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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 139   140   141   142   143 
The effect of adenosin triphosphate in reducing duration of first stage of labour R. Soeharyono R. Soeharyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 04 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A double blind randomized clinical trial was done at Dr. Sardjito General Hospital, Yogyakarta, to evaluate the effect of adenosin triphosphate (ATP) in reducing duration of first stage of labour and incidence of complicated labour. The subjects of the study were 100 normal parturients fulfilling the inclusions criteria of 20 to 30 years of age, parity less than 4, gestational age of 38 to 42 weeks, in a latent period with intact membranes and an estimated body weight of 2500 to 3500 gram. They were randomly allocated into treatment (50 cases) and control (50 cases) groups. The treatment group received 1 ampule ATP intramuscularly during the latent period of labour and was repeated in every 6 hours if the cervical dilatation had not completed yet. The control groups were given placebo of physiological saline solution in the same procedure. The duration of the first stage of labour was calculated from the onset of labour until fully dilatation of the cervix. Those with complicated labour pregnancy was terminated and was analyzed in a separate group. Other variables included in the analysis were age, parity, fertility states, hemoglobin concentration, nutritional states, and infant body weight. Among 100 parturients, 10 cases were terminated due to unprogress labour: of 3 cases from the treatment group and 7 other cases from control group. The adenosin triphosphate use could shorten the duration of first stage of labour by 1.5 ± 1.3 hours compared to the control group. Adenosin triphosphate was effective in reducing the duration of labour and the incidence of complicated labour.Key words: adenosin triphosphate (ATP) - first stage of labour - complicated labour
Pharmacokinetic profile of iron serum after ingestion of ferrous sulfate tablet 2 300 mg taken shortly after meal and 2 hours after meal in women with iron deficiency anaemia E.Kristin M.Hakimi, S.K.Soejono L.Hakim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Iron supplementation is a common strategy used to control iron deficiency anaemia in developing countries. Despite of that, the prevalence of anaemia is still high. Several factors causing the failure of iron supplementation program were reported. The increase in haemoglobin concentration after iron supplementation was determined by several factors, that is, the dose, iron absorption, body iron store, diet, food, and pregnancy. There had been studies on iron pharmacokinetic profile after ingestion of iron tablet taken shortly after meal compared to 2 hours after meal in healthy women, but there was no study on women with iron deficiency anaemia.Aim: The aim of this study was to find out the effect of ferrous suphate @ 300 mg taken shortly after meal and 2 hours after meal on the iron pharmacokinetic profile in women with iron deficiency anaemia.Materials and method: This study was conducted with cross-over design, so that every subject had 2 interventions with an interval (washed-out period) of 7 days. In intervention 1, ferrous sulfate tablet @ 300 mg was taken shortly after meal, and in intervention 2, the tablet was taken 2 hours after meal. Serum samples were taken serially at 0, 0.25, 0.5, 1, 1.5. 2, 2.5, 3, 4, 6, 8, 10 and 12 hours after taking iron tablets. Ferric iron concentration in serum was determined by Vitros Fe Slides method, and iron pharmacokinetic profile was determined using non-compartmental method.Result: The values of pharmacokinetic parameter from the first and second interventions were compared by t test, and the result (mean:t SEMI were: Cmox 274.25 :t 28.18 and 232.92 :t 33.25 ug/dl, T mox 3.21:t 0.30 and 4.25 :t 0.64 hours, K.0.437 :t 0.0011 and 0.3808 :t 0.0065 hour'" Kel 0.1375 :t 0.0132 and 0.1855 :t 0.0048 hour". T'/2e' 5.76 :t 0.74 and 5.81 :t 1.16 hours and AUCO-,2 2157.37 :t 264.55 and 1869.54 :t 330.60 ug/dl.hours. There are no significant differences in all pharmacokinetic parameters between both interventions.Conclusion: There are no differences in iron pharmacokinetic profiles after ferrous sulfate tablet @ 300 mg taken after meal and 2 hours after meal in women with iron deficiency anaemiaKata kunci:iron concentration, pharmacokinetics, ferrous sulfate, anemia, effect of food
Aspek Imunobiologik Fagositosis dan Penyakit Marsetyawan HNE Marsetyawan HNE
