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Academia Open
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 27147444     DOI : 10.21070/acopen.11.2026.12985
Core Subject : Health,
Medicine & Pharmacology Public Health
Academia Open is published by Universitas Muhammadiyah Sidoarjo published 2 (two) issues per year (June and December). This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal aims is to provide a place for academics and practitioners to publish original research and review articles. The articles basically contains any topics research or review. Academia Open is available in online version. Language used in this journal is Indonesia or English.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 2,389 Documents
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Ventricular Septal Defect: A Review Article: Cacat Septum Ventrikel: Artikel Ulasan Hajer S. Essa
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10557

Abstract

Of all congenital heart abnormalities, up to 40% are caused by anomalies in the ventricle septum. A wide variety of abnormalities are included in the diagnosis, including those linked to other congenital cardiac deformities and solitary problems. The age of the patient, the size and anatomical correlates of the defect, and the degree of diagnostic and interventional expertise in the field all influence the presentation, signs, course, and treatment of abnormalities in the ventricular septum. Highlights: Cause & Diagnosis: Ventricular septal anomalies cause 40% of congenital heart defects. Influencing Factors: Age, defect size, anatomy, and medical expertise affect symptoms. Treatment & Course: Diagnosis and intervention determine management and patient outcomes. Keywords: Ventricular Septal Defect, Review
Investigation of Antioxidants and Some Biochemical Parameters in Sheep and Cattle Infected With Toxoplasmosis: Investigasi Antioksidan dan Beberapa Parameter Biokimia pada Domba dan Sapi yang Terinfeksi Toksoplasmosis Maysoon Mustapha Jasim; Rasha Shamil Hussein Al-Douri
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10558

Abstract

The current study aimed to evaluate the effect of infection with Toxoplasmosis gondii in the serum and milk of sheep and cows on some enzymes and biochemical parameters. 200 samples from sheep and 125 samples from cows that suffered from miscarriages at different stages of pregnancy and were suspected of being infected with toxoplasmosis were collected from different areas of Salah Governorate. Using the latex agglutination test, it was found that the percentage of infection with toxoplasmosis in sheep is 47.5% and 33.6% in cows. According to the statistical results of biochemical tests, sheep and cows exposed to Toxoplasma showed an increase in glutathione peroxidase levels (GSH-PX) in their serums, whereas infection did not significantly affect the activity of creatine phosphokinase in sheep or cows, as did creatine phosphokinase. As a result of this infection, zinc levels in sheep and cows' serum were significantly decreased, which resulted in a significant increase in copper and phosphorus levels. Toxoplasma infection resulted in a decrease in milk parameters including protein and fat, as well as lactose in cow's milk, while it did not significantly change in sheep's milk compared to the control group. Highlights: Effect of Toxoplasma gondii on serum and milk biochemical parameters in livestock. Infection impact: Increased GSH-PX, decreased zinc, increased copper and phosphorus levels. Milk quality decline: Reduced protein, fat, and lactose in cows; minimal change in sheep. Keywords: toxoplasmosis, toxoplasmosis in sheep,Oxidation enzymes.
Evaluation of β2-microglobulin, IL17, Endostatin  levels, and some biochemical variables  in patients with Chronic kidney disease  in Kirkuk city: Evaluasi kadar β2-mikroglobulin, IL17, Endostatin, dan beberapa variabel biokimia pada pasien penyakit ginjal kronis di kota Kirkuk Zina Abdulmunem Abdulrazaaq; Nagham Imad Abdul Hameed
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10566

Abstract

Chronic kidney disease is the most common disease in developed countries of the world and thus poses a major challenge to public health throughout the world , Method:- Samples were collected randomly from patients hospitalized in Kirkuk General Hospital, in addition to some outpatient medical clinics. 55 samples were collected for patients with chronic kidney disease CKD, whose ages were (40-75) for one year for the period (1/6/2024 to 25/10/2024) Also, 30 blood samples were collected from healthy people (as a control group) .5 ml of blood sample was collected from patients and healthy people and separated using a centrifuge to obtain the serum, after which the level of the studied variables, represented by β2-microglobulin, Interlukin-17- IL-17, Endostatin, and some biochemical variables, which included (Urea, Creatinin, Uric acid, Ferritin )Result:- This study showed a significant rise in the (Β2-MG, Endostatin, IL-17, Urea, Creatinin, Uric acid, and ferritin ) in patients with CKD compared to healthy subjects. Highlights: Chronic kidney disease challenges public health worldwide. Study analyzes β2-MG, IL-17, Endostatin, and biochemical markers in CKD patients. Results show significant biomarker elevation in CKD versus healthy subjects. Keywords: Chronic kidney disease, β2-microglobulin, IL-17, Endostatin
Molecular Study and Detection of The Causative Bacteria of Urinary Tract Infection of Transfusion Dependent Thalassemia Patients Who Are Being Treated with Iron Chelators: Studi Molekuler dan Deteksi Bakteri Penyebab Infeksi Saluran Kemih pada Pasien Thalassemia yang Bergantung pada Transfusi yang Diobati dengan Chelator Besi Lubna Hussein Al-Abidy; Salem Rheef Arian Al-Aidy
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10567

