Global Medical and Health Communication
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, health communication, health promotion, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Articles
45 Documents
<![CDATA[Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Profiling for Quinolinone Alkaloids and Phenolic Metabolites in a Bioactive Fraction of Indonesian Yacon (Smallanthus sonchifolius) Tuber Extract ]]>
<![CDATA[Eka Hendryanny]]>;
<![CDATA[Widayanti]]>;
<![CDATA[Lelly Yuniarti]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 13 No. 3 (2025): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v13i3.8796
<![CDATA[Yacon (Smallanthus sonchifolius) is a functional tuber rich in fructooligosaccharides, phenolic compounds, and diverse secondary metabolites with potential health-promoting properties. Despite its increasing use, the comprehensive characterization of its bioactive constituents, particularly those derived from plants cultivated in Indonesia, remains limited. This study aims to identify and characterize the major bioactive components of ethanolic yacon tuber extract using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This descriptive, exploratory investigation of natural product phytochemistry was conducted from June to July 2025—fresh tubers were collected from Lembang, West Bandung. The samples were subjected to ethanol maceration, and LC-MS/MS analysis was performed on a bioactive fraction (Rf 0.52) obtained from preliminary thin-layer chromatography (TLC) fractionation of the crude ethanolic extract, using positive electrospray ionization and gradient elution. Compound annotation was performed using UNIFI software. LC–MS/MS profiling revealed 15 predominant secondary metabolites, with retention times ranging from 5.41 to 13.18 minutes and mass-to-charge (m/z) ratios of 255.35–459.48. Early-retention peaks comprised polar constituents, such as sucrose and nicotianamine, a metal-chelating amino acid known to enhance iron bioavailability. Mid-retention peaks included phenolic acids and flavonoids, notably chlorogenic acid and jaceosidin. High-retention peaks were dominated by hydrophobic alkaloids, with 4,7,8-trimethyl-3-(3-methylbut-2-enyl)-1H-quinolin-2-one identified as the most abundant compound (56.42%), followed by senecionine (9.36%) and nonadecan-2-amine (6.75%). In conclusion, West Bandung yacon tubers contain a diverse spectrum of alkaloids, flavonoids, and phenolic derivatives that may contribute to their pharmacological potential. The results provide an essential phytochemical foundation for future studies evaluating bioactivity and toxicological assessment using targeted in vitro and in vivo approaches.]]>
<![CDATA[Meropenem Use for Bacterial Infection at a Hospital in Bandung City ]]>
<![CDATA[Winni Maharani]]>;
<![CDATA[Usep Abdullah Husin]]>;
<![CDATA[Syahrir Zein Rumatumia]]>;
<![CDATA[Tresna Ridha Nurramadhani]]>;
<![CDATA[Lia Marlia Kurniawati]]>;
<![CDATA[Djatnika Setiabudi]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 1 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i1.8874
<![CDATA[Meropenem is a beta-lactam antimicrobial agent used to treat broad-spectrum bacterial infections and is classified as a reserve antibiotic. The Antimicrobial Resistance Control Program (PPRA) at the hospital monitors the use of meropenem to ensure it is used appropriately and in accordance with antimicrobial stewardship principles. This study aims to determine the preliminary pattern of meropenem antibiotic use at the hospital, Bandung, during 2019–2020. It is an observational descriptive study using secondary medical record data with a total sampling method. A total of 182 study subjects were all patients treated with meropenem from various departments, and the diagnoses met the criteria for culture results. Data analysis included the distribution proportion of the observed variables. This study shows that the pattern of meropenem use over two years is characteristic of patient age with the most similar patterns in the age categories under 0–10 years, 51–60 years, and 61–70 years (21–26%), however, there were differences in gender in 2019, female patients were more numerous than male patients, while in 2020 were the opposite. Other results show similar diagnostic patterns in both years, with the most common diagnoses being respiratory tract infections, which continued to increase in the following years (27% and 35%). Conversely, the majority of culture results in the two years were negative (58% and 72%). The possibilities here relate to specimen preparation or to prior antimicrobial use before hospital admission. In conclusion, the pattern of meropenem antibiotic use at the hospital is similar in characteristics, diagnostics, and culture results. The PPRA Committee is expected to improve the policy on meropenem use in accordance with government regulations and prevent antimicrobial resistance.]]>
