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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 34 Documents

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Search results for , issue "Vol 50, No 1 (2018)" : 34 Documents clear

Onset to Hospital Admission Time and Disability in Patients with Ischemic Stroke Andre Dharmawan; Rizaldy Taslim Pinzon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The predictive factors of disability in stroke patients are still varied and subject to debate. Lower onset to admission time has been known produces excellent outcomes with significantly lower rates of morbidity and mortality. Previous study about the onset admission time in patients with stroke ischemic in Indonesia is very limited. This was a retrospective cohort study using secondary data from electronic medical record and electronic stroke registry of Bethesda Hospital Yogyakarta Indonesia. A total of 1657 patients with ischemic stroke was admitted between 2015-2017 and 313 patients were included in this study adjusted by inclusion and exclusion criteria. Factors such as age, gender, onset, previous stroke, comorbidities and complications were assessed. Multiple logistic regression analysis showed onset > 6 hour (RR: 4.567; 95% CI: 2.372-8.792;p: 0.000), age (RR: 2.366; 95% CI: 1.357-4.125;p:0.002) and patients with complications (RR: 12.403; 95% CI:2.443-62.968;p:0.002) were independently significant increasing the risk of disability in patient with ischemic stroke. Onset to hospital admission time > 6 hour was significantly increasing disability on ischemic stroke patients. Giving treatment less than 6 hours could save the patient from disability.

Surgical Management for Resistant Gestational Throphoblastic Neoplasia: Yogyakarta Experience Greta S Gulo; Nirwan Darmawan; Bob Irsan; Wisnu Prabowo; Ardhanu Kusumanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Gestational trophoblastic neoplasia (GTN) is a highly responsive to chemotherapy, but sometimes can be resistant, or relapse and require salvage chemotherapy with or without surgery. We use descriptive studies with case series to determine prognosis patient GTN with chemotherapy resistant manage with surgical procedure in Sardjito Hospital, Yogyakarta. GTN-resistant chemotherapy patients that undergoing hysterectomy showed significant decreases in hCG levels. Hysterectomy also help us to stop vaginal bleeding. However, complications from continuous bleeding can worsen patient condition. The decision to take a hysterectomy action varies depending on the patient's condition. At the Sardjito hospital, the patient was diagnosed with the fastest hysterectomy within the first 12 hours of treatment due to continuous bleeding, and shortly after 4 years of treatment with 5 different types of chemotherapy.

Insecticide resistance and mechanisms of aedes aegypti (Diptera: Culicidae) in Yogyakarta, Indonesia Budi Mulyaningsih; Sitti Rahmah Umniyati; Tri Baskoro Tunggul Satoto; Ajib Diptyanusa; Dwi Aris Agung Nugrahaningsih; Yahiddin Selian
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

For several decades, applications of organophosphates and pyrethroids insecticides have been extensively used to control Aedes aegypti as the primary dengue vector. Hence it is important to study dengue vector resistance status and its mechanisms in relation to long term use of insecticides. This study aimed to determine the resistance status and to characterize mechanisms of Ae. aegypti to organophosphates and pyrethroids using biological, biochemical and molecular assays. Larvae and puppae of Ae. aegypti were collected in the field of Plosokuning, Minomartani, Sleman, Yogyakarta, Indonesia. The biological assay was carried out using CDC Bottle Bioassay to test the resistant status to malation and cypermetrin. The biochemical assay was conducted using microplate assay with substrate α-naphthyl acetate to test the presence of esterase elevated activity, and the molecular assay was done using PCR with AaSCF7 and AaSCR7 primer to detect of point mutation at 1534 site, that located in the area of segment 6 of domain III. The biological assay showed Ae. aegypti suggests the possibility of resistance to malathion (mortality 82%) that needs to be confirmed further and already resistant to cypermetrin (mortality 76%). The biochemical assay of Ae. aegypti showed the presence of non-specific esterase elevated activity. The PCR method showed specific DNA bands were formed with the size of 748bp, and with sequencing showed there has been F1354C point mutation of voltage gated sodium chanel gene in the area of segment 6 of domain III. Long term use of insecticides did not successfully eliminate the targeted dengue vector, because Ae. aegypti mosquitoes were resistant to both insecticides. The results demonstrate the importance of designing better health policies regarding insecticide usage

Risk Factors of Malaria Incidence in Endemic Area of Central Java Renti Mahkota; Fajaria Nurcandra; Fitria Dewi Puspita Anggraini; Annisa Ika Putri; Bambang Wispriyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Malaria caused 212 million cases worldwide in 2015 which associated to environmental factors, ecology, and the presence of vectors. Annual paracite incidence (API) in Indonesia in 2011-2015 decreased. Unfortunately, malaria incidence always exist in Purworejo District which known as one of endemic area in Central Java. This research aimed to determine risk factors of malaria incidence in endemic area especially in Purworejo, Central Java. Logistc regression showed that period of residency 19-34 years (OR=1.612; 95% CI 0.853-3.046), period of residency >34 years (OR=2.050; 95% CI 1.036-4.060), male (OR=2.349; 95% CI 1.365-4.043), and education level less than junior high school (OR=1.677; 95% CI 0.976-2.882) as contributing risk factor to malaria incidence in Purworejo District.

