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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 107   108   109   110   111 
The relationship between p53 expression, cell proliferation index and epidermal thickness in psoriasis Sekar Djatiningrum Sekar Djatiningrum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The specific process among psoriatic lesions is keratinocyte hyperproliferation state, and one of the genes that controls cell cycle is wild type of p53 gene. The correlation between p53 overexpression and psoriatic keratinocytes hyperproliferation has not been established yet. Objective: To clarify the relationship between p53 overexpression and psoriatic keratinocyte proliferation index, as well as the epidermal thickness resulted from this proliferation.Methods: 50 paraffin-embedded tissue sections were chosen from block collection of Pathologic Anatomy Department. The p53 overexpression was measured by counting the number of positive cell among 500 cell stained by antibody anti p53. The cell proliferation index was measured by counting the number of black dot among 100 epidermal cells stained by silver nitrate. The epidermal thickness, represented by the thickness of epidermal rete ridges was measured by using calibrated micrometer in hematoxillin stained section.Results: p53 expression was significantly correlated in fairly degree with cell proliferation index (r, = + 0,47; P < 0,001) and significantly correlated in moderately degree with epidermal thickness (r, = + 0,57; P < 0,001). Cell proliferation index was significantly correlated in fairly degree with epidermal thickness (r1 = + 0,37; P < 0,004).Keywords: psoriasis - p53 - cell proliferation index - Ag NOR - epidermal thickness
Insertion of Norplant by midwives and physicians: A comparative cohort study Risanto Siswosudarmo Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 04 (1991)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A comparative cohort study on the insertion of Norplant by midwives and physicians had been carried out to compare its safety. A total of 500 acceptors participated in the study, 292 of which belonged to the midwive group and 202 to the physician group. They came from suburban areas surrounding the city of Yogyakarta. Although both groups were statistically differen tin terms of age and body weight, they were no t so clinically. Norplantwas delivered outside the hospital during the mass campaign (safari susuk), but standardized hospital asepsis was taken. Follow-up was done one week thereafter to detect the presence of complications or side-effects, such as pain, inflammation, abscess and sense of itching. t-test, chi-square test and relative risk were statistical analyses used in the study.Results showed that midwives inserted Norplant more rapidly compared to physicians (2.36 vs 3.45 minutes respectively), although it did not have clinical importance. 23.6% of cases among the in idwive group showed a variety of complications while that of the physician group was 19.7%, the relative risk being 1.20 (0.82-1.75). More detailed complications such as pain, inflammation, abscess and itching did not show significant difference. The risk of complication in all cases was influenced neither by the. duration of insertion nor by the level of education.The study concluded that midwives could insert Norplant as safe as physicians.Key Words: norplant-midwive-contraception-obstetrics-family planning
Association between HLA-DQ alleles and Leprosy in Indonesia Javanese population Hardyanto Soebono Hardyanto Soebono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 01 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Previous studies showed that susceptibility to leprosy and antibody response toward M. leprae in Javanese population was under control of HLA-DR alleles. To investigate whether this susceptibility was also associated with HLA-DQ, the study had been continued with phenotyping of HLA-DQ alleles and antibody assay to the same population which consisted of 79 leprosy patients, 41 tuberculoid (TT/BT) and 38 lepromatous (LL/BL) type, and 50 healthy controls. The HLA-DQ typing had been performed by using a sequence specific oligonucleotyping (SSO). method, while the anti M. leprae antibody had been tested by ELISA and INHIBITION-ELISA.The results show that HLA-DQB501 is associated with leprosy, either tuberculoid or lepromatous type (OR 3.27; 95% Cl 1.42-7.60). When all HLA-DQ1 alleles are analyzed, a significant association is found only with lepromatous leprosy (OR 9.18; 95% Cl 1.89-86.30). IgG antibody anti 36 kD M. leprae is found to be associated with HLA-DQ102. The level of this antibody is higher in HLA-DQ102 positive individuals compared to those negative one (P). No correlation is found between HLA-DQ alleles and the seropositivity of either IgM or IgG.In conclusion, the susceptibility to leprosy in this population is also controlled by genes in HLA-DQ locus. This study also supports the previous findings that HLA-DQ1 is a universal marker for the susceptibility to lepromatous leprosy, while the infection with M. leprae per se is not controlled by HLA genetic factor.Key words : leprosy - M. /eprae - genetic factor - HLA-DQ - HLA-DQ1 - HLA-DQB501
