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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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The Effecttiveness of topical cyclosporine 0.05% compared to topical fluorometholone 0.1% in the therapy of vernal keratoconjunctivitis Edy Ariston Suhardjo Agus Supartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Vernal keratoconjunctivitis (VKCI is a chronic and often severe form of bilateral tarsal and or bulbar conjunctivitis. Several studies have reported that topical corticosteroid therapy was effective and cyclosporine was very effective in the treatment of moderate and severe VKC. In this study we wanted to know the effectiveness of topical cyclosporine 0.05% compared to topical fluorometholone 0.1 % in VKCObjective: The objective of this research was to know the effectiveness and side effect on the raise of intraocular pressure of 0.05% cyclosporine eyedrop compared 0.1 % fluorometholone on patients suffered from vernal keratoconjunctivitisMethods: A double blind randomized controlled trial was performed on the subjects suffered from vernal keratoconjunctivitis who fulfilled inclusion and exclusion criteria. The subjects were allocated into two groups by block randomization. The first group was given 0.05% cyclosporine eye drops, whereas on the other group was given 0.1 % fluorometholone eye drop. All the subjects were examined for the clinical symptoms and signs, intraocular pressure, eosinophil count with Giemsa staining before and one month after treatment. The cyclosporine group consisted of 21 subjects whereas the 0.1 % fluorometholone group was 22 subjects. The ages of both groups were within the age range of 4-36 years old.Results: Both groups showed improvement of symptoms and signs and were not statistically significant difference (p = 0.311; 95% CI: 0.102-0.3131. xxxx The use of 0.1% fluorometholone eyedrops for one month was not associated with any increase of lOP compared to 0.05% cyclosporine (p = 0.11 and p = 0.12). There was improvement in the eosinophil count in both groups and no statistical significant difference (p = 0.301. The side effect of pain was more in 0.05% cyclosporine administration and the difference was statistically significant (p=0.0011 with number needed to harm (NNHI of 2.69.Conclusion: It was concluded that the use of 0.05% cyclosporine eyedrop was as effective as the use of 0.1 % fluorometholone but the side effect of pain occured more often. No statistical difference was found between either the intraocular pressure increase or the eosinophil count in the use of 0.05% cyclosporine eyedrop compared to 0.1 % fluorometholone.Keywords: Vernal keratoconjunctivitis - cyclosporine 0.05% - fluorometholone 0.1 % - side effects, eosinophil count
Sexual dimorphism in morphognostic features of the inhabitants of the island of Palue Josef Glinka Josef Glinka
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 02 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The island of Palue belongs to the Lesser Sunda Islands, north of the island of Flores. The data given here arc of 526 men and 296 women. Nine features are presented: 1. the hairform, 2. the position of the aperture of the palpebra, 3. the epicanthus, 4. the size of the aperture of the mouth, 5. the thickness of the lips, 6. the profile of the forehead, 7. the profile of the nose, 8. the profile ofthe upper integ-umental lip, and 9. the prognathism. According CO the 12 >3 test only the 1st,the 4th, the 6th and the 7th features are significantly dimorphic. According to the chi-square test in contingency tables, besides this four, also the 2nd, the 8th and the 9th features could be accepted as dimorphic with the risk of P = 0.03, P 0.01 and P 0.056 respectively.Key Words: Indonesia - Lesser Sunda Islands - Palue - sexual dimorphism - morphognosric
PENELITIAN PENDAHULUAN TERHADAP KEMUNGKINAN ADANYAA KEKURANGAN THIAMIN YANG SUBKLINIS Siti Dawiesah Ismadi Siti Dawiesah Ismadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 8, No 02 (1976)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

kata kunci : kekurangan thiamin
Epidemiological study on chronic otitis media in school children in Bantul regency Soenarto Sastrowijoto Soenarto Sastrowijoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 01 (1991)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

