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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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Evolusi Otak Primates T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 02 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Otak adalah rekaman evolusi yang terbaik, karena is merupakan alat pengintegrasi dalam tubuh hewan. Dari bentuk luar otak bcberapa struktur dan ciri-ciri mempunyai makna evolusioner, yang akan kita ringkaskan sebagai berikut:1. index prosencephalon. Ia memperlibatkan pertambahan yang tetap dan berangsur-angsur dari wauwau ke manusia, baik menurut isi maupun berat. Index tersebut menunjukkan derajat kernahiran tangan.2. index diametricus. Makin bertambah dari wauwau ke Pan karena merosotnya rhinencephalon, pembesaran daerah parietal dan kelambatan dalam perkembangan lobus frontalis. Kurangnya kecenderungan untuk brakykefalisasi pada gorilla dan manusia disebabkan oleh pembesaran lobus frontalis yang menyolok.3. sulci cerebri. Pola sulci semakin komplex dan jclas. Pada wauwau fissurasi yang terjelas terdapat di dacrah parietotemporal; pada mawas pola di daerah occipital dan frontal mulai bertambah rumit dan mencapai puncaknya pada manusia. Mulai dari mawas sulcus centralis lebih jelas dan sulcus lateralis cerebri lebih horizontal. Pada manusia sulcus ini hampir horizontal dan sulcus simiarum lenyap.4. lobi cerebri. Cerebrum makin lama makin lebih kuadrilobuler bentuknya dan pembesaran lobus frontalis semakin menyolok.5. pola konvolusi. Bertambah komplexitasnya karena bertambahnya sal-sal otak. Lobus frontalis mernpunyai pola terkaya pada manusia.6. concavitas orbitalis dan segi interorbital. Yang disebut pertama semakin kurang nyata, disebabkan oleh pembesaran hemispherium cerebri. Pada gorilla berkurangnya nyata sekali. Demikian pula halnya dengan segi interorbital yang kurang nyata pada Pan dan lenyap selurubnya pada manusia.7. concavitas cerebellaris dan pembesaran cerebellum. Concavitas cerebellaris, yang masih nyata pada Pongo dan Pan, mulai tak nyata pada gorilla dan hampir sama sekali lenyap pada manusia. Pada kera-kera anthropoid permukaan tentorial cerebellum mernperlihatkan kecenderungan untuk kehilangan cristanya dan vallecula menjadi lebih nyata, sedangkan verniis relatif menjadi Iebih kecil. Pada Homo sapiens permukaan tentorialnya. hampir datar, valleculanya makin dalam dan vermis inferiornya sangat tidak nyata.8. truncus cerebri. Pyramis, pons dan pedunculi cerebri mengalami pembesaran yang menyolok, terutama karena differensiasi tangan. Clava dan cuneus rnemperlihatkan pembesaran yang berangsur-angsur dan hubungan yang berubah; clava mengecil dibandingkan dengan cuneus.9. perkembangan indera. Kita saksikan mengccilnya rhinencephalon dan colliculi mesencephalon, serta pembesaran cortex cerebri, berturutturut akibat mundurnya indera pembau serta pemindahan funksi penglihatan dan pendengaran ke tingkat yang lebih tinggi.
