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Joseph
Published by Universitas An Nuur
ISSN : -     EISSN : 28098196     DOI : -
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Joseph: Journal of Science and Pharmacy merupakan jurnal ilmiah yang diterbitkan oleh Universitas An Nuur sebagai media publikasi dan diseminasi hasil penelitian di bidang ilmu pengetahuan alam dan farmasi. Jurnal ini bertujuan untuk mendorong kemajuan ilmu pengetahuan melalui penyebaran informasi ilmiah yang berkualitas, relevan, dan berdampak bagi dunia akademik, praktisi, serta masyarakat luas. Sebagai bagian dari kontribusi Universitas An Nuur dalam pengembangan ilmu dan teknologi, Joseph: Journal of Science and Pharmacy hadir untuk menjadi sarana ilmiah yang kredibel, inovatif, dan berorientasi pada pemecahan masalah nyata di bidang sains dan farmasi, baik di tingkat nasional maupun internasional. Joseph: Journal of Science and Pharmacy An Nuur menerbitkan makalah secara berkala satu kali setahun, pada bulan Desember. Edisi pertama terbit pada bulan April 2021. Jurnal Joseph: Journal of Science and Pharmacy diterbitkan oleh LPPM Universitas An Nuur dan telah terdaftar di LIPI dengan e-ISSN: 2809-8196 untuk online media.
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Articles 31 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN PEGAGAN (Centella asiatica (L.) Urban) TERHADAP BAKTERIStaphylococcus epidermidis Miki Rofi’atun Masriah; Supriyanto; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: Acne is a skin problems characterized by the appearance of papules, pustules, blackheads, and nodules. Acne can be exacerbated by the bacteria Staphylococcus epidermidis which infects inflamed skin tissue. Antibiotic can be used to treat infections, but they can cause side effects. Therefore it is necessary to do alternative medicine using natural ingredients. Pegagan (Centella asiatica (L.) Urban) leaves contain active compouds such as alkaloids, triterpenoids, saponins, flavonoids, and tannins which are antibacterial because they can damage bacterial cell walls. Purpose: The aim of this research was to determine the antibacterial activity of pegagan (Centella asiatica (L.) Urban) leaf extract against Staphylococcus epidermidis bacteria. Method: This type of research is an experimental study with the disc diffusion method. Pegagan (Centella asiatica (L.) Urban) leaves were extracted by maceration method using 70% ethanol as solvent. Pegagan (Centella asiatica (L.) Urban) leaves extract at made contrations of 60%, 80%, 100%. Results: The results showed that pegagan (Centella asiatica (L.) Urban) leaf extract with concentrations of 60%, 80% and 100% had an average zone of inhibition of 18,39 mm, 21,24 mm and 22,61 mm. Conclusion: Pegagan (Centella asiatica (L.) Urban) leaf extract has antibacterial activity against Staphylococcus epidermidis bacteria  
UJI AKTIVITAS ANTIBAKTERI SEDIAAN FACE TONER EKSTRAK ETANOL 70% DAUN SALAM (Syzygium polyanthum) TERHADAP BAKTERIStaphylococcus aureus Sony Hartono; Wahyu Purwanjani; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: Salam leaves contain several chemical compounds including alkaloids, flavonoids, saponins, triterpenoids and tannins which are active compounds that are effective as drugs that can cure infectious diseases caused by bacteria. Purpose: The purpose of this study was to determine the antibacterial activity of bay leaf extract face toner preparations against Staphylococcus aureus bacteria. Method: Bay leaves are extracted with 70% ethanol by maceration. The ethanol extract of bay leaves is formulated into a facial toner preparation and then tested for antibacterial activity using the disc diffusion method or the Kirby Bauer method. Results: The results of the research show that the face toner preparation with 70% ethanol extract of salam (Syzygium polyanthum) contains alkaloid compounds, flavonoids, saponins, triterpenoids and tannins. Ethanol extract of salam leaf has antibacterial activity against Staphylococcus aureus with the inhibition zone diameter of F1 of 10.28 mm, F2 of 11.24 mm, and F3 of 12.24 mm. Conclusion: Facial toner preparation of bay leaf extract (Syzygium polyanthum) provides the strongest antibacterial activity in F3 against the growth of Staphylococcus aureus bacteria with an inhibitory zone diameter of 12.24 mm  
