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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 93   94   95   96   97 
The state of body iron in women anemic patients at Dr. Sardjito General Hospital Setyawati Setyawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Disorders resulting from body iron overload (hemosiderosis in reticgoendothelial cells or accumulation within parenchymal cells of the liver, heart and other organs) may octal- in patients who have undergone frequent blood transfusions or under other excessive iron therapy to treat the anemia. Therefore, every iron preparation especially by repeated parenteral route or blood transfusions must be accompanied by monitoring of body iron status.In the present study the most useful indirect measurement of ,body iron status, included serum ferritin (SF), serum iron (SI), total iron binding capacity (TIBC), transferin saturation (TS) and the erythrocyte, were studied in 34 women anemic patients at the Dr. Sardjito General Hospital.The results of the study are as follows: among 30 subjects with anemia caused by other than iron deficiency, included chronic renal diseases, inflammation or infection, hematologic and other organ malignancy, idiopathic thrombocytopenic purpura, the mean of SF level increased to 210,85ng/ml; but SI level (66,941g/d1) and TIBC (271, 07/µg/dl) showed no useful information about the state of iron stores, because its large biologic and analytic variability.In overall there was normal percentage of TS (25,58%), but among them 7 cases showed evidence of blood loss with TS less than normal, and erythrocyte indices within normal range.In 4 patients with uncomplicated iron deficiency anemia the mean of SF and 1'S were low (4,62ng/ml and 11,85% respectively), although SI only slightly decreased (38,7/tig/d1), and the TIBC was normal (340,3ffig/d1). The blood smears showed variation of size in the erythrocyte, with many smaller than normal and pale RBCs.It is concluded that ferritin serum measurement was the most sensitive and non invasive indicator for early stage of iron deficiency assessment. However, in fact no single indicator or, combination of indicators is ideal for the evaluation of body iron status in all clinical circumstances, because each indicator may be by other conditions such as infections, inflammations, liver, chronic, renal disease and malignancy.Key Words: anemia - serum ferritin - serum iron - total iron binding capacity - transferin saturation
Borderline, white coat and sustained hypertensia: A comparative study a normotensia in personnels of 18-42 year old at Dr. Sardjito General Hospital, Yogyakarta Suradi Suradi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A Study of Cross Sectional Survey on 350 subjects from 1216 non physician staffs aged 18-42 at Dr. Sardjito General Hospital was done. There were 51 persons with Borderline Hypertension (15%), consisted of 35 males (68,6%) and 16 females (31,4%), with self monitoring blood pressure at home. The subjects whose average home blood pressure Mean + 1SD and Mean + 2SD, having borderline hypertension had sustained hypertension (SH) and blood pressure while normotensive Mean + 1SD had White Coat Hypertension (WCH). This study found WCH in 25 subjects (49%) and SH 26 subjects (51%). Heart rate of WCH group (83,7-+-5,7) had no significant difference, compared to SH group (86,2 ± 4,1), but was more rapid than normotensive group (74,5 ± 3,6) (p<0.05). There were no significant difference of blood total cholesterol, HDL, LDL, triglyceride between WCH and SH group, but in blood total cholesterol, LDL, triglycerides, were significantly different was compared to normotensive group. A blood HDL of WCH and SH groups had a lower significant different compared to normotensive group (total cholesterol levels 222,4 ± 36,4 vs 217,6 ± 39,7 vs 194,6 ± 33,2), LDL cholesterol (158,2 ± 48,7 vs 156,2 ± 49,1 vs 144,8 ± 33,81, triglycerides (143,6 ± 86,2 vs 146,9 ± 80,2 vs 99,8 ± 51,1). Fasting blood glucose, Insulin and Insulin/glucose ratio in three groups had no significant differences. The conclusions are that total cholesterol, HDL, LDL and triglycerides, and heart rate from WCH group have no significant differences to SH group, but these two groups were significantly different to normotensive group. Fasting blood glucose, insulin, insulin/glucose ratio have no significant difference among the white coat, sustained, and normotensive groups. Key Words: borderline hipertension - white coat hypertension - sustained hypertension - blood chemistry
The effect of zinc supplementation on collagen of periodontitisrat Praptiwi, Siti Fatimah Muis Soeharyo Hadisaputro, Suryono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Zinc,cofactors of DNA-and RNA-polymerase, having great role in tissue heal-ing. In periodontitis, collagen type 1 the main fiberconstituting periodontal structure is des-troyed and be the main cause of lost of teeth among adult in Indonesia. Zndeficiency is still a nutritional problem. The aim of the study is to obtain the influence of 500 pg Zn supplementation (Zn,1and 200 pg (Zn2)per day for 7 days to periodontal collagen of Periodontitis (PI rat through histologic feature. Method: inthe experimental study with factorial design, 29 adult male Wistar rat were used. Subjects were grouped simple randomly into 6 i.e Healthy (H)at the start, Hatthe end, p, P+Te-tracycline IT), ,P + T+ Zn" and P+ T+ Zn2.Subject other than Hgroups were induced periodontitisby Porphyromonasgingivalisbacteria. Zn concentration was measured by AAS Flame, Periodontal tissue was stained with Mallory,s. T test and ANOVAwas used to analyse difference between mean of Znconcentration of groups studies. Result: There were similarity in the feature of groups H at the start, Hat the end, and P+ T+ Zn" in sense of regularity, length, and solidity of collagen. P group had irregular, and short collagen. Groups of P+ T with shorter collagen, had similarity to Health at the end. P+ T+ Zn2with shorter collagen similar to P+T+ Znl. There was significant difference inZn concentrat-ion between Hat the end and Pgroup. Nosignificant differencies among Zn concentrations of Psubject groups. Great variety of Zn concentration found among subjects of groups prob-ably were the cause of absence of difference, although means of the Zn concentration values depicted it. Conclusion: Zn supplementation dosage 500 pg/day given to periodontitis rat beside Tetra-cycline, gives better effect to collagen structure compared to 200 pg/day.
