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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 50   51   52   53   54 
Influence of Norplant on T3, T4 and TSH concentration in acceptor in endemic goiter area Zainal Arifin Nang Agus, Zainal Arifin Nang Agus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 03 (1995)
Publisher : Universitas Gadjah Mada

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Abstract

Norplant contains a potent progesteron, namely levonorgestrel. It induces iodine excretion in urine and simultaneously stimulates the thyroid function.The objectives of this study were to examine the T3, T4 and TSH concentration of the Norplant acceptors for 3 months. The subjects were 8 acceptors of Norplant taken from an endemic goiter area in Cangkringan, Sleman, Yogyakarta.The results of this study showed that T3, T4 and TSH were in normal range but they were in the low level. Three months after using Norplant, T3 and T4 level increased, but they are not significant (p>0,05). On the other hand, T4 level decreased significantly (p<0,05). Based on those data, there is an early stage of hipothyroid. It is strongly suggested that it would be much better if similar study could be conducted in longer time period.Key words: Norplant - T3, T4 and TSH - endemic goiter - hypothyroidism
Tinjauan Aspek Metabolik Vitamin A Zainal Arifin Nang Agus, Zainal Arifin Nang Agus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 17, No 02 (1985)
Publisher : Universitas Gadjah Mada

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Abstract

Vitamin A deficiency canoccur not only from inadequate intake but also because of poor in testinal absorption or inadequate conversion of provitamin A, as occurs in diseases of the liver or malnutrition. It has recently been reported that Zinc, Vitamin E and Vitamin C are necessary to-maintain normal concentrations of vitamin A in the plasma. Hypervitaminosis A may occur as a consequence of the administration of large doses of vitamin A concentrates. Vitamin A toxicity causes increases in levels of lipids, glycogen and citrate in the liver. As important therapeutic for vitamin A deficiency, supplementations of protein, lipid, Zinc, Vitamin E and vitamin C increase the efficacy of vitamin A therapy. Key Words: vitamin A deficiency - malnutrition - xerophthalmia - carotene - hypervitaminosis
The Role of Lipids in Atherogenesis Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Universitas Gadjah Mada

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Abstract

Hiperkolesterolemia, hipertensi, diabetes dan merokok telah lama diakui sebagai faktor risiko utama penyakit jantung koroner. Komponen utama bercak aterosklerotik adalah timbunan lipid, terutama ester kolesterol dan kolesterol, proliferasi dan perubahan sel otot polos intima arteri. Timbunan lipid dalam intima arteri terutama berasal dari low-density lipoprotein (LDL) yang telah termodifikasi dalam darah. Hal ini terjadi sebelum proliferasi otot polos intima timbul. Walaupun hubungan kausal antara hiperkolesterolemia dan penyakit jantung koroner sudah lama diterima para pakar, namun mengenai peran trigliserida dan jenis lipoprotein lainnya (high density lipoprotein, HDL) masih belum didapatkan kesepakatan. Dalam makalah ini dibahas pecan lipid dalam proses aterogenesis.Disimpulkan bahwa kelainan lipid yang berupa peninggian kolesterol (dan LDL) dan trigliserida (VLDL, terutama VLDL-sisa), dan.penurunan HDL merupakan faktor risiko bebas aterogenesis. Faktor hormonal ikut berperan dalam proses aterogenesis, dan diduga melalui efek hormon terhadap metabolisme lipid.Key Words : atherosclerosis - lipid - lipoprotein - apolipoprotein - coronary heart disease
Toksoplasmosis pada Wanita Hamil Risanto Siswosudarmo, Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 03 (1989)
Publisher : Universitas Gadjah Mada

