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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol 55, No 2 (2023)" : 11 Documents clear
Health-related quality of life of the elderly after natural disasters: a scoping review Pujiatun Pujiatun; Anindya K Zahra; Detty Siti Nurdiati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202310

Abstract

Every nation on earth is experiencing an increase in the number and proportion of elderly people. This vulnerable population may experience a decline in health-related quality of life (HRQOL) following a natural disaster. This scoping review aimed to have a better understanding on the elderly’s HRQOL following natural disasters, its influencing factors, and the state of the research on this topic. A literature search was conducted using four databases (PubMed/MEDLINE, Cochrane Library, Science Direct, and ProQuest) for the last 10 years (2013–2022). The summary of the selected relevant articles and analysis data were used to present the findings. There were seven articles included in our review. One article was about floodsand the rest was about earthquake.Two out of the six earthquake articles involved tsunamis. All of the studies were conducted during the recovery phase and revealed that the elderly had poor HRQOL after natural disasters. Several aspects, including demographics, physical, psychological, social, and environmental factors, were identified as having impacts on the elderly‘s HRQOL following a disaster. The relocation had a significant negative impact on the mental health of the elderly, with a mean difference of -3.69 (-5.60, -1.77). In conclusion, the HRQOL of the elderly after a natural disaster is low and affected by several factors. To improve it, a stronger research agenda and disaster management programs that take these factors into account are required.
High resolution ultrasonography of thyroid nodules: can ultrasonographic assessment obviate the need for invasive aspiration cytology in ultrasonographically benign lesions? Shadab Maqsood; Inzimam Wani; Omair Shah; Tariq Gojwari; Zubaida Rasool; Bashir Laway; Shujaut Farooq
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202302

Abstract

The use of high-resolution ultrasound (HRUS) thyroid imaging has resulted in a significant revolution in the treatment of thyroid nodules. The enigma of thyroid nodules has been a blind spot for radiologists for a long period. Reporting a thyroid nodule as benign or malignant is quite difficult and many times not accurate. The American Collage of Radiology-Thyroid Imaging Reporting and Data System (ACR-TIRADS) 2017 classification has solved this problem to a large extent. However, the classification needed pathological confirmation for it to be highly accurate. We compared our HRUS-based TIRADS labeling of thyroid nodules with thyroid cytopathology using revised Bethesda classification system. Patients detected with thyroid nodules by HRUS were categorized using ACR-TIRADS and further were taken for fine needle aspiration cytology (FNAC) in our department. The pathological results were compared with the initial TIRADS category of the nodule and the effectiveness of the TIRADS classification in categorizing nodules into benign and malignant was assessed using various statistical variables. The initial USG and the FNAC were performed by a single radiologist with over 10 years of experience. A total of 201 patients underwent HRUS followed by FNAC after obtaining written consent in our department. The thyroid nodules labeled as true benign on ACR-TIRADS (TIRADS 2) were all true benign on Bethesda cytopathology (less than Bethesda III), confirming the high accuracy of HRUS. The diagnostic accuracy of HRUS in cases of ACR-TIRADS 3 nodules was approximately 90.6% with an error rate of 9.4%. Nodules labeled as ACR-TIRADS 4 and 5 had error rates of 47% and 10% in labeling nodules as malignant. The ultrasound-based ACR-TIRADS system can accurately predict the likelihood of specific nodules being benign. There is a strong concordance between Bethesda cytology and ACR-TIRADS classification, particularly for benign nodules. In resource-constrained system like ours, patients with TIRADS 2 and 3 nodules can be safely followed obviating the need for an invasive procedure like FNAC.
Effects of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one on serum levels of antioxidant enzymes in hyperlipidemic rats . Prasetyastuti; Noviyanty Indjar Gama
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202301

Abstract

Hyperlipidemia triggers oxidative stress caused by an imbalance between oxidant and antioxidant levels due to the excess production of reactive oxygen species (ROS). The increase of ROS can decrease antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). 7-OH-2-(4-OH-3-Methoxyphenyl)-chroman-4-one is exogenous antioxidants isolated from mahogany seeds (Swietenia macrophylla King). This study aimed to evaluate the effects of the 7-OH-2-(4-OH-3-methoxyphenyl)-chroman-4-one on serum levels of SOD, CAT, and GPx in hyperglycemic rats. Thirty-six male Wistar rats (Rattus norvegicus) were divided into the following six groups: (N) normal group, (HL) hyperlipidemia group, (P) hyperlipidemia group with simvastatin, F10, F30, and F90 hyperlipidemia group with 7-OH-2-(4-OH-3-methoxyphenyl)-chroman-4-one 10, 30 and 90 mg/200g body weight (BW), respectively.  Hyperlipidemia was induced by feed enriched with cholesterol and cholic acid. Treatments were administered orally by gavages. After 4 weeks of treatments, blood sample was drawn and serum levels of SOD, CAT, and GPx enzymes were analyzed using a spectrophotometric method. Serum levels of SOD, CAT, and GPx in hyperlipidemic rats treated with 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one at dose 10, 30 and 90 mg/200g BW were higher than HL group. In addition, no significantly different on serum SOD and CAT between group F90 and group P was observed (p>0.05)
Relationship of bizygomatic and bigonial breadth with the suitability of surgical masks Diana Samara; Magdalena Wartono; Nany Hairunisa; Lie T. Merijanti; Alvin M. Ridwan; Ridwan Harrianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202305

