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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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The effect of bee propolis against Plasmodium berghel Infection in Swiss mice Mahardika AW, Mahardika AW
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 2 (2003)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Malaria is one of the most important parasitic disease and still as one of the worlds public health problems among another tropical diseases.. One of the difficulty on controlling malaria is the resistance of malaria parasite to antimalaria drugs, therefore it is needed further researches to find alternative drugs of antimalaria. Propolis, a beehive product widely used in this folk medicine, has attracted the attention of researchers to elucidate its biological properties. Its anti-microbial properties are not confined to bacteria. Both in vitro and in vivo tests have shown propolis to be excellent in inhibiting the growth of many protozoa such as Trichomonas vaginalis and Giardia lamb/ia.Objective: This study was undertaken to know the propolis effect on Plasmodium berghei infection in Swiss miceMethods: Swiss mice were divided into 8 groups of 20 mice. Four groups were given 3.9 mg propolis orally every 2 days for two weeks before infection while the other four groups were not. Infection with P. berghei 1x107 was given intraperitoneally. Each four groups were treated after infection as follows : propolis , combination of propolis and chloroquine, chloroquine and none as negative control. Treatment with chloroquine injection was given within 3 days started at day-1 after infection with dose of 1.56, 1.56, and 0.8 mg. Treatment with propolis was given within 3 days also at dose of 3.9 mg/day. The effect of propolis was evaluated according to the percentage parasitemia counted every day started at day-1 after infection and the pathologic effect on the liver, spleen kidney and brain.Result: Propolis could not overcome the infection but inhibit the growth of Plasmodium in the erytrocytes and prolong life span of the mice. Pathologic affect propolis on the liver is mild inflammation while on the spleen, kidney and brain seems to inhibit organ damage.Conclusion: Those result showed the effect of propolis as an Immunomodulator.Key words: malaria - propolis - parasitemia - pathologic effect - immunomodulator.
Peran Adrenoseptor B-Prasinaptik dalam Patofisiologi Hipertensi Ngatijan, Ngatijan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 02 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The pathophysiological concept of hypertension is still in debate since many factors are involved in the development of the disease. Stress plays a role in the pathophysiology of hypertension through its effect on adrenaline secretion and sympathetic tone.In the development of adrenoceptor concept some studies showed that presynaptic P.adrenoceptors are of (32 subtype. Since the evidence for noradrenaline activating presynaptic 13-adrenoceptors is mostly negative, the question arises whether presynaptic 13-adrenoceptors have a physiological activator. Many studies showed that adrenaline is suggested to be the putative activator through its role as cotransmitter.Since there was correlation between stress; and the increase in the concentration of plasma adrenaline and blood pressure, it is suggested that presynaptic fl-adrenoceptor has an important role in the development of hypertension.Key Words: adrenaline — cotransrnitter — hypertension — presynaptic B— adrenoceptors — sympathetic transmission
Current issues in Colorectal Cancer Marijata, Marijata
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 04 (1999)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Three issues about colorectal cancer are now blooming among surgeons and oncologists. The first issue is trend the younger the age of the patients suffering from colorectal cancer. The second is the younger the age of the patients the higher malignant of the cancer. The third issue is the delay of the management of colorectal cancer.Methods: A retrospective study on the colorectal cancer patients who were managed in Patmasuri Surgery Hospital, Yogyakarta, during a 10-year period (1989 - 1998).Results: The first and second issues were not proved, but the third issue was proved. The cause of delay came from the patient and the physician in establishing the diagnosis and in considering the operative procedure.Key words : colorectal cancer - younger age - higher malignant
Prognosis Epilepsi Harsono, Harsono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 03 (1998)
Publisher : Universitas Gadjah Mada

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Abstract

Prognosis is defined as the chance of recovery from a certain condition. Strictly, in epilepsy this means the chance of terminal remission once a patient has established a pattern of recurrent epileptic seizures. Questions concerning duration of treatment and long-term prognosis in childhood epilepsy are often raised by parents whose children are starting therapy with antiepileptic drugs. Many studies have focused on those issues and have examined the risk factors for poor prognosis as well as the risk of recurrence of seizures. The wide variation found in the risk of recurrence among those who have had a first seizure seems to be explained by differences In study design or differences in the characteristics of the study groups. In addition, the study of the prognosis of epilepsy has been confounded because of the fact that epilepsy is an expression of so many different underlying etiologies and syndromes.Prognosis of epilepsy should be informed clearly to the patients and/or parents. The clear information will improve the patient compliance in taking medication for a long time.Key Words : prognosis of epilepsy - remission - antiepileptic drugs - risk factors - recurrent epileptic seizures
Wilms tumor associated with Cushing s syndrome - A case report Madarina Julia, Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Ectopic ACTH syndrome associated with Wilms tumor is ver
The correlation between blood glucose control obesity and diabetic duration, with frequency of dermatophytosis among type II diabetic patients. Dwi Retno AW, Dwi Retno AW
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Abstract

Objectives: The aim of this study was to determine the correlation of blood glucose control and frequency of dermatophytosis among type II diabetic patients. In addition we also assessed the dermatophytosis in correlation with obesity and diabetic duration.Materials and Methods: The study was performed using a cross-sectional study design. The subjects of this study were 180 type II diabetic patients, divided into two groups of blood glucose level (good and poor glycemic control groups). In addition, these subjects were examined for evidence of dermatophytosis, and compared between good glycemic control and poor glycemic control. Among the subjects suspected to have dermatophytosis lesions were further examined using potassium hydroxide and fungal cultures.Results: The result showed that there was seemed to be an increased frequency of dermatophytosis in poor glycemic control group in comparison with the good glycemic control group (8.3% vs 6.1 %). Statistically this difference was significant (p0.05). The combination of glycemic control and obesity in this study was seemed to have a significant correlation too.Conclusion: poor glycemic control and or obesity increased the risk for suffering from dermatophytosis in the type II diabetics, while the diabetic duration did not increase.Keywords: dermatophytosis - type II diabetes - glycemic control - obesity - diabetic duration
The Subfornical organ and limbic system of albino rats Daryanto, Daryanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