Prolonged Kidney Ischemia-Reperfusion Injury Associates with Inflammation, Vascular Remodelling, and Myofibroblast Formation Nur Arfian*; Hilma Kholida Ats-tsani; Pratiwi Indah Sayekti; Dwina Agrila Lakabela; Amelia Amelia; Toni Febriyanto; Hana Rutyana Putri Antonio; Dian Prasetyo Wibisono; Dwi Cahyani Ratna Sari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Prolonged kidney ischemia-reperfusion injury (IRI) is the important risk factor for leading to chronic kidney disease (CKD). Persistent hypoxia and inflammation are considered as the main pathogenesis of chronic injury, followed by myofibroblast expansion and fibrosis process. Tubular injury, cell proliferation, and vasoconstriction, as acute compensatory responses, are restored in chronic phase. The aim of the study was to investigate the relation between inflammation, vascular remodeling, and myofibroblast formation as response to ischemia injury after prolonged kidney ischemia-reperfusion (I/R). Fifteen male Swiss mice aged 3-4 months were used as kidney I/R injury model after bilateral pedicle renal clamping. Rats were divided into 3 groups with five rats in each group i.e. control group (sham operation/SO), acute I/R model (IR1), and chronic I/R model (IR12). PAS staining was used for scoring tubular injury. Fibrosis was assessed using sirius red and a-SMA immunostaining for myofibroblast expansion. PCNA and CD68 immunostaining were used for identifying cell proliferation and macrophage infiltration. RT-PCR was conducted for assessing MCP-1, HIF-1a, and ppET-1 expression, which were quantified using ImageJ software. Data were analyzed using one way ANOVA and Kruskal-Wallis test with significance level of p<0.05. Significantly increase of tubular injury score (p<0.001) and PCNA positive cell (p<0.001) in IR1 group compared to SO were observed, otherwise HIF-1a of IR12 enhanced (p<0.05). Macrophage cell count (p<0.01) and MCP-1 expression (p<0.05), were significantly increase in IR1 and IR12 injury, compared to SO. Wall thickness of arteries was significantly increase (p<0.05) as well as decrease of vascular lumen area (p<0.05), followed by enhancement of ppET-1 expression (p<0.01) in IR1 group and restored significantly (p<0.05) in IR12 group. Fibrosis fraction-area and myofibroblast expansion were significantly increase gradually from IR1 to IR12 injury (p<0.01). In conclusion, prolonged kidney I/R injury induces the sustainability of hypoxia and inflammatory response, which promotes myofibroblast formation, and decrease the response of vascular remodelling.

LDL/HDL ratio association with out-patient NIHSS score and Dyslipidemic Drug intake status as Metabolic Syndrome Criteria of ischemic stroke patients at RSUP Dr. Sardjito, Yogyakarta Felicia Elberta; Abdul Ghofir; Imam Rusdi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

LDL-C/HDL-C ratio (numeric) is a more significant predictor of the progression of IMT than LDL-C or HDL-C alone (2). The Objective is to check whether being dyslipidemic or metabolic syndrome shown by the ratio, affects the data of NIHSS results obtained to measure functional outcome. the data was analyzed using Pearson Chi-square with contingency table post-hoc analysis and Spearmann’s Correlation with additional simple-linear regression.Out of 189 subjects, only 156 data are complete and valid. 70 patients were dyslipidemic, 65 were non-dyslipidemic and the rest were unknown. There is a significant association of LDL/HDL ratio cut off point above 2,3 with dyslipidemic drug intake likely to produce a mild NIHSS outcome category (z score 2,1) (calculator is P value = 0,035729), but not with other NIHSS categories. There is significant association of patients that do not take dyslipidemic drug with whatever LDL/HDL cut off point to the predictor outcome of Mild NIHSS category, but not with other NIHSS categories. The correlations are also insignificant between the LDL/HDL ratio and NIHSS score in one tailed (p<0,36) and at two tailed (p<0,72).Moreover, simple linear regression reveal that LDL/HDL ratio predicts 16% of NIHSS score, while taking anti dyslipidemic drugs which mean the person is dyslipidemic, and LDL/HDL ratio predict 31% of NIHSS outcome. Therefore LDL/HDL ratio have weak predictor value to NIHSS outcome, should not be an independent predictor.

