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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 199 Documents
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Paraoxonase 1 Activities and Lipid Parameters in Hypertension and Their Association with Chronic Alcoholism Sudeep Kumar; Jyoti Batra; Sumesh Prasad Sah; Dinesh Kumar; Shahid Iqbal; Manisha Arora; Shivani Sharma
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2595

Abstract

Objective: To determine lipid profile, antioxidant vitamin (E and C), and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD) levels and paraoxonase 1 (PON 1) activities in alcoholic hypertensive patients.Methods: Five hundred subjects were selected for this study consisting of 250 normal healthy individuals and 250 alcoholic hypertensive subjects. Total cholesterol, triglyceride, and HDL levels were measured using the enzymatic method while the LDL and VLDL levels were calculated by Friedwald equation. The MDA level were measured using thiobarbiturate (TBA) and the Vitamin E and C were measured using the enzymatic method. The SOD and PON 1 activities were measured using phenyl acetate as the substrate.Results: Total cholesterol, triglycerides, LDL, VLDL, and MDA levels were found to be significantly high while the HDL and Vitamin E and C levels decreased among the alcoholic hypertensive subjects when compared to the control. Furthermore, significant decreases in SOD and PON 1 activities were also found among the alcoholic hypertensive subjects as compared to control.Conclusion: Alterations in lipid parameters, antioxidant vitamin levels, MDA level, SOD activities, and PON 1 activities are associated with hypertension that may be enhanced by alcohol intake, which may lead to the development cardiovascular disease. 
Unexpected Infective Endocarditis in Corrected Congenital Heart Disease: A Case Report Cool, Charlotte Johanna; Serulina, Rachmi; Saboe, Aninka
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2166

Abstract

Objective: To describe patients with corrected Congenital Heart Disease (CHD) who experienced Infective Endocarditis (IE).Methods: Two cases of IE were observed in 2019. The first case involved a 36-year-old woman with previous percutaneous transcatheter perimembranous ventricular septal defect (VSD) closure four months before admission. Echocardiography showed vegetation at noncoronary cusps of the aortic valve. Patient received antibiotics for six weeks and underwent surgery for evacuation of vegetation and device, along with VSD closure with a cardiovascular patch (Gore-tex). The second case involved a 43-year-old woman with a history of surgical closure in secundum atrial septal defect (ASD) by pericardial patch two months before admission. Echocardiography showed vegetation at the tricuspid valve. Patient received antibiotics for four weeks and planned for surgery to evacuate vegetation.  Results: IE is one of the major complications in CHD, whether uncorrected, treated, or corrected. The risk of IE increased with an invasive procedure. Post closure IE is rare. Poor dental hygiene and immunocompromised also increased patient's risk to be exposed to IE as shown in the first patient who had dental caries and the second patient who was on methylprednisolone for post-surgical pericardial effusion treatment. Conclusion: The risk of IE increases with invasive procedures in CHD patients. Although the incidence of IE is quite rare, its possibility should become of a serious concern among physicians.
Secondary Chronic Immune Thrombocytopenia in Diffuse Large B-cell Lymphoma: A Rare Case Report Putri Vidyaniati; Fransisca Fransisca; Kiki Akhmad Rizki; Amaylia Oehadian
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2603

Abstract

Objective: To present a case of rare secondary chronic immune thrombocytopenia in diffuse large B-cell lymphoma.Methods: A case of secondary ITP associated with diffuse large B-cell lymphoma (DLBCL) in a 58-year-old woman suffering from hemorrhagic tendencies that was refractory to conventional treatments of ITP was reported. This case is a rarity because there are not many cases of secondary chronic ITP due to DLBCL have been reported to date.Results: A 58-year-old woman was diagnosed with ITP around 11 months before she was admitted to the Emergency Room with bleeding. Previous treatment with steroid and azathioprine was only temporarily effective. During the course of treatment, splenomegaly and lymphadenopathy were identified, but lymph node biopsy was delayed by the thrombocytopenia. The drug was then replaced to the eltrombopag, which showed good response. However, the patient had to undergo splenectomy because of the mechanical effect of splenomegaly, with the biopsy result showed DLBCL. Immune thrombocytopenia then went into a complete remission after splenectomy.Conclusion: In cases of ITP that are refractory to conventional treatments, a thorough search for secondary ITP might be helpful, even if no underlying disorder is detected at the initial presentation.
Differential Diagnosis of Fever of Unknown Origin in Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Kevin Fachri Muhammad; Ferdy Ferdian; Andri Reza Rahmadi
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2198

