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Joseph
Published by Universitas An Nuur
ISSN : -     EISSN : 28098196     DOI : -
Core Subject :
Joseph: Journal of Science and Pharmacy merupakan jurnal ilmiah yang diterbitkan oleh Universitas An Nuur sebagai media publikasi dan diseminasi hasil penelitian di bidang ilmu pengetahuan alam dan farmasi. Jurnal ini bertujuan untuk mendorong kemajuan ilmu pengetahuan melalui penyebaran informasi ilmiah yang berkualitas, relevan, dan berdampak bagi dunia akademik, praktisi, serta masyarakat luas. Sebagai bagian dari kontribusi Universitas An Nuur dalam pengembangan ilmu dan teknologi, Joseph: Journal of Science and Pharmacy hadir untuk menjadi sarana ilmiah yang kredibel, inovatif, dan berorientasi pada pemecahan masalah nyata di bidang sains dan farmasi, baik di tingkat nasional maupun internasional. Joseph: Journal of Science and Pharmacy An Nuur menerbitkan makalah secara berkala satu kali setahun, pada bulan Desember. Edisi pertama terbit pada bulan April 2021. Jurnal Joseph: Journal of Science and Pharmacy diterbitkan oleh LPPM Universitas An Nuur dan telah terdaftar di LIPI dengan e-ISSN: 2809-8196 untuk online media.
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Articles 34 Documents
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ANALISIS NATRIUM SIKLAMAT PADA TEH JUMBO DI KABUPATEN GROBOGAN DENGAN METODE KUALITATIF DAN KUANTITATIF iman cahyani_putri; Maulita Saraswati; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Background: Jumbo tea is a popular drink because it is practical and affordable. However, manufacturers often add sodium cyclamate, an artificial sweetener that is 30 times as sweet as sucrose and is known to be cheap, to reduce production costs. Excessive use of sodium cyclamate can cause health problems. Purpose: This research aims to analyze the presence and levels of sodium cyclamate in jumbo tea drinks circulating in Grobogan Regency. Method: This research used 10 jumbo tea samples taken from 5 sub-districts in Grobogan Regency using a purposive sampling method, namely samples that had an excessively sweet taste. Analysis was carried out qualitatively using the deposition method and quantitatively using the UV-Vis Spectrophotometry method. Results: Of the 10 samples tested, the qualitative test results showed that 3 samples were positive for containing sodium cyclamate (samples C2, E1, and E2) which were characterized by the formation of a white precipitate. The quantitative test results on the three positive samples showed the following sodium cyclamate levels: sample C2 was 0.08104 g/kg, sample E1 was 0.04693 g/kg, and sample E2 was 0.06242 g/kg. Conclusion: There were 3 out of 10 jumbo tea samples in Grobogan Regency that tested positive for sodium cyclamate15. However, the sodium cyclamate levels found in the three samples were still below the maximum limit permitted by BPOM (3 g/kg).
UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL 96% DAUN BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI GLISERIN Nike Wijayanti; Wahyu Purwanjani; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Bilimbi leaves (Averrhoa bilimbi L.) contain secondary metabolites that have potential as antioxidants. The development of cream preparations requires evaluation of physical stability, Glycerine as a humectant plays a role in influencing the physical stability of the preparation. Purpose: This study aimed to evaluate the effect of varying glycerine concentrations on the physical stability of 96% ethanol extract creams from starfruit leaves. Method: The extract was obtained by maceration using 96% ethanol and formulated into three cream formulations with glycerine concentrations of 10%, 15%, and 20%. Accelerated stability testing was conducted using the cycling test method for 6 cycles (12 days). Qualitative analysis included the identification of secondary metabolite compounds using thin-layer chromatography (TLC) as well as descriptive evaluation of organoleptic properties, homogeneity, and cream type. Quantitative analysis included pH, spreadability, adhesion, and viscosity tests, which were statistically analysed using the One Way ANOVA test if the data were normally distributed and homogeneous (p ≥ 0.05), while data that did not meet the requirements were analysed using the Kruskal–Wallis and Mann–Whitney tests. Results: Starfruit leaf extract was found to contain flavonoids, saponins, alkaloids, and tannins. All cream formulations showed good physical stability with pH suitable for skin, spreadability and adhesion meeting requirements, viscosity in accordance with SNI standards, and an oil-in-water (O/W) type. Conclusion: The 96% ethanol extract cream of starfruit leaves with varying glycerin concentrations showed good organoleptic characteristics, was homogeneous, had an oil-in-water (O/W) type, and met the requirements for pH, viscosity, spreadability, and adhesion before and after stability testing in all formulations. Varying glycerin concentrations affected the physical stability of the preparation. Formulation III with a glycerin concentration variation of 20% showed more optimal and stable physical stability compared to other formulations.
