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International Journal of Biomedical Science and Travel Medicine
Published by Universitas Warmadewa
ISSN : 30477441     EISSN : 30477433     DOI : https://doi.org/10.22225/ijbstm
Core Subject : Health,
Medicine & Pharmacology Public Health
International Journal of Biomedical Science and Travel Medicine is published twice (March and September) a year. The objective is to promote articles on biology and medicine. International Journal of Biomedical Science and Travel Medicine publishes original research work related to biological and medicine. The journal publishes Original articles, Short Reports, Case Reports, and Review articles. All articles published in International Journal of Biomedical Science and Travel Medicine (IJBSTM) are peer-reviewed and published online for immediate access and citation. International Journal of Biomedical Science and Travel Medicine (IJBSTM) publishes the Original clinical and experimental research studies, Review articles, Case reports on topics but not limited to: Biocemistry, Genetics and molecular biology, Medicine, Environmental health, Tropical diseases, Diseases in tropics, Global health, Pharmacological sciences, Biomedical sciences, Public health, Infection, Epidemiology and clinical epidemiology, Molecular biology, Microbiology, Travel Medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 24 Documents
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Factors Related to the Severity of Dengue Infection in Adult Patients Treated at Sanjiwani Regional General Hospital Ida Bagus Made Agastya Pranata; Saraswati Laksmi Dewi; Putu Aryagiri Prebawa; Komang Trisna Sumadewi
International Journal of Biomedical Science and Travel Medicine 1-6
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.1-6

Abstract

Dengue infection remains a major global health problem. This study aimed to determine factors associated with the severity of dengue infection among adult patients treated at Sanjiwani Gianyar Regional General Hospital in 2023. An analytical observational study with a cross-sectional design was conducted using consecutive sampling. A total of 100 adult patients with confirmed dengue infection were included. Severity was classified as Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) based on WHO criteria. Chi-square analysis and crude odds ratio (OR) estimation were performed. Age >60 years was significantly associated with severe dengue (OR = 2.94; 95% CI: 1.25–6.92; p=0.014). Female gender was also associated with higher odds of severe dengue compared to males (OR = 2.33; 95% CI: 1.05–5.15; p=0.039). Secondary infection status showed the strongest association with severity (OR = 5.40; 95% CI: 2.24–13.04; p=0.001). In conclusion, age, gender, and infection status were significantly associated with dengue severity. These findings may assist clinicians in identifying patients who require closer clinical monitoring.
Phytotherapy for Bacterial Vaginosis with Piper Betle: from Mechanism to Safety Satria Bintang Samudra; Prawesty Diah Utami; Grissabel Bethrin Jiantoro; Jessica Euodia Adidharma; Rayhan Ali Fadli
International Journal of Biomedical Science and Travel Medicine 7-16
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.7-16

Abstract

Background: Bacterial vaginosis (BV) is a prevalent vaginal dysbiosis characterized by depletion of Lactobacillus and overgrowth of anaerobic bacteria, commonly including Gardnerella vaginalis. Clinical management is complicated by high recurrence rates, which are closely linked to polymicrobial biofilm persistence and the limited microbiome selectivity of conventional antimicrobials. This narrative review aimed to synthesize current evidence on the phytotherapeutic potential of Piper betle in BV, focusing on antimicrobial and anti-biofilm mechanisms, modulation of vaginal microbiome ecology, and safety and standardization considerations relevant to translational development and recurrence prevention. Methods: An exploratory literature search (2015–2025) was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar, complemented by manual reference screening, and last searched on 30 September 2025. Results: Findings across in vitro studies, observational reports, and mechanistic literature indicate that P. betle extracts and key phenolic constituents, particularly hydroxychavicol and eugenol, exhibit antibacterial activity against BV-associated taxa and anti-virulence effects consistent with biofilm weakening and interference with quorum-sensing–regulated behaviors. Importantly, several studies suggest comparatively limited inhibitory effects on Lactobacillus spp., supporting the plausibility of a microbiome-sparing profile that may facilitate restoration of vaginal eubiosis. Nevertheless, the evidence base is constrained by heterogeneous methodologies, predominance of preclinical models, and substantial variability in phytochemical composition across preparations. Conclusion: Overall, P. betle emerges as a biologically plausible adjunctive or preventive candidate for preventing BV recurrence, warranting standardized formulations, marker-based quality control, and rigorous clinical evaluation with recurrence-focused endpoints.
Anticholinergic Syndrome Following Datura metel Ingestion in an Adolescent: A Case Report Lucia Pudyastuti Retnaningtyas; Nur Flora Nita Taruli Basa Sinaga
International Journal of Biomedical Science and Travel Medicine 24-28
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.24-28

Abstract

Background: Datura metel, locally known as kecubung, contains tropane alkaloids that may induce anticholinergic toxicity. Adolescents may intentionally ingest the plant due to curiosity about its psychoactive effects. Case presentation: A 13-year-old boy presented with agitation, delirium, palpitations, and incoherent speech three hours after ingesting approximately one glass of a decoction made from Datura metel flowers. Examination revealed altered mental status (Glasgow Coma Scale E3V4M6), bilateral mydriasis with sluggish light reflex, and dry mucous membranes. Vital signs were stable. Laboratory investigations, including blood glucose and serum electrolytes, were within normal limits. Electrocardiography showed sinus arrhythmia. The patient received supportive management including oxygen therapy, intravenous fluids, activated charcoal, and oral neostigmine. He was admitted to the Pediatric Intensive Care Unit and showed clinical improvement within eight hours, with complete recovery after three days. At one-week follow-up, the patient remained asymptomatic. Conclusion: Early recognition of anticholinergic toxidrome based on clinical features and exposure history is essential. Supportive management can result in favorable outcomes even when specific antidotes are unavailable.
Impact of Increased Gadget Use on Kindergarten Children’s Behavior During the COVID-19 Pandemic Sarah Kirana Ridwan; Lucia Pudyastuti Retnaningtyas; Ervin Dyah Ayu Masita Dewi
International Journal of Biomedical Science and Travel Medicine 17-23
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.17-23

Abstract

Background: The COVID-19 pandemic caused major disruptions in educational systems worldwide, including early childhood education. Kindergarten learning shifted from face-to-face instruction to online learning, increasing children’s exposure to digital devices. Increased screen exposure may influence children’s behavioural development, particularly emotional regulation, discipline, and social interaction. Objective: This study aimed to explore behavioural changes associated with increased gadget use among kindergarten children during the COVID-19 pandemic. Methods: This qualitative study employed an interpretative descriptive approach. Data were collected through semi-structured interviews with six parents of kindergarten students and one teacher as a triangulation source at Dharma Wanita Persatuan Pepelegi Kindergarten, Waru, Sidoarjo, Indonesia. Participants were selected using purposive sampling. Interview recordings were transcribed verbatim and analysed using inductive thematic analysis. Results: Children’s gadget use increased during the pandemic due to online learning demands and environmental factors such as limited supervision and restricted outdoor activities. Although social interaction with peers remained relatively maintained in some contexts, increased gadget exposure was associated with emotional responses including irritability and frustration when use was restricted, as well as reduced behavioural discipline such as delaying tasks and decreased responsiveness to parental instructions. Conclusion: Increased gadget use during the pandemic was associated with behavioural changes among kindergarten children, particularly in emotional responses and discipline. Environmental conditions and parental supervision played important roles in moderating these effects. Structured guidance and balanced digital media use are therefore essential to support healthy behavioural development in early childhood.

Page 3 of 3 | Total Record : 24

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