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Abstract

A literature review of toxoplasmosis in pregnant women has been carried out. The airn..of this review is.to recognize the epidemiology, pathogenesis, mode of transmission, clinical manifestation, diagnosis and mariagernent. Toxoplasrnosis is a parasitic disease catiiedby ToxoplasinO gondii. Two groups of people being higly VuLnerable to the disease are the deieloping fetus and thoseWhO are inimtmodeficient. In humans, prevalence of positive serologic test titers increases with age. There are considerable differences in prevalence rate between, countries.. The prevalence rate of positive serologic test among pregnant women varies between 15% to 96% depending on the geographic area and age group, while the incidence of congenital toxoplasmosis varies from one to seven per 1000 live births.Toxoplasma invade every organ in the body; but the most vulnerable organ or tissue are those where access to circulating antibody is.impeded (e.g., brain and retina). The barrier to passive diffusiOn Of antibodies into brain and eye has been given as an explanatiOn of the continued proliferation of theparasite on theie sites at the same time that his disappearing from eirtraneural sites, giving rise to latent infection. The developing fetus is usually infected transplacentally. The risk of fetal infection is related to the time when maternal infection occurs. if Toxoplasma infection is acquired late in pregnancy, the protozoa are most frequently transmitted to the fetus but the infection is subclinical in the newborn. If, however, the mother is infected early in pregnancy (for example-during the third month) transmission to the fetus occurs less often but frequently results in severe disease to the new born. There is no clinical signs and symptoms pathognomonic for the disease in pregnant women. In the infant, there is usually a clinical triad — hydrocephalus, chorioretinitis and intracranial calcifications. However, definitive diagnosis of Toxoplasma infection is established by isolation of Toxoplasma gondii from blood or body fluid.,deniostration of cyst in the placenta or tissues or by serologic tests. Sulfonamides, pyrimethamine and spiramycine are drugs considered tole effective in killing the organism. Seronegative pregnant women is .the group of people in which avoidance of infectionKey Words: Toxoplasma gondii --pregnancy --congenital toxoplasmosis serologic test -- pyrimethamine
Allometrical correlation of biacromial and bicristal breadth to height growth in 7-15 years old children in Bantul Regency Yogyakarta Province Janatin Hastuti, Janatin Hastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Changes in body measurements during growth period cause change in their proportion, and this relationship can be measured using allometrical method. Growth of biacromial and bicristal in children are specific, because they can indicate the sexual dimorfism between boys and girls. Objective: The aims of this studi are to know the relationship between growth of biacromial and bicristal breadth to growth of height in 7-15 years old boys and girls in Bantul Regency, Yogyakarta Province. Methods: Investigation was conducted in 284 children of 7 up to 15 years old which consist of 136 boys and 148 girls. The samples were divided into 9 groups and were measured on height, biacromial and bicristal breadth. The datas were analysed using allometrical method expressed by an exponential regression equation. Student-t analysis was use to determine the difference of each measurement between boys and girls at the same age.Result: The result showed that biacromial breadth grew faster proportionally to height in 7 up to 11 and 13 up to 15 year old boys, and on the 7, 8, and 10 up to 15 years old girls. Bicristal breadth grew faster proportionally to height for all groups of age. Biacromial breadth grew faster proportionally to bicristal breadth th 8 up to 9 and 13 up to 15 year old boys and 7 year old girls. Girls of 8 up to 15 years old grew slower on biacromial breadth compared to bicristal growth.Conclusions: The conclusion was biacromial and bicristal breadth grew faster proportionally to height of boys and girls for almost all of age. Biacromial breadh of boys grew faster than bicristal breadth. In contrast, biacromial breadth of girls in the same age grew slower than bicristal breadth.Key words: growth-stature-biacromial breadth-bicristal breadth-allometrical method
Observations on The Life Cycle of An Eimeria SP.Of Chikens In Peninsular Malaysia Budihardjo, Budihardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 04 (1975)
Publisher : Universitas Gadjah Mada