An epidemiological study on Chronic Otitis Media (COM) in children in Bantu[ regency, especially its prevalence in relation to socioeconomic status and index ofachievement has been done. The study used two-step cluster random sampling. The subject of the study was 16 primary schools with 2896 children, taken out from 17 districts consisting of 514 primary schools with a total number of 90 000 children.The study was carried out for six months from May 1990, and the result showed that the prevalence of COM was 5.28%, consisting of 2.10% serous COM and 3.18% suppurative COM, and middle ear cholesteatoma was found in three of them. A number ofrisk factors, the educational level and job of the father, the mother's educational level, the economic status based on the value of their property, nutrition and tidiness, the status of children, and the size of the family were also studied.The resultof the study showed that the economic status (P <0.05) and the mother's educational level (P < 0.01) had a significant indirect relation to the prevalence of COM. The index of achievement of children in natural sciences, Indonesian language, and mathematics was not influenced by the serous COM, but was significantly (P < 0.01) influenced by the duplex suppurative COM.The study of increasing the mother's educational level, the economic status, and the managementofCOM cases by giving hearing aid or developing national program ofmicracar-sugeryservices are suggested.Key Words: chronic otitis media - school age children - middle ear cholesteatoma - index of achievement - micro-ear-surgery
Characterization of a monoclonal antibody against surface coat of infective larvae of Brugia malayi. Soeyoko Soeyoko
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 03 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Malayan filariasis is an important public health problem in Indonesia. A diagnosis of filariasis is normally based on clinical, parasitological and immunological examinations but the methods have limitations. There is an urgent need to improve immunodiagnostic techniques for malayan filariasis using monoclonal antibodies to detect circulating antigen. Recently, many types of monoclonal antibodies have been produced following immunization of mice with various stages of filarial antigens. Those monoclonal antibodies have different characteristics.The objective of this study was to explore the characteristic of specific monoclonal antibodies against the surface coat of infective stages of Brugia malayi larvae.This monoclonal antibody recognized antigen of 40.000 MW protein which is present among the antigens of surface coat of Brugia malayi larvae, as detected by an immunoblotting technique. Classification using EUSA techniques indicates that those antibodies are IgGi, IgG2b and IgG3 subclasses. In addition, these antibodies also demonstrate a low level reactivity with surface antigen of Brugia pahangi, Ascaris lumbricoides and hookwormKey words : surface coat - infective larvae - monoclonal antibody - circulating antigen - Brugia malayi
Mutagenicity Activity of Jatropha Curcas L. (Euphorbiaceae) Latex Fazwishni Siregar I.Kristiani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Folklore uses of Jatropha curcas L. latex are to cure toothache, as a mouth rinse to treat bleeding gums, as a hemostatic and a wound dressing and many others. Even though the latex has been used traditionally as a plant medicament, scientific investigation including toxicological studies was very limitedObjective: The purpose of this study was to evaluate the mutagenicity of J. curcas latex by Ames method. Materials and Methods: Five increasing concentrations of diluted latex (312-5000 !-tg) were mixed with phosphate buffer or 59 mix and cultured bacteria, incubated, and then added to top agar solution. The mixture was poured into a Petri dish on top of minimal glucose agar. After incubation for 2 days, the reverted coloni were counted. If the number of revertant increases with the dose and the number are more then twice as many as that of spontaneous revertant per plate, the compound should be judged to be positive.Result: Results showed that there were no increased numbers of colonies treated with increasing concentration of J. curcas latex. This finding is observed in all bacteria used. Conclusion: J. curcas latex is not mutagenic assessed by Ames method.Key words: Jatropha curcas latex, mutagenicity test, Ames test, traditional medicament, toxicology.