Abstract

Objective: To describe an unusual case of drug reaction with eosinophilia and systemic symptoms presenting as fever of unknown origin (FUO) and the diagnostic hurdles that come with the presence of differential diagnosis of FUO, which is tuberculous lymphadenitis.Methods: A 34-year-old female with a chief complaint of fever that has lasted for 3 weeks accompanied with jaundice and skin rashes for 2 weeks was admitted with an indication of FUO. She had a history of carbamazepine consumption for trigerminal neuralgia 2 months prior. Cervical lymphadenopathy was palpable bilaterally and hepatomegaly, elevated liver enzyme, as well as hyperbilirubinemia were observed. After excluding differentials for many causes of prolonged fever, patient was treated for Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and was given intravenous steroid injections. Fine needle aspiration biopsy was performed for her cervical lymphadenopathy.Results: Biopsy presented a mix of sialadenitis and tuberculous lymphadenopathy. Clinical improvement was observed on the second day after steroid administration. Patient was discharged on the seventh day after steroid administration.  Conclusion: FUO is one of the possible manifestations of DRESS; however, thorough investigation still needed to be done considering the possibility of more than one entity of disease that can cause FUO in patients, such as tuberculous lymphadenopathy seen in this case.
Correlation between serum KL-6 level and severity of SARD-related ILD Emmy Pranggono; Alvy Syukrie; Valentine Natasya Moenadri; Sumartini Dewi
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2652

Abstract

Objective: To understand the correlation between serum KL-6 level and severity of SARD-related ILD in Indonesia.Method: This was a cross-sectional study to evaluate the correlation between serum KL-6 level and Interstitial Lung Disease (ILD) severity based on Chest High-Resolution Computed Tomography (Chest HCRT) among patients with Systemic Autoimmune Rheumatic Disorders (SARD) who visited the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital during the period of January 2019 to February 2020. Secondary data were retrieved from a study on the Effects of Ciplukan Herbs on Organ Fibrosis. KL-6 serum concentration was measured from stored biological material and the correlation between the serum KL-6 level and ILD severity was analyzed by Rank Spearman's test.Results: Thirty-four patients participated in this study with a median age of 37 years-old. Most of the participants were female (94.1%), Sundanese (64.7%), and had systemic sclerosis as an underlying disease (48.5). The median serum KL-6 level was 57.1 U/ml (21.6-444.1). Most participants belonged to severe ILD group (58.8%) with a mean serum KL-6 level of 65.1±48.9 U/ml. The highest mean serum KL-6 level (111.6±121.8) was observed in the moderate ILD group comprising of 32.4% of the participants. The remaining 11.8% participants belonged to mild ILD group with a mean serum KL-6 level of 61.1±24.9 U/ml. Serum KL-6 level was demonstrated to have a weak correlation with ILD severity (r=-0.229, p=0.193).Conclusion. There is an insignificant weak correlation between serum KL-6 level and ILD severity based on chest HRCT in SARD patients.
Depression, Anxiety, and Stress due to Changes in Employment Status during COVID-19 Pandemic: A Study in Badung Districts, Bali, Indonesia Made Violin Weda Yani; Made Sindy Astri Pratiwi; Agus Indra Yudhistira Diva Putra; Ni Ketut Sri Diniari
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2541

Abstract

Objective:  To determine the relationship between depression, anxiety, and stress with the employment status of people in Bali during Covid-19 pandemic.Methods: This study was a cross-sectional analytical study conducted in Bali, Indonesia, in 2021. The instrument used was DASS-21 questionnaire, which was distributed to a total sample size of 96 people. The relationship between variables were analyzed with a p-value of <0.05 as the cut-off for a significant relationship.Results: Depression symptoms had a significant relationship with gender (p=0.024) while anxiety symptoms had a significant association with the employment status during the pandemic (p=0.027). Similarly, stress symptoms also had a significant relationship with gender (p=0.007) and employment status during COVID-19 pandemic (p=0.007).Conclusion: There is a relationship between depression, anxiety, and stress due to changes in employment status during the COVID-19 pandemic in Badung Districts, Bali.
Indications and Complications of Orthopedic Hardware Removal in an Indonesian Tertiary Hospital: A Descriptive Study Shadrina Affifa Azzahra; Raden Andri Primadhi; Titing Nurhayati; Muhammad Naseh Sajadi; Achadiyani Achadiyani
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2695

Abstract

Objective: To acquire clinical data regarding indications of implant removal and complications in orthopedic metal implant removal. Methods: This was a cross-sectional observational descriptive study using patient medical records. The inclusion criterion was all patients who underwent orthopedic metal implant removal during 2018-2020 while the exclusion criterion was unintentional implant removal due to subsequent injury or loosening. Data regarding anatomic regions, indications, and complications were collected and presented in tables.Results: In 112 patients participated in this study consisting of 75 (67%) men and 37 (33%) women, the implants were mainly located in thigh, lower leg, and ankle (53% combined). The most common indication for metal implant removal was conversion (31%), followed by infection (25%) and patient's request (20%). The only complication observed in orthopedic metal implant removal in this study was disturbed wound healing in a small percentage of the patients (16%). Most patients (84%) did not experience any complication due to metal implant removal.Conclusions: Indications for metal implant removal may vary, with or without symptoms. Disturbed wound healing is a complication observed in metal implant removal. Despite the advantages of removal, further analysis and guidelines are needed to avoid unnecessary hardware removal considering the risk of complications.
Renal Parameters in Mild, Moderate, and Chronic Cigarette Smokers Dinesh Kumar; Preeti Sharma; Sudeep Kumar; Sumesh Prasad Sah; Manisha Arora; Shahid Iqbal; Pradeep Kumar
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2558

