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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 113   114   115   116   117 
Organisasi Registrasi Kanker Population-Based di Indonesia Soeripto Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 17, No 03 (1985)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Based on technique of cancer registration there are three types of cancer registry. These types are: 1.pathology department-based cancer registry 2.hospitl -based cancer registry 3. population-based cancer registry. Each of these types has its own method and characteristics. The aim of pupulation-based cancer registry is ib evaluate and control the trends of cancer in the community. This field has very close relation with cancer epidemiology. The prospect of the population-based cancer registry in Indonesia depends on various conditions. It is concluded that the Special Province of Yogyakarta could fulfill the conditions for the purpose of developing population-based cancer registry in Indonesia, while Bali is an ideal place for population-based cancer registry in Indonesia. Therefore, other conditions are needed for this purpose. Key Words: population-based cancer registry - technique of cancer registration - characteristics of cancer registry - cancer control in the community - cancer epidemiology
Kedokteran jiwa dan pedukunan R. Soejono Prawirohardjo R. Soejono Prawirohardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 03 (1978)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : Kedokteran jiwa dan pedukunan
The efficacy of artemether and primaquin versus chloroquine-primaquine on uncomplicated malaria: A study on children in Kokap, Samigaluh area, and Oirimulyo Puskesmas, Kulon Progo Margareta Yuliani Margareta Yuliani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 01 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Malaria is one of infectious diseases influencing mortality of newborns, infants, and delivering mothers, Chloroquine is a standard anti-malaria or fist-line antimalarial drug for treatment and chemoprophylaxis of susceptible uncomplicated malaria in Indonesia. Increased resistance toward standard medications turns out to be one of difficulties in malaria prevention, especially in endemic areas. To solve the problem, a new antimalaria drugs i.e. artemether is now under extensive studies. Objective: To know the efficacy of artemether-primaquine therapy compared to chloroquine-primaquine therapy in children with uncomplicated malaria.Methods: Sixty-three children were enrolled in this study through active case detection (ACD) and passive case detection (PCD) from April to July 2004 in Kokap, Samigaluh and Girimulyo Puskesmas, Kulon Progo; they fulfilled inclusion criteria of uncomplicated malaria, were willing to participate in 28-day study by signing informed consent form. Subjects were randomly divided into two groups of treatment. Clinical and parasitological observation were done on DO, D1, D2, D3, D7, D14, D21, D28. WHO (2003) therapeutic response criteria was used to evaluate the therapeutic efficacy. The result of academic clinical and parasitological response (ACPR) was compared to treatment failure (early treatment failure/ ETF and late treatment failure/LTF). Statistical analysis was done using Pearson X2.Results: Final results revealed that artemether-primaquine group showed ACPR and failed therapy of 30/ 32 (93.8%) and 2/32 (6.3%) respectively, while chloroquine-primaquine group 22/31 (71%) and 9/31 (92%) respectively. These results were statistically significant (p<0.05). The average rate of fever clearance time (FCT) and parasite clearance time (PCT) in artemether-primaquine group were 24.63 t 8.65 hours and 32.61 t 13.1 hours, respectively, while in chloroquine-primaquine group were 42 ± 8.65 hours and 32.61 t 18.9 hours, respectively. Nausea and abdominal pain as side effects of both therapy occurred in 18.8% and diarrhea in 6.3% of subjects, they recovered with no treatment. In chloroquine-primaquine group nausea or vomiting were found in 22.6% of subjects; in addition abdominal pain, headache, blurred vision and itching in 12.9%, 32.3%, 6.5%, and 3.2% respectively.Conclusion: Artemether-primaquine showed better therapeutic efficacy (92,8%) compared to chloro- quine-primaquine (71%) on children with uncomplicated malaria. Key words: artemether-primaquine - chloroquine-primaquine - uncomplicated malaria - therapeutic response side effects 
Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR
Laparoscopic Assessment of Pelvic Inflammatory Diseases Among IUD Users Ibnu Pranoto Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 03 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Penyakit Radang Panggul (PRP) adalah salah satu komplikasi terpenting yang terjadi pada pemakaian IUD. Telah diteliti 390 talon akseptor sterilisasi ligasi tuba secara laparoskopi, dengan perincian 194 kasus (49,7%) akseptor IUD dan 196 (50,3%) bukan akseptor IUD; dilakukan eksplorasi rongga panggul untuk melihat adanya PRP sebelum dilakukan sterilisasi ligasi tuba. Didapat angka risiko relatif 95% PRD pada aksep for IUD sebany-ak 2,52 dibandingdengan non-IUD. Makin lama pemakaian IUD, makin besar risiko terjadinya PRP clan kenaikan yang tajam PRP se telah pemakaian 2 tahun. hisersi IUD oleh bidan atau dokter umum mempunyai risiko hampir sama untuk terjadinya PRP. Bila insersi dilakukan dengan tempat dan peralatan medis yang kurang baik, maka risiko kejadian PRP lebih besar.Disimpulkan bahwa laparoskopi eksplorasi memberikan keuntungan yang lebih dalam mendiagnosis PRP, terutama yang secara klinis ridak dapat ditentukan.Key Words: pelvic inflammatory disease - laparoscopic sterilization - IUD - family planning program - gynaecology
Ketepatan MESS (mangled extremity severity score) pada penentuan amputasi dini fraktur terbuka tibia tipe III sesuai klasifikasi Gustilo Armis Armis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The amputation and reconstructive procedure of the management of open tibial fracture type III is still of interest and controversy because the amputation effort is considered as a punishment of primary treatment but a reconstructive method in massive lower extremity trauma is difficult. The MESS is a scoring system that can be applied to mangled extremity and help one determines which mangled limb will eventually come to amputation. The record of 28 open tibial fracture type III patients had been reviewed at the SARDJITO hospital 1990-1995. All seven open tibial fracture type Ill C patients with MESS of greater than seven were amputated. According to four tables of blind comparison analyzing MESS value those patients of more than seven was found to have a positive predictive of 100 % that may be best treated by primary amputation. In conclusion the MESS is an early and accurate predictor for identifying the extremity that may be best treated by amputation or reconstruction.Key words : open fracture - MESS - tibial fracture - amputation - mangled extremity
Prevalence and risk factors of hand dermatoses among pandan handicrafters Erni Setiyawati Devi Artami S, Sri AwaliaFebriana, Fajar Waskito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 03 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Pandan handicraft is one of the industrial sectors which has a significant role in employing people in Kulonprogo, Yogyakarta. Development in this industry makes higher material exposure to the hands during the production procedures, that makes it essential to study the risk of suffering from hand dermatoses among the handicrafters.Objective: To determine the prevalence and risk factors of hand dermatoses among pandan handicrafters. Methods: Cross-sectional study was conducted on 80 subjects who was taken randomly from Pandan handicrafter population in Tanjungharjo village, Kulonprogo, Yogyakarta. Prevalence data were analyzed descriptively. Risk factors were analyzed using estimation of prevalence ratio (pr), 95% Confident Interval (el), and chi-square test.Results: Out of 74 subjects fulfilled the criteria, 58 (78.4%) were suffered from hand dermatoses. Callus was the most common disease occurred in 49 (66.2%) subjects, followed by irritant contact dermatitis (lCD) in 18 (24.3%) subjects. History of atopy was proven as risk factor for ICD (p = 0.025, pr = 2.872; 95%el = 0.913-9.032). Types and duration of work were not proven as risk factors, as well as no gloves protection during work.Conclusion: Callus was the most common hand dermatosis occurred among pandan handicrafters, followed by ICD. History of atopy was identified as a risk factor for ICD.Key words : pandan - handicrafter - hand dermatosis - occupational-atopy