Diabetic retinopathy diagnostic with ophthalmoscope by trained doctor Imam Masduki Angela Nurini Agni Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Introduction. Diabetes mellitus patient is in high risk to be complicated by retinopathy. Visual loss and decrease of visual acuity become a significant social burden. Early detection is essensial for treatment. Ophthalmoscopy was highly effective for screening, easily used and accessed by ophthalmologist and other physician and has been applied in many developed countriesPurpose : This study was aimed to know the validity of ophthalmoscopic test done by a trained doctor in diagnosing diabetic retinopathy..Materials and methods : The subjects were diabetic patients without cataracts. The examiner was a resident of Internal Medicine Department who had been trained in ophthalmoscopy. After the training, the resident was assessed and the result was compared with the trainer and showed agreement with kappa 1.00.Results: The study was done from February to May 2007. Total subjects were 98 patients (196 eyes I consisted of 50 females (51%1 and 48 males (49%1 with mean age of 61 :t7.92 years old. Mean diabetes duration was 6.6:t 5.94 years and all of them were diabetes type 2. Some patients had hypertension (44.9%1, dyslipidemia (17.7%1, heart disease (6.1%), and kidney disease (5.1%1. From 196 eyes, 6 (6.1 %1 eyes had cataract and were excluded. Mean visual acuity was 0.7726 :to.31 08. Diabetic retinopathy was found in 41 eyes among 190 eyes (21.57%1, consisted of 22 eyes with mild NPDR (53.65%1, 7 eyes with moderate NPDR (17.07%), 7 eyes with severe NPDR (17.07%1, 5 eyes with advance PDR (12.19%1. Sensitivity, specificity, PPV, NPV and accuracy resulted by 5 hour trained doctor examinations were 63.41%, 67.78%, 36.62%, 67.78%, and 66.78% respectively R (+1 and LR (-I were 1.968 and 0.5397, respectively.Conclusion: Direct ophthalmoscopic examination by a trained doctor to detect retinopathy is promisalble in Indonesia.Keywords : diabetic retinopathy, direct ophthalmoscopy, diagnostic value, traineddoctor
Zingiber officinale volatile oil: clinical trial on Brugia Malayi infection in Kalimantan area Mulyaningsih Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 03 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: According to the fact, there is chance that the Zingiber officinale volatile oil can be developed for treatment elephantiasis in man. However, up to now there was no study yet on the efficacy of the phytopharmaca against filaria.Objective: The clinical trial was designed to know the effect and the safety of application of Zingiber officinale volatile oil as anti-filariasis agent in the treatment of Brugia malayi infection in Kalimantan area.Methods: In this study, 40 patients suffered from filariasis malayi were divided into 2 groups. Zingiber officinale volatile oil in honey syrup was given to each patient of group I. Honey syrup as plasebo was given to each patient of group II. The treatment was given for 28 consecutive days each. The density of microfilariae before and after treatment of each group were recorded and assessed using Pre-test and Post-test by using probit analysis.Results: This study showed' that the average value of microfilaria density before and after treatment count per 60 ul blood in placebo group were 64.9 ± 96.4 and 90.4 ± 122.0. While in volatile oil's group were, 92.1 ± 118.3 and 56.6 ± 77.0 respectively. MfD50 of placebo group before and after treatment is 27.75, and 44.99. MfDso of volatile oil's group before and after treatment is 44.42, and 37.06.Conclusion: Zingiber officinale volatile oil can be developed for treatment elephantiasis in man.Key words : microfilaria density - phytopharmaca - volatile oil - filariasis malayi - elephantiasis.
Fetal outcome of operative delivery and its risk factors in Sardjito Hospital Risanto Siswosudarmo Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 04 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A study on operative delivery was carried out during the period of 1988 to find out the fetal outcome and some of the risk factors. A cohort study was used, consisting of the exposed group (operative delivery, 212 cases) and the control group (spontaneous delivery, 212 cases) selected randomly using a computer generated random number. Only singleton pregnancy, gestational age 28 weeks or more or birthweight 1000 g or more were included into the study. All babies were followed up during their neonatal period in the neonatal care unit. Neonatal morbidity was defined as asphyxia, birth traumata and diseases such as fever, vomiting etc. found during the early neonatal period. Data were processed with IBM personal computer using version 2.0 SPSS program. t-test, chi–square test and relative risk were statistical analyses used in this study.Result showed that the incidence ofoperative delivery during that period was 24.62%. The most common one was cesarean section (39.2%) and the least common was internal podalic version and laparotomy (1.9%). Age more than 30 years, parity more than two (gravidity more than three) and referral cases seemed to be the risk factors for termination of delivery by an operative procedure.The risk of deliveringasphyxic babies was much more common in the exposed group compared to the control. The rate of severely asphyxic babies was 50.5% compared to only 5.9% and the rate of slight asphyxia was 38% compared to 11.3% respectively for the exposed and control groups. Mean one minute Apgar score was 3.87 vs 7.29 and mean five minutes Apgar score was 6.89 vs 9.15. The number of babies suffering from one or more morbidities were 94.0% in the exposed group vs23.6% in the control group. There was a significant difference in term of perinatal mortality but not in neonatal mortality, although it seemed to be clinically important.The study concluded that although fetal outcome in the operative delivery was worse, but with careful maneuver and intensive neonatal care the risk of neonatal mortality could be minimized.Key Words: high-risk labor - operative delivery - perinatal morbidity and mortality - asphyxic babies Apgar score