Post-operative complications after cataract surgery with pseudophakos implantation at Dr Sardjito hospital Suhardjo Suhardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 01 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Principally, complications of post operative cataract surgery with pseudophakos implantation cover those complications due to the operation, and those due to the existence of pseudophakos within the eye ball. In Dr. Sardjito hospital, this operation has been done since 1988. There are many kinds of complication of this operation. This retrospective study is limited to those complications in the form of anterior uveitis, endophthalmitis, secondary glaucoma, and endothelial decompensation which occurred within 1992-1994 period.A study has been performed on 405 cases, consisting of 397 cases with posterior chamber pseudophakos implantation and 8 cases with posterior chamber pseudophakos implantation. In the same period, a study on 432 cases with extra capsular cataract extraction without pseudophakos implantation was performed. The complication in the group with pseudophakos implantation were: anterior uveitis (2.96%), secondary glaucoma (1,48%), endhopthalmitis (0,99%), endothelial decompensation (0.74%) and other complications such as iris prolapse and subluxation of pseudophakos. The complication in the group without pseudophakos implantation were anterior uveitis (0.23%), endothelial decompensation (0.23%), and prolapse of iris 0.46%. In this study, the complication in the form of endophthalmitis occurred 1 week after surgery in 3 cases, and 2 weeks after surgery in one case. One case was caused by fungi infection. The complication in the form of secondary glaucoma mostly related with the occurence of post anterior uveitis surgery. The anterior uveitis in post cataract surgery with pseudophakos implantation was considered to be related with the kind of lens implanted.Key words : post operative complications -- cataract surgery -- pseudophakos implantation -- anterior uveitis -- kind bf lens implanted
An increased susceptibility of Staphylococcus aureus to tetracyclin during exposure to rifampicin Hera Nirwati Hera Nirwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 03 (1998)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

acterial resistance to antibiotics has been an important problem worldwide. Discoveries and clinical use of new antibiotics have always been followed by emergence of strains of bacterial resistant to the antibiotics in question within relatively short period of time. Various efforts have been attempted to overcome the problem, one of which being the use of two or more different antibiotics in combination. In this study the effect of rifampicin on alternation of susceptibility of S. aureus to tetracycline was evaluated. Sixty seven isolates of tetracycline resistant S. aureus determined by standard disk diffusion method of Kirby-Bauer were collected during the period from August 1997 to January 1998. Minimal Inhibitory Concentration (MIC = KHM) values of rifampicin for this isolates were determined by broth dilution method. MIC of tetracycline for each isolate was determined while the bacteria were exposed to rifampicin at sub MIC. At the same time determination of the MIC was also performed without exposing the bacteria to rifampicin and this procedure served as control. Results showed that 91% (61 of 67) rifampicin - exposed isolates have increase susceptibility to tetracycline as reflected by the decrease of MIC values. It is concluded that there is synergistic effects of tetracycline and rifampicin on S. aureus. The number of isolate with increased susceptibility to tetracycline during exposure to rifampicin was statistically significant (p < 0.05).Key Words : rifampicin - Staphylococcus aureus - susceptibility - tetracycline
Effects of amodiaquine on Brugia pahangi infection in Aedes togoi Sugeng Juwono Mardihusodo. Sugeng Juwono Mardihusodo.
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 02 (1987)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A primary screening of amodiaquine as a filaricide using Brugia pahangi .Aedes togoi model infection was carried out. The drug dissolved in 10% sucrose water solution in the concentrations of 100 mg%, 200 mg% and 400 mg% fed ad libitum to the uninfected and infected mosquitoes for 4, 8 and 12 days showed definite insecticidal and filaricidal activities. Key words: primary filaricide screening - amodiaquine - Brugia pahangi - Aedes togoi model infection - filariasis - parasitology
Filsafat Kedokteran Radiopoetro Radiopoetro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 12, No 04 (1980)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Katakunci: Filsafat Kedokteran