Abstract

Use of masks is mandatory to prevent the transmission of COVID-19. Appropriate masks that match the face size is very important to avoid leakage. This study aimed to evaluate the relationship between bizygomatic and bigonial breadth with the suitability of surgical masks. It was an analytic observational study with a cross-sectional design conducted at the Occupational Medicine Laboratory, Faculty of Medicine, Universitas Trisakti, Jakarta during March to April 2021. A total 132 employees of Faculty of Medicine, Universitas Trisakti aged from 20 to 64 y.o. who meet the inclusion and exclusion criteria participated in this study. No significantly difference in age (p=0.248) and body mass index (BMI) (p=0.226) was observed. However, there was a significantly difference in bizygomatic width (p=0.000) and bigonial width (p=0.001) between men and women. The use of appropriate surgical masks was observed in 89 respondents, but not suitable for 43 respondents. There was no significantly difference between BMI, bizygomatic width and bigonial width with the suitability of surgical masks. However, old age was significantly more appropriate for using surgical masks than young people. In conclusion, BMI, bizygomatic width, and bigonial width are not substantially different with the suitability of surgical masks. However, older age is more suitable for employing surgical masks than younger age.
The facial measurements in health workers at Dr. Sardjito General Hospital, Yogyakarta Nadiya Husna Aliya; Neni Trilusiana Rahmawati; Janatin Hastuti; Sri Awalia Febriana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202306

Abstract

The appropriate mask is based on facial anthropometric measurements that may be affected by sex, race, age, and body mass index (BMI). This study aimed to determine the difference and relationship between the bizygomatic width (BW) and nasion-menton height (NMH) with sex and BMI in health workers. This descriptive-analytical study used a cross-sectional method. The subjects were 39 health workers (nurses and doctors) at Dr. Sardjito General Hospital, Yogyakarta consisting of 15 male subjects and 24 female subjects, aged between 25-55 years old. Anthropometric measurements were performed on the subjects, including body weight, height, NW, and NMH. The data were analyzed using the Shapiro-Wilk test, independent t-test, and Pearson’s test. There was a significant difference in the BW between male and female subjects (p<0.05), with the males’ BW (13.1 ± 0.76 cm) being larger than that of the female subjects (12.35 ± 0.62 cm). There were no differences in the BMI and nasion-menton height between the male and female subjects (p>0.05). The Pearson’s test results showed no significant relationship between the BW with BMI in both the male subjects (r=0.351; p=0.199) and the female subjects (r=0.349; p=0.094), and between the nasion-menton height with BMI in both the male subjects (r=0.101; p=0.721) and the female subjects (r=0.390, p=0.060). In conclusion, the males’ BW was larger than the female health workers. It is necessary to consider facial anthropometric measurements in face mask manufacturing to provide comfort and good protection.
The impact of COVID-19 pandemic on decreasing hospitalization rates and management of acute coronary syndrome: a study from single centre hospital in Yogyakarta, Indonesia Hendry Purnasidha Bagaswoto; Ferdinandus Bayu Satria; Hani Khairina; Nahar Taufik; Budi Yuli Setianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202303

Abstract

The Corona virus disease-2019 (COVID-19) pandemic has an impact on the medical field, one of which is service for patients with acute coronary syndrome (ACS). Studies in other countries showed a sudden decrease in admission rates, and percutaneous coronary intervention (PCI), one of ACS treatments, has an impact due to this pandemic. This study aimed to ascertain the effect of COVID-19 on the admissions and management of patients with ACS in Yogyakarta, Indonesia. It was an observational single center study conducted by collecting data for ACS patients at Dr. Sardjito General Hospital, Yogyakarta. Admission data for March 2019 to February 2020 were pre pandemic data, while those gathered from March to December 2020 were pandemic data. Data from 864 (pre pandemic period) and 338 patients (during the pandemic period) were further analyzed. The results showed a decrease in ACS patients’ admission during the pandemic. The most remarkable reduction occurred in those with ST-segment elevation myocardial infarction (STEMI), followed by non-STEMI (NSTEMI) and unstable angina pectoris (UAP) (63.4, 61.4, and 40.9%, respectively). Furthermore, the PCI procedure decreased compared to the period before the pandemic. No significant differences in patients’ characteristics was observed (p>0.05), except for the incidence of pneumonia (p <0.001). Finally, the mortality rate was higher during the pandemic than before (14.8 vs 13.2%), although it was not significant (p>0.05). This study showed that COVID-19 caused a sensible reduction in the admission rates for ACS patients and the number of PCI procedures have been performed. On the other hand, their mortality rate did not increase significantly. However, it is essential to improve healthcare services for ACS patients considering the uncertainty of ending the COVID-19 outbreak.
Reconsidering the limited role of right heart catheterization on severe pulmonary hypertension-due to progressive interstitial lung disease in young male patient : a case report Megawati Abubakar; Anggoro Budi Hartopo; Ika Trisnawati; Eko Budiono; Dyah Wulan Anggrahini; Lucia Kris Dinarti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202307