Influence of Norplant on T3, T4 and TSH concentration in acceptor in endemic goiter area Zainal Arifin Nang Agus Zainal Arifin Nang Agus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 03 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Norplant contains a potent progesteron, namely levonorgestrel. It induces iodine excretion in urine and simultaneously stimulates the thyroid function.The objectives of this study were to examine the T3, T4 and TSH concentration of the Norplant acceptors for 3 months. The subjects were 8 acceptors of Norplant taken from an endemic goiter area in Cangkringan, Sleman, Yogyakarta.The results of this study showed that T3, T4 and TSH were in normal range but they were in the low level. Three months after using Norplant, T3 and T4 level increased, but they are not significant (p>0,05). On the other hand, T4 level decreased significantly (p<0,05). Based on those data, there is an early stage of hipothyroid. It is strongly suggested that it would be much better if similar study could be conducted in longer time period.Key words: Norplant - T3, T4 and TSH - endemic goiter - hypothyroidism
The effect of fructooligosaccharide (FOS) in Children With Diarrhea Mohammad Juffrie Yunri Istari, Nenny Sri Mulyani Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Latar belakang: Penyakit diare masih merupakan penyebab penting kesakitan dan kematian bayi dan anak di negara berkembang. Penyakit diare ini disebabkan oleh ketidakseimbangan flora usus yang dipengaruhi oleh jumlah bakteria yang menguntungkan . FOS dapat menstimulasi pertumbuhan bakteri yang menguntungkna dan menghambat bakteri pastogen yang menyebabkan infeksi saluran cerna Tujuan: Mengetahui efekFructooligosaccharide pada diareBahan dan cara: penelitina kendali acak dilakukan di 8 puskesmas di Yogyakarta. Seratus delapan belas sampel ikut dalam penelitian ini, 93 masuk dalam kelompok FOS yang mendapat FOS 2,5 gram atau 5 gram per hari sesuai umur, dan 25 masuk dalam kelompok plasebo. Lamanya diare dan keasaman tinja diukur selama penelitianHasil: Lama diare lebih pendek secara bermakna pada kelompok FOS dibanding plasebo p
Beberapa Dokumen Tentang Etik Kedokteran Ramlan Mochtar Ramlan Mochtar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 03 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The author reminds the Indonesian medical profession of various codes of medical ethics guiding medical practice and research. Among others the following codes are discussed: the Hippocratic Oath, the Declaration of Geneva, the International Code of Medical Ethics, the Indonesian Code of Medical Ethics, the Declaration of Helsinki, the Declaration of Sydney, and the AMA Prin ciples of Medical Ethics.Key Words: medical ethics - Hippocratic Oath - Oath of Indonesian Physicians - biomedical research - statement on death
Evolusi Otak Primates T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 01 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Di seluruh ordo Primates kita lihat berbagai perubahan evolusioner dalam perilaku hewan itu yang mengandung makna yang penting. Pcnyesuaian diri tcrhadap kehidupan arboreal menghasilkan perkembangan ekor prchensil ataujdan perubahan adaptif tangan dan kaki serta alat-alat indera pelihat. Perubahan ke kehidupan terrestrial membutuhkan penyesuaian kembali mata dan pengaturan keseimbangan. Yang teramat penting adalah sikap orthograd dengan akibat-akibatriya yang bersegi banyak. Pembebasan anggota muka dan Ienyapnya ekor meninggalkan bekas-bekas pula pada struktur otak.Tidaklah cukup hanya menyelidiki bentuk luar otak saja dalam mempelajari evolusi. Tidak dapat dihindari kesimpulan bahwa segala adaptasi progressif yang sudah disebutkan itu melontarkan bayangannya pula pada struktur dalamnya. Tilncy (1928:993) rnalahan menyatakan bahwa «ciri-ciri permukaan sering memperdaya» dan bahwa «organisasi intern otak yang haliis bahkan dapat membantah kesimpulan yang didasarkan atas pendaahan pada permukaanKehidupan arboreal mengakibatkan terkorbankannya indera pembau dan peluasan indera pelihat. Maka kita lihatlah pengecilan rhincncephalon dan perkembangan lobus occipitalis, bertambah panjangnya decussatio oculomotorii, bertambah kecilnya arti colliculus superior dan membcsarnya nucleus olivaris. Akibat_yang tidak kurang pentingnya pula adalah prehensilitas dan differensiasi anggota tubuh yang diperlukan dalam kehidupan di pohon. Syarat-syarat ini tercermin dalam pembesaran pyramis, oliva inferior, nuclei sensorii dorsales, nuclei vestibulares, nuclei pontes, nuclei cerebellar-es dan hubungan interokular, serta merosotnya colliculi mesencephalon. Penglihatan stereoskopis_meinberi dasar yang baru dan lebih luas bagi kemahiran tangan, dan gerakan-gerakan trampil yang komplek in.i sclanjutnya membutuhkan - pusat-pusat. pengaturan dan - koordinasi yang lebih balk. Kinesthesis yang progressif tak dapat dielakkan dan hal ini kemudian memberi dasar-dasar baru pula bagi neokinesis. Dengan demikian kita berhadapan dengan reaksi rantai evolusi dan aneka warna faktor yang mengambil bagian dalam proses tersebut terjalin dengan rumit dalam suatu jaringan yang harmonis.

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