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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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Risk predictor for ma/aria in pregnancy and the role of chloroquine in /ow endemic area Iwan Dwiprahasto Iwan Dwiprahasto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Pregnant women in malaria-endemic areas are uniquely susceptible to infection with Plasmodium falciparum and this susceptibility is greatest during first pregnancies. Malaria causes serious complications in pregnant women, especially in those who have a low level of acquired immunity before pregnancy.Objective: to assess the risk predictors for malaria during pregnancy and the role of chloroquine in low endemic area of malaria in Jepara districtDesign: A longitudinal study of all pregnant mother was carried out in Batealit and Mayong I subdistricts of Jepara district between June 1997-August 1999. All pregnant women were screened for peripheral parasitaemia through active surveillance. Women who had parasitaemia were treated with chloroquine for 3 days. Blood smears were then examined on days 4, 7, 14 and 21 after completion of the chloroquine course. All women irrespective of the blood smear results at enrolment were followed up once every two weeks until delivery.Results: Among 3099 pregnant women enrolled in the study, only 58 women had malaria infection, giving an incidence rate of 1.9/100 pregnant women. In this study low income is a significant risk predictor for malaria (OR= 11.03; 95%Cl: 3.91-31.08). Women who had reported a history of malaria or history of taking antimalarial drugs 6 months before their last menstrual period (LMP) showed an increased risk of developing malaria during pregnancy (OR= 10.56; 95%Cl: 4.57-23.72 and OR = 10.90; 95%Cl: 4.4825.61) respectively. Among those infected by P.falciparum and P. vivax and treated with chloroquine, complete parasite clearance was found in day 7.Conclusions: This study shows that low income, history of malaria within 6 months before LMP and history of taking antimalarial drugs within 6 months before LMP are best predictor for malaria in pregnancy in low endemic area. This study also shows that chloroquine is still effective for treating malaria falciparum in pregnancy in Batealit and Mayong I subdistricts, JeparaKeyword: malaria - pregnancy - low endemic area - risk-predictor - chloroquine
Efficacy of corticosteroid in pulmonary and extrapulmonary tuberculosis Barmawi Hisyam Barmawi Hisyam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Tuberculosis is one of major health problems all over the world. The epidemiologic data shows an increase in its morbidity and mortality. Infection of tuberculosis involves almost every organ of the body, ie. respiratory organ, known as pulmonary tuberculosis and other organs, known as extrapulmonary tuberculosis. The World Health Organization (WHO) has recently published programme guidlines for the treatment of tuberculosis. In certain cases, especially extrapulmonary tuberculosis, a combination of anti-tuberculous drugs and corticosteroid is assumed to be useful.Key words : pulmonary tuberculosis - extrapulmonary tuberculosis - anti tuberculous drug - corticosteroid
Lingkungan masa depan Anonim Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Kata Kunci: Lingkungan
AccomodaUve esotropia combined-type. A case report Wasisdi Gunawan Wasisdi Gunawan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A 10 year old girl suffering from esotropia for distant vision since she was 4 years old has been reported. Distant correction of S+3 to S + 4 dioptries resulted in orthophoric eye whereas esotropia still developed during the close work. By adding S+3 dioptries for close work this esotropia disappeared. Until now the patient has been using bifocals with comfort. Accommodative esotropia is a type of esotropia accommodative factor. This condition can be caused by hypermetropic refractive anomaly alone so that it is called refractive accommodative esotropia. Consequently corrective measure of underlying refractive errors will correct the eye deviation. Meanwhile esotropia that manifests during the accommodation alone, such as In close work and not due to refractive error is called non refractive accommodative esotropia. This type of esotropla is due to a higher AC/A ratio. Accommodative esotropia combined type is a combination of these two types of esotropia mentioned above. In this type, esotropia still occurs in close work (accommodation) although its refractive anomaly has been corrected. In this case, addition of positive lens 2-3 dioptries for close work (near vision) will cure this accommodative esotropia. The patient needs a bifocals.Key words : accommodative esotropia - non accommodative esotropia - AC/A ratio - distant correction - addition for close work.
The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Agung Pranoto; Satiti Retno Pudjiati; Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.