Abstract

This study was conducted for the purpose of detecting some virulence factor genes of the bacterial species isolated from the urine transfusion dependent beta Thalassemia TDT with UTI, 173 urine samples were collected from both study group TDT patient with UTI and control group, Results showed that sample (n=38, 21.96%) of the total samples studied gave positive bacterial growth, while (n=135, 79.03%) gives negatives growth on media cultivation in control samples. In patient with beta Thalassemia have shown positive growth of 38 samples (21.96%) and samples (135) (79.03%) were not give any growth. the purpose of study is to detecting some virulence factors for gram negative studied isolates, DNA was extracted for all isolates. (n=17) gram negative isolates were taken, represented by (n=9, 23.7%) isolates of E. coli and (n=3, 7.9%) isolates of E. cloacae, (n=5, 13.2%) of K. pneumonia their isolated from transfusion dependent thalassemia with UTI with use of universal primers for each bacterium and partial 16s rRNA sequence for diagnosis of this isolated bacteria. Highlights: Detecting virulence factor genes in bacteria from transfusion-dependent beta thalassemia UTI patients. 173 urine samples, 38 (21.96%) showed positive bacterial growth, 135 negative. DNA extraction, 17 gram-negative isolates identified: E. coli, E. cloacae, K. pneumoniae. Keywords: universal primers, Thalassemia, Urinary tract infection, Virulence Factors.
Inhibition of Propolis on the Growth of Aggregatibacter Actinomycetemcomitans: Daya Hambat Propolis terhadap Pertumbuhan Aggregatibacter Actinomycetemcomitans Novita Pratiwi; Anis Khoirin Hayati; Nurul Maulidah
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10589

Abstract

General Background: Periodontitis, a chronic inflammatory disease, leads to tooth loss, with Aggregatibacter actinomycetemcomitans playing a key role in its pathogenesis. Specific Background: The rise of antibiotic resistance necessitates alternative treatments. Propolis, a bee-derived resin, has shown antimicrobial properties. Knowledge Gap: Limited research exists on the inhibitory effects of propolis against A. actinomycetemcomitans at varying concentrations. Aims: This study evaluates the antibacterial activity of propolis extract on A. actinomycetemcomitans in vitro. Results: Propolis exhibited significant antibacterial effects, with a minimum inhibitory concentration of 12.5% (125 mg/mL), attributed to flavonoids and apigenin. Statistical analysis confirmed significant differences across concentrations (p < 0.05). Novelty: This study highlights the concentration-dependent antibacterial efficacy of propolis against A. actinomycetemcomitans, suggesting its potential as a natural therapeutic. Implications: Propolis may serve as a complementary antimicrobial in periodontal therapy, reducing antibiotic reliance and resistance. Highlights: Effective Antibacterial Agent – Propolis inhibits A. actinomycetemcomitans growth at a minimum concentration of 12.5% (125 mg/mL). Bioactive Components – Flavonoids and apigenin in propolis disrupt bacterial membranes and biofilm formation. Clinical Potential – Propolis may serve as a natural alternative to antibiotics in periodontal therapy. Keywords: Periodontitist, Propolis, Aggregatibacter Actinomycetemcomitans, Antimicroba
Tonsillectomy in Children: Review Article: Tonsilektomi pada Anak: Ulasan Artikel Kadhim Jawad Awad
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10602

Abstract

One of the most frequent surgical operations on children in Australasia is tonsillectomy. For a non-surgical audience, this study attempts to give a current evaluation of the procedure's indications (and the evidence basis for each of these indications), together with a discussion of the surgical technique, perioperative care, and risks. Recurrent pharyngotonsillitis and obstructive sleep apnea (OSA) are the main causes of tonsillectomy; tonsillectomy is typically done in combination with adenoidectomy for both conditions. Tonsillectomy has been shown to enhance quality of life, child behavior, and objective measurements of OSA in sleep studies. It is less clear how surgery affects cognitive function. Highlights: Common pediatric surgery: Tonsillectomy for recurrent pharyngotonsillitis & obstructive sleep apnea. Benefits: Improves quality of life, behavior, and OSA measurements. Uncertainty: Cognitive effects of surgery remain unclear. Keywords: Tonsillectomy, Children, Review
Physiology of Nerve Supply for Renal System: Fisiologi Suplai Saraf untuk Sistem Ginjal Wathiq Faraon Hussein
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10605