Abstract

Pulmonary hypertension (PH)-associated with interstitial lung disease (ILD) develops as a consequence of progressive underlying lung disease or disproportionately to the underlying disease. The PH investigation by right heart catheterization (RHC) for defining PH severity is recommended in patients with ILD who show more severe symptoms than expected from lung disease, appearance of right heart failure, and clinical deterioration not matched by the declining lung function. In patient with progressive ILD, RHC is only considered if it affects the future treatment such as lung transplantation or enrollment in clinical trial/registry. The decision to undertake the RHC in progressive ILD was still fraught with doubts. Here we reported a young adult male patient with ILD whom developed progressive signs and symptoms.  By RHC, he had severe precapillary PH with hemodynamic parameters indicated the presence of pulmonary vascular disease. A PH-specific treatment, sildenafil citrate, was administered, and patient responded well and was clinically stable during the addition of sildenafil citrate. This case highlights the clinical implication of performing RHC in progressive ILD, which can change the treatment decision by PH-specific drugs. Therefore, the RHC decision making in patient with progressive ILD need reconsideration.
Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review Donny Hendriyanto; Helmi Helmi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202309

Abstract

Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa has been scientifically proven to have numerous benefits included to prevent adverse effect of a drug. This literature review aimed to evaluate the protective role of N. sativa oil against cisplatin-induced ototoxicity. Relevant publications were searched  from PubMed and Google Scholar databases within the last 10 years. Ototoxicity due to cisplatin can occur through the intrinsic and extrinsic pathways. Cisplatin causes endoplasmic reticulum stress, DNA damage, increased reactive oxygen species (ROS) and inflammatory processes, resulting in increased apoptosis of cochlear outer hair cells. The active constituents of N. sativa including flavonoids, phenolics and thymoquinone can prevent the cisplatin-induced ototoxicity. Examination of endogenous antioxidants, antiapoptotic, and proinflammatory could be used as primary approach to evaluate the protective role of N. sativa against cisplatin-induced ototoxicity.
Acute compartment syndrome of the forearm after trans-radial approach to percutaneous coronary intervention: a case report Istan Irmansyah Irsan; Satria Pandu Persada Isma; Alifian Alifian; Muhammad Alwy Sugiarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202308

Abstract

Percutaneous coronary intervention (PCI) through transradial pathway is associated with lower risk of severe vascular problems comparing to transfemoral. It is reported that the acute compartment syndrome (ACS) in forearm is significant lower comparing to leg. A 47 y.o. male with ACS following a transradial approach of PCI due to inferior myocardial infarction was reported. The patient experienced pain and swelling in his right forearm for 7 hr after the procedure and was later brought to hospital and treated with emergency of fasciotomy. The patient showed good post-fasciotomy recovery on the first 2 wk and showed good DASH score after 4 wk. Quick diagnosis with prompt treatment makes a better outcome for the patient. Consequently, a high level of awareness to make the diagnosis as quickly and accurately management as possible could prevent morbidity caused by late and unrecognized management compartment syndrome eventually could make a better clinical outcome.
Correlation between the degree of leukoaraiosis and hyperlipidemia in post-ischemic stroke patients Dian Angraeni; Lina Choridah; Evi Artsini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202304

Abstract

Leukoaraiosis is a neurological imaging in the periventricular area and the centrum semiovale. This condition occurs due to abnormalities in the small blood vessels in the brain that lead to hypoxia. It is often observed in patients with ischemic stroke and accompanied by risk factors for hyperlipidemia. This study aimed to evaluate the correlation between the degree of leukoaraiosis and hyperlipidemia in post-ischemic stroke patients. A cross-sectional study retrospectively was conducted on post-ischemic stroke patients who underwent brain MRI (magnetic resonance imaging) on T2 and FLAIR (fluid-attenuated inversion recovery) sequence at the Department of Radiology, Dr. Sardjito General Hospital, Yogyakarta, from January 2021 to March 2022. A total of 36 patients were involved in this study. The leukoaraiosis of patient was examined by brain MRI. Degree of the leukoaraiosis was determined based on Fazekas classification. Serum cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and triglyceride levels of patients were then examined. The data obtained were then analyzed using Spearman correlation test. A positive correlation was observed between the degree of leukoaraiosis and triglyceride level (p = 0.042; r = 0.292) and age (p= 0.004; r = 0.464). However, no correlation was observed between the degree of leukoaraiosis and cholesterol, HDL, and LDL (p>0.05). In conclusion, the leukoaraiosis degree is correlated with serum triglyceride levels and age in post-ischemic stroke patients.

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