Genetic heterogeneity of retinitis pigmentosa Hartono Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Genetic heterogeneity is a phenomenon in which a genetic disease can be transmitted by several modes of inheritance. The understanding of genetic heterogeneity is important in giving genetic counselling.The presence of genetic heterogeneity can be explained by the existence of:1.different mutant alleles at a single locus, and2.mutant alleles at different loci affecting the same enzyme or protein, or affecting different enzymes or proteins.To have an overall understanding of genetic heterogeneity, the heterogeneities of chronic hemolytic anemia caused by beta-globin abnormality, chronic hemolytic anemia due to thalassemias, and mucopolysaccharidoses have been chosen as examples.'The article is focused on the genetic heterogeneity of retinitis pigmentosa, a kind of retinal hereditary disease. The genetic heterogeneity of retinitis pigmentosa can be known by the facts thata.Retinitis pigmentosa can be either an isolated disease or a part of a certain syndrome.b.Retinitis pigmentosa as isolated disease can be genetic or non-genetic in nature.c. Retinitis pigmentosa as a genetic disease can be transmitted either by autosomal dominant, autosomal recessive, or X-linked recessive genes.The frequency of isolated hereditary retinitis pigmentosa varies between 30% to 50%. Clinically the dominant form is milder than the recessive form. Certain syndromes associated with retinitis pigmentosa which need to be mentioned are Usher syndrome, Laurence-Moon-Bardet-Biedl syndrome, and Kearn-Sayre syndrome.Key Words: genetic heterogeneity - retinitis pigmentosa - genetic disease - hemolytic anemia - Usher syndrome
PENGGUNAAN E.M.G DAN ASPEK-ASPEK DIAGNOSTIKNYA Boedi Sarojo Boedi Sarojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 8, No 03 (1976)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Elektromiograti telah dikernbangkan penggunaannya di klinik oleh Wed-del et al. tahun 1943, Solandt tahun 1945, Bousden tahun 1954, dan ahli•ahli lain dari berbagai negaraDengan penggunaan E.M.G. kita akan dapat:a. Membuat diagnose banding macam-macam penyakit L.M.N.b. Membuat diagnose topik pada penyakit L.M.N.c. Prognosa lesi saraf perifir setelah periode pengobatan.d. Sebagai indikator prognostik pada kasus-kasus dengan lesi saraf perifir. e. Merekam dan menganalisa terhadap spasmus, tremor, gerak involunter lain-lain.I. Membuat diagnose dini pada myasthenia gravis, atropi muskular, distropi. SF EMG (Single Fibre Electromyography) adalah bentuk E.M.G. yang dapat merekam sate serabut saraf, sehingga dapat dipakai untuk mengadakan penyelidikan pada polyneuropathia yang timbal karena berbagai sebab Kemudian secara singkat dikupas arti E.M.G., teknik penggunaannya, penggunaan di klinik dan interpretasinya
Hubungan antara bay! beret lahlr rendah den gangguan perkembangan bicara di Poliklinik Tumbuh Kembang Anak RS. Dr. Sardjito Yogyakarta Desi Kamadewi Desi Kamadewi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 3 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Latar Belakang: Perkembangan merupakan periode penting dalam kehidupan seorang anak, khususnya pada masa anak berusia di bawah lima tahun. Beberapa faktor dapat menjadi risiko terjadinya gangguan perkembangan, di antaranya bayi berat lahir rendah (BBLR). Seiring dengan makin pesatnya kemajuan di bidang perawatan neonatal, maka angka harapan hidup BBLR meningkat secara bermakna. Di sisi lain kondisi ini menimbulkan kekhawatiran karena BBLR mempunyai risiko tinggi mengalami gangguan perkembangan, di antaranya gangguan perkembangan bicara.Tujuan: Untuk mengetahui hubungan antara bayi berat lahir rendah dan gangguan perkembangan bicara, mengetahui apakah BBLR memiliki risiko yang lebih tinggi untuk terjadinya gangguan perkembangan bicara dibandingkan BBLC, serta mengetahui hubungan antara jenis kelamin dan terjadinya gangguan perkembangan bicara pada BBLR.Desain Penelitian: Kohort retrospektif.Bahan dan Cara: Subyek penelitian adalah anak-anak berusia kurang atau sama dengan 6 tahun yang memiliki riwayat berat lahir rendah dan telah dilakukan Denver Developmental Screening Test (DDST) di Poliklinik Tumbuh Kembang Anak RS Dr. Sardjito Yogyakarta selama tahun 2000-2002. Data lengkap diperoleh dari rekam medik di bagian catatan medik RS.Dr. Sardjito Yogyakarta.Hasil: Tiga ratus bayi diikutsertakan dalam penelitian (150 BBLR sebagaikelompok yang diteliti dan 150 BBLC sebagai kontrol). Tidak terdapat perbedaan yang bermakna antara BBLR dan kelompok kontrol dalam hal gangguan perkembangan bicara nilai RR 1,07 (IK 95% 0,94-1,22), demikian pula antar jenis kelamin dalam hal gangguan perkembangan bicara tidak berbeda bermakna pada kelompok BBLR ( RR 1,07; IK 95% 0,90-1,27).Simpulan: Tidak terdapat perbedaan yang bermakna antara BBLR dan BBLC dalam hal gangguan perkembangan bicara. Tidak terdapat perbedaan yang bermakna antara jenis kelamin laki-laki dan perempuan dalam hal gangguan perkembangan bicara pada BBLR.