Efek Teratogenik Sinar X Arif Faisal Arif Faisal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 03 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The application of X-rays in the medical field has positive and negative effects. The effects of X-ray radiation to the intrauterine embryo and foetus depend on the period of gestation. In the first trimester the embryo may be resorbed and aborted and may also be born with serious defects. In the late trimester radiation may cause less serious defects and it may disturb the function of organs. Many defects involve nerve names and are associated with symptoms of mental retardation.To prevent radiation exposure to embryo and foetus, it is necessary to observe the "ten -day rule", when X -ray examination is performed. The threshold doses for embryo and foetus are still unknown.Key Words: physical deformity - mental retardation - radiobiology - radiation injury - teratogenic effect
Correlation Between Nutritional Status of Lactating Mothers With The Composition of Breast Milk and The Growth of Babies In Selected Samples Siti Dawiesah Ismadi Siti Dawiesah Ismadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 01 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

key words: lactating, breast milk
The difference of Natural Killer cell activities of the people live in the aircraft noise area of Adi Soemarmo Airport Boyolali, Surakarta, Indonesia Hartono Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Exposure to noises contributes to a health risk. There is sufficient scientific evidence that noise exposure couldinduce hearing impairment, hypertension and ischemic heart disease, annoyance, sleep disturbances, and decreasedschool performance. Other evidence as changes in the immune system and birth defects is limited. The aims of thisstudy is to find out the difference of Natural Killer (NK) cell activities of the people live in the aircraft noise area ofAdi Sumarmo Airport, Boyolali, Surakarta, Indonesia. The research design was an analytical with a cross sectionalapproach, taking location at the Dibal and Gagak Sipat Villages, Ngemplak Sub district, Boyolali District. The studywas conducted from June 2008 to June 2009. The number of subjects involved was 39. They were divided into 3groups. Group 1 was exposed to 52.17 dB of noise level (13 respondents). Group 2 was exposed to 71.79 dB ofnoise level (13 respondents), and Group 3was exposed to 92.29 dB of noise level (13 respondents). The cytotoxicitiesof NK cells was measured by flowcytometric and using a non-radioactive method. The samples were taken using asimple random sampling. The data were analyzed by Anova followed by Post Hoc Test using LSD test completedwith Homogenous Subsets. The results showed that the activity of NK cells of Group 1, 2 and 3 were 12.50 +3.25%,17.20 3.06%, and 22.33 6.30 %, respectively. The Anova test showed that there was a significantdifference of NK cell activities, in the groups of respondents (p =0.000). In conclusion, there was a significantdifference of the NK cell activities of the people live in the aircraft noise area of Adi Sumarmo Airport, Boyolali,Surakarta, Indonesia.Key words : noise-immune system-flowcytometric-blood mononuclear cells-health risk
The prevention of the occurence of ultraviolet B (UVB) induced hypoxanthine guanidine phosphoribosyl transferase (HGPRT) mutant cells by several commercial sunscreens An in vitro study Noor Ikhtiyati Noor Ikhtiyati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 03 (1998)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This study was aimed at comparing the effect of three different SPF (Sun Protecting Factors) of sunscreens in the prevention of UVB (Ultraviolet B) Induced mutant fibroblast cells. The study was done using a simple experimental study design. Three commercially sunscreens were coated on the plate cover surface of fibroblast culture wells. Fibroblasts were isolated from ten young boy foreskins and subcultured in 3 to 5 passages. Mutagenic transformation was done by Irradiation with 6.5 J/m2 Coerman Solarium CTL 3111 as a source of UVB. In addition there were two groups which were unprotected for control group and untreated with UVB for counting cumulative population doubling ratio (cpd). Three days after UVB irradiation, the culture, except for an unirradiated group, were incubated in HGPRT (hypoxanthine guanidine phosphoribosyl transferase) enriched medium, and fibroblast which survived in those medium considered as mutant cells. Cpd was calculated based on cell multiplication of the untreated group. The ratio of mutant cell population (mcp) is quantified by dividing the number of mutant cells with cpd. The difference of mean mcp between three subgroup of sunscreens and unprotected group was analyzed with Student's t test, and the difference of mean mcp among three subgroup of sunscreens was analyzed with ANOVA. The result showed that the mean mcp of sunscreen covered cultures were lower compared to the uncovered cultures and the higher SPF had lower mean of mcp significantly (P). Therefore sunscreen was proven to protect the induction of HGPRT mutant fibroblast although the protection was not totally, and the higher SPF sunscreen showed higher protection.Key words : sunscreens - SPF - UVB - HGPRT gene mutation - fibroblast culture.

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