cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Della Dwi Ayu
Contact Email
della.dwi.ayu@upnvj.ac.id
Phone
+62318945444
Journal Mail Official
notification@umsida.ac.id
Editorial Address
Jl. Mojopahit 666 B Sidoarjo, Jawa Timur 61215
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Academia Open
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 27147444     DOI : 10.21070/acopen.11.2026.12985
Core Subject : Health,
Medicine & Pharmacology Public Health
Academia Open is published by Universitas Muhammadiyah Sidoarjo published 2 (two) issues per year (June and December). This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal aims is to provide a place for academics and practitioners to publish original research and review articles. The articles basically contains any topics research or review. Academia Open is available in online version. Language used in this journal is Indonesia or English.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 2,389 Documents
 119   120   121   122   123 
Flavonoids from Verbascum thapsus Protect Against Nephrotoxicity in Rats: Flavonoid dari Verbascum thapsus Melindungi Terhadap Nefrotoksisitas pada Tikus Hawraa Chasib Bukhibkh
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10298

Abstract

General Background: Nephrotoxicity induced by carbon tetrachloride (CCl4) poses significant health risks, prompting the exploration of natural antioxidants for renal protection. Specific Background: Verbascum thapsus, a plant known for its flavonoid content, has shown potential in mitigating oxidative stress, but its specific protective effects against CCl4-induced nephrotoxicity remain under-investigated. Knowledge Gap: While previous studies have indicated antioxidant properties of flavonoids, their efficacy in renal preservation in vivo has not been fully elucidated. Aims: The study evaluated the antioxidative and nephroprotective properties of flavonoids from Verbascum thapsus leaves in a rat model of CCl4-induced nephrotoxicity.Results: Rats were divided into three groups: control, CCl4-treated, and flavonoid plus CCl4-treated. Biochemical analyses revealed that CCl4 significantly elevated malondialdehyde (MDA), urea, creatinine, and uric acid levels while decreasing superoxide dismutase (SOD) and glutathione (GSH) levels. Notably, flavonoid administration markedly reduced MDA, urea, creatinine, and uric acid levels and enhanced SOD and GSH levels compared to the CCl4-only group. Novelty: This study uniquely highlights the protective role of flavonoids from Verbascum thapsus against nephrotoxicity, demonstrating both their antioxidative capacity and renal preservation in an experimental model. Implications: The findings support the potential use of Verbascum thapsus as a therapeutic agent in the management of kidney diseases, suggesting further investigation into its application in clinical settings to address nephrotoxicity and related renal disorders. Highlights: Nephroprotective: Flavonoids significantly protect against CCl4-induced kidney damage. Biochemical Enhancement: Improved antioxidant levels; reduced harmful biochemical indicators. Therapeutic Potential: Supports natural treatments for kidney diseases. Keywords: Verbascum thapsus, flavonoids, nephrotoxicity, antioxidants, carbon tetrachloride
Highlighting the Urgent Need for Reforms in the Face of Financial Failures at State-Owned Enterprises in Iraq: Menyoroti Kebutuhan Mendesak untuk Reformasi dalam Menghadapi Kegagalan Keuangan pada Perusahaan Milik Negara di Irak Ibrahim Naeem Hasan
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10299