<![CDATA[Family Health Outcomes during Economic Crises: the Role of Household Nutrition Coping Strategies ]]>
<![CDATA[I Nyoman Adiyasa]]>;
<![CDATA[Aliah Bagus Purwakania Hasan]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 1 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i1.8936
<![CDATA[The prolonged economic downturn at both national and household levels has significantly disrupted food access, altered dietary patterns, and increased the risk of nutrition-related health problems. This study aimed to identify household nutrition coping strategies during economic hardship and examine their association with family health outcomes, particularly among vulnerable groups such as women and young children. A cross-sectional survey was conducted from February to April 2025 involving 210 households in Denpasar (Bali) and Mataram (West Nusa Tenggara). A purposive sampling technique was applied to select households experiencing income decline and changes in food consumption. Data were collected using a structured questionnaire assessing food security status, dietary patterns, and coping behaviors, complemented by basic health indicators. Data were analyzed using descriptive statistics, chi-square tests, and Spearman correlation analysis. The results indicate that 68% of households reduced meal portions, 63% substituted nutritious foods with cheaper alternatives, and 47% reduced meal frequency. A significant association was found between coping strategy categories and household health symptoms (p<0.05). Furthermore, a moderate positive correlation was observed between coping intensity and family health symptom scores (r=0.482, p<0.01), indicating that households employing more coping strategies tended to report higher levels of health-related complaints. Approximately 36% of households reported weight loss among children, and 29% reported decreased appetite. These findings suggest that while coping strategies serve as short-term adaptive mechanisms, their frequent use is associated with declining dietary quality and increased health vulnerability among family members. Strengthening community-based nutrition resilience programs and integrating responsive social protection policies are essential to mitigate the long-term health impacts of economic crises. This study provides empirical evidence on the relationship between coping behavior and household health outcomes in vulnerable urban and semi-urban populations.]]>
<![CDATA[The Relationship between Nutritional Status and Menstrual Blood Volume among Adolescent Girls at A Boarding School ]]>
<![CDATA[Qonita Luthfiah]]>;
<![CDATA[Eva Rianti Indrasari]]>;
<![CDATA[Yafma Femin Helta Heriady]]>;
<![CDATA[Mirasari Putri]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 1 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i1.8998
<![CDATA[Menstruation is an essential physiological process in adolescent girls. Reflecting not only reproductive health but also overall health status. Menstrual disorders, particularly heavy menstrual bleeding (menorrhagia), are common among adolescents, with a prevalence of approximately 12–37%. Nutritional status plays a key role in menstrual health. In adolescents with overnutrition, excess body fat can increase estrogen production, which may subsequently affect the menstrual cycle, including the volume of menstrual blood. In boarding school settings, where students live under structured schedules and share dietary patterns, nutritional imbalances are common and may disrupt menstrual patterns. This study aimed to determine the relationship between nutritional status and menstrual blood volume among adolescent girls at a boarding school in Bogor, West Java, Indonesia, in 2025. It was an observational analytic study with a cross-sectional design involving 85 adolescent girls aged 15–17 years, selected through stratified random sampling according to predefined inclusion and exclusion criteria. Primary data were obtained from menstrual pictogram forms and measurements of body mass index (BMI) and waist circumference. Data were analyzed using univariate and bivariate analyses with the chi-square test. Among the 85 participants, 35 experienced menorrhagia, including all 15 who were classified as overnutrition based on BMI, and 11 participants with increased waist circumference. Fisher’s Exact tests for both BMI and waist circumference against menstrual blood volume yielded p-values <0.001 (p<0.005), indicating a highly significant association. In conclusion, higher BMI and greater waist circumference were strongly associated with increased menstrual blood volume among adolescent girls at a boarding school in Bogor. Nutritional balance and weight control are essential to support healthy menstrual patterns in this population.]]>
