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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 110   111   112   113   114 
Hepatitis C seoconversion and risk factors in hemodialyzed patients: a follow-up study Mochammad Sja'bani Mochammad Sja'bani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Telah dilakukan studi follow-up untuk menentukan serokonversi (SK) anti hepatitis C dan taktor risiko potensial pada penderita gagal ginjal terminal dengan hemodialisis (HD) rutin di Unit Renal RSUP DR. Sardjito antara Oktober 1992 sampai April 1993.Penderita yang diikutsertakan dalam penelitian adalah penderita dengan gagal ginjal terminal yang menjalani HD rutin 2 kali seminggu dengan dialisat asetat. Tidak seorangpun dari penderita yang mempunyai riwayat penyalahgunaan obat intravena. Lama HD dan riwayat transtusi darah juga dicatat. Pada awal penelitian dan 6 bulan sesudahnya dilakukan pemeriksaan darah serial, meliputi anti-HCV, titer AST, ALT dan ALP. Penderita yang meninggal dalam 6 bulan follow-up dikeluarkan dari penelitian.Selama penelitian dijumpai 26 penderita dengan anti-HCV negatif (18 laki-laki dan 8 perempuan dengan umur rerata 48,84± 11,34 tahun, lama HD rerata 14.63± 12,98 bulan dan trekuensi transtusi darah rerata 2,30 ± 1,37 kali) dan 32 dengan anti-HCV positit (24 laki-laki dan 8 perempuan dengan umur rerata 48,40 ± 15,30 tahun, lama HD rerata 13,38 ± 16,62 bulan dan trekuensi transtusi darah rerata 3,86 ± 3,36 kali). Penderita dengan anti-HCV positit memiliki trekuensi titer AST abnormal (Iebih dari 1,5 nilai normal) tidak berbeda bermakna (15,6% vs 11,5%, p>0.05), trekuensi titer ALT abnormal (lebih dari 1,5 nilai normal) tak berbeda bermakna (40,6% vs 50,0%, p>0,05) dibandingkan penderita dengan anti-HCV negatif pada awal penelitian. Sebelas penderita dengan anti-HCV negatit drop-out selama 6 bulan follow-up. Di antara 21 penderita dengan anti-HCV negatit yang dianalisis dijumpai SK hepatitis C sebanyak 12 (57,1%) kasus. Penderita dengan SK menunjukkan trekuensi titer AST abnormal Iebih tinggi (75% vs 22,22%, p0,05) dibandingkan dengan penderita tanpa mengalami SK.Disimpulkan bahwa penderita dengan SK memiliki trekuensi titer AST dan ALT abnormal yang Iebih tinggi dibandingkan dengan penderita tanpa mengalami SK.Key words: hepatitis C -- seroconversion -- hemodialysis -- liver function -- risk factor
Clinical signs as diagnostic test to assess hypoxemia in children with acute asthma exacerbation Latifah Hanum Roni Naning Endy Paryanto Prawirohartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Asthma attack can cause hypoxemia. One of the methods to detect hypoxemia is by using pulseoximetry. However, this tool is not always available in some health care centres. Therefore, amore rapid and simple diagnostic tool is needed as an alternative method to detect hypoxemia.This study aimed to assess signs and symptoms as diagnostic tools for hypoxemia in childrenwith asthma. This was an analytical observational with cross-sectional design performed inDepartment of Pediatrics, Dr. Sardjito General Hospital/Faculty of Medicine, Universitas GadjahMada, Yogyakarta. The study was started in Februari 2010 until the sample size was sufficient.Seventy seven children with asthma between 0 – 18 years old who were presented to EmergencyDepartment and Respiratory Outpatient Clinic were involvoled in this study. All subjects wereexamined for clinical signs and oxygen saturation as the gold standard. The prevalence ofhypoxemia in children with asthma in this study was 18.2%. The best single clinical predictor ofhypoxemia was tachycardia that yielded a sensitivity of 86% (95%CI: 67 – 100%) and specificityof 59% (95%CI: 49 – 71%), and nasal flaring yielded a sensitivity of 79% and specificity of79%. The combination of 2 clinical signs namely chest wall retraction-nasal flaring increased asensitivity of 79% and specificity of 71%, chest wall retraction-tachycardia increased a sensitivityof 86% and a specificity of 76%, chest wall retraction-tachypnoe increased a sensitivity of 86%and a specificity of 51%, tachycardia-tachypnoea increased a sensitivity of 79% and a specificityof 76%. The combination 3 clinical sign namely chest wall retraction-tachycardia-tachypnoeayielded a sensitivity of 79% and specificity of 79%. In conclusion, chest wall retraction andtachycardia have higher diagnostic score than other clinical signs to assess hypoxemia in childrenwith asthma on acute exacerbation.Keywords: asthma - hypoxemia - clinical signs - children - assessment