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Abstract

The life cycle of an unidentified Eimeria sp. from domestic chickens in Malaysia was studied. Sporulation of oocysts was completed in 34 hours at room temperature (30° C). Oocysts are ellipsoidal to ovoid averaging 21 by 18 millimicron with a yellowish double waIl. There is a polar granule. Sporocystsare elongated and ovoid averaging 11 by 6 millimicron in size with a Stieda .body and containing a sporocysts residuum.First generation schizonts develop throughout the intestine, mainly in the crypt of Lieberktihn but also in the muscularis muscosae, lamina propria and epithelial cells above the host nucleus. About 1.4 morozoites are produced.Second generations also develop throughout the intestine, mainly in the lamina propria, below the host nucleus. About 12 morozoites are produced.Gametoytes are most numerous in the mid-intestine, large intestine and cecum and are mainly in the lamina propria.Pathogenicity was mild. Diarrhea and mucoid edema were the only clinical signs observed and the infection was self-limiting, ending after about 20 days.
Antifilarial Activity of Diethylcarbamazine in Brugia Pahangi Aedes Togoi Model Infection Sugeng Juwono Mardihusodo, Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 01 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Sejak tahun 1947 dietilkarbamasin (DEC) diketahui khasiatnya sebagai antifilarial. Penelitian lanjutannya :ebih banyak mengarah kepada khasiatnya sebagai mikrofilarisida dan makrofilarisida pada Venebrata. Kejelasan aktivitas DEC terhadap stadia perkembangan cacing filaria dalam nyamuk Vektomya sangat sedikit diketahui, yang sebenamya juga penting untuk mengungkap makna obat itu dalam pengendalian penularan filariasis. Penelitian ini bedujuan untuk mengungkap lebih rind tentang daya DEC sebagai filarisida pada nyamuk Acdcs togoi yang diinfeksi dengan Brttgia pahangi.Penelitian dilaksanakan dengan memberikan pakan secara langsung kepada Ae. togoi yang dikolonisasi dengan larutan DEC dalam air sukrose 10% dengan konsentrasi 200, 100, 50 dan 0 mg%. Angka modalitas (AM), angka infeksi (Al), angka infektif (Alm), jurnlah larva per nyamuk terinfeksi (JUN), jumlah larva infektif per nyamuk terinfeksi (JL1PN), perlyebaran larva B. pahangi dalam tubuh nyamuk, dan ukuran (panjang badan) larvae, setelah nyamuk Ae. togoi dikolonisasi selama 12 hari setelah pemberian pakan darah infeks dan kucing yang terinfeksi B. pahangi, di tetapkan.Pedambahan AM nyamuk Ae. togoi yang tanpa maupun dengan infeksi B. pahangi tidak bermakna, dan tidak bergantung kepada konsentrasi DEC, menunjukkan bahwa DEC tidak bersifat insektisidal. Perbedaan di antara AM nyamuk tanpa dan dengan infeksi filarial diduga karena daya merusak filaria parasit selama perkembangan dan migrasi dalam tubuh nyamuk.Al dan Aln nyata menurun pada had ke 12. Larva H (U) B. palzangi masih ditemukan dalam tubuh Ae. togoi yang diberi pakan larutan DEC selama 12 hari; hal ini mengesankan bahwa DEC menghambat perkembangan sebagian larvae B. pahangi. Selama 12 hari persentase larvae B. pahattgi di bagian kepala nyamuk Ae. togoi nyata lebih rendah daripada yang pada nyamuk pembanding; hal ini menunjukkan hahwa DEC juga menghambat migrasi sebagian larvae filaria. Disimpulkan hahwa DEC nyata berIchasiat parsial sebagai anti filarial pada infeksi model B. pahangi - Ae. togoi.Key Words: diethylkarbamazine B. pahangi Ae. togoi insecticidal effect inhibitory effect
The ethics of scientific research T. Jacob, T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 04 (1981)
Publisher : Universitas Gadjah Mada

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Abstract

Considering the importance of scientific ethics in research, especially if it involves human experimentation, the author discUsses various ethical points in conducting research from the preparation of research until the publication of its results. Emphases are placed upon responsibility CO the source of information, colleagues, research material, both human and animal, and humanity at large; scientific objectivity; and intellectual honesty.The need for research ethics cannot be overemphasized since deviation from the ethical principles are currently occurring even in the scientifically most advanced countries, due to, among others, the publish or perish" principle, pressure from funding agencies and research institutions, professional rivalries between individuals or institutions, and fights for priorities of discoveries and inventions.In the less developed countries the deviations are more elementary, but with the increasing quantity of research, complex problems are making their debut.Key Words: scientific ethics - human experimentation - informed consent - research review board - scientific objectivity
Early defection of thyroid function disturbance on Norplant acceptor in goiter endemic area Zainal Arifin Nang Agus, Zainal Arifin Nang Agus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 04 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

In the surrroundings of mountainous area, many people are suffering from goiter due to low iodine contents in their diet. This study was aimed at examining T3, T4 and TSH concentration of the Norplant and IUD acceptors for 6 months. The acceptors were from an endemic goiter area in Cangkringan, Sleman, Yogyakarta. The results of this study showed that T3, T4 and TSH were in the normal range but relatively low level. Six months after using Norplant comparing with that using IUD, the T3 concentration decreased, while T4 and TSH concentration increased, but they were not significant (p>0,05). Based on those data, there was an evidence that after 6 months of using Norplant, the thyroid gland was hyperactive to produce tyroxine. After a long time period it would be a hyperplasia and hypertrophy of thyroid. Similar, further studies for a longer time are needed.Key words: Norplant - T3 - T4 - TSH - endemic goiter
Penetapan Kadar Protein Total Serum Secara Refraktometrik Pramono Sidhi, Pramono Sidhi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 02 (1974)
Publisher : Universitas Gadjah Mada

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Abstract

Keyword : Kadar Protein Total Serum

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