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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 62   63   64   65   66 
The efficacy of artemether and primaquin versus chloroquine-primaquine on uncomplicated malaria: A study on children in Kokap, Samigaluh area, and Oirimulyo Puskesmas, Kulon Progo Margareta Yuliani, Margareta Yuliani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 01 (2005)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Malaria is one of infectious diseases influencing mortality of newborns, infants, and delivering mothers, Chloroquine is a standard anti-malaria or fist-line antimalarial drug for treatment and chemoprophylaxis of susceptible uncomplicated malaria in Indonesia. Increased resistance toward standard medications turns out to be one of difficulties in malaria prevention, especially in endemic areas. To solve the problem, a new antimalaria drugs i.e. artemether is now under extensive studies. Objective: To know the efficacy of artemether-primaquine therapy compared to chloroquine-primaquine therapy in children with uncomplicated malaria.Methods: Sixty-three children were enrolled in this study through active case detection (ACD) and passive case detection (PCD) from April to July 2004 in Kokap, Samigaluh and Girimulyo Puskesmas, Kulon Progo; they fulfilled inclusion criteria of uncomplicated malaria, were willing to participate in 28-day study by signing informed consent form. Subjects were randomly divided into two groups of treatment. Clinical and parasitological observation were done on DO, D1, D2, D3, D7, D14, D21, D28. WHO (2003) therapeutic response criteria was used to evaluate the therapeutic efficacy. The result of academic clinical and parasitological response (ACPR) was compared to treatment failure (early treatment failure/ ETF and late treatment failure/LTF). Statistical analysis was done using Pearson X2.Results: Final results revealed that artemether-primaquine group showed ACPR and failed therapy of 30/ 32 (93.8%) and 2/32 (6.3%) respectively, while chloroquine-primaquine group 22/31 (71%) and 9/31 (92%) respectively. These results were statistically significant (p<0.05). The average rate of fever clearance time (FCT) and parasite clearance time (PCT) in artemether-primaquine group were 24.63 t 8.65 hours and 32.61 t 13.1 hours, respectively, while in chloroquine-primaquine group were 42 ± 8.65 hours and 32.61 t 18.9 hours, respectively. Nausea and abdominal pain as side effects of both therapy occurred in 18.8% and diarrhea in 6.3% of subjects, they recovered with no treatment. In chloroquine-primaquine group nausea or vomiting were found in 22.6% of subjects; in addition abdominal pain, headache, blurred vision and itching in 12.9%, 32.3%, 6.5%, and 3.2% respectively.Conclusion: Artemether-primaquine showed better therapeutic efficacy (92,8%) compared to chloro- quine-primaquine (71%) on children with uncomplicated malaria. Key words: artemether-primaquine - chloroquine-primaquine - uncomplicated malaria - therapeutic response side effects 
RESOCIALIZING EFFECT OF PIMOZIDE ON CHRONIC INSTITUTIONALIZED SCHIZOPHRENIC PATIENTS Soebagyo Hadinoto, Soebagyo Hadinoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 8, No 02 (1976)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A clinical trial of pimozide has been conducted, on 20 chronic institutionalized schizophrenic patients. using the "same subject design". The aim was to check the resocializing effect of pimozide such as reported in same papers.A psychotest was constructed to obtain quantitative data concerning obedience and cooperativeness to do a task, work and work capacity. The quantitative data obtained were supplemented with the data observed qualitatively by the experimenting team.The effect of pimozide appeared to be positive and significant with minimal side effect
Biopsi hepar pada penderita malnutrition Preliminary report Tonny Sadjimin, Tonny Sadjimin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 5, No 03 (1973)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

keywords: biopsi, malnutrisi, hepar, tractus digestivus
Experience with anterior resection for rectal cancer. One case with rapid local recurrence and one case with cancer regression after preoperative radiation Marijata, Marijata
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 02 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