Sensitivity and specificity test of fine needle aspiration biopsy in determining thyroid nodule diagnosis Ahmad Aryono Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 42, No 01 (2010)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Based on guideline of the American Association of Clinical Endocrinologist, fine needle aspiration (FNA) is believedas effective method to differentiate between benign and malignant thyroid nodule. At Dr. Sardjito Hospital,during2004 – 2008 there were 12 cases of false negative from 14 cases of thyroid malignancy. The high false negativevalue raised question about the role of FNA in determining thyroid nodule diagnosis. The purpose of this study is tofind out sensitivity and specificity of FNA in determining thyroid nodule diagnosis at Dr. Sardjito Hospital Yogyakarta.Patients underwent FNA and surgery for thyroid nodule were collected between January 2004 until December2008. The result of FNAwas compared to histopathological result then sensitivity and specificity test were performedrespectively. The fine needle aspiration was conducted to 120 patients. It consist of 23 men and 97 women, mostly41 – 50 years old. The results of FNA were four of malignancy, 74 of benign, and 42 of follicular neoplasm.Histopathological result showed malignant in 23 patients and benign in 97 patients. The FNA at Dr. Sardjito Hospitalshowed 14.29%of sensitivity, 96.86%of specificity, 50%of PPV, 83.78% of NPV, 4.55 of LR +0.884 of LR-,18.92% of prevalence, and 86.49% of accuracy. The thyroid FNA at Dr. Sardjito Hospital showed low value ofsensitivity and high value of specificity. Futhermore, the thyroid FNA showed minimal role in determining thyroidnodule diagnosis.Keywords : thyroid nodule-diagnosis-fine needle aspiration-sensitivity-specificity
Hypertensi M. Soeroso M. Soeroso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 5, No 04 (1973)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

keywords: vasokonstriksi, hypertensi, lumen arterioale
The Use of Monoclonal Antibody in the Detection of Circulating Antigen in Malayan Filariasis Cases: a Preliminary Report Soeyoko Soeyoko
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Filariasis (penyakit kaki gajah) di Indonesia disebabkan oleh cacing filaria. Wuchereria bancrofti, Brugia malayi dan Brugia tintori. Dan ketiga spesies tersebut, B. malayi merupakan penyebab utama filariasis terutama di daerah endemik di luar Jawa. Diagnosis filariasis sampai saat ini masih didasarkan atas hasil pemeriksaan klinis, parasitologis dan imunologis konvensional, namun ketiga cara tersebut banyak kelemahannya.Dalam era bioteknologi, dengan diternukannya teknik hibridoma; dapat dihasilkan antibodi monoklonal yang spesifik terhadap filaria B. malayi dan mampu mengikat circulating antigen dalam senim penderita filariasis.Dengan teknik pemeriksaan dot-blot didapatkan serum yang mengandung circulating antigen sebagai berikut: 75% pada serum kelompok penderita simtomatik-rnikrofilarernia; 40% serum kelompok penderita shntomatik-amikrofilaremia; 88,8% serum kelompok penderita asimtomatik-mikrofilarernia; dan 19,6% serum kelompok penderita asimtomatik-amikrofdarentia.Antibodi monoklonal dapat membantu diagnosis filariasis terutama pada yang asimtomat ik-amikrofilarem ia.Key Words: Brugia malayi- filariasis-filarial circulating antigen-antifilarial monoclonal antibodies-dot-blot assay
Antiviral activity of Momordica charantia: a preliminary study on in vitro anti herpes simplex virus Praseno Praseno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 03 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Traditional medication has been used by Indonesian people since long time ago and still continuing up to the present time. Many of them proved to be effective in curing various diseases. In this study an in vitro activity of Momordica charantia againts Herpes Simplex Virus type 2 has been evaluated by standard method of plaque reduction assay. The aim of this study is to determine whether traditional medicine we are searching has an antiviral activity. The results showed that total inhibition of plaque formation on HSV 2-infected Vero cell line was achieved at concentration of 8% v/v of crude extract, whereas the concentration of 1% v/v was capable of reducing the number of plaques by approximately 50% (inhibitory dose50= ID50). These results were very interesting as even with only small amount of crude extract we could get ID50. We expect that much lower concentration will be required to obtain ID50 if we use purified extract in the assay. Further studies are needed to elucidate other properties of the extract, including its in vivo antiviral activity, possible effect on other viruses, and mechanism of action.Key words: antiviral activity - herpes simplex virus - Momordica charantia - traditional medicine - plaque reduction assay
Mengembangkan dan Menyebarkan Gagasan Perdamaian T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 17, No 02 (1985)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This articles described various definitions of peace and peace science, and put special emphasis on operational ones which are relevant for our survival. Our main and immediate concern is the threat of a nuclear war which endangers the global ecosystem. Several reasons are brought forth why this problem has not been widely discussed in the Third World. Furthermore, the articles pointed out that old ideas on the biological necessity and unavoidability of war are obsolete and incorrect, and the assumption that nuclear arms race is just a political game to preserve peace is no longer valid. Also, the possibility of human survival after a nucleanholocallst is categorically rejected. Finally, the responsibility of the university in the preservation of peace is proposed. Key Words: peace studies - structural violence - nuclear warfare - human survival - peace-oriented education

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