Cacat Mental Pada Penyakit Kromoson Hartono Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 17, No 03 (1985)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Genetic diseases are divided into genic diseases, chromosomic diseases and embryopa shies. There are 23 pairs of chromosomes in each human somatic cell. According to their shape and the location of their centromer, chromosomes are classified into 8 groups, namely group A, B, C, D. E. F and G. Chromosomic diseases are caused by either numerical or structural derangements of chromosomes. Chromosomic diseases cause metabolic disorders during conception until post-natal period. The degree of physical as well as mental disorders depend on the degree of lack or surplus of chromosomic materials. Chromosomic diseases may be lethal. i. e. they can cause spontaneous abortion as well as fetal and neonatal death. Some chromosomic diseases and their IQ scores will be presented here. Special attention will be given to trisomy 13, trisomy 18. trisomy 21, XXX syndrome and XYY syndrome. Key Words : mental defect - chromosomic disease - chromosome classification - IQ score - embryopathies -
Teknik dermatoglyphi Yang diterapkan dalam Kedokteran Adi Soekarto Adi Soekarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 03 (1978)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : Teknik dermatoglyphi
Diagnostic test of huffy coat smear with Gram staining at sepsis neonatorum. Christina Kastanti Nugrahani, Christina Kastanti Nugrahani,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 01 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Neonatal sepsis is known as a leading cause of neonatal morbidity and mortality. It is hard to diagnose clinically sepsis due to its nonspecific manifestations. Blood culture has been the gold standard for neonatal sepsis. Unfortunately, it takes time to get the result, it is costly, and it is not easily performed. Buffy coat smear with Gram stain in attempt to diagnose neonatal sepsis is less costly and easily performed.Objective: To know the diagnostic value of buffy coat smear with Gram staining to diagnose neonatal sepsis.Methods: This cross sectional study was carried out at the Maternal-Perinatal Installation of Dr. Sardjito Hospital, Yogyakarta, between October 131, 2003 to March 3111, 2004. The inclusion criteria was clini-cally sepsis neonates (0-28 days old). Neonates with blood disorder, congenital anomaly, or had got antibiotic previously were excluded from this study. The buffy coat smear with Gram staining was examined and than was blindly validated with blood culture.Result: There were 127 neonates enrolled in this study. Buffy coat smear with Gram stain to diagnose neonatal sepsis produced sensitivity 77% (95% Cl, 65-88), specificity 85% (95% Cl, 77-93), positive predictive value (PPV) 78% (95% Cl, 67-90), negative predictive value (NPV) 84% (95% Cl, 76-92), positive likelihood ratio 5,24 (95% Cl, 2,98-9,24), and negative likelihood ratio 0,3 (95% Cl, 0,16- 0,45).Conclusion: Buffy coat smear with Gram stain was sufficiently accurate as diagnostic test for neonatal sepsis. The diagnostic value of buffy coat is expected to be useful for clinicians to predict neonatal sepsis earlier and guide them in making decision for clinical management.Keywords: neonatal sepsis - diagnostic test - buffy coat - gram positive staining 
Usage of propranolol to attenuate catabolism process in burn victim : A case report Ishandono Dahlan Ishandono Dahlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Burn is still a common injury faced by the surgeons. The mortality is considerably high. One of the improvement in the mortality and outcome of the treatment over the last decades can be attributed to the modulation of the hypermetabolic response to trauma. It was reported by researchers in Shrinners Hospital that propranolol administration during the hospitalization attenuates the hypermetabolism and reverses muscle catabolism. Our case is a 16 year old male burn victim admitted to DR Sardjito Hospital, after 24 hour hospitalization in a District Hospital. He was assessed as 40% grade II-III of electric injury. Fluid resuscitation with Baxter Formula and debridement of the wound were performed as the initial treatment. In the first 12 weeks of hospitalization the plasma protein was decreasing due to hypermetabolic response to the severe burn and the albumin concentration was never reach 2 g/L. That's why the plan to do skin grafting was postponed. It was decided then to apply the Shrinners Hospital protocol, i.e. propranolol administration, to make reversal effect of catabolism. After five weeks of oral propranolol administration the albumin concentration was increasing from 1.8 to 2.9 g/I, so that we could perform split thickness skin grafting procedure. Two weekks later about 95% of the skin graft donor were viable. We came to the conclusion that the administration of oral propranolol could attenuate catabolism process and directly increase the plasma albumin concentration.Keywords : burn - propranolol - hypermetabolism slowing effect - plasma albumin concentration