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 02 (1983)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This article describes the process and mechanism of phagocytosis, especially their immunological aspects. Phagocytosis is one of the body's second line of defence against foreign particles, e. g. infectious and non-infectious material. The macrophage system, mononuclear and polymorphonuclear cells are responsible for phagocitizing and processing those particles, moreover they serve the processed material to the specific immunocompetent system.In addition CO the normal mechanism of phagocytosis, this article describes some disturbances which interfere with each step of phagocytosis as chemotaxis, opsonization and intracellular killing; this inadequacy results as a certain disease.Key Words: mononuclear phagocyte system - non-specific immune response - inflammation - receptor of the phagocyte cell - opsonin
Mata 70-an Pranowo Pranowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 03 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

key words: mata usia lanjut, hubungan antara hidup manusia dengan hidup matanya
Marine Sponge Jaspis sp, A Potential Bioactive Natural Source against Infectious diseases Puji Astuti Puji Astuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 03 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The high incidence of microbial infection and the emergence of drug resistant and multidrugresistant microbes as well as the lack of any current chemotherapy augmented the necessity to search for new and better antimicrobial drug. Marine invertebrates are known as rich sources of compounds with unique chemical structures and pronounced chemical and biological activities, which suggests potential value as lead structures for the development of new pharmaceuticals.Objective: This study aims to screen potential antiinfective of sponges extracts collected from Barrang Lompo island and report on their antibacterial and antifungal properties.Methods: Testing for anti-infective agents was conducted using dilution method. Nutrient Agar was used as the testing media and nutrient broth for the inoculation of microorganisms. Staphylococcus aureus, Escherichia coil and Salmonella thypi were used as the testing bacteria and Candida albicans for the testing fungi. Chloramphenicol was used as positive control for antibacterial testing and ketocozaole for antifungal testing.Results: From the 11 acetone extracts tested, BL-02, BL-09, BL-10 and BL-12 was found to inhibit the growth of microorganisms and the extract of BL-10 was found to be the most active. Bioautography results suggest that the polar fractions were responsible for the growth inhibition.Conclusion: the polar fraction of acetone extract of BL-10 was considered to be potential compounds for further characterization as anti infective agents.Key words: screening, sponge, antibacteria, antifungi
Secretion of tumor necrosis factor and reactive oxygen intermediates from soluble antigens of Plasmodium falciparum stimulated-peritoneal mouse macro-phages Mahardika Agus Wijayanti Mahardika Agus Wijayanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 01 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Malarial infection is stil one of major health problems in the world. In Indonesia, malarial infection is especially caused by Plasmodium falciparum and Plasmodiun vivax. Host immune responses to malarial infection are complex mechanisms, including the humoral immunity by antibody and cellular immunity by T cells and activated effector cells. Macrophages as an effector cells kill malarial parasite by oxidative and non-oxidative mechanism. Tumor necrosis factor (TNF) and reactive oxygen intermediates (ROI) are mediators produced by macrophages which represent as non-oxidative and oxidative killing respectively.Objectives: Understanding the secretion ability of tumor necrosis factor and reactive oxygen intermediates from soluble antigens of P. falciparum stimulated-peritoneal mouse macrophages.Method: In this. study, soluble antigens of P. fa/p/parum stimulated-peritoneal mouse macrophages were tested to produce TNF and ROI in vitro. Secretion of TNF was measured by MTT assay dan ROI by NBT reduction assay. Swiss mice were divided into two groups of 15 mice each. One group was stimulated by soluble antigens as experimental group and the other as control group.Result: Secretion of TNF and ROI by soluble antigens of P. falciparum stimulated-peritoneal mouse macrophages were significantly higher (p<0,01) than control group.Conclusion: Soluble antigens of P. falciparum could activate mouse peritoneal cells in vivo. Therefore, mouse macrophages provide a convenient system for investigating the human malarial soluble antigens.Key. words : Soluble antigens of Plasmodium fa/ciparum - Cellular Immunity - Macrophages – Tumor - Necrosis Factor - Reactive Oxygen Intermediate
Return to Fertility After Discontinuation of Copper IUD Usage A study on 55 pregnancies with Multiload Cu-250 users among private patients in Indonesia R. Soeprono. R. Soeprono.