<![CDATA[Association of Lubricants, Foreplay, and Communication with Lower Dyspareunia Pain among Perimenopausal Women ]]>
<![CDATA[Karwati Karwati]]>;
<![CDATA[Damai Yanti]]>;
<![CDATA[Sri Maryati]]>;
<![CDATA[Rochmawati Rochmawati]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 1 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i1.9030
<![CDATA[Dyspareunia, or pain during sexual intercourse, is common among perimenopausal women, negatively affecting their quality of life, sexual satisfaction, and relationships. Limited observational data exists on non-pharmacological self-management strategies for pain relief, particularly in Indonesia. This study examines the associations between three self-management strategies—vaginal lubricants, enhanced foreplay, and couple communication—and the reduction of dyspareunia pain in Indonesian perimenopausal women. A cross-sectional study involving 63 women (aged 40–55) with dyspareunia who had used at least one self-management strategy for at least four weeks was conducted at Puskesmas Cimahi Utara, Cimahi, Indonesia, from January 2024 to June 2024. Participants were divided into four groups: lubricants (n=14), foreplay (n=30), communication (n=8), and combined approaches (n=11). Pain intensity was assessed using the Numerical Pain Rating Scale (NPRS). Pre-strategy scores were obtained retrospectively, and post-strategy scores reflected current pain levels. Welch ANOVA and Games-Howell post-hoc tests analyzed mean pain reduction across groups. Significant differences in pain reduction were found among the groups (F(3.59)=24.36, p<0.001, η2=0.553). Lubricants showed the greatest reduction in pain (mean=1.86±0.95 points; 95% CI=1.30–2.41), significantly more than communication (p=0.0295, Cohen's d=0.68) and approaching significance compared to foreplay (p=0.0542, Cohen's d=0.68). All groups reported statistically significant pain reductions. In conclusion, vaginal lubricant use led to the greatest reduction in self-management strategies for dyspareunia pain among perimenopausal women in Indonesia, outperforming enhanced and foreplay couple communication strategies.]]>
<![CDATA[Spiritual Well-being and Depression Levels among Patients with Acute Coronary Syndrome in the Cardiac Intensive Care Unit: A Cross-sectional Study ]]>
<![CDATA[Rahmalia Amni]]>;
<![CDATA[Mohammad Rizki Akbar]]>;
<![CDATA[Aan Nuraeni]]>;
<![CDATA[Yudi Akbar]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i2.9183
<![CDATA[Depression in acute coronary syndrome ACS has a fatal impact on patients, especially worsening infarction and increasing morbidity and mortality. The incidence of depression during the acute phase of ACS is high, and spiritual well-being is believed to prevent depression. This study examines the relationship between spiritual well-being and depression levels among ACS patients treated in a cardiac intensive care unit at a referral hospital in Bandung City. This quantitative study used a correlation analytic design with a cross-sectional approach. The population consisted of ACS patients receiving treatment in the cardiac intensive care unit at a referral hospital in Bandung City during January and February 2020. A total of 84 respondents were selected by purposive sampling. Data were collected using the spiritual well-being scale and the cardiac depression scale, and then analyzed using the Pearson correlation test, as both variables were normally distributed. There was a significant negative correlation between spiritual well-being and depression levels among ACS patients in the cardiac intensive care unit (p<0.01, r=−0.629). In conclusion, the higher the spiritual well-being, the lower the depression experienced by patients, and vice versa. Further studies are recommended to analyze multivariate factors influencing depression in ACS patients during the acute phase.]]>