UJI STABILITAS FISIK SEDIAAN SERUM WAJAH EKSTRAK DAUN BELIMBING MANIS (Averrhoa carambola L.) DENGAN VARIASI KONSENTRASI PROPILEN GLIKOL SEBAGAI HUMEKTAN Devi Kurnia Saputri; Gigih Kenanga Sari; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: Sweet star fruit leaf (Averrhoa carambola L.) is a plant that contains antibacterial compounds such as alkaloids, flavonoids, saponins, tannins and triterpenoids that are used as acne therapy. Several product dosage forms have been developed for serum, one of which is in form slightly viscous. Humectants serve to improve the stability of the material over long period of time. Purpose: This research was conducted to find out at what oncentration propylene glycol as a humectant meets the physical stability test of a good serum preparations. Method: Sweet star fruit leaf (Averrhoa carambola L.) was extracted using the maceration method using methanol. The serum preparation consists of 3 formula with different concentrations of propylene glycol, namely formula I 15%, formula II 20% and formula III 25%. Evaluation of physical stability was carried out with 12 days in an accelerated test (Cycling test) with organoleptic testing parameters, homogeneity, pH, viscosity, adhesion and spreadability. Results: Serum preparations of weet star fruit leaf extract (Averrhoa carambola L.) in formula I, formula II and formula III have physical characteristics and stability that comply with SNI standards. Conclusion: The concentration of propylene glycol 25% in formula III shows the most stable serum stability properties compared to formula I and formula II  
UJI AKTIVITAS ANTI JAMUR SEDIAAN GEL EKSTRAK DAUN TURI PUTIH (Sesbania grandiflora L.) TERHADAP JAMUR Candida albicans Sinta ardani; Supriyanto; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: One of the plants that has anti-fungal potential is the white Turi Plant (Sesbania grandriflora) white turi leaf extract (Sesbania grandiflora) which is suspected to be able to inhibit the growth of Candida albicans, one of the fungi that cause candidiasis. Purpose: This study aims to determine the antifungal activity of Sesbania grandriflora white turi leaf extract gel against the fungus Candida albicans, determine the minimum inhibitory concentration (KHM) and determine the content of secondary metabolite compounds. Method: The leaves (Sesbania grandriflora) are extracted by maceration with a 70% ethanol solvent. The extracts obtained were subjected to phytochemical screening tests. The antifungal activity test of turi leaf extract gel was carried out by the well method against Candida albicans. The positive control used was the 2% dandruff gel while the negative control used was the gel preparation without the extract. Results: White turi leaf extract gel (Sesbania grandriflora) has antifungal activity against Candida albicans. Conclusion: Based on the results of the research on the Antifungal Activity Test of Sesbania glandriflora White Turi Leaf Extract Gel Preparation against Candida albicans Fungus, it can be concluded as follows: 1. Sesbania glandriflora (L.) white turquoise leaf extracthas the content of Saponins, flavonoids, and tannins  2.  Sesbania glandriflora (L.) white turquoise leaf extractgel preparation has the activity of inhibiting the fungusCandida albicans   The most effective formulation of Sesbania glandriflora (L.) white turi extract gel preparation against the growth of Candida albicans fungus is Formulation 3 with a concentration of 8% of 20.65 mm, included in the very strong group    
UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP BAKTERI Staphylococcus epidermidis Iva Juliyanti; Maulita Saraswati; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: Red dragon fruit skin has many benefits, but currently the utilization of red dragon fruit skin has not been carried out optimally so that it becomes environmental waste. One of the benefits is as an antibacterial because it contains flavonoids, alkaloids, saponins, and tannins. Purpose: To determine the potential of red dragon fruit peel extract in inhibiting bacterial growth against Staphylococcus epidermidis bacteria. Method: Red dragon fruit peel was macerated with 70% ethanol, characterized by specific parameters and nonspecific parameters and tested for antibacterial activity using the disc method with concentrations of 10%, 20%, and 40%, then the results of the antibacterial data obtained were tested by oneway-Anova analysis and Post Hoc Tukey. Results: The yield results obtained were 10.66%, dark brown in color, sour smell, sticky and thick texture. Red dragon fruit peel extract contains flavonoids, alkaloids, tannins, saponins, and phenols. The extract is free from ethanol. The moisture content of the powder was found to be 9.85±0.057. Specific gravity 0.956±0.006. Bacterial test results obtained 10% concentration 4.1mm, 20% concentration 8.1mm, 40% concentration 16mm, positive control 31.2mm. The results of data analysis are significant at 0.000, and each concentration has a significant difference. Conclusion: Red dragon fruit peel extract has antibacterial activity against Staphylococcus epidermidis  
