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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Core Subject : Science,
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Articles 2,170 Documents
Displacement of bilirubin from human albumin by drugs Achmad Surjono Achmad Surjono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 18, No 02 (1986)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The displacing effect of 18 commonly used drugs on bilirubin-albumin binding were studied quantitatively. The competitive results of certain concentrations of drugs were measured by peroxidase oxidation method on standard bilirubin-albumin solution (bilirubin 0.255 mmol, albumin 0.45 mmol. bil /alb 0.56). Sulfisoxazole, the known clinically potent bilirubin-displacer was used as control. The apparent binding constant to the high-affinity site of albumin (Kd) of mephenamate (1.4 X 105), 'indomethacin (1.23 X 105), diflunisal (8.4 X 104), diazepam (6.7 X 104) and furosemide (3 X 104) were stronger than sulfisoxazole (1.72 x 104). Latamoxef, aminophylline and cefalotin were slightly lower than sulfisoxazole. The maximal displacing factors (MDF) were also determined, whereas sulfisoxasole was 2.29. Taking the MDF 1.2 as the upper limit for significant danger of displacement, mephenamate (4.02), latamoxed (1.63) and diflunisal (1.24) showed a higher risks Moderate to slight risks of displacement were recorded on indomethacin, cevalotine, cefotaxime, acetyl salicylic acid, aminophylline, phenobarbital, furosemide and ampicillin. No possible bilirubin-displacer were shown by sulir. idac, diazepam, doxapzam, digoxin, amikacin, gentamicin and kanamycin. Caution and substitution should be considered in giving non-steroid and-inflammatory drugs for closure of patent ductus arteriosus and latamoxef for sepsis in premature infants because of their potential risk of bilirubin encephalopathy. Key Words: albumin-bilirubin-binding drugs - displacing effect - kernicterusanti-inflam matory drugs - bilirubin encephalopathy
Icterus Neonatorum Akibat Gangguan Metabolisme Karbohidrat Dalam Eritrosit Abdul Salam M. Sofro Abdul Salam M. Sofro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 12, No 01 (1980)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Neonatal jaundice is not uncommonly found in newborn infants during the first few days of life. Usually the jaundice is mild. However, in a relatively small number of cases, the jaundice would progressively increase. Hyperbilirubinemia is observed in this clinical situation.In general it may be said that hyperbilirubinemia is due either to excessive erythrocyte breakdown which results in an increase of indirect reacting bilirubin in the blood, or to the failure of conversion of indirect reacting bilirubin to the direct reacting bilirubin.It has been known that carbohydrate metabolism is the constant source of metabolic power which is required by the human red cell in order to survive in the circulation and maintain its function. Metabolic defects in the red cells may result in premature ageing of the erythrocytes and consequently hemolysis and hyperbilirubinemia occur.Key Wards: neonatal jaundice - hyperbilirubinemia - erythrocyte breakdown - indirect reacting bilirubin - direct reacting bilirubin
Influence of catheterization on the prostate specific antigen level in patient suffering from prostate disorder Osman Sianipar Osman Sianipar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 03 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The increase of life expectancy may increase the number of patients suffered from prostate disorder. In Indonesia prostate cancer is in the top ten malignancies in men and is the second most frequent malignancies in urology clinics. Early detection may decreasies its fatality rate and increase the quality of life. Prostate specific antigen (PSA) is clinically the most useful tumor marker; its serum level has positive correlation with the prostate cancer. Serum PSA level will also increase in inflammation, benign prostate hyperplasia (BPH) and interventions like catheterization, digital rectal examination and biopsy.Objective: The objective of this study is to examine the catheterization effect for the result of PSA test in patients with prostate disorder.Methods: Subjects of study are all of patients who present symptoms related prostate. Venous blood samples are taken using aseptic technique then processed further to collect serum. Level of PSA is determined by ELISA technique from the serum. Study population is grouped according to result of histopathologist examination namely benign prostate hypertrophy, benign prostate hypertrophy with prostatitis, benign prostate hypertrophy with prostate intraepithelial neoplasm and prostate cancer. In addition, patients are also grouped into group that already catheterized and those who have not been catheterized before blood sample was taken. One-way ANOVA and Pearson correlation were used to analyse the effects.Result: Mean of PSA level in patients sufferring from benign prostate hypertrophy, benign prostate hypertrophy with prostatitis, benign prostate hypertrophy with prostate intraepithelial neoplasm respectively were 17.61 ng/mL, 17.33 ng/mL and 19.77 ng/mL. This was significantly different compared to those in the same group but without catheterization before blood collection. Mean of PSA level in prostate cancer patient was 38.3 ng/mL. It was not significantly different to those in prostate cancer patient but without catheterization before blood collection.Conclusion: Urine catheterization prior to determination of PSA level showed an effect to increase PSA level in the group of patients presenting complain of related prostate but it is not found in protate cancer patient.Key words: PSA - prostate disorder - prostate cancer - catheterization 
Micro-vascular surgery in fingertip injury treatment: Case report Rosadi Seswandhana Teddy OH Prasetyono Chaula Sukasah
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A high priority for fingertip injury reconstruction is the restoration of skin cover to protect underlying bone, tendon,and nerve structures. Other priorities are to maintain or maximize sensibility, preserve digit length, and minimizecosmetic deformity. Because it is so highly visible, though, the appearance of the reconstructed digit should be asnormal as possible. Therefore, microvascular surgery has an important role in management of fingertip injuries togive a normal shape of the digit. In this case, a clinical experience using microvascular surgery in the treatment offingertip injury was reported. In early 2007, there were two fingertip injury cases which were reconstructed usingmicrovascular surgery modality. The first case was a 34 years old male who had defect in soft tissue of the fourthfinger in his right hand caused by pressed machine. We performed elective wound reconstruction by transferring theskin and soft tissue freely (free pulp transfer) along with the vasculatures taken from fibular side of great toe in theright foot. Revascularization was performed by connecting deep plantar artery/vein with common digital artery/veinat the injured digit. The second case, was a 29 years old female with clean-cut amputation of the distal part of thethird finger in the right hand (Allen’s type IV). We performed replantation in the first 16 hours after injury. Wereanastomosed the ulnar side of digital artery only without vein and nerve reanastomosis. To avoid the distal edema,we did not perform any skin suture and let the oozing from the vein backflow. In both cases, we have excellentappearance result, moderate usefulness of the finger, but still poor in sensibility.Key words: clinical experiences - fingertip injury - soft tissue defect - clean cut amputation - microvascular surgery- free pulp transfer - replantation.
Molecular pathogenesis of thalassemia Sunarto Sunarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 02 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Since the first description in 1925, thalassemia has been studied intensively and extensively. Thalassemia is inherited by Mendelian recessive genes, in which there is a mutation or deletion of the DNA nucleotide or results in defective production of one or more globin chains of the hemoglobin. There are two important forms of tha/assemias, a- and ft-thalassemia that are health problems in the tropical belt, extending from Africa and Meditenanian countries up to West Melanesia. The molecular studies of thalassemia and other hemoglobinopathies had discovered such a lot of abnormal hemoglobin structures and pathogenesis of the disease, so that the hemoglobin is now indeed a paradigm for our understanding of gene action at the molecular level. The thalassemia occurs essentially due to deletion, whereas 13thalassemia is mostly due to mutation of the gene(s). The understanding of the molecular pathogenesis of thalassemia is very essential for the diagnosis of the trait and especially for prenatal diagnosis, and in the future might be for genetic therapy.Key Words: thalassemia gene deletion gene mutation polymerise chain reaction haemoglobin
The basal membrane destruction in benign prostatic hyperplasia, prostatic intraepithelial neoplasma, and prostatic adenocarcinoma. A study on basal membrane type IV collagens Irianiwati Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Basal membrane (BM), a selective permeable membrane is mainly composed of type IV collagen. A tumor invasion, therefore, may only occur if this membrane is destroyed by an active process of tumor producing proteolytic enzymes. It has been found that prostatic intraepithelial neoplasia (PIN) is a prostatic premalignant lesion. Although both benign prostate hyperplasia (BPH) and prostatic adenocarcinoma required an androgenic hormone for their growth, the correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinoma should be clarified. This can be studied by observing the continuity of periacinair BM. In order to understand the correlation among prostatic lesions, the BM continuity of 40 paraffin block specimens (15 BPH, 11 PIN, and 14 Prostatic adenocarcinomas) were studied. The BM of these specimens were stained immunohistochemically with MoAB anti human Type IV collagens. The periacinair BM continuity was scored 0-5. The Spearmans correlation test was used to analyze their possible relationship.The result shows that there is a significant correlation between the degree of destruction of basal membranes and BPH, PIN, and Prostatic adenocarcinomas (r = 0.898; p<0.05). In conclusion, based on periacinair BM des-truction, there is a positive correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinomas.Key words : collagen type IV - prostatic adenocarsinoma - prostatic intrapithelial neoplasia - benign prostate hyperplasia - basal membrane
Diagnosis dan Kelasifikasi Diabetes Mellitus Ahmad H. Asdie Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 02 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This paper presented the main recommendations for the definition and classification.of diabetes mellitus and of impaired glucose intolerance in non-pregnant adults.Diabetes mellitus is not a disease in the classical sense but is more probably a syndrome best characterized as a state of chronic hyperglycemia of various etiology. It may present with acute symptoms that include polyuria, polydipsia and unexplained weight loss and these can progress to life threatening ketoacidosis or hyperosmolar coma. Chronic hyperglycemia may be asymptomatic, but it has long been recognized as a predisposing factor for specific microvascular complications, namely neuropathy, retinopathy and nephropachy.Blood glucose concentration is the most common, variable used to define diabetes mellitus, but the increased blood glucose is not the sole pathological manifestation, nor has it been proved beyond doubt to be first in the pathological sequence. The limit between physiological and pathological values of blood glucose concentration is still debatable. An area of particular difficulty is the evaluation of situation that are near the physiological limit.New criteria for the diagnosis of diabetes mellitus and other catagories of glucose intolerance have been developed by National Diabetes Data Group (1979) and these have been endorsed by World Health Organization in 1980 and revised in 1985.Key Words: diabetes mellitus — target screening — chronic hyperglycemia — glucose intolerance -- hyperosmolar coma
Insidensi streptococcus beta-haemolyt cus pada anak dengan pharyngitis A. Samik Wahab A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 9, No 03 (1977)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Pharynx-swabs using filter paper strip method were done on children with pharyngitis, and 3,8% positive Streptococcus beta-haemolyticus group A and 4,8% positive non-group A werefound.Clinical manifestations were: fever (100%), hyperaemic pharynx with exudate 54%, without exudate 46% and with cough 27%. Blood examinations were done on 40 positive cases of which 60% showed leucocytosis.Months with a high incidence were: January — February 27%, May — June 36% and September' — October 27%.
Clinical aspect and management of basal cell carsinoma Agus Supartoto Agus Supartoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 3 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Objective: To identify the pattern, clinic:al aspect and management of Basal Cell Carsinoma (BCC) at Ophthalmology Department, Dr. Sardjito Hospital, Yogyakarta from 1997 to 2002.Methods: The author reviewed eligible medical records of all patients with BCC diagnosis based on clinical symptoms and histopatologic examination. Operative management with frozen section procedure. Results: Based on the collected data we found 31 cases of BCC in 1997 to 2002. Most of these cases (30) were noduloulcerative types, while 1 case was morphea in type. Most location of lesion were inferior palpebral region. In these cases, the range of age was between 49-75 years. Wide excision with skin graft was performed on 11 cases and 9 cases with orbital exenteration and skin graft, 6 cases with wide excision and skin flap, 5 cases orbital exenteration –wide excision– skin graft, as well as the ensuring 17 cases with radiotherapy. Most of the cases (30 cases) were good at follow up with a period of follow up between 2-14 month, while 1 case died.Conclusions: The most frequent of BCC were ulcerative nodular type, most location in the inferior palpebral region. Wide excision and skin graft management in the majority of cases clinical good result.Key words: BCC-Noduloulcerative type- Wide excision and skin graft.
Hypertension as one of the risk factors for age-related macular degeneration Soni Priartso Soni Priartso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Age-related macular degeneration (ARMD) is one of the causes of loss of central vision in older people. While age is the undisputed, the most important risk factors such as genetic, race, sex, sunlight exposure, diet, vitamin, smoking, cardiovascular disease, hypercholesterolemia, and hypertension have been incriminated to be associated with the development of ARMD. The study of ARMD is very rare in Indonesia.Objectives: To investigate the possible association of presumed hypertension, and other risk factors in patients with age-related macular degeneration.Methode: A case-control study of 120 subjects, 60 cases with ARMD and 60 cases of normal control in Dr. Sardjito General Hospital and Dr. YAP. Eye Hospital, Yogyakarta. ARMD and normal control were compared. Interview, eye examination, blood pressure, and blood sample were performed. Results: Hypertension was observed in 38 (76%) of 60 patients with age-related macular degeneration. Of 60 normal control patients, only 12 (24%) had hypertension. Statistical analysis result showed that hypertension was one of the risk factors for the development of age-related macular degeneration OR: 6,909 (3,037-15,720). But hypertension was not a predictor for the development of age-related macular degeneration (regression coefficient = 0,0000).Conclusion: Besides other risk factors, hypertension is one of the risk factors for the development of age-related macular degeneration.Keywords: age-related macular degeneration - central vision - older people - risk factors - hypertension

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