Abstract

General Background: The financial analysis of companies' reports is critical for assessing their past performance, forecasting future results, and identifying operational strengths and weaknesses. Specific Background: Financial failure, which occurs when a company cannot generate adequate returns to cover costs and capital expenses, poses significant risks to stakeholders. For state-owned companies, the implications of financial failure are especially profound, given their integral role in national economies, such as Iraq's. Knowledge Gap: There is limited understanding of the extent to which state-owned companies in Iraq utilize financial analysis to predict financial failure, particularly in the context of economic transitions and privatization pressures. Aims: This study aims to evaluate the dependence of Iraqi state-owned companies on financial analysis as a predictive tool for financial distress and to identify the key factors contributing to their financial failures. Results: The research reveals that 42% of the companies examined have experienced financial failure, as measured by the Argenti index. Contributing factors include employment challenges, insufficient financing, and the transition from a socialist to a capitalist economy, which has left companies vulnerable to privatization. Novelty: The study provides novel insights into how economic transition impacts the financial stability of state-owned companies, highlighting the practical application of the Argenti index in diagnosing financial weaknesses. Implications: The findings underscore the urgent need to support state-owned enterprises by revitalizing the industrial sector, improving administrative efficiency, and adopting more systematic financial analysis tools. Additionally, the research recommends creating an accessible information center for investors and creditors, which would enhance transparency and support decision-making. This approach could help mitigate financial distress and attract new investment, ultimately contributing to Iraq’s economic recovery. Highlights: Financial analysis helps predict failures in state-owned companies. 42% of companies fail, based on the Argenti index. Privatization and economic shifts increase financial risk. Keywords: Financial analysis, Argenti index, state-owned companies, financial failure, privatization
Removal of Toxic Heavy Metals Using Genetically Engineered Microbes: Molecular Tools, Risk Assessment, and Management Strategies: Penghapusan Logam Berat Beracun Menggunakan Mikroba Hasil Rekayasa Genetika: Alat Molekuler, Penilaian Risiko, dan Strategi Manajemen Ola Abdulwahhab Muslim; Hayder Mohammed Bakr; Abdulhussain Kadhim Jwaziri; Kawther Mohammed Radah Ali
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10300

Abstract

Background: The growing occurrence of heavy metal pollutants in many environmental sources requires effective methods for treatment. Genetically engineered microorganisms, namely bacteria such as Shewanella oneidensis and Cupriavidus metallidurans, have been highly useful for the specific removal of heavy metals. Purpose: This study aims to examine the effectiveness of genetically modified Shewanella oneidensis and Cupriavidus metallidurans, obtained from MB Genetics, in removing harmful heavy metals from various environmental sources. Methods: Genetically modified strains were obtained from MB Genetics, a company specializing in the creation of transgenic microbes. Shewanella oneidensis and Cupriavidus metallidurans were utilized to mitigate the presence of harmful heavy metals in water under different pH levels. Results: The study showed a notable effectiveness, as both bacterial strains successfully eliminated 91% of Lead at pH 7. The study highlighted the substantial impact of pH on the levels of heavy metals in the environment. Conclusion: The need to eradicate harmful heavy metals in the present time can be efficiently tackled by using genetically modified bacteria. Shewanella oneidensis and Cupriavidus metallidurans demonstrated remarkable efficacy in the removal of heavy metals. Highlights: Modified bacteria remove 91% of lead at neutral pH. CRISPR/Cas9 enhances bacteria for efficient heavy metal removal. pH optimization is key for effective heavy metal absorption. Keywords: Toxic heavy metals, Pseudomonas aeruginosa, Shewanella oneidensis, Cupriavidus metallidurans
Higher Serum Level of MMP-3 and Homocysteine in Patients Admitted With COVID-19: Tingkat Serum MMP-3 dan Homosistein yang Lebih Tinggi pada Pasien yang Dirawat dengan COVID-19 Nasrin Hayawi; Masoud Youssefi; Mohammad Soukhtanloo; Lida Jarahi; Elham Pishbin; Farnaz Zahedi Avval
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10301

Abstract

Background: SARS-CoV-2 predominantly affects the lungs, leading to severe acute respiratory syndrome (ARDS). The lack of specific biomarkers underscores the urgent need for novel indicators for early diagnosis and severity assessment of COVID-19. Specific Background: Matrix metalloproteinase-3 (MMP-3) is implicated in various inflammatory diseases, particularly viral infections, while homocysteine (Hcy) plays a crucial role in maintaining cell homeostasis and regulating inflammatory responses. Knowledge Gap: Despite their relevance in inflammation, the potential of MMP-3 and Hcy as biomarkers for COVID-19 remains underexplored. Aims: This study aimed to evaluate the serum levels of MMP-3 and Hcy in COVID-19 patients and assess their utility in diagnosis and severity prediction. Results: A study analyzing 90 serum samples from 60 ICU patients and 30 healthy controls found elevated CRP levels, higher Hcy and MMP-3 levels in the moderate group, but lower in the ICU group, with a significant correlation between MMP-3 activity and Hcy levels. Novelty: This research highlights the potential role of MMP-3 and Hcy as valuable biomarkers for COVID-19 diagnosis. Implications: While MMP-3 and homocysteine may aid in the diagnostic process, they could not be reliably used to predict severity outcomes in COVID-19 patients. Further studies are warranted to clarify the clinical implications of these biomarkers in the context of COVID-19. Highlights: MMP-3 and homocysteine identified as potential COVID-19 biomarkers. No correlation found between biomarkers and disease severity. Further research needed for clinical utility assessment. Keywords: COVID-19, MMP-3, homocysteine, biomarkers, diagnosis
Study of Some Apoptotic Protein Expration in Human Mesenchymal Stem Cells During Toxoplasma Gondii Infection: Studi Ekspresi Beberapa Protein Apoptosis pada Sel Punca Mesenkim Manusia Selama Infeksi Toxoplasma Gondii Suhair Sameer Jasim; Safa Yassin Mohammed; Suha Sulaiman Erzayek; Rand Hatem Hussein; Ridhab Ajeel Jasim
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10302