During three years periode from August 1989 to August 1992 eight patients underwent anterior resection for rectal cancer, five patients in Sardjito Central General Hospital and three patients in Patmasuri Special Surgery Hospital. Five patients with high rectal cancer and three patients with middle rectal cancer underwent anterior and low anterior resection respectively. Intestinal obstruction due to local recurrence occured four months after operation in oae patient who underwent low anterior resection and cancer regression after preoperative radiation occured pathologically in one patient.Key W ords: high rectal cancer anterior resection middle rectal cancer low anterior resection cancer regression
Genetic counselling Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 02 (1983)
Publisher : Universitas Gadjah Mada

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Abstract

Genetic counselling is a relatively new medical activity. There.are some conditions that usually need genetic counselling.•The classification of genetic disorders, their mode of inheritance and the method of establishing the diagnosis must be well understood before giving the counselling. The mode of inheritance of genic disorders and some difficulties in the diagnosis need special attention. Chromosomic disorders and embryopathies have been shortly explained ,as well.Finally, a short explanation of prenatal diagnosis, carrier detection and some methods of treating genetics disorders have been proposed so that genetic counselling can be given effectively.Key Words: genetic counselling - genetic disorders - genic disorders - prenatal diagnosis - carrier detection.
Risk factors of neonatal mortality in Maternal Perinatal Installation Dr. Sardjito Hospital, Yogyakarta Tri Yanti, Tri Yanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 4 (2004)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Neonatal mortality rate in Indonesia is still relatively high. There are many factors influencing the outcome of neonatal life. Identifying the risk factors is important to prevent neonatal mortality. The intervention could be done by avoiding or minimizing the risk factors.Objective: To know the risk factors of neonatal mortality in Maternal Perinatal Installation, Dr. Sardjito Hospital Yogyakarta, and the contribution of these risk factors.Methods: One hundred and twenty three newborns in Maternal Perinatal Installation Dr Sardjito Hospital from 1 February 2003 to 28 February 2004 were enrolled in this study, consisting of 41 infants birth alive and all died during hospitalization, and 82 infants alive when discharged from the hospital as control. The data was taken from medical records. Cases were infants those died and control were infants alive when discharged from hospital, and then risk factors were identified.Result: The risk factors that significantly related to neonatal mortality in univariate analysis were sepsis (OR=4.26; 95%C1:1.9-9.4), prematurity (OR=3.26; 95%C1:1.5-7.2), low birth weight (OR =3.41; 95%C1:1.6-7.5), major congenital anomaly (OR =4.29; 95%C1:1.6-11.5), low Apgar score at 5 minute (OR 4.68; 95% CI:1.8-11.9) and hyalin membrane disease (OR =12.90; 95% C1:2.7-62.3). By multivariate analysis, in order of higher contribution, major congenital anomaly (OR =34.80; 95% C1:6.7-182.2), hyalin membran disease (OR =15.00; 95% C1:2.3-96.5), low Apgar score at 5 minute (OR=9.16; 95% C1:1.8-48.0), and sepsis (OR 6.04; 95% C1:1.9-18.9) were significantly related to neonatal mortality. Conclusion: Major congenital anomaly, hyalin membrane disease, sepsis neonatorum and low Apgar score at 5 minute were risk factors of neonatal mortality.Key words: neonatal mortality - sepsis neonatorum - low birth weight - major congenital anomaly - low Apgar score at 5 minute - hyalin membrane disease.
Streptococcal Infection A. Samik Wahab, A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 03 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Pharingitis karena Streptococcus punya hubungan erat dengan terjadinya glomerulonephritis dan demam rheumatik. Incidensnya bevariasi antara 0,3 - 3%. Di Indonesia incidens demam rheumatik masih tinggi, sehingga dengan demikian kita dapat mengambil kesimpulan bahwa inciderns infeksi streptococcus juga tinggi.dengan demikian kita dapat mengambil kesimpulan bahwa incidens infeksi streptococcus juga tinggi.Gejala klinis dari pharingitis karena steptococcus tidak khas, sehingga sukar untuk didifferensiasi dengan pharingitis karena virus. Ada tiga tingkatan gejala klinis, yalah berat, medium dan ringan, dan semuanya ini dapat merupakan pendahuluan dari demam rheumatik.Infeksi streptococcus yang berulang-ulang akan memberatkan kerusakan valvula pada kelainan jantung rheumatik, sehingga pada kelainan ini perlu dilakukan profilaksi. Tapi profilaksi ini tak perlu dikerjakan pada penderita glomerulonephritis, karena padanya infeksi ulang tak memberatkan.Bakteri streptococcus dapat diklasifikasikan sebagai berikut:a). Didasarkan pada sifat-sifat haemolisisnya pada agar darah kambing, maka bakteri ini diberi nama: alpha-, beta-, dan gamma-haernolisis.b). Didasarkan pada test serologis maka diberi nama grup A — Q (tanpa I dan J), sedang grup A sendiri dibagi jadi paling sedikit 45 tipe (subgrup).Strain group A dapat melepaskan sejumlah antigen extracellular.Pengobatan: Bila kita melakukan pengobatan awal dan cukup berarti kita mencegah terjadinya demam rheumatik dan kelainan jantung rheumatik. Obat-obat yang paling baik untuk infeksi ini yalah: penicilin, erythromycin dan Lincomycin. Sulfa tidak dapat digunakan sebagai pengobatan, karena resikonya lebih besar daripada kegunaanya. Tapi sulfa dapat digunakan sebagai profilaksi.
Insertion of Norplant by midwives and physicians: A comparative cohort study Risanto Siswosudarmo, Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 04 (1991)
Publisher : Universitas Gadjah Mada