Sepsis risk factor in mount Merapi eruption victims with 2nd or 3rd degree of burn injury Yamoguna Zega; Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Sepsis is one of the fatal complications of burns. It is the most common cause of deathfrom burns. Burn sepsis usually occurs after a burn injury develops into infection. Thisstudy was conducted to determine correlation between age, burn area, inhalation trauma,enteral nutrition start time, escarotomy time, and albumin level of sepsis in patientswith 2nd or 3rd degree burn injury. This was a cross sectional study during May to June2012. The subjects in this study were 39 victims of mount Merapi eruption in 2010 whosuffered 2nd or 3rd degree of burns injury. The result showed the correlation betweenwidespread burns, inhalation trauma, time of escarotomy, and albumin levels with sepsis(p < 0.05). In conclusion, the risk factor for sepsis in patients with 2nd or 3rd degree ofburns injury are the area of burns (> 50%), inhalation trauma, time of escarotomy (> 72hours), and albumin levels (<3.5g/dL).

Cinnamomum burmannii improves insulin serum level in the normal obese subjects : preliminary study Hari Hendarto; Flori R Sari; Chris Adhyanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Obesity is characterized with excessive accumulation of the body fat which occurs whenthe energy intake exceeds the expenditure. It is routinely associated with insulin resistanceand hyperinsulinemia. Additionally, suppressing insulin level protects female mice fromweight gaining. Cinnamon [Cinnamomum burmannii (Ness) Bl. Cortex] suppresseshyperinsulinemia condition in the type 2 diabetic rat suggesting the possible beneficial itsrole in the obesity. We aimed to investigate the effect of Cinnamon extract in the normalobese subjects. In this preliminary cross-over clinical trial, 24 normal obese subjectswere recruited and divided randomly into two groups i.e. treatment and placebo. Twograms of the cinnamon extract were given twice daily for 56 days in the treatment group.Normal obese subjects given placebo were allocated as the placebo group. After thetreatment, each of the group ran a one month run-in period, then the groups were crossoveredfor the next 56 days. Body mass index (BMI), insulin serum level, cholesterol andtriglyceride plasma levels were measured at the beginning and at the end of the study.No diet restriction nor exercise intervention was given during the study. At the end of thestudy, BMI in the treatment group (58%) were slightly reduced when compared to theplacebo group (33%), however, it was not significantly different (p>0.05). Moreover,significantly reduction in the insulin serum level was observed in 63% subject in thetreatment group compared to 33% subject in the placebo group (p < 0.05). Additionally,there were no significant differences of cholesterol and triglyceride plasma level observedin the both group. In conclusion, cinnamon extract may give beneficial role in the normalobese subjects by suppressing the serum insulin level. Further studies are required toelucidate the specific role of cinnamon in preventing weight gain.

Expression of Tumor Necrosis Factor - α (TNF-α) and Interleukin 1-β (IL1-β) in Chronic Tubotympanic Suppurative Otitis Media Anton Budhi Darmawan; Marsetyawan HNE Soesatyo; Ratna Dwi Restuti; Agus Surono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Chronic Suppurative Otitis Media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment. It is also one of the neglected disease especially in developing countries. Cytokines are a group of glycoproteins that play a role in strengthening the immune and inflammatory reactions in various diseases, including inflammation of the middle ear. Some of the important inflammatory mediators found in middle ear fluids are Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β). Cytokines are thought to play a role in the ongoing inflammatory regulation. The aim of this study was to compare the expression of TNF-α and IL-1β in tubotympanic CSOM and in healthy control group. The mean of TNF-α serum level in tubotympanic CSOM was 0,553±1,59 pg/ ml, and 0,587±2,13 pg/ ml in control group. There was no statistically different of TNF-α between two groups (P > 0,05). Mean of IL-1β serum level in the tubotympanic CSOM and control group were 0,633±0,92 and 0,302±0,48, respectively. Although IL-1β levels were higher in the patient group, the difference was not statistically significant (P > 0,05).

Food poisoning at a Javanese wedding tradition at Wirogunan Building on July 23rd 2017 Rieski Prihastuti; Meliana Depo; Trisno Agung Wibowo; . Misinem
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

suspected food poisoning outbreak of 5 cases was reported from Mergangsan primary health care to the Yogyakarta Health Office on July 24th 2017. Objective of this study were to ensure food poisoning outbreak and identify source and route of transmission. A total of 166 respondent was included. All of 83 cases got diarrhea. Epidemic curve showed a common source with incubation period 1-23,5 hours and median incubation was 12 hours. Based on its clinical symptoms and incubation period, this outbreak suspected caused by S.aureus contamination. Statistical analysis showed that the greatest attack rate ratio and odds ratio was found in rendang (AR 3,15 and OR 6,6135; 95% CI 2,7812-16,874). Limitation of this study was there were no sample of food/feces/vomit to confirm the agent.

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Contact Name
Nurhadiyahya

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nurhadiyahya@ugm.ac.id

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+6289672800034

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA