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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Core Subject : Science,
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Articles 2,170 Documents
Body Composition in Javanese Adult: Some Anthropometric Dimensions Related to Body Fat Hastuti, Janatin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Body composition is an integral component of entirely health and physical fitness. Measurement of fat component in assessing body composition is necessary on account of its relation to several health risks. Some anthropometric measurements such as waist to hip ratio (WHR), waist and hip circumferences, skinfold thickness, and sagittal abdominal diameter are demonstrated to be valuable for evaluating body composition, and further for identifying some health risk factors. Objectives: This study is addressed to know body composition and some anthropometric measurements related to percent body fat in Javanese adults living in Yogyakarta province. Methods: As many as 201 (98 males and 103 females) Javanese adults living in Yogyakarta province, aged 18 to 65 years were entrolled in this study. Measurements of body weight, height, waist, abdominal, and hip circumferences, sagittal abdominal diameter, and total skinfold thickness of triceps, biceps, subscapular, suprailiac were performed on the subjects. Body composition was assessed based on those measurements included percent body fat, body density, and skeletal muscle mass. Body mass index and waist-to-hip ratio were determined and categorized. The data then were analysed using independent Hest, Pearson correlation of product moment, linear regression, and chi-square test. Results: The result indicated that in a general sense, Javanese adults in Yogyakarta province had thin to medium body constitution and risk factor categorized of low to medium risk for males and medium to high risk for females. Javanese adult males were considerably heavier, taller, had greater means of body density, WHR, and muscle mass. By contrast, Javanese adult females were significantly higher in BMI, percentage of BF, and hip circumference. Statistically, there is no significant difference in total skinfold, abdominal circumference, and SAD, however, females indicated to a certain greater than the males. In the same manner, males had larger waist circumference. Conclusions: All of anthropometric dimensions including skinfold thickness, body density, waist circumference, abdominal circumference, WHR, sagittal abdominal diameter, and muscle mass are strongly correlated with body composition assessed with BMI and % BF. However, associations with BMI are fairly better than those of with percentage of BF. Among those measurements WHR showed the weakest correlation. There was also a different tendency in the power of correlation between anthropometric dimension with BMI and percentage of BF in males and females. Yet, all the measurements were supposed to be performed to incorporate evaluation on human body composition. Key words: body composition - Javanese adults - anthropometric measurements - percentage of body fat.
Serum iron level shortly after iron supplementation shortly after and 2 hours after meal in women with iron deficiency anemia Sri Kadarsih Soejono,,Lukman Hakim, ErnaKristin, Muhammad Hakimi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 03 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Incidence of anemia in women in developing countries is still high, that is, around 43%. This incidence rate is far more higher that that in industrial countries, which is ranged between 10-12 %. The prevalence of iron deficiency anemia is still high, particularly in developing countries. The cause of the high prevalence of iron deficiency anemia is not known, since it involves various factors. Two of the probable etiologic factors is variability in dosage administration, and the effect of co-administered food. Studies on the pharmacokinetic of iron after single dose iron tablet administration in women with anemia and pharmacokinetic of iron coadministered with food in healthy women have been done, but study on repeated dose has never been conducted. Objective: To understand serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in women with iron deficiency anemia. Method: The research design was a fase II clinical trial. Subjects were 24 women with iron deficiency anemia, classified into two groups, who were treated as follows: the first group was consisted of 12 women with iron deficiency anemia, treated with twice-a-day ferrous sulphate tablet @ 300 mg orally, given shortly after meal for 12 weeks; the second group was consisted of 12 women with iron deficiency anemia, treated with twice-a-day ferrous sulphate tablet @ 300 mg orally, given 2 hours after meal for 12 weeks. Blood samples were taken in week 2,4, 6, 8, 10, and 12 after treatment. Serum (ferric) iron level was measured with Vitros Fe Slides method. Result: Minimum, maximum, and average steady-state iron levels (Css min, Css max, Css average) of treatment 1 were 108,78:t 13.79 ug/dL, 121 .44:t 15.79 ug/dL, and 115.11 :t 13.13 ug/dL (mean:t SEM), respectively; while minimum, maximum, and average steady-state iron levels (Css min, Css max, Css average) of treatment 2 were 115.15 :t 46.27 ug/dL, 141.36:t 61.36 ug/dL, and 124.92:t 53.43 ug/dL (mean:t SEM), respectively. No statistical significant difference were found within treatment in minimum steady-state level between week 2, 4, 6, 8, 10, 12 after treatment. There was also no significant difference in minimum steady-state level between treatment group in week 2, 4, 6, 8, 10, and 12. , Conclusion: There were no differences inserum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in women with iron deficiency anemia. Key Words: iron supplementation-serum iron-iron deficiency anemia-steady-state iron level
Atypical carcinoid of the lung: A case report Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

A 3D-year old woman came to Dr Sardjito Hospital with chief complain of dyspneu that she had since 1 month before her visit. Clinicalexamination revealed a dull percussion below. The second intercostal of the left chest. The chest X ray revealed massive pleural effusion in the left chest, could not exclude a mass in left lung. Thoracoscopic biopsy of the left lung mass was done. Macroscopic examination of lung tissue sample revealed fragmented tissue, with volumeof 0.25 cc, blackcolour, and rubberyconsistency. The diagnosis of atypicalcarcinoid with small cell carcinoma as a differential diagnosis was determined based on morphological pattern. Immunohistochemical staining examination showed expression of cytokeratin, CAM5.2, and synaptophysin, but showed negative expression of chromogranin, CD56, and TTF-1 .A diagnosis of an atypical carcinoid was confirmed based on the immunohistochemicalexamination. A very rare case of atypical carcinoid of the lung in a non-smoker 3D-yearoldwoman with morphologicaldiagnostic problem solved by immunohistochemical staining was reported.
Comparison of daily vs. weekly single-dose ferrous sulphate treatment in female junior high students with iron deficiency anemia Madarina Julia, Dedy Afandi, Sri Mulatsih,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Universitas Gadjah Mada

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Background: Complianc~ of daily treatment of iron deficiency anemia in children is still low. The compliance will be increased if the iron supplementation is given weekly. Previous study showed that there was no significant difference in the increase in hemoglobin level between daily and weekly treatment in prepubertal children. Objective: To study the difference in the increase in hemoglobin and serum ferritin levels between daily and weekly sirigle-dose treatment of ferrous sulphate in female junior high school students with iron deficiency anemia after menarche. Methods: This was a quasi-experimental study recruiting 179 and 174 anemic female students in the weekly and daily group, respectively. They receive weekly or daily single-dose of ferrous sulphate capsules. Hemoglobin levels were measured before and after the 12 weeks treatment, while serum ferritin levels were measured before and after in a subset of the study subjects. Result: Mean:t SD levels of hemoglobin before and after iron supplementation were 11.18:1: 0.51 and 12.79:t0.63 g/dl (p=0.001) in the weekly group, and 11.17:1:0.61 and 12.68:1:0.57 g/dl (p=0.001) in the daily group. Mean:l: SD levels of ferritin before and after iron supplementation were 6.95:1: 1.85 and 41.5:1:33.93 ng/ml (p=0.001) in the weekly group, and 6.61 :1:2.17 and 40.7:1:22.73 ng/ml (p=0.001) in the daily group. The prevalence of anemia after supplementation is similar in both groups, i.e. 6.7% in the weekly group and 8.0% in the daily group (p = 0.631. There were no significance difference in the occurrence of side effects of diarrhea and nausea in both groups (p>0.05). Conclusion: This study concluded that daily vs. weekly ferrous sulphate supplementation did not result in significantly different level of both hemoglobin and serum ferritin after treatment. The difference in the occurrence of side effects was also not statistically significant. Key words: anemia iron deficiency - hemoglobin level - serum ferritin level - ferrous sulphate
The effect of topically extravirgin olive oil on the UVB-induced immunosuppression AriefBudiyanto, Irianiwati, Vohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 03 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Background: UVBradiation may act as an immunosuppressive agent through Langernans cells (LCs)depletion correlated with cyclobuthane pyrimidine dimer (CPD), as the most mutagenic photoproducts. Other studies showed that olive oil can prevent various human cancers, which are defect of immune-surveillance. The effect of olive oil in the UVBinduced LCs depletion is still unclear. Objective: To discover the topical effect of extravirgin-olive-oil in the LCs depletion. Methods: A simple experimental study was performed on foreskins collected from 8 circumcised boys. Each of them was cut into 3 pieces of 0.5 cm2, grouped randomly to: (Olive oil+ UVB)group, (placebo + UVB)group, and unirradiated group. They were cultured in DMEM for 24 hours, irradiated with 100mJs/cm2 UVB, and olive oil or placebo were then applied immediately after irradiation. All specimens were fixed in buffered-formalin, paraffin blocked, and cut to be 2 slides, and each of them was stained with anti-CD 1a or anti-CPD antibody. The pixels of AEC signats were digitally counted based on Photoshops selected color histogram.The pixel means of various groups were analyzed by Kruskal-Wallis test and post hoc analysis by Mann Whitney test. Results: Olive oil treated groups showed a very significant (P
Human sexual dimorphism: from an evolutionary perspective to practical . overview Suriyanto, Rusyad Adi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

This paper goal is to discuss human sexual dimorphism in evolutionary perspective and practical overview. Evolution of human sexual dimorphism has wide implication !n human biological study and many applications to medical field. Human sexual dimorphism has experienced changes and adaptations along its proceeding to current time and space. These changes are natural consequences. Understanding this problem as process and products of evolution, we can enter this problem into medicine and be a background. Understanding as a background, as human natural history, we will understand why human can be so now and why he! she will change, including sexual dimorphism problem. The understanding of background is needed to avoid creation of human with narrow vision, highly specialized, excessive fanatics for self competency, easily astonished, panic and immediately tricked in real life which is complex and continuously changing. Human anatomy knowledge, as one basic medical aspect, sexually presents understanding that there are changing and developing characteristics among men (males) and women (femalesl over time. The medical intentions are aspects of sexual dimorphism directly applied and related closely to medicine. The paper begins with sexual dimorphism discussion, and continued by evolutionary perspective discussion, and followed up by practical discourse. This continuity is an effort to illustrate that Homo sapiens species, like us, is always dynamic and changing, like nature which is never static neither stable.
The effect of Pandanus conoideus Lam. oil on pancreatic (i-cells and glibenclamide hypoglycemic effect of diabetic Wistar rats Maliyah Madiyan, Nur Anisah, Winarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Oxidative stress has been implicated in pathogenesis and progression of many degenerative disorders including naturally occuring and chemically-induced diabetes mellitus. In addition to the increased production of free radicals, antioxidant defense systems are disturbed in diabetes mellitus. As a result, oxidative stress may cause oxidative damage of cellular, including Ii-cells of pancreas. Objective: This study was aimed at investigating the effect of P. eonoideus Lam. on hypoglycemic activity of glibenclamide and histochemical changes in pancreatic islets. Methods: Thirty male Rattus norvegicus rats were used in the study, and randomly selected. The animals were divided into two groups, each group consisted of 15 rats. Each group was devided into 3 subgroups, the first subgroups were subgroup 1; 2, 3 and the second was subgroup 4, 5, 6. Streptozotocin was injected intraperitoneally at a single dose of 60 mg/kg for induction of diabetes in the second group. Subgroup 1 and 4 did not receive anything, subgroup 2 and 5 received glibenclamide 0.09 g/kgBW/day and subgroup 3 and 6 received P. eonoideus Lam. 0.3 mLlkgBW/day and glibenclamide 0.09 g/kgBW/day. Rats were given P. eonoideus Lam. and glibenclamide everyday for 14 days. Hypoglycemic activity was evaluated in overnight fasted at day 1, 7 and 14, and the acute hypoglycemic activity was evaluated at time 0, 1, 2, 4, and 6 hour aher treatment at day 14. Blood was collected from orbital sinuses. Blood glucose level was determined using GOD-PAP method. At 15 day rat were killed, the pancreas was removed. The data was compared statistically using one-way analysis of variance (AN OVA) followed by post-hoc test and student unpaired t-test. For the analysis of immunohistochemical data, a non parametric test (Kruskal-Wallis) was used. Results: The combination of P. eonoideus Lam. and glibenclamide produced significant reduction in blood glucose in the serial study at day 1, 7 and 14 and comparable with that of standard drug, glibenclamide also control groups in normal and diabetic rats. It also produced significant reduction of blood glucose in the serial study at time 0, 1, 2, 4, and 6 hour after treatment at day 14. Significant increasing histoscore, number and diameter of Langerhans islets were observed in P. eonoideus Lam. treated rats. Conclusion: P. eonoideus Lam. could increase hypoglycemic effect of glibenclamide and histoscore, number, and diameter of Langerhans islets in diabetic rats. Key words: minyak buah merah - pancreas B-cells - glibenclamide hypoglycemic effect - diabetes
The Comparison of Hydration Effect of 1% Aloe Vera Extract Cream and 10% Urea Cream as Moisturizer for Non Dermatotic Skin Fajar Waskito, Laily Noor Qomariah, Sunardi Radiono,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
Publisher : Universitas Gadjah Mada

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Background: Xerotic or dry skin is a condition with manifestation of scaly, coarse skin with itchy sensation. Moisturizers have been used as treatment to alleviate xerotic skin. Aloe vera is a traditional medicinal plant which has been used as skin moisturizer for a long time, however, the hydration effect of this material had not been studied. Urea is a humectant material that has been widely used as moisturizer. Objective: This study was aimed to compare the hydration effects of 1 % Aloe vera extract cream with 10% urea cream as moisturizer for non-dermatotic dry skin. Methods: This research was a single-blinded randomized controlled trial. Thirty research subjects who met inclusion criteria were given 2 types of interventions (1 % Aloe vera extract cream or 10% urea cream). Randomization was conducted to determine which cream was applied on the subjects lower arm. Cream was given as a single application. Evaluation of stratum corneum hydration level was conducted objectively using corneometer instrument: before application, 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours after single application. Data of the two groups were analyzed with paired t-test. Results: There was no significant difference of stratum corneum hydration level between 1 % Aloe vera extract cream treatment and 10% urea cream at each time of measurement (p > 0.05). Conclusion: 1 % Aloe vera extract cream showed similar or equivalent hydration effect with 10% urea cream as moisturizer for non-dermatotic dry skin. Key words: aloe vera - urea - skin moisturizer - skin hydration.
The effectiveness of rivanol tampon" compared with burowi tampon in acute diffuse otitis externa (ADOE)patients Bambang Udji Djoko Rianto, I Wayan Marthana Kedel, Edhie Samodra
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 03 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Acute diffuse otitis externa (ADOE) is one of the common diseases in ENT Department, Dr. Sardjito Hospital, with the frequency of 9-1 2%. The most common microorganism found is Pseudomonas aeruginosa. Infection usually occurrs after taking a bath, washing hair, and scratching the external ear canal. Treatment of acute diffuse otitis externa which consists of topical preparations, Le. antibiotics and antiinflammation tampon or ear drop, is relatively expensive. A rationale, high recovery rate, cheap, and easily found preparation is needed. Burowi solution is one of the recommended treatment, but it is less popular. Objective: The goal of this study was to know the effectiveness of Rivanol" tampon compared with Burowi tampon in acute diffuse otitis externa. Methods: A randomized single-blind controlled trial (RCT)was performed at the outpatient clinicof ENTDepartment of DrSardjito General Hospital, Yogyakarta. Sixty-five subjects who werediagnosed as ADOEwho met inclusion criteria were randomly allocated into two groups, that is, Rivanol"group and Burowi group. The ear canal was cleaned, and then Rivanol"tampon or Burowi tampon was applied. Evaluation was performed on day 3 and 5. Primary outcome was the recovery rate, and secondary outcomes were adverse reaction and marginal costeffectiveness. Results: Of 65 subjects, 33 were alloc8ted into Rivanol"group and 32 were. allocated into Burowi group. The recovery rate in Rivanol"group was 75.4%, while in Burowigroups was 49.3%. The difference in recovery rate between the two groups was statistically significant (p: 0.018; RR4.350; 95% CI1.225-15.442). Adverse reaction in Rivanol"group was dampness and soggy feeling in the ear canal (1.5%), while in the Burowigroup the adverse events were pain and burnt sensation inthe ear canal (3.1%), but they could be tolerated and disappeared on day 5. Analysis on marginal cost-effectiveness showed that the cost to cure one acute diffuse otitis externa patient with Rivanol"tamponwas Rp 1,000. Conclusion: Rivanol"tampon was more clinicallyeffective and more cost-effective than Burowitampon for acute diffuse otitis externa treatment. Key words: acute diffuse otitis externa, Rivanol(!),Burowi,.clinical and cost effectiveness
Fibroadenoma of the breast with florid epithelial cells hyperplasia: a case report Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Universitas Gadjah Mada

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Abstract

Fibroadenoma is a benign biphasic tumor of the breast, composed of an epithelial and a stroma component. Fibroadenoma with epithelial cells hyperplasia may contribute to the higher risk of breast cancer, especially for florid and atypical hyperplasia. The distinction between fibroadenoma with florid epithelial cells hyperplasia, in-situ carcinoma and invasive duct carcinoma of the breast ban be difficult morphologically. To solve the problem, immunohistochemical staining with specific andibodies will be helpfull in distinguishing usual duct hyperplasia from ductal carcinoma in situ. A case of fibroadenoma with florid epithelial cells hyperplasia has been reported. Morphologically, this tumor is difficult to be differentiated from ductal carcinoma. Immunohistochemical staining with High molecular weight cytokeratins 34BE12, Smooth Muscle Actin (SMA),E-cadherin could be used to determine the diagnosis of this tumor.

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