<![CDATA[Community Perceptions of Sungkai (Peronema canescens) for Immune Support in Central Java ]]>
<![CDATA[Diniyati Diniyati]]>;
<![CDATA[Neni Susilaningsih]]>;
<![CDATA[Syarief Taufik Hidayat]]>;
<![CDATA[Endang Mahati]]>;
<![CDATA[Dwi Pudjonarko]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i2.8025
<![CDATA[Sungkai (Peronema canescens) leaves are traditionally used in Indonesia to support general health and immune function; however, information on community perceptions and patterns of use remains limited. This study aimed to assess community perceptions of sungkai leaves as a traditional preparation for supporting immune health and to identify sociodemographic factors associated with regular use. An analytical cross-sectional survey was conducted from April to June 2025 among 240 adults in Banyumas, Cilacap, Purbalingga, and Banjarnegara Regencies, Central Java. Participants were recruited using purposive sampling. Data were collected through face-to-face interviews and Google Forms using a validated structured questionnaire and analyzed using descriptive statistics, chi-square tests, and multivariable binary logistic regression. Overall, 62.9% of respondents agreed or strongly agreed that sungkai leaf preparations may help support immune health, while 24.6% were neutral and 12.5% disagreed or strongly disagreed. A total of 136 respondents (56.7%) had used sungkai leaves, and 81 (59.6%) reported regular use in the previous month. Age, educational attainment, and domicile were significantly associated with regular use. Respondents aged >55 years had higher odds of regular use than those aged 18–35 years (adjusted odds ratio [aOR]=2.61, 95% CI=1.38–4.92). Rural residents (aOR=2.13, 95% CI=1.22–3.71) and respondents with primary or junior high school education (aOR=1.84, 95% CI=1.07–3.14) also had higher odds of regular use. In conclusion, communities generally view sungkai leaves positively as a traditional preparation that supports immune health. These findings reflect perceptions and reported use rather than clinical efficacy. Further pharmacological, toxicological, and clinical studies are needed to establish their safety and potential health effects.]]>
<![CDATA[Effect of Glutathione Supplementation on Glutathione Peroxidase Levels and Melasma Severity Index in Patients with Melasma ]]>
<![CDATA[Dita Eka Sartika Putri Dewi]]>;
<![CDATA[Fen Tih]]>;
<![CDATA[Julia Windi Gunadi]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i2.8501
<![CDATA[Melasma is a hyperpigmentation disorder characterized by increased melanin production, commonly affecting women. Chronic UV exposure increases reactive oxygen species (ROS), and when ROS exceed the body's antioxidant capacity, oxidative stress occurs and is mitigated by glutathione peroxidase (GPx). However, evidence linking oral glutathione supplementation to endogenous GPx activity in patients with melasma remains limited. This study aims to evaluate the effect of glutathione supplementation on GPx levels and melasma severity in patients with melasma. A quasi-experimental, single-blind, pre-post study with a placebo control group was conducted at CITO Laboratory in South Jakarta among 54 women aged 30–59 years with melasma between December 2023 and May 2024. The participants were randomly allocated into two groups: a treatment group receiving oral reduced L-glutathione 500 mg once daily for one month, and a control group receiving a matched placebo tablet. GPx levels were measured in serum by ELISA, and modified melasma area and severity index (mMASI) scores were assessed before and after treatment; data were analyzed using the Wilcoxon signed-rank test for within-group comparisons and the Mann-Whitney U test for between-group comparisons at baseline. In the glutathione group, the median GPx level increased from 11.70 to 16.67 (p<0.001) and the median mMASI score decreased from 4.1 to 2.0 (p<0.001), whereas the placebo group showed no significant change in either GPx level (11.81 to 12.26, p=0.279) or mMASI score (0.6 to 0.6, p=0.250). In conclusion, these findings indicate that oral glutathione supplementation increases GPx levels and reduces melasma severity, suggesting that its clinical benefit may be mediated by strengthening the endogenous enzymatic antioxidant defense. Oral glutathione may therefore be considered a potential adjunct therapy for melasma; however, larger multicentre, double-blind trials with longer follow-up and additional oxidative stress biomarkers are needed to confirm these findings.]]>
