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Academia Open
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 27147444     DOI : 10.21070/acopen.11.2026.12985
Core Subject : Health,
Medicine & Pharmacology Public Health
Academia Open is published by Universitas Muhammadiyah Sidoarjo published 2 (two) issues per year (June and December). This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal aims is to provide a place for academics and practitioners to publish original research and review articles. The articles basically contains any topics research or review. Academia Open is available in online version. Language used in this journal is Indonesia or English.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 2,389 Documents
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Isoxazolidine Derivatives Exhibit Selective Antitumor Activity Against Breast Cancer Cells: Turunan Isoxazolidine Menunjukkan Aktivitas Antitumor Selektif Terhadap Sel Kanker Payudara Wijdan Abbas Eneama; Husam Hamza Salman; Mazin N`adhim Mousa
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8148

Abstract

Breast cancer, a leading cause of cancer-related mortality in women, necessitates effective therapeutic interventions. Heterocyclic compounds, prevalent in FDA-approved pharmaceuticals, play a pivotal role in drug development. This study focuses on isoxazolidine derivatives, a subgroup of nitrogen and oxygen-containing heterocycles, known for their potential in antitumor applications. A series of novel isoxazolidine compounds were synthesized and evaluated for their anticancer efficacy using MTT assays against MCF-7 and HdFn cell lines, alongside normal cells. Structural elucidation employed FT-IR, 13C-NMR, 1H-NMR, and E-I mass spectroscopy. Results revealed compound (IZ3) with an IC50 value of 32.49 µg/ml, demonstrating notable antitumor activity in MCF-7 cells compared to HdFn. Notably, compounds (IZ1 and IZ2) exhibited IC50 values of 64 µg/ml and 128 µg/ml, respectively. These findings underscore the potential of isoxazolidine derivatives as promising candidates for targeted breast cancer therapies, warranting further investigation in preclinical models and clinical trials. Highlight: Novel Isoxazolidine Compounds: Synthesized and Evaluated Selective Antitumor Activity: Demonstrated in MCF-7 Breast Cancer Cells Promising Therapeutic Candidates: Isoxazolidine Derivatives for Targeted Breast Cancer Therapy Keyword: Breast cancer, Isoxazolidine Derivatives, Antitumor Activity, Heterocyclic Compounds, Drug Development
Improving The Learning Concentration Of Children Aged 4-5 Years Through The Tebona Game Method (Patting Colored Balls) In TK Aisyiyah Bustanul Athfal 3 Bulusidokare: Meningkatkan Konsentrasi Belajar Anak Usia 4-5 Tahun Melalui Metode Permainan Tebona (Tepuk Bola Warna) Di TK Aisyiyah Bustanul Athfal 3 Bulusidokare Izatul Fikro; Agus Salim
Academia Open Vol. 8 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.8157

Abstract

Learning concentration is an important component in the learning process, with high learning concentration for each child, it will be able to support the child to be ready for further education. This research aims to increase the learning concentration of children aged 4-5 years through the tebona game method (patting colored balls) at Aisyiyah Bustanul Athfal 3 Bulusidoakre Kindergarten. This type of research uses classroom action research (PTK), the design used in this research is the Kemmis and Mc Taggrat model of classroom action research design. The subjects of this research were 10 students in group A3 aged 4-5 years, children. Data collection techniques by means of observation, documentation and interviews. The results of the research show that children's learning concentration increases in each cycle. Before the action, the concentration percentage only reached 46% in the pre-cycle, 66.5% in cycle 1 and 94.5% in cycle II. So it can be concluded that increasing the learning concentration of children aged 4-5 years through the tebona playing method at Kindergarten Aisyiyah Bustanul Athfal 3 Bulusidokare was declared successful. Highlights: Importance of Learning Concentration: Learning concentration is crucial for children's readiness for further education. Tebona Game Method: Tebona game method involves patting colored balls to enhance concentration. Classroom Action Research (PTK): PTK design allows for systematic observation and assessment of educational interventions. Keywords: Learning Concentration, Tebona Games, Early Childhood
Comparative Analysis of Lutein Content in Leaves and Fruit of Lycium barbarum: Implications for Medicinal Applications: Analisis Perbandingan Kandungan Lutein pada Daun dan Buah Lycium barbarum: Implikasi untuk Aplikasi Obat Omaima Saddam Zirjawi; Ula M Noor Almousawi; Amjed Haseeb Khamees
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8158