Glaucoma early finding and prognosis Mu'tasimbillah Ghozi Mu'tasimbillah Ghozi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 03 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Glaucoma is a unity of complex eye disorders with abnormal intraocular pressure that is enough to cause increasing cupping-ratio and visual field defect. Blindness due glaucoma is irreversible. The progress of early glaucoma can be prevented by controlling intraocular pressure at normal range using either medicament or alternative treatment i.e. massage onto the eyeball to increase the outflow facility through the trabeculum meshwork. Therefore, early diagnosis is very important and professional examination is essential. A case of an early glaucoma is reported. Treatment with asetazolamide and thymolol maleate eye drop, continued with massage onto the eyeball, had been successfull to decrease and control the intraocular pressure at normal range. Pain was disappearing and visual field defect returned to normal. Futher follow up is needed.Key words: Glaucoma - early diagnosis - controlling intra occular pressure - massage onto eyeball
The therapeutic effect of citrus aurantifolia swingle in idiopathic hypocitraturic calcium nephrolithiasis Mochammad Sja’bani, Mohammad Ismadi, Siti Dawiesah Ismiati, Raja Pingkir Sidabutar, Djoko Rahardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 04 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Hypocitraturia is one of the main risks of stone appearance or renal stone recurrence that iseasily interfered. A sphere citrus fruit (Citrus aurantifolia Swingle) was reported to contain the highestcitrate compared to other citrus fruits.Aims: We aimed to determine the effect of Citrus aurantifolia Swingle on the management of hypocitraturia,compared with potassium citrate.Materials and Methods: Seventy two patients with idiopathic calcium renal stone with hypocitraturia wererandomly divided into two groups, therapy and placebo groups. The first group was given potassium citratetreatment (2x20 mEq/day), while the second one was given 2x1.5-g pure lactose. After 6 months,patients without stomachache complaints were given 40ml citrus juice diluted in 2 glasses of water, takenimmediately after dinner for 10 days. Observation was done on risk factors in urine collected for 8, 16 and24-hours, including volume, pH, potassium, magnesium, oxalate, citrate, calcium, sodium, phosphate,sulphate, uric acid, ureum and creatinine. The setting of this study was 1 hospital in Yogyakarta and 2hospitals in Jakarta.Results: The increase of urine volume, pH, level and total citrate value, level and total potassium, and thedecrease of calcium ratio to citrate urine. The changes of those metabolite levels could lessen the chanceof colic and hematuria complaints, as seen after 6 months administation of potassium citrate. Similarresults were obtained from the administration of citrus juice, except for calcium level, which was notdecreased.Conclusion: The administration of potassium citrate 2x20mEq/day in 6 months improved patient’s complaintsand occurrence of renal colic, while consumption of Citrus aurantifolia Swingle in idiopathic calcium renalstone with hypocitraturia was concluded to increase the urine volume, pH level and total citrate value,level and total potassium, and the decrease of calcium ratio to urine citrate.Key word: renal stone- hypocitraturia- Citrus aurantifolia Swingle

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