Abstract

Objective: To explore the link between cigarette smoking and kidney function through renal parameter assessment.Methods: The present study was performed at the Department of Biochemistry Santosh Medical College, Ghaziabad, India, from September 2019 to April 2021. In this study, 140 subjects were included, out of which 35 were non-smokers, 35 smoked  <5 cigarette per day, 35 smoked 5-10 cigarette per day, and the remaining 35 smoked more than 10 cigarettes per day.Results: Blood urea, serum creatinine, urinary albumin, and uACR levels were found to increase significantly (p<0.001) in smokers as compared to non-smokers. These increases were higher among chronic cigarette smokers (p<0.001) as opposed to mild and moderate smokers. In contrast, serum uric acid, e-GFR, and urinary creatinine levels decreased significantly (p<0.001) in smokers when compared to non-smokers, with a higher decrease observed in chronic cigarette smokers (p<0.001) as opposed to the mild and moderate cigarette smokers.Conclusion: Alterations in urinary albumin, serum urea, serum creatinine, urinary creatinine, and e-GFR are associated with the risk of renal dysfunction.
Knowledge and Practice of Menstrual Hygiene and Reproductive Tract Infection in Adolescent Girls in Doda District of Jammu and Kashmir Territories, India Suresh Kotwal; Garima Charak; Sudeep Kumar; Sudhanshu Shekhar; Kasturi Lal Gupta
International Journal of Integrated Health Sciences Vol 10, No 2 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n2.2751

Abstract

Objective: To assess knowledge and practices regarding menstrual hygiene and reproductive tract infection in adolescent girls in Doda District of Jammu and Kashmir Territories, India.Methodology: This cross-sectional study was performed on adolescent girls attending schools in Doda district of Jammu and Kashmir territories, India. Data were collected through interviews using a predesigned semi-structured questionnaire and results were analyzed using MS Excel.Results: A total of 450 adolescent girls from public and private schools of Doda district of Jammu and Kashmir were included in this study. Most participants were in the 14-16 years of age. The most common source of information about menstruation identified in this study was mother (56.2%), sister (13.1%), teacher (12.7%), and friends (9.6%). In terms of menstrual hygiene, 53.1% girls used sanitary pads, 24% girls used dry cloths/towel and 10.7% girls used homemade and sanitary pads during their menstrual period. About 42% of the participant were absent from school during their menses and most participants take daily bath during their menses.Conclusion: Awareness regarding menstruation and menstrual hygiene needs to be improved with the emphasize on providing accurate and adequate information on this topic to adolescent girls. Information and provision on affordable absorbent napkins or pads during menstrual period are also important for these girls.
Validity and Reliability of The Indonesian Version of Patient Allergic Rhinitis Questionnaire and Allergic Rhinitis Prevalence in A Class Of 2018-2019 Medical Students of Universitas Padjadjaran, Indonesia Sheila Rafifah Yuliantoputri; Melati Sudiro; Arif Dermawan; Lina Lasminingrum; Sally Mahdiani
International Journal of Integrated Health Sciences Vol 10, No 2 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2711

Abstract

Objective: To determine the validity and reliability of the Indonesian version of Patient Allergic Rhinitis Questionnaire as a screening tool for AR and the prevalence of AR in a class of 2018-2019 medical students of Universitas Padjadjaran, Indonesia.Methods: A cross-sectional descriptive study was performed during the period November-December 2021 on a class of 2018-2019 medical students of Padjadjaran University. The Indonesian version of the pre-validated Patient Allergic Rhinitis Questionnaire was distributed online. Allergic rhinitis was determined from history taking by identifying a history of a previous diagnosis of AR and/or 2 or more symptoms (watery runny nose, sneezing, nasal congestion, itching, or conjunctivitis) for more than 1 hour on most days.Results:. The validity of the Indonesian version of the Patient Allergic Rhinitis Questionnaire was good with a 0.895 Cronbach's Alpha coefficient, reflecting a reliable questionnaire. The prevalence of AR was 35.8% with most were female (69.2%). There were 59.9% of respondents who had a history of allergy in their parents. The most common symptom was nasal congestion (85.7%) and the moderate-severe persistent (49.2%) was the most common ARIA-WHO classification. Dusty places (92.1%) were the most common cause of symptoms. The most common comorbidity was rhinosinusitis (35%). The mean symptom severity score was 6.7.Conclusions: The Indonesian version of the Patient Allergic Rhinitis Questionnaire is valid and reliable as a screening tool for AR. The prevalence of AR in this study is quite high, with moderate-severe persistent as the most prominent classification.

Page 13 of 20 | Total Record : 199

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