Anthropologi Untuk Fakultas Kedokteran T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 02 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This article discusses the problem of and justification for teaching anthropology in the medical school. It delineates the aspects and orientation of anthropology for the medical profession by distinguishing and explaining anthropology of medicine, anthropology in medicine and an• thropological medicine. Subsequently, a bioculturai account of the contents of those three subjects pertinent to medicine are presented, with special consideration on anthropology as basic, background knowledge in medicine. The wide use of biological anthropology in various medical dis- ciplines, in terms of diagnosis, therapy, rehabilitation, prevention, and promotion of health, are discussed more extensively.The growing discontent in the biologistic, or even physicochemical and mechanistic, approach in medicine, the increasing acceptance of holistic medicine, and the need for humane and man•centered medical science in the rising tide of modern technology constitute strong reasons for the inclu- sion of anthropology in the medical curriculum. In addition, the spectacular advances in molecular biology and the dramatic growth of hisses faire or market medicine have to be counterbalanced by population medicine; but this, in turn, enhances the need for knowledge of sociocultural aspects of man at supraindividual levels of the living system.For Indonesia which has a complex evolutionary history, and as results, has a population with high biological and cultural variability, the introduction and spread of modem medicine create problems of anthropological nature. Therefore, we think it is essential that anthropology is taught in the medical school. Suggestions are made for the course contents of anthropology most relevant to medicine.Key Words: medical anthropology - anthropological medicine - holistic medicine - medical - education -- living systems
Peranan Universitas Gadjah Mada Dalam Pengembangan Ilmu Pengetahuan T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 04 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : Peran UGM dalam pengembangan ilmu pengetahuan
Distal embolization durante percutaneous coronary intervention: a case report Budi Yuli Setianto Betty Dwi Lestari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Distal embolization is an acute complication of percutaneous coronary intervention (PCI). Distal embolization ofplaque and thrombus material is considered as a major cause of insufficient reperfusion despite a fully patent infarctrelatedartery, apart from ischemic microvascular damage and reperfusion-induced regional inflammatory responses.In a recent study, angiographic evidence of distal embolization was associated with an 8-fold increase in 5-yearmortality.We reported on our experience with distal embolization durante PCI which lead the patient developed STElevationMyocardial Infarct (STEMI) inferior and posterior accompanied with severe chest pain and was treated inthe Intesive Coronary Care Unit (ICCU). Distal embolization is the case that we should be put into our awarenessbecause it can worse the after procedural outcome.Key words: distal embolization-percutaneous coronary intervention-insufficient reperfusion- myocardial ischemiaangiographic
The effect of Aloe vela on fibroblast cell growth Sri Herwlyantl Sri Herwlyantl
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 02 (1998)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The study was designed to Investigate the effect of Aloe vera on fibroblast cell growth in vitro. The fibroblast cell culture in a microplate was prepared from twelve day old chicken embryos. Each well was added with 0.3 cc fibroblast suspension. Various concentrations, i.e: 0.010 g/m1; 0.015 g/ml and 0.020 g/ml of Aloe vera were then added into the well, incubated afterwards for 24, 48 and 72 hours at 37° C and were examined under a phase contrast microscope. The results showed that the density and number of fibroblast were Increased, proportionally to the concentration of Aloe vera. The control wells were added with fibroblast only suspension. In the control groups, however, there was only a slight increased and density of cells occured. In conclusion, Aloe vera could stimulate the fibroblast growth.Keywords: Aloe vera - fibroblast - cell culture - chicken embryo - growth factor
Supravengricular tachycardia in children: The role of infectious diseases and its relationship to serum enzyme A. Samik Wahab A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 18, No 03 (1986)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In twenty four children an episode of supraventricular tachycardia occurred before 15 years (median age 12 months). Fourteen male and 10 female children were reviewed, of which one had a congenital heart disease. Lown-Ganong-Levine syndrome was present on surface ECG in 1/24 (4 per cent). Forty six per cent of children were undernourished as determined by the weight to height ratio according to the WHO criteria (1983), and 58 per cent of them were anemic, according to the WHO criteria (1972). All children have had fever, mostly above 38.5° C. In ten children with an SVT episode the serum enzyme level, was also studied, i. e. the serum glutamine oxalo-transaminase (SCOT), lactate dehydrogenase (LDH) and creatinine phosphokinase (CPK). Five out of 11 children had a high serum enzyme level, ranging 25-68 U/dI (mean: 40.88 ± 16.30) for GOT, 315 889 U/dI (mean: 482 ± 232.53) for LDH, and 57-581 U/d1 (mean: 251.33 ± 287.02) for CPK, instead of a normal level range of 1-19 U/c11, 80-240 U/dl and 0-50 U/dl respectively. It is concluded that the episode of SVT often occurs in children with infection, especially gastrointestinal intention, meningitis, encephalitis. bronchopneumonia and septicemia. Fever, undernutrition and anemic status are considered as precipitating factors. Preexitation syndromes, such as WPW and LGL syndromes, were infrequently found. Digitalis treatment has to be changed with other preparations which are often used such as calcium antagonist or ATP, especially for patients who do not respond to digitalis. Physicians who work in the surgery department, should be aware of an SVT episode, especially if the children have fever, undernutrition and anemia. Key Words: supraventricular tachycardia - anemia - undernutrition - WPW syndrome - LGL syndrome