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 04 (1987)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Pemulihan kesuburan setelah penggunaan IUD Multiload Cu-250 Pemulihan kesuburan, setelah penggunaan IUD Multiload Cu-250 dihentikan, terjadi datam waktu yang singkat. Hal ini merupakan kesimpulan penelitian reirospektip sclama tujuh tahun, mencakup 53 pemakai ML Cu-250 yang minta dilepas IUD-nya karena menginginkan anak lagi, dan meliputi 55 kehamilan yang kemudian terjadi. Rata-rata umur 25,02 tahun dan paritas 1,25: Lama pemakaian IUD antara 1,00 dan 66,42 bulan, rata-rata 27,28 bulan. Setang waktu antara pelepasan IUD dan hari pertama menstruasi terakhir sebelum konsepsi (REM-LMP) berkisar antara —0,51 dan 49,03 bulan, rata-rata 5.90 bulan. Empat wanita tidak lagi haid setelah IUD dilepas. Terjadi 35 (63.64%) kehamilan dalam waktu 6 bulan dan 7 (12,72%) dalam 6 bulan berikutnya. Dan 55 kehamilan yang terjadi 46 (83,63%) terjadi dalam waktu 1 tahun, dan 52 (94,54%) dalam waktu 2 tahun setelah IUD dilepas, Lama pemakaian ML Cu-250 tidak berpengaruh aims kelancaran pemulihan kesuburan, kecuali bila ada komplikasi infeksi panggul, Kehamilan dan anak yang dilahirkan tidak juga terpengaruh. Pada 14 wanita pemakai IUD di alas tiga tahun, lama rata-rata REM-LMP hanya 4,15 bulan. Kecuali 2 keguguran, 1 persalinan prematur dan 2 postmatur, 1 perdarahan postpartum atonis dan 1 kematian neonatal pada bayi dengan sindrom Down, semua kehamilan lain berlangsung genap bulan, dengan berat lahir rata-rata bagi 43 bayi 3387 g. Dari 42 anak yang diketahui jenis kelaminnya, 26 (61,90%) lelaki dan 36 (38,10%) perempuan. Angka banding bayi lelaki terhadap perempuan sebesar 162,50 ini jauh lebih tinggi dad angka banding normal sebesar 105 -106. Apakah fakta ini bermakna dalam hubungannya dengan pemakaian IUD bertemliege sebelumnya pantas diselidiki lebih lanjut. Key Wards: copper IUD - Multiload Cu-250 - removal for planned pregnancy - return to fertility -- outcome of pregnancy and offspring
Protective immure responses against fatal malarial infection in mice with blood stage malaria vaccin. Supargiyono Supargiyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Studies were carried out to establish suitable infection and immunization method to facilitate investigation on the protective host immune responses against acute malarial infection. Combinations of experimental model using two species of rodent malaria parasites Plasmodium vinckei vinckei and Plasmodium vinckei petteri, two immunization methods were tested, to determine which model are suitable for studying any aspect of host immune responses during protective malarial immunization.The results indicated that the infection of P. v. vinckei and P. v. petteri in LACA or in BALB/c mice generally produce acute and lethal infections. Infection of P.v.vinckei in these experimental models seems more severe than P. v. petteri, and neither intravenous nor intraperitoneal immunization gave significant protection against homologous infection. However, immunization using 108 blood stage parasite P. v. petteri could protect LACA mice from the lethality of homologous challenge, and it seems that cell mediated mechanisms play an important role in host responses against infection. Therefore, P. v. petteri infection in LACA mice and immunization using 10 blood stage parasites given intravenously or intraperitoneally represent a suitable model to study some aspects of host immune response mechanism during malarial immunization.Key Words : Plasmodium vinckei vinckei - Plasmodium vinckei petteri - immune response - cellular immunity - homologous parasites
Prognostic factors for normal postnatal growth rate in low birth weight infants Kristia Hermawan Djauhar Ismail Setya Wandita
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Postnatal growth restriction in low birth weight infants is associated with long term adverseneuro-developmental sequel. Meanwhile, infants with excessive weight gain in early weeks oflife have a greater likelihood of later obesity, cardiovascular disease, and diabetes. Identifyingfactors associated with acceptable growth rate in low birth weight infants is important toprevent this potential long term morbidity. The aim of this study was to identify factors associatedwith acceptable growth rate in low birth weight infants. Prospective cohort study was conductedamong 73 low birth weight infants. Growth rate of these infants was determined by serialweight measurement during perinatal care and after being discharged until 46 – 50 weeks postmenstrual age. Growth rate was considered normal if average daily weight gain is 10 – 20 g/kg/day. Factors associated with this acceptable growth rate were analyzed by univariate andmultivariate statistical analysis. Normal growth rate was found in 62.7% subjects (42/67).Significant rate difference of average daily growth was found between small for gestational age(SGA) infants and appropriate for gestational age (AGA) infants (mean difference -2.90 g/kg/day; 95%CI: -5.68 - -0.12). The SGA infants had a greater risk for gaining weight below acceptablegrowth rate (adjusted RR= 2.9; 95%CI: 1.1 – 8.5). In conclusion, SGA is the only factor whichcan be associated with normal growth rate in low birth weight infants. Moreover, SGA infantsare in a greater risk for having slower growth rate compared to AGA.Keywords: growth rate - post natal - low birth weight – prognostic - gestational rate
Pengaruh Nikethamide Terhadap Effek Tidur Phenobarbital Pada Rattus Armis Armis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 01 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Telah diselidiki pengaruh nikethamide terhadap sleeping time phenobarbital pada 8 ekor albino rat, strain laboratorium sendiri; di mana terIihat perpanjangan sleeping time pada suntikan nikethamide 10 menit sesudah suntikan phenobarbital.Juga terlihat perpanjangan sleeping time pada female rat bila dibanding dengan malerat.Oleh karena itu dalam penggunaan nikethamide sebagai antidoturn keracunan barbiturat masih diragukan sesuai dengan pendapat sebagian buku, dan untuk lebih rnemastikan nikethamide adalah kontra indikasi perlu pengumpulan data klinik yang lengkap

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