevent muscle wasting to reduce risk sarcopenia and improve quality of life in the elderly. Abstract: Muscles have an important role as a regulator of glucose and triglyceride metabolism. Some researches show the correlation between skeletal muscle mass and metabolic diseases, such as diabetes. Skeletal muscle mass decrease occurs due to chronic illness or physiological process of aging, thus increasing the risk of metabolic diseases as well as motion difficulty in the elderly. Skeletal muscle mass depends on balanced protein synthesis and degradation, controlled through a variety of signal transduction pathways including the AKT. AKT or protein kinase B increases protein synthesis through the mTOR and GSK3β and controls the degradation of proteins through FoxO transcription factors. Another factor that has an alleged role in the regulation of skeletal muscle is the satellite cells which provide remarkable ability to regenerate skeletal muscle. A comprehensive understanding of the biomolecular mechanism of muscle mass regulation is important to develop effective treatment or prevention of muscle atrophy in many cases, either caused by pathological conditions, such as chronic diseases, or the process of aging.
Back Matter Vol.58 No.1 March 2022 Matter, Back
Folia Medica Indonesiana Vol. 58, No. 1
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Splenectomy for Aseptic Splenic Abscess Pranata, Andy Kusuma; Danardono, Edwin Don
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • A 26-year-old woman have sterile aerobic and anaerobic bacterial cultures. • Pus and splenic tissue examination revealed no bacterial proliferation, while the surgery revealed a splenic abscess. Abstract: We presented a rare case, a 26-year-old woman have sterile aerobic and anaerobic bacterial cultures. Clinical examination of the patient showed a dense cystic mass in the left upper abdomen. Ultrasonography examination suspected a dermoid cyst. However, MRI examination of the abdomen showed turbid cystic lesions. The surgery revealed a splenic abscess, while pus and splenic tissue examination revealed no bacterial proliferation. Based on the literature, the patient had a good prognosis.
Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin Kurniasari, Hamidah; Rejeki, Purwo Sri; Kahar, Hartono; Sunarti, Sri
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Adiponectin is an important protective factor for cardiovascular disease and increased insulin sensitivity. • Ketogenic diet effect on adiponectin level in mice besides decrease weight gain was determined. • The difference in serum adiponectin level and body weight is uncorrelated. Abstract: Ketogenic diet is a popular diet to reduce weight gain quickly. This diet has become a lifestyle . The ketogenic diet has been reported to affect adiponectin level, although it is still contraindicated. Adiponectin is a biomarker for metabolic disease that plays an important role as a protective factor for cardiovascular disease and increase insulin sensitivity. This study aimed to explore the effect of the ketogenic diet on adiponectin level in mice, besides decrease weight gain. This study was an experimental laboratory study with a randomized post-test-only control group design. Fourteen male mice (20-30 g) aged 2-3 months were divided randomly into K1 (n=7, standard diet) and K2 (n=7, ketogenic diet), were given diet for eight weeks, ad libitum. Body weight was measured at the pre and post-intervention, whereas adiponectin level were measured at the post-intervention using ELISA. The statistical analysis using SPSS version 16. The Shapiro Wilk test was used to determine normality, Independent T-Test was used to determine mean difference for normal distribution, Mann Whitney Test was used to determine mean difference for abnormal distribution, and Pearson Correlation was used to determine correlation. Difference (∆) of body weight on K1 (12.00±6.26) g, K2 (1.29±7.41) g with p=0.02. Serum adiponectin level of K1 (0.082±0.014) µg/ml and K2 (0.096±0.008) µg/ml with p=0.035. This study showed ketogenic diet-induced higher serum adiponectin level and slower weight gain. There is no correlation between the difference in body weight and serum adiponectin level (p=0.403).
Front Matter Vol.58 No.1 March 2022 Matter, Front
Folia Medica Indonesiana Vol. 58, No. 1
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