The objective of this study is to provide an account of anatomically connections between the subfomical organ and limbic system, using an immunofluorescent study with single fluorescent labeling tracer DAPI (4-6-diamidino-2-phenylindol dihydrochloride), on seven adult albino rats of Wistar strain weighing between 250 - 350 g.The result of this study revealed that the subfomical organ, anatomically connected to the limbic system.Key Words: subfomical organ - limbic system - DAPI - albino rat - inunUnofluorescent
Filariasis caused by nonperiodic form of Brugia malayi among school children in the settlement of Dayak indigenous people and transmigrants in East Kalimantan FA Sudjadi, FA Sudjadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 01 (1999)
Publisher : Universitas Gadjah Mada

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Abstract

Background: New filarial worm subspecies, i.e. nonperiodic form of Brugia malayi Lichtenstein, was recently reported from East Kalimantan in addition to the previously known subperiodic and periodic form of the species, which was endemic in some rural areas in Indonesia.Objectives: (1) To search new endemic areas of filariasis in the indigenous people and newcomers. (2) To know current status of the disease among schoolchildren in the study areas.Subjects: Schoolchildren in the settlement of Dayak indigenous people (Krayan and Kayungo villages) and transmigrants (Petung UPT: Girimukti and Petung villages), belonging to Long Ikis and Penajam subdistricts, the district of Pasir.Methods: Based on the microfilarial character of aperiodic, blood examinations by simple or concentration method on schoolchidren were carried out at day time within school hours in 1987/1988.Results: (1) Endemic areas of the B. malayi subspecies were discovered, not only in the villages where the schools were situated, but their vicinities as well, i.e. the school childrens home villages. The other schoolchildrens home villages found as endemic areas were Jemparing, Nipaulo, Olung, Sepingan around the Dayak settlements and Lawe-lawe, Tanjung Jumlai, Salakloang, Tunan around the UPT of Petung. (2) Higher microfilaremia rates were found in schools in Krayan (26,0% or 52/200 children) and Kayungo (14,8% or 16/108 children). In the transmigrant settlement, although the concentration methods of examinations were adopted, lower microfilaremia rates were recorded such in schools in the villages of Girimukti (6,9% or 34/490 children) and Petung (3,5% or 33/950 children).Conclusions: Day-time blood survey at school was proved to be a simple method to discover endemic areas of the nonperiodic form of B. malayi in East Kalimantan.Key words: B.ma/ayi - nonperiodic form - daytime examinations - school children
Improving the use of antibiotics in primary health centres through a problem-based pharmacotherapy training approach Iwan Dwiprahasto, Iwan Dwiprahasto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 3 (2003)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Inappropriate use of antibiotics in the treatment of common diseases such as acute respiratory infection (ARI) and diarrhoea has been the major health problems in primary health centres (PHCs). Beside increasing the risk of adverse event, excessive use of antibiotics has also led to bacterial resistance worldwide.Objective: To improve the quality of prescribing of Primary Health Centers (PHCs) physicians and paramedics particularly in the treatment of ARI and diarrhoea.Design: Prospective intervention study with control group involving 113 PHCs physicians in both arms. Thirteen districts were randomly selected for study area, in which intervention was carried out in 8 districts while 5 other districts as control group. A systematic problem-based approach of 3 days training were carried out in the intervention group using 3 sets of modules, followed by self monitoring & regular visit & feedback by a Training Team. Evaluation on prescribing was carried out 3 times, i.e at the 6th , 12th, &18th month after intervention.Results: More than 17 thousands and 8600 prescriptions for ARI and diarrhoea were collected during the study. There was a significant reduction in the use of antibiotics for ARI in the intervention group from 92.3 before the study, to 67.4, 52.8 and 39.5%, 6, 12, & 18 month after the study (p0.05). There has been significant antibiotics prescribing shift toward more rational choice in the intervention group 18 months after the study.Conclusions: A systematic problem-based pharmacotherapy training followed by self monitoring & regular visit & feedback significantly improved antibiotic prescribing for ARI and diarrhoea.Key words: antibiotics - prescribing - problem-based pharmacotherapy training - acute respiratory infection - diarrhoea
Seroimmunologicaf aspect of TORCH infection in infer le woman Budi Mulyono, Budi Mulyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 01 (1998)
Publisher : Universitas Gadjah Mada

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Abstract

Infertility is a problem among child bearing age couples. TORCH infection as one of causative factors infertility must be investigated of its role. The objective of this study is to compare TORCH antibodies seropositivity of infertile cases to pregnant women. Sera from 67 infertile women and 21 pregnant women were used for the study. The results are as follows: the mean of IgG anti-CMV and IgG anti-HSV2 titre of Infertile group are significantly higher than titre of pregnant group. The individual who has been exposed to HSV-2 will have a higher risk to Infertility than who has not. Coincidence infections of TORCH are similar between two groups. It can be concluded that problems of TORCH in infertility must be inferred to any other related factors.Key Word: TORCH - infertility - seroimmunological test - IgG anti-CMV - IgG anti-HSV2

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