Analysis of Rhodamine B Levels in Lip Tints Circulating in Tawangharjo District TAWANGHARJO Dhiva Mariska; Renno Ramadhani Ika Baruna; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Abstract

Latar Belakang: Rhodamin B merupakan zat pewarna sintetis yang dilarang penggunaannya dalam kosmetik karena bersifat karsinogenik dan dapat menimbulkan gangguan kesehatan. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi dan menentukan kadar Rhodamin B pada 10 sampel lip tint yang beredar di Kecamatan Tawangharjo. Metode: Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik pengambilan sampel secara purposive sampling. Identifikasi Rhodamin B dilakukan menggunakan Kromatografi Lapis Tipis (KLT) dengan fase diam silika gel GF254 dan fase gerak n-butanol asetat (10:4:5). Penentuan kadar Rhodamin B dilakukan secara spektrofotometri UV-Vis pada panjang gelombang maksimum 542 nm. Hasil: Hasil identifikasi menggunakan KLT menunjukkan bahwa enam sampel positif mengandung Rhodamin B dengan nilai Rf berkisar antara 0,42–0,60, yang mendekati nilai Rf baku sebesar 0,62, sedangkan empat sampel lainnya menunjukkan hasil negatif. Hasil analisis kuantitatif menunjukkan bahwa seluruh sampel positif mengandung Rhodamin B dengan kadar berkisar antara 0,0188–0,5450 mg/kg atau setara dengan 0,00019%–0,00545%. Kadar Rhodamin B tertinggi ditemukan pada sampel R3, yaitu sebesar 0,5450 mg/kg. Kesimpulan: Berdasarkan hasil penelitian, dapat disimpulkan bahwa produk lip tint yang beredar di Kecamatan Tawangharjo tidak memenuhi persyaratan keamanan kosmetik sesuai dengan ketentuan BPOM karena ditemukan adanya kandungan Rhodamin B yang merupakan zat pewarna yang dilarang penggunaannya dalam kosmetik.   Kata Kunci: Lip Tint, Rhodamin B, KLT, Nilai Rf, Spektrofotometri UV-Vis
UJI KUALITATIF DAN KUANTITATIF BAHAN KIMIA OBAT (BKO)PADA JAMU PEGAL LINU DI WILAYAH KABUPATEN GROBOGAN Alya Iffa Nalia; Wahyu Purwanjani; Renno Ramadhani Ika Baruna
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Latar Belakang: Banyaknya penambahan bahan Kimia obat (BKO) seperti paracetamol, Dexamethasone, natrium diklofenak pada jamu pegal linu di kabupaten grobogan yang masih beredar luas. Tujuan: untuk mengetahui keberadaan bahan kimia obat pada jamu pegal linu yang beredar luas. Metode: Analisis kualitatif menggunakan uji klt ( kromatografi lapis tipis) dan analisis kuantitatif menggunakan spektrofotometri uv-vis untuk mengukur bahan kimia obat yang terkandung pada sampel jamu pegal linu di lima kecamatan grobogan, dan kemudian dianalisis di laboratorium. Hasil: Hasil penelitian menunjukkan bahwa kadar tertinggi yang di dapat pada masing-masing sampel yaitu Paracetamol terdapat pada sampel C 29,82%; Dexamethasone terdapat pada sampel A 12,50%; dan Natrium Diklofenak terdapat pada sampel C 44,64%. Kesimpulan: Hasil penelitian menunjukkan bahwa beberapa sampel jamu pegal linu masih banyak ditambahkan bahan kimia obat (BKO) seperti paracetamol, Dexamethasone, natrium diklofenak. Oleh karena itu, masih butuh pengawasan lebih lanjut dan peningkatan kesadaran mengenai resiko penggunan bahan kimia obat secara terus menerus.   Keyword: Bahan Kimia Obat ( BKO), Kromatografi Lapis Tipis (KLT), Spektrofotometri UV-Vis 

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