Abstract

Background: Toxoplasma gondii (T. gondii) infection is a significant health concern, particularly during pregnancy, as it can lead to fetal harm and birth abnormalities. Specific Background: The role of apoptosis in managing T. gondii infection remains poorly understood, particularly regarding its molecular mechanisms. Knowledge Gap: The impact of T. gondii infection on apoptosis in mesenchymal stem cells (MSCs) derived from human umbilical cords has not been thoroughly studied in existing literature. Aims: This study aimed to investigate the activation of apoptosis and its regulatory mechanisms in human Wharton’s Jelly mesenchymal stem cells (WJ-MSCs) during T. gondii infection. Results: Using non-enzymatic techniques, we isolated T. gondii from infected and aborted phase-specific placentas. Our findings demonstrated a significant increase in the expression of apoptosis-activating genes (CASP2, CASP3, Bak1) in WJ-MSCs following infection, with a marked decrease in cell viability observed within 2 to 4 hours of exposure to the parasite (P≤0.05). Novelty: This study provides novel insights into the relationship between T. gondii infection and apoptosis in WJ-MSCs, highlighting the specific gene expression changes that occur in response to infection. Implications: Research on T. gondii's apoptotic pathways is crucial for developing therapeutic strategies to mitigate pregnancy-related adverse effects and improve maternal and fetal health outcomes. Highlights: Increased Apoptosis: T. gondii enhances apoptosis in mesenchymal stem cells. Cell Viability Impact: Significant decrease in WJ-MSC viability after infection. Clinical Relevance: Insights can inform strategies to reduce fetal infection risks. Keywords: Toxoplasma gondii, apoptosis, Wharton’s Jelly mesenchymal stem cells, pregnancy, gene expression
Classification of Rice Grains by Image Processing: Klasifikasi Butir Beras dengan Pemrosesan Citra Zainab Naser Azeez; Aseel.A. Qasim; Najlaa Muhammed Mohie
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10303

Abstract

General Background: The assessment of the surface quality of pre-treated rice grains is crucial for determining their market acceptability, storage stability, processing quality, and overall consumer satisfaction. Traditional evaluation methods are often time-consuming and yield subjective classifications. Specific Background: The lack of a comprehensive tagged image dataset hinders the application of advanced convolutional neural networks (CNN) for detailed damage classification of healthy rice grains. Knowledge Gap: Existing datasets and methods limit the effective exploration of sophisticated CNN models for categorizing rice types, particularly in identifying subtle damage characteristics. Aims: The study aims to create a robust rice grain classification system using image processing techniques, primarily deep learning algorithms, to improve the classification of rice varieties. Results: Utilizing a dataset of 75,000 images across five widely cultivated rice varieties in Turkey, we achieved classification accuracies of 100% for CNN, 99.95% for deep neural networks (DNN), and 99.87% for artificial neural networks (ANN). Novelty: The proposed approach represents a significant advancement in rice classification technology, employing a combination of image acquisition, feature extraction, and machine learning to streamline the process, effectively addressing the challenges faced in traditional methods. Implications: The findings underscore the potential for improved sorting and grading efficiency in the rice industry, facilitating better market outcomes and consumer satisfaction through enhanced quality control Highlights: Innovative: Uses CNN for accurate rice variety classification. Data-Driven: Analyzes 75,000 images for enhanced quality evaluation. Impactful: Increases efficiency in sorting and grading processes. Keywords: Rice Classification, Image Processing, CNN, Machine Learning, Agricultural Technology
Prevalence of a Subtype in Iraqi Donations of National Blood Transfusion Center: Prevalensi Subtipe pada Donasi Pusat Transfusi Darah Nasional Irak Yaqoob A. Wahid; Esraa K Shanyoor; Eman N. Naji; Marwah A Abduljabar
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10304