Hepatotoksikosis Awal Keracunan Kronis Aflatoksin B1 Pengarahnya Terhadap Spektruro Lipid Plasma Darah tikus Wiryatun Lestariana Wiryatun Lestariana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 02 (1989)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Plasma lipid spectrum studied included total lipid plasma, plasma triglyceride, plasma phospholipid and plasma cholesterol concentration in rats.1-listologically earlier hepatotoxicosis showed hyperplasia and metaplasia, and metaplasia of bile duct epithelial cells.The two groups of rats, the control group and the treatment group (each group comprised 10 rats). 3•month old, healthy, and 12 —16 g % haemoglobin concentration, were used as experimental animals. -All of them were fed and given water ad libitum, and 0.2 ml of propylen glycol per oral was also provided by sonde for 60 days. The treatment group was supplemented 10 mg of aflatoxin B, (AFB1) diluted in 0.2 ml propylen glycol.At the end of the treatment, histologically epithelial cells of bile duct showed extensive hyperplasia and metaplasia in rats supplemented with 10 rag AFB1. The plasma lipid spectrum between the control group and the treatment group was:plasma total lipid concentration (X ± 1 SD): 496.0 ± 12.61 mg/I00 ml and SO4M ± 10.46 mg/100 ml, plasma triglyceride concentration (X * 1 SD) 93.4 ± 14.83 mg/ l00 ml and 101.2 12.62 mg/100 ml. plasma phospholipid concentration (X ± 1 SD) 9.3 ± 4.21 mg/ l00 ml and 8.9 ± 3.92 mg/100 ml, plasma cholesterol concentration (X ± 1 SD) 106.9 t 17.56 mg/100 ml and 104.2 ± 12.53 mg/100 ml. The analysis test showed that there were no significant differences between blood plasma parameter of the two groups (p > 0.05).The result suggests that AFB, chronic toxicity on plasma lipid spectrum of rats is not proven despite the occurrence of earlier hepatotoxicosis. -Key Words: aflatoxin Bt -- hepatotoxicosis -- bile duct epithelial cells -- plasma lipid spectrum -- rat
Pengarahan identifikasi jenazah Soegandhi Soegandhi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 9, No 01 (1977)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

keywords: identifikasi mayat
Risk factors of neonatal mortality in Maternal Perinatal Installation Dr. Sardjito Hospital, Yogyakarta Tri Yanti Tri Yanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 4 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Neonatal mortality rate in Indonesia is still relatively high. There are many factors influencing the outcome of neonatal life. Identifying the risk factors is important to prevent neonatal mortality. The intervention could be done by avoiding or minimizing the risk factors.Objective: To know the risk factors of neonatal mortality in Maternal Perinatal Installation, Dr. Sardjito Hospital Yogyakarta, and the contribution of these risk factors.Methods: One hundred and twenty three newborns in Maternal Perinatal Installation Dr Sardjito Hospital from 1 February 2003 to 28 February 2004 were enrolled in this study, consisting of 41 infants birth alive and all died during hospitalization, and 82 infants alive when discharged from the hospital as control. The data was taken from medical records. Cases were infants those died and control were infants alive when discharged from hospital, and then risk factors were identified.Result: The risk factors that significantly related to neonatal mortality in univariate analysis were sepsis (OR=4.26; 95%C1:1.9-9.4), prematurity (OR=3.26; 95%C1:1.5-7.2), low birth weight (OR =3.41; 95%C1:1.6-7.5), major congenital anomaly (OR =4.29; 95%C1:1.6-11.5), low Apgar score at 5 minute (OR 4.68; 95% CI:1.8-11.9) and hyalin membrane disease (OR =12.90; 95% C1:2.7-62.3). By multivariate analysis, in order of higher contribution, major congenital anomaly (OR =34.80; 95% C1:6.7-182.2), hyalin membran disease (OR =15.00; 95% C1:2.3-96.5), low Apgar score at 5 minute (OR=9.16; 95% C1:1.8-48.0), and sepsis (OR 6.04; 95% C1:1.9-18.9) were significantly related to neonatal mortality. Conclusion: Major congenital anomaly, hyalin membrane disease, sepsis neonatorum and low Apgar score at 5 minute were risk factors of neonatal mortality.Key words: neonatal mortality - sepsis neonatorum - low birth weight - major congenital anomaly - low Apgar score at 5 minute - hyalin membrane disease.

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