UJI STABILITAS FORMULASI FACE TONER EKSTRAK DAUN PEGAGAN (Centella asiatica) DENGAN VARIASI KONSENTRASI GLISERIN Rumanis Afifah; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: The cosmetics industry continues to grow with increasing interest in natural ingredients. Gotu kola leaves (Centella Asiatica) contain bioactive compounds with antioxidant, anti-inflammatory, and skin repair effects, making them potential ingredients for face toners. Toners refresh and balance the skin's pH, while glycerin acts as a humectant to maintain moisture, but its concentration affects the stability and comfort of the preparation. This study formulated a gotu kola extract face toner with varying glycerin concentrations and evaluated its stability through a cycling test (±4 °C and ±40 °C, six cycles). This test is important for assessing the physical and chemical quality of the product while meeting cosmetic registration requirements. Purpose: 1.To determine the compounds contained in gotu kola leaf extract (Centella Asiatica). 2. To determine whether there is an effect on physical quality and stability in variations of glycerin in gotu kola leaf extract (Centella Asiatica) face toner formulations. 3. To determine the face toner formulation that has good stability with variations in glycerin concentration.. Method: Pegagan leaves (Centella asiatica) were extracted using the maceration method with 70% ethanol solvent.   The extract obtained was subjected to phytochemical testing and TLC testing, followed by the preparation of formulations according to the predetermined formulation. A cycling test was conducted for 12 days with 6 cycles, followed by physical quality testing of the face toner formulation.Results: Pegagan extract compounds contain alkaloids, flavonoids, and tannins. There were no significant differences between formulations 1, 2, and 3 with variations in humectants (glycerin). Formulation F2 showed the most optimal stability because both viscosity and pH were relatively stable during six storage cycles. Conclusion: Based on this study, it was found that face toner preparations containing gotu kola leaf extract (Centella Asiatica) at concentrations of 2%, 4%, and 6% had fairly good physical stability parameters.
PENGARUH VARIASI KONSENTRASI TRIETHANOLAMINE TERHADAP STABILITAS FISIK LOTION EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) Yulia Rika Femina; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Fragrant pandan leaves (Pandanus amaryllifolius Roxb.) are known to contain various secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and terpenoids, making them potentially useful as ingredients in herbal cosmetic formulations, especially lotions. Triethanolamine acts as an emulsion stabilizer for oil-in-water (O/W) emulsions. Variations in triethanolamine concentration are expected to affect the physical stability of the lotion, thus further research is needed to optimize the formulation. Purpose: This study aims to evaluate the effect of triethanolamine concentration on the physical stability of formulated pandan leaf lotion, and to determine the triethanolamine concentration that is most stable and effective. Method: Fragrant pandan leaves were extracted with ethanol through maceration. The lotion preparation consisted of 4 formulations with different concentrations of triethanolamine (0%, 2.5%, 3%, and 3.5%). Physical stability was evaluated through organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesiveness, and type of emulsion under room temperature, cooling, and storage conditions for 6 cycles. The data were analyzed using ANOVA, if the data were not normal, the Kruskal–Wallis test was used. Results: The preparation of lotion from the extract of fragrant pandan leaves (Pandanus amaryllifolius Roxb.) in formula 0, formula I, formula II, and formula III has physical characteristics and stability that comply with SNI standards Conclusion: The lotion preparation with 3.5% triethanolamine concentration shows the most stable lotion properties compared to formulation 0, I, and formula II.