Abstract

General Background: The ABO blood group system is essential in blood transfusion, with subtypes of A and B groups influencing clinical outcomes. Specific Background: Subtypes A1 and A2 differ in the amount of antigen on red blood cells, impacting blood typing accuracy. Knowledge Gap: The prevalence of A2 and A2B subtypes in Iraqi donors remains underexplored, and their detection in routine screening can be challenging. Aims: This study aimed to determine the prevalence of A2 and A2B subtypes among Iraqi blood donors and evaluate the necessity of Anti-A1 reagent in accurate subtype identification. Results: In 2022, type O blood donors were the most prevalent, followed by B, A, and AB. A routine screening identified 0% A2 and 0.7% A2B subtypes, but 5% and 14.2% were A2B. Novelty: This study highlights the limitations of routine serological testing in detecting A subtypes, demonstrating that the use of Anti-A1 reagent significantly improves accuracy. Implications: Given the low rate of discrepancy between forward and reverse grouping, the Anti-A1 reagent should be routinely used for detecting A subtypes in clinical settings. Additionally, molecular techniques may be required to distinguish between rarer A subtypes such as A3, Ax, and Am. Highlights: ABO subtypes A1 and A2 are vital for precise blood transfusion typing. Routine tests miss A2; Anti-A1 reagent ensures accurate subtype detection. Molecular techniques help identify rarer subtypes like A3 and Ax. Keywords: ABO system, blood subtypes, Iraqi donors, Anti-A1 reagent, blood typing
Self-efficacy as a Predictor of Self-Management Capacity in Cancer Patients: Efikasi Diri sebagai Prediktor Kapasitas Manajemen Diri pada Pasien Kanker Zahraa Abbass
Academia Open Vol. 9 No. 1 (2024): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10305

Abstract

Background: Self-efficacy, a fundamental concept in psychology, reflects an individual’s confidence in their ability to accomplish specific tasks and achieve goals. It significantly influences cancer patients' coping mechanisms, treatment adherence, psychological distress management, and overall well-being. Specific Background: While existing literature highlights various aspects of self-efficacy among cancer patients, few studies comprehensively address the relationship between self-efficacy and socio-demographic variables. Knowledge Gap: There remains a paucity of research examining the interaction between self-efficacy and demographic characteristics such as age, gender, and educational attainment among cancer patients. Aims: This study aims to assess the level of self-efficacy in cancer patients and explore its correlation with socio-demographic characteristics. Results: A cross-sectional descriptive design was employed with a purposive sample of 107 cancer patients. The findings revealed that 83% of participants exhibited a high level of self-efficacy, while only 6.50% demonstrated low self-efficacy. A statistically significant association was identified between age and self-efficacy levels (P-value = 0.000). Novelty: This research is among the first to highlight the influence of age and chronic illness on self-efficacy in cancer patients while showing no significant relationships with gender, education, or social status. Implications: The study underscores the importance of promoting self-efficacy in cancer care, particularly through targeted interventions that consider age and chronic disease status. Enhancing self-efficacy can improve treatment adherence and psychological adjustment, thereby positively impacting the overall health outcomes of cancer patients. Highlights: 83% of cancer patients had high self-efficacy levels. Age significantly correlates with self-efficacy (P-value = 0.000). Self-efficacy unaffected by gender, education, or social status. Keywords: self-efficacy, cancer patients, socio-demographic characteristics, treatment adherence, psychological well-being
Nurses' Knowledge of Nonalcoholic Fatty Liver Disease: A Cross-sectional Study: Pengetahuan Perawat tentang Penyakit Hati Berlemak Nonalkohol: Sebuah Studi Cross-sectional Eman H. Rahi; Zahraa Mahmoud Hussain Al-Hejaj; Ali Malik Tiryag
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10306