Abstract

Herbal medicine stands as a pivotal realm of contemporary research, offering substantial benefits with minimal side effects. Lycium barbarum, recognized for its abundant bioactive compounds, holds promise in treating various ailments, particularly in antiaging and antioxidative capacities. Carotenoids, notably lutein and zeaxanthin, constitute key bioactive compounds with diverse functions in both plant physiology and human health, including photo protection against intense light and detoxification of reactive oxygen species. This study meticulously examines the lutein content within leaves and fruit of L. barbarum, employing a uniform extraction method and solvent. The investigation illuminates significant variations in lutein content between the leaves and fruit, shedding light on potential applications in herbal medicine and nutraceuticals. Highlight: Herbal Medicine Advancements: This study underscores the pivotal role of herbal medicine in contemporary research, emphasizing its potential for providing substantial benefits with minimal side effects. Lycium barbarum's Therapeutic Potential: The research highlights Lycium barbarum's significance due to its rich array of bioactive compounds, particularly in addressing antiaging and antioxidative requirements. Bioactive Carotenoids in Focus: The study delves into the functions of essential bioactive compounds, lutein and zeaxanthin, elucidating their roles in plant physiology and human health, including their photoprotective and detoxifying properties. Keyword: Herbal Medicine, Lycium Barbarum, Bioactive Compounds, Carotenoids, Lutein Content
Overview of Prosocial Behavior for Student SMK Sepuluh Nopember at the Sidoarjo : Gambaran Perilaku Prososial Pada Siswa SMK Sepuluh Nopember di Sidoarjo Evi Nabella; Effy Wardati Maryam
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.8159

Abstract

General Background: Prosocial behavior plays a crucial role in adolescent social development and character formation within educational settings. Specific Background: In vocational high schools, students’ social interactions reflect helping, sharing, cooperating, honesty, and generosity, which contribute to a positive school climate. Knowledge Gap: However, empirical data describing the level and distribution of prosocial behavior among vocational high school students remain limited, particularly in specific institutional contexts. Aims: This study aims to describe the prosocial behavior profile of students at SMK Sepuluh Nopember Sidoarjo. Results: Using a quantitative descriptive design with proportional stratified random sampling, the findings indicate that students’ prosocial behavior generally falls within the moderate category. The helping and cooperating aspects show the highest percentages, while sharing appears at a relatively lower level compared to other dimensions. Novelty: This research provides a context-specific empirical mapping of prosocial behavior among vocational students using a structured multidimensional approach. Implications: The findings offer practical considerations for guidance and counseling programs and character education strategies to strengthen positive social engagement among students in vocational education setting Keywords: Prosocial behavior, Adolescents, Vocational High School Students, Character Education, Quantitative Descriptive Study Key Findings Highlights: Students demonstrate a moderate overall level of social-oriented actions. Cooperative and helping tendencies dominate the observed dimensions. Sharing-related actions appear less frequent compared to other indicators.
Indonesia's Public Satisfaction Soars Despite Service Quality Shortcomings: Kepuasan Masyarakat Indonesia Melonjak Meski Ada Kekurangan dalam Kualitas Layanan mochamad mansur nur hidayat; Isna Fitria Agustina
Academia Open Vol. 9 No. 1 (2024): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8160

Abstract

This study evaluates the quality of population administration services in Bangsal District, focusing on public satisfaction and aspects such as physical facilities, reliability, responsiveness, assurance, and empathy. Using a qualitative approach with interviews, observations, and documentation, the findings reveal that, despite inadequate physical facilities and reliability issues, public satisfaction is relatively high due to effective communication and improved security measures. However, staff responsiveness and empathy need improvement, with key challenges including limited staff and infrastructure. The study suggests enhancements in physical infrastructure and staff training to further improve service quality, offering insights for policy changes and resource allocation. Highlight: Public Satisfaction: High due to effective communication and improved security. Physical Facilities: Inadequate infrastructure impacts service quality. Staff Responsiveness: Needs improvement through better training and support. Keyword: Population administration, service quality, public satisfaction, Bangsal District, qualitative research
Optimizing Village Economy Through Improved BUMDes Management in Indonesia: Mengoptimalkan Ekonomi Desa Melalui Peningkatan Pengelolaan BUMDes di Indonesia Bella Ayu Sabrina; Lailul Mursyidah
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8161

Abstract

This study examines the management of BUMDes Sedayu Prima Makmur in Kludan Village, Sidoarjo, identifying issues that hinder significant progress. Using a qualitative descriptive approach, data were collected through observation, interviews, and documentation. Analysis revealed that while goal-setting and procedures are well-implemented, poor marketing limits product visibility. Organizational challenges include a lack of management members and insufficient village government knowledge about BUMDes. Despite good guidance and coordination, supervision is weak due to the absence of annual reports and limited village government involvement. The study highlights areas for improvement to enhance BUMDes performance and support village economic development. Highlight: Effective planning is hindered by poor marketing of existing programs. Organizational structure suffers from insufficient management members. Supervision lacks due to absence of annual reports and limited involvement. Keywoard: BUMDes, village economy, management, marketing, organizational challenges
Global Dynamics through MSME Purchases Influenced by Price, Quality, and Digital Factors: Dinamika Global melalui Pembelian UMKM Dipengaruhi oleh Faktor Harga, Kualitas, dan Digital Ferra Puspa Prasiwi; Mas Oetarjo
Academia Open Vol. 9 No. 1 (2024): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8171