H-reflex amplitude depression as a marker of presynaptic inhibition in Painful Diabetic Neuropathy (PDN). Ahmad Asmedi; Samekto Wibowo; Lucas Meliala
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 01 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

ABSTRACTPainful Diabetic Neuropathy (PDN) is a common complication of diabetes mellitus (DM). Disruption in presynaptic inhibition in dorsal horn of the spinal cord has been proposed as one of the pathomechanism of PDN. Previous research showed that presynaptic inhibition can be detected by H-reflex examination. The aim of this study was to know whether the reduction of presynaptic inhibition in spinal dorsal horn of PDN patients really exist, and detectable by H-reflex examination. It was cohort prospective involving 141 (58 men, 83 women) patients with DM and impaired glucose tolerance (IGT) between the ages of 40 and 61 years from several health facilities in Yogyakarta. All patients underwent clinical, laboratory and electrodiagnostic examination. Demographic, clinical and electrodiagnostic data were collected and analyzed. By survival analysis there were 25 new cases of PDN (12.12% cumulative incidence). Using survival Kaplan Meier analysis, the significant hazard ratio for PDN were 12.81 for median motor nerve amplitude, 5.74 for median nerve distal latency, 3.71 for median sensory nerve amplitude, 6.33 for median sensory latency, 3.4 for tibial nerve amplitude, 3.48 for tibial nerve distal latency, 2.29 for sural nerve amplitude, 4.47 for sural nerve latency, 3.99 for H-reflex latency, 5.88 for H-reflex amplitude, and 17.83 for Diabetic Neuropathy (DN) status. Using hazard proportional cox analysis, only H amplitude and DN status (DNS score) were significantly correlated with PDN (p= 0.026; hazard ratio = 15.450; CI 95%= 1.39 – 171.62 for H amplitude and p= 0.030; hazard ratio = 10.766; CI 95%=1.26 – 92.09 for DN status). This study showed that depression of H-reflex amplitude was correlated with the occurrence of PDN. This result proves that there was presynaptic inhibition process in PDN that manifests as low H-reflex amplitude.
Transcatheter Arterial Embolization and Continuous Intraarterial Infusion Chemotherapy in Hepatoma Arif Faisal Arif Faisal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 03 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Terapi einbolisasi intraarterial melalui kateter (transcatheter arterial embolization) merupakan upaya terapi alternatif pada penderita hepatoma yang sudah tidal( dapat dilakukan terapi operasi (unresectable hepatoma). Kemajuan dalam bidang kemoterapi mendorong dilakukannya terapi kombinasi embolisasi. dengan infus intraarterial berkesinambungan (continuous inkaarterial infusion). Basil yang dicapai dengan metode di atas cukup efektif, cumulative survival rate 66,6% untuk 6 bulan dan 55,4% untuk 1 tahun.Efek samping terapi kombinasi lebih banyak, tetapi masih dalam Batas-Batas toleransi. Sebab kematian penderita hepatoma dalam penelitian ini terutarna gagal hati (hepatic failure).Key Words: chemotherapy - arterial embolization - hepatoma - hepatic failure - infusion chemotherapy
Biophysical vs hormonal assessment in the detection of fetal distress Sulchan Sofoewan Sulchan Sofoewan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 04 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Fetal monitoring was carried out in 63 high risk pregnancies at Dr. Sardjito Hospital. Cardiotocographic examination (CTG) was used to evaluate 20 patients, and biochemical fetoplacental test. Urinary estriol (E3) and serum hPL were used to evaluate 43 patients. There were patients with postterm, preeciampsia, eclampsia and prolonged labor. Diagnostic test to predict fetal distress was analyzed for both CTG and biochemical test. CTG had a sensitivity of 87.5%, specificity of 58.3%, and accuracy of 70%. Urinary estriol level had a sensitivity of 25%, specificity of 89.7% and accuracy of 83.7%. The sensitivity, specificity and accuracy of serum hPL level were 25%, 92.3%, and 86%, respectively. There was correlation between relative birth weight and serum hPL level (r-z 0,3363), relative birth weight and urinary estriol (r=0.3427).Biophysical assessment Is more favourable compared to hormonal measurement in the detection of fetal distress.Key words: biophysical - hormonal assessment - fetal distress

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