Abstract

General Background: The renal nervous system regulates kidney function through sympathetic and sensory neurons, impacting blood pressure and fluid balance. Specific Background: Renal nerve hyperactivity is linked to hypertension and metabolic disorders, prompting interest in renal denervation as a treatment. Knowledge Gap: The precise mechanisms by which renal nerves influence disease remain unclear, and clinical outcomes of renal denervation are inconsistent. Aims: This review explores renal nerve structure, neurotransmission, and functional roles in health and disease. Results: Sympathetic nerves release norepinephrine and co-transmitters, affecting vascular resistance and sodium handling, while sensory nerves modulate sympathetic output. Novelty: It integrates recent findings on renal neurophysiology, emphasizing afferent-sympathetic interactions. Implications: Advancing knowledge of renal nerves could refine treatments for hypertension and kidney disorders. Highlights: Renal nerve signaling controls blood pressure and kidney function through neurotransmitters like norepinephrine and ATP. Renal denervation therapy shows potential for treating hypertension but has inconsistent clinical outcomes. Afferent-sympathetic interaction plays a crucial role in kidney function and systemic homeostasis Keywords: Renal Nerves, Sympathetic Regulation, Hypertension, Neurotransmitters, Renal Denervation
Utilizing Ethnographic Resources to Enhance Tourism Effectiveness in Uzbekistan: Memanfaatkan Sumber Daya Etnografi untuk Meningkatkan Efektivitas Pariwisata di Uzbekistan Khаkimоv Dilyоr Zаfаrоvich
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10629

Abstract

This аrticle аnаlyzes the prоblems аnd оppоrtunities fоr the effective use оf ethnоgrаphic resоurces in the develоpment оf tоurism in Uzbekistаn, аs well аs explоres new pоssibilities fоr the regiоn. The specific feаtures аnd fоrms оf ethnоgrаphic tоurism аre exаmined. Wаys tо efficiently utilize ethnоgrаphic resоurces fоr the develоpment оf tоurism аre prоpоsed. Highlights: Challenges and opportunities in utilizing ethnographic resources for tourism. Exploration of new possibilities and forms of ethnographic tourism. Strategies for efficient ethnographic resource utilization in tourism development. Keywоrds: tоurism, ethnоgrаphic tоurism, аttrаctiоns, ethnоgrаphic museum, ethnо-nоstаlgic tоurism, tоurism оf nаtiоnаl аrt, tоurism оf nаturаl-histоricаl imаges, tоurism оf nаtiоnаl crаfts, tоurism оf nаtiоnаl gаmes, cаve tоurism, tоurism аt internаtiоnаl wrestling cоmpetitiоns.
The Evolution of Management Theory: A Literature Review : Evolusi Teori Manajemen: Sebuah Tinjauan Literatur Djalilov Jakhongir
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10630

Abstract

The evolution of management principles is evaluated throughout this review through an examination of their historical progression starting from pre-industrial times up to modern theories. The research emphasizes traditional management theories by linking Taylor’s Scientific Management and Fayol’s Administrative Principles to modern behavioral theories including Human Relations Movement and Maslow’s Hierarchy of Needs and McGregor’s Theory X and Theory Y. The research investigates strategic management frameworks especially Porter’s Five Forces and the Resource-Based View in detail to determine their capacity to resolve organizational difficulties. This analysis explores both the timeless value of management principles and the requirement to adjust them according to current global market shifts alongside technology progress and temporary staffing practices. The multidimensional evaluation demonstrates to both academic researchers and organizational professionals how management grew in the past while providing approachable methods to resolve present-day organizational intricacies. Highlights: Historical evolution: From pre-industrial management to modern theories. Key frameworks: Scientific Management, Administrative Principles, Behavioral Theories, Strategic Models. Relevance today: Adapting principles to global markets, technology, and staffing trends. Keywords: Management evolution, classical theories, modern management, scientific management, organizational behavior, management practices, managerial trends.
Comparative Analysis of Investment Efficiency Factors in Regional Industrial Development: Analisis Perbandingan Faktor Efisiensi Investasi dalam Pengembangan Industri Daerah Hojikulova Feruza Dona kizi
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10633

Abstract

The research focuses on evaluating investment performance within Surkhandarya's regional industry sector along with its factors which promote industrial enterprise development and sustainability. The study establishes an essential position for investment efforts because they drive economic stability alongside employment growth and technological development. Research shows a considerable lack of information about how efficient investments impact enterprise numbers in regional economic settings. The research implements correlation and regression analysis through econometric modeling with statistical data spanning from 2010 until 2023. The research shows clear positive relations between investment amounts and the growth of industrial enterprises because every 1% investment growth results in 0.63% industrial enterprise expansion. A 1% increase in the labor force leads to additional 0.42% participation in the workforce according to study findings. The research findings demonstrate how investments focused on underdeveloped areas especially agriculture sector development projects lead to improved regional economic diversification. The research demonstrates that investment optimization through strategic distribution improves industrial development and requires data-based decision-making. Data-driven policy-making together with improved infrastructure and innovation-based funding and balanced sectoral funding must be used to enhance regional development and economic policies and investment management. The field requires more research into specific industrial investment effects together with improved econometrics to better capture external economic influences for complete understanding about regional industrial development investments. Highlights: Investment drives economic stability, employment, and industrial growth. Econometric analysis shows positive investment impact on enterprise expansion. Strategic, data-driven policies enhance regional industrial development. Key words: Regional industrial sector, GRP, investment efficiency, comparative models, investment factors

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