Hasil Pengamatan Diagnosa Klinik Terhadap Diagnosa Patologi pada Penderita Radang Usus Buntu Prawito Prawito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 12, No 02 (1980)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The purpose of this paper is to review 309 patients of appendicitis operated in the Department of Surgery, Gadjah Mada University Hospital, Yogyakarta, between 1972 - 1976. Among the pa. tients 81 are males and 228 are females. The peak incidence of appendicitis is between 15 - 20 years of age. Results of the clinical diagnosis compared with the pathological diagnosis are as follows;81,8% is chronic appendicitis; 44,4% is acute appendicitis; 64,4% is chronic appendicitis with acute exacerbation; 60% is periappendicular infiltrate and 1,9% is normal appendix.Fecaliths within the lumen-of the appendix are found in 136 patients (44%); eggs of elscaris in 8 patiens (2,6%).Key Words: appendicitis - periappendicular infiltrate - Ascaris - normal appendix - fccaliih
The Pahang and Kalimantan variant of nocturnally subperiodic form of Brugia Malayi (Nematoda:Filarioidea) the causative agent of filariasis. CrSiti Utari CrSiti Utari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 03 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Backgound: the nocturnally subperiodic form of B.malayi has been reported as health problem both in East Pahang, Semenanjung, West Malaysia and Kakap, West Kalimantan, Indonesia. The filarial worm is transmitted mainly by the same mosquito vector ie Mansonia uniformis.Objectives: to detect any difference of microfilarial behavioral pattern in peripheral blood in East Pahang ang West Kalimantan endemic areas by statistically meta analysis on available data published by previous workers.Methods: using Aikat and Das formula of statistical analysis.Results: B.malayi' s microfilariae still tended to show nonperiodically in East Pahang and periodically already those found in West Kalimantan.Conclusion: nocturnally subperiodic form of B.malayi shows as different variant (subsubspecies) of those found in East Pahang, Malaysia and West Kalimantan, Indonesia. Key words: B. Ma/ayi's microfilaria - nocturnally subperiodic - nocturnally periodic                  - nonperiodic - metaanalysis
Polymorphisms of organic cation transporter 1 and the drugs response Dyah Aryani Perwitasari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Polymorphisms of proteins which have an important role in drug transport, metabolism, and disposition in the bodycould affect the drugs efficacy and toxicity. The organic cation transporter 1 (OCT1), encoded by SLC22A1 gene,has been known as one of the polyspecific protein transporters which could affect some of the cationic drugresponse such as metformin, levodopa and imatinib. However, the findings of many studies an association of OCT1polymorphisms and drug response both in Caucasian and Asian were still inconsistent. Moreover, this study’s topicin Asians was still uncommon. This review was aimed to explore the polymorphisms of OCT 1 in Asians and Caucasiansand to find the challenges of the next studies in Asians. The articles about OCT1 polymorphisms were searched inthe PubMed with the keywords; OCT1 or SLC22A1, polymorphisms. There were ten articles of OCT1 polymorphismswhich are related to the drug response and most of the studies were performed in Caucasian subjects. In Caucasians,the rs622342 variant might associated with the response of metformin and levodopa. Moreover, the R61C and420del variants still showed the inconsistent findings associated with metformin response. The non-synonymousvariants which were found in Caucasians were not found in Asian. However, the new non-synonymous variantswere found in Japanese, Chinese, Indian and Korean population and some of them were associated with the metforminresponse. The recent findings found in Caucasians cancer patients, were related to the association of non-synonymousvariants haplotype and the 5-Hydroxytriptamine Receptor Antagonists drug response. The inconsistent results ofOCT1 polymorphisms studies could be related to the study’s sample size and design of the studies. Further studieswhich exploring the association of OCT1 polymorphisms and drug pharmacokinetic profiles and/or drug response,which were adjusted by genetic variants of proteins involved in drug tansport, metabolism and disposition are stillneeded in both Caucasians and Asians. Additional large studies also considering non-genetic risk factors are warranted,to implement the results of the various studies into clinical practice.Key words: OCT1- polymorphisms – Asians – Caucasians - drug response

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