Abstract

General Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions, including simple steatosis, cirrhosis, liver cancer, and non-alcoholic steatohepatitis (NASH). Specific Background: Given the increasing prevalence of NAFLD, understanding healthcare professionals' knowledge about this condition is crucial for effective patient care and management. Knowledge Gap: However, there is limited research assessing nurses' knowledge regarding NAFLD, particularly in the context of Basrah City Center Hospitals. Aims: This study aimed to evaluate nurses' knowledge of NAFLD and investigate its relationship with demographic characteristics such as gender, age, years of experience, and departmental affiliation. Results: A cross-sectional survey involving 150 nurses revealed that 57.3% possessed high levels of knowledge regarding NAFLD, while 34% had moderate knowledge. Notably, a significant correlation was found between nurses working at Al-Shifaa Hospital and their knowledge levels. The majority of participants were female (64.7%) and aged 20-30 (72%), with a predominant educational background from Nursing Institutes (39.3%) and fewer than five years of experience (56%). Novelty: This study is pioneering in assessing the knowledge of NAFLD among nurses in Basrah, highlighting specific areas of strength and weakness in their understanding. Implications: The study highlights the need for targeted educational interventions to improve nurses' understanding of NAFLD, leading to improved patient care and outcomes in liver disease management. practice. Highlights: Increasing NAFLD prevalence necessitates enhanced healthcare provider awareness. Nurses showed significant knowledge levels about NAFLD. Knowledge varies significantly by hospital affiliation. Keywords: Non-alcoholic fatty liver disease, nurses' knowledge, Basrah City, cross-sectional study, healthcare education.
Immunological Changes and Complement Proteins in Major Thalassemia Patients Proteins Post-Splenectomy: Perubahan Imunologi dan Protein Komplemen pada Pasien Talasemia Mayor Protein Pasca-Splenektomi Eman A. Mizher
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10310

Abstract

Background: Thalassemia is one of the most prevalent genetic disorders worldwide, with infections being a leading cause of mortality due to compromised immune function. Specific Background: Prior studies suggest that major thalassemia patients are highly susceptible to microbial infections, possibly due to altered immunological profiles, particularly immunoglobulin (IgG, IgM) and complement (C3, C4) levels. Knowledge Gap: However, the specific immunological changes pre- and post-splenectomy in these patients remain underexplored. Aims: This study aims to assess the levels of immunoglobulins (IgG and IgM) and complement proteins (C3 and C4) in major thalassemia patients both before and after splenectomy compared to healthy controls. Results: Our analysis of 50 thalassemia patients (34 males, 16 females) and 30 healthy individuals revealed that thalassemia patients exhibited significantly lower levels of C3 and C4 (88.52±24.49, 21.20±6.66) compared to healthy controls (123.50±19.04, 32.87±9.77). IgG and IgM were elevated in patients (1288.12±467.87, 153.46±51.29) compared to controls (1129.93±295.96, 148.67±50.17). Post-splenectomy, patients showed a significant decline in IgG (1001.56±154.14) and IgM (110.08±25.83) levels, along with further decreases in C3 (83.28±24.13) and C4 (17.48±4.86). Novelty: This study provides novel evidence of the immunological shifts in thalassemia patients post-splenectomy, demonstrating significant reductions in both immunoglobulins and complement proteins, thereby elevating the risk of infection. Implications: These findings highlight the spleen's crucial role in maintaining immune competence and suggest that splenectomy in thalassemia patients requires careful post-operative immune monitoring to mitigate infection risks. Highlights: Splenectomy lowers IgG, IgM, C3, and C4 levels in thalassemia patients. Post-splenectomy patients face higher infection risk due to immune weakening. Highlights spleen's crucial role in immune defense for thalassemia patients. Keywords: Thalassemia, Splenectomy, Immunoglobulins, Complement Proteins, Immune Competence

Page 121 of 239 | Total Record : 2389

 119   120   121   122   123 

Filter by Year

2019 2026


Reset
Filter By Issues
All Issue Vol. 11 No. 1 (2026): June Vol. 10 No. 2 (2025): December Vol. 10 No. 1 (2025): June Vol. 9 No. 2 (2024): December Vol. 9 No. 1 (2024): June Vol. 8 No. 2 (2023): December Vol. 8 No. 1 (2023): June Vol. 7 (2022): December Vol. 6 (2022): June Vol. 5 (2021): December Vol. 4 (2021): June Vol. 3 (2020): December Vol. 2 (2020): June Vol. 1 No. 2 (2019): December Vol. 1 No. 1 (2019): June More Issue