Abstract

This study investigates the impact of digital marketing, service quality, and price on purchasing decisions at MSMEs Rabit Buket Sidoarjo, East Java. Using a quantitative approach, data were collected from 96 respondents through questionnaires and analyzed with SPSS software. Results show that digital marketing, service quality, and price positively and significantly influence purchasing decisions. These findings suggest that MSMEs should enhance their digital marketing, maintain high service quality, and offer competitive pricing to boost customer purchases. Future research should consider additional variables for a more comprehensive analysis. Highlight: Digital marketing enhances purchasing. High service quality influences buyers. Competitive pricing drives purchase decisions. Keyword: Digital marketing, service quality, price, purchasing decisions, MSMEs
Brand, Price, and Word of Mouth Impact Global Consumer Choices: Pengaruh Merek, Harga, dan Promosi dari Mulut ke Mulut terhadap Pilihan Konsumen Global Achmad Riski Kurniawan; Mas Oetarjo
Academia Open Vol. 9 No. 1 (2024): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8172

Abstract

This study examines the influence of brand image, price, and Electronic Word of Mouth (E-WOM) on purchasing decisions in the e-commerce platform, Shopee. Using a quantitative approach, data from 96 respondents in Sidoarjo Regency were analyzed through Smart-PLS Version 3.0. Results reveal significant effects of brand image, price, and E-WOM on purchasing decisions, with brand image reflecting reputation, effectiveness, and trustworthiness, while price considerations include affordability, quality alignment, competitiveness, and benefit congruence. E-WOM's impact is seen through intensity, content, and valence of opinion. These findings highlight the importance of these factors in influencing consumer behavior on Shopee. However, the study's focus on these three variables suggests a need for future research to explore additional factors impacting e-commerce purchasing decisions, contributing to a deeper understanding of consumer behavior in online retail settings. Highlights: Consumer Behavior: Brand image, price, and E-WOM influence Shopee purchasing decisions. Data Analysis: Smart-PLS analyzes 96 respondents' data on e-commerce behavior. Research Implications: Further exploration needed for comprehensive understanding of online consumer behavior. Keywords: e-commerce, Shopee, purchasing decisions, brand image, Electronic Word of Mouth (E-WOM)
Efficiency Challenges Amid Budget Success in Indonesia: Tantangan Efisiensi di Tengah Keberhasilan Anggaran di Indonesia Intan Setyaningrum; Nihlatul Qudus Sukma Nirwana
Academia Open Vol. 9 No. 1 (2024): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8173

Abstract

This study assesses the budget implementation of the Sidoarjo Regency Government from 2019 to 2022, focusing on effectiveness, efficiency, and economic performance. Using a descriptive quantitative approach with document analysis, the findings indicate that while the government has met economic criteria and shown improved effectiveness, efficiency has been less satisfactory, particularly in 2022. Despite surpassing budget revenue targets, inefficiencies arose due to higher expenditures than revenues. The study highlights the need for better budget management and resource allocation to enhance overall performance. Highlight: Economic Criteria Met: Consistent economic performance over four years. Improved Effectiveness: Surpassed budget revenue targets. Efficiency Issues: Lower efficiency, especially in 2022. Keyword: Budget implementation, effectiveness, efficiency, economic performance, Sidoarjo Regency
Unveiling the Impact of Factors on Taxpayer Compliance: Mengungkap Dampak Faktor-Faktor terhadap Kepatuhan Wajib Pajak Nova Atul Arini; Herman Ernandi
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8175

Abstract

Tax compliance significantly impacts tax revenue, with increased compliance correlating to heightened state revenue. This study investigates the influence of taxpayer awareness, taxation understanding, tax sanctions, and tax service quality on tax compliance among motor vehicle taxpayers at the Sidoarjo Samsat Office. The research employs a quantitative descriptive approach, utilizing primary data gathered through questionnaires. The population consists of 955,635 registered taxpayers, with 100 selected through incidental sampling. Findings reveal that taxpayer awareness, taxation understanding, tax sanctions, and service quality positively influence tax compliance. This study addresses a gap in understanding taxpayer behavior and provides insights for policymakers to enhance compliance strategies, thereby optimizing tax revenue. Highlight: Descriptive quantitative approach: Primary data collected via questionnaires. Key findings: Factors affecting tax compliance elucidated. Policy insights: Informing strategies for enhancing tax compliance and revenue. Keywoard: Tax compliance, Awareness, Understanding, Sanctions, Service quality.

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