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Abstract

A comparative cohort study on the insertion of Norplant by midwives and physicians had been carried out to compare its safety. A total of 500 acceptors participated in the study, 292 of which belonged to the midwive group and 202 to the physician group. They came from suburban areas surrounding the city of Yogyakarta. Although both groups were statistically differen tin terms of age and body weight, they were no t so clinically. Norplantwas delivered outside the hospital during the mass campaign (safari susuk), but standardized hospital asepsis was taken. Follow-up was done one week thereafter to detect the presence of complications or side-effects, such as pain, inflammation, abscess and sense of itching. t-test, chi-square test and relative risk were statistical analyses used in the study.Results showed that midwives inserted Norplant more rapidly compared to physicians (2.36 vs 3.45 minutes respectively), although it did not have clinical importance. 23.6% of cases among the in idwive group showed a variety of complications while that of the physician group was 19.7%, the relative risk being 1.20 (0.82-1.75). More detailed complications such as pain, inflammation, abscess and itching did not show significant difference. The risk of complication in all cases was influenced neither by the. duration of insertion nor by the level of education.The study concluded that midwives could insert Norplant as safe as physicians.Key Words: norplant-midwive-contraception-obstetrics-family planning
Penelitian Kasus Trachoma pada Murid Sekolah Dasar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 12, No 03 (1980)
Publisher : Universitas Gadjah Mada

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Abstract

Trachoma is a specific communicable keratoconjunctivitis, usually of chronic evolution caused by an agent belonging to the psittacosis - lymphogranuloma - trachoma group of atypical viruses and characterized by follicles, papillary hyperplasia, pannus, and in its later stages, by cicatrizadon". it is a well known eye disease in Indonesia, since many districts have their specific names for trachoma. The progress of trachoma depends on sociohygienic condition in the environment. The progress of trachoma in an area is indicated by its frequency in the area.An investigation of the disease among pupils will give a lower frequency than in the community, but it is valid as a parameter of the progress of the disease.Key Words: communicable disease - trachoma eradication - school health units - keratoconjunctivitis - trachoma
Clinical features of outpatients with allergic rhinitis at E.N.T. department, Faculty of Medicine, Gadjah Mada University/Dr. Dardjito General Hospital Yogyakarta Supomo Sukardono, Supomo Sukardono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 01 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

Clinical study was conducted on allergic rhinitls in ENT Department, DR. Sardjito Hospital for one year. The study included incidence, clinical symptoms, other test, and other treatment. The treatment having been conducted included allergen, desensitization and symptomatic therapy. Symptomatic therapy and allergen avoidance were the most often done

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