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN BELIMBING MANIS (Averrhoa carambola L.)TERHADAP Staphylococcus epidermidis Indriani Dini Mustava; Gigih Kenanga Sari; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: A major factor in the development of acne is bacterial activity within infected hair follicles. One of the bacteria involved in acne formation is Staphylococcus epidermidis. Star fruit leaf extract (Averrhoa carambola L.) contains alkaloids, flavonoids, tannins, triterpenoids, and saponins, which can act as antibacterial agents. Purpose: This study aims to formulate gel preparations of star fruit leaf extract (Averrhoa carambola L.) at concentrations of 3%, 4%, and 5%, and to evaluate their antibacterial activity against Staphylococcus epidermidis. Method: Star fruit leaves were extracted using the maceration method with 70% ethanol. The extract was formulated into gel preparations at concentrations of 3%, 4%, and 5%, followed by antibacterial activity testing against Staphylococcus epidermidis using the well diffusion method. Results: The study showed that the star fruit leaf extract (Averrhoa carambola L.) contains alkaloids, flavonoids, saponins, tannins, and triterpenoids. The gel formulations exhibited antibacterial activity with inhibition zones of 8,61 mm, 9.48 mm, and 11,50 mm for the 3%, 4%, and 5% concentrations, respectively. Conclusion: The gel preparation of star fruit leaf extract (Averrhoa carambola L.) with the highest antibacterial activity was the Formula 3 gel containing 5% extract
Uji Stabilitas Fisik Facial Wash Gel Ekstrak Daun Mengkudu (Morinda citrifolia L.) Dengan Variasi Carbopolol Sebagai Gelling Agent Eva Natalia; Maulita Saraswati; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Noni leaves (Morinda citrifolia L.) are a plant with antibacterial properties. One of the most commonly used antibacterial cosmetic preparations is facial wash gel. Purpose: This study aims to formulate a facial wash gel preparation containing noni leaf extract (Morinda citrifolia L.) which has antibacterial content with variations of carbopolol.. Method: Noni leaf extract (Morinda citrifolia L.) was macerated with 96% ethanol solvent and tested for specific parameters in the form of organoleptic, ethanol-free, phyrochemical screening, and Thin Layer Chromatography tests and non-specific parameters in the form of drying loss. Then tested for physical quality, organoleptic test, homogeneity, pH, foam stability, viscosity, adhesive power. Then tested for physical stability for 6 cycles with 2 temperatures, 4 ° Celsius and 40 ° Celsius. with carbopolol concentrations of 0.5%, 1%, 1.5%, and 2%. Results: The research results showed that noni leaf extract can be used as a facial wash gel and contains flavonoids, alkaloids, terpenoids, and saponins. The noni leaf extract (Morinda citrifolia L.) facial wash gel produced good quality and physical stability. The best facial wash gel was formula three (2% carbopolol concentration). Conclusion: Noni leaf extract (Morinda citrifolia L.) can be made into a facial wash gel with good quality and physical stability and produces the best facial wash gel formula in the FIII preparation (2% carbopolol concentration).
Analisis Zat Pengawet Boraks pada Cilok dan Pentol Bakso yang Dijual di Kabupaten Grobogan Salma Ellya Sayidina; Wahyu Purwanjani; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: The increasing use of borax as an unauthorized preservative in foodssuch as cilok and pentol bakso sold in Grobogan Regency poses a threat to public health. Purpose: to examine the presence and concentration of borax in cilok and pentol bakso samples circulating in the area. Method: Qualitative analysis using boric acid test kits and quantitative analysis using Spectrophotometry UV-Vis to measure boric acid levels in the samples. Samples were collected from various street vendors, prepared and then analyzed in the laboratory. Results: The study results showed that borax was detected in one cilok sample with a the highest concentration reaching 112.22 μg/kg.  Conclusion: The study results indicate that some food vendors are still adding borax to their products. Therefore, further supervision and increased awareness regarding the risks of using borax in food are necessary.

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