<![CDATA[Association of Hematocrit and HbA1c as Indicators of Glycemic Control in Diabetes Mellitus ]]>
<![CDATA[Yuke Andriane]]>;
<![CDATA[Sara Puspita]]>;
<![CDATA[Ratna Damailia]]>;
<![CDATA[Fajar Awalia Yulianto]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i2.8985
<![CDATA[Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood sugar levels that can damage various organs, including the heart, blood vessels, kidneys, and nerves. Diagnosing DM typically involves assessing blood glucose levels and hemoglobin A1c (HbA1c), which reflects average glucose levels over the past 2 to 3 months. HbA1c testing has limitations, including interference from red blood cell lifespan, relatively high costs, and limited availability in some laboratories in Indonesia. Hematology parameters are crucial for diagnosis, including hematocrit, which is associated with blood viscosity, inflammation, and hyperinsulinemia. These conditions are closely associated with the clinical state of Diabetes mellitus. This research aims to analyze the association between hematocrit and HbA1c to identify alternative tests for predicting glycemic status. A cross-sectional study was conducted among 603 patients with diagnosed type 2 diabetes who visited the outpatient department at Al Islam Hospital from January 2018 to December 2019, selected through total sampling. Data were analyzed using multiple linear regression to assess the association between hematocrit and HbA1c, adjusting for confounders. A p-value <0.05 was considered statistically significant. The mean hematocrit level is 41.23±6.21, and HbA1c is 7.87±2.49. The results demonstrated a positive association between increased hematocrit and increased HbA1c, although the effect size is small and statistically insignificant after adjusting for age and sex (β=0.03; 95% CI=−0.004, 0.06; p=0.08; adjusted R-squared=0.004), where an increase of 1 unit of hematocrit is associated with a rise of 0.03 units of HbA1c in this study. In conclusion, hematocrit levels cannot yet serve as a substitute for HbA1c for assessing a patient’s glycemic status.]]>
<![CDATA[Structured Positive Affirmations and Third-trimester Pregnancy Anxiety: A Quasi-experimental Study ]]>
<![CDATA[Lina Fitriani]]>;
<![CDATA[A Fatimah Jamir]]>;
<![CDATA[Evi Rahayu]]>;
<![CDATA[Supriadi Supriadi]]>;
<![CDATA[Rochmawati Rochmawati]]>
<![CDATA[ Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2 ]]>
Publisher : <![CDATA[UPT Publikasi Ilmiah Universitas Islam Bandung ]]>
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DOI: 10.29313/gmhc.v14i2.9247
<![CDATA[Anxiety affects approximately 10% of third-trimester pregnant women globally and contributes to adverse maternal outcomes, including pregnancy-induced hypertension, a recognized factor in Indonesia's maternal mortality. Positive affirmations represent an accessible non-pharmacological intervention combining cognitive restructuring with relaxation techniques. This research aimed to determine the effectiveness of structured positive affirmation interventions in reducing anxiety levels among third-trimester pregnant women at the UPTD Salugatta Health Center in Central Mamuju Regency in 2025. A quasi-experimental one-group pretest-posttest design enrolled 60 third-trimester pregnant women through purposive sampling between January and June 2025. Participants received standardized positive affirmations delivered four times daily over seven consecutive days. Anxiety levels were measured using the validated Hamilton Anxiety Rating Scale before and after intervention. Data were analyzed using the Wilcoxon signed-rank test and multiple linear regression (α=0.05, 95% CI). Mean anxiety scores decreased significantly from 20.23±6.21 to 15.47±4.29, representing a 4.76-point reduction (95% CI=3.82–5.70; p<0.001, Cohen's d=0.89). Non-anxious participants increased from 0% to 67%, while severe anxiety was eliminated. Multivariate analysis revealed primigravida status (β=0.42, p<0.001), younger age (β=0.28, p=0.021), and higher education (β=0.24, p=0.032) as significant predictors of greater anxiety reduction, with the model explaining 52.4% of variance. In conclusion, in this single-group study, structured positive affirmation interventions were associated with a significant reduction in third-trimester pregnancy anxiety and a large effect size, supporting further evaluation—ideally with a controlled design—for integration into routine antenatal care.]]>
