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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 906 Documents
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High-Flow Nasal Cannula Oxygenation pada Pasien Lanjut Usia dengan Kegagalan Pernafasan Akut Terkait SARS-CoV-2: High-Flow Nasal Cannula Oxygenation in Older Patients with SARS-CoV-2-Related Acute Respiratory Failure Faris Putra Haryanto; Khadafi Indrawan; Ari Wahyuni
Medula Vol 11 No 2 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i2.313

Abstract

Currently, In this World, many cases about comparing the mortality and comfort associated with method of high-flow nasal cannula oxygenation (HFNCO) and high-concentration mask (HCM) in older SARS-CoV-2 infected patients done hospitalized in non-intensive care units. In this retrospective cohort study, author included all consecutive patients aged 75 years and older who were hospitalized for acute respiratory failure in either an acute geriatric unit or an acute pulmonary care unit, and tested positive for SARS-CoV-2. This journal compared the in-hospital prognosis between patients treated with HFNCO and patients treated with HCM. To determinate another bias factor, this journal created a propensity score for HFNCO. From March 2020 to January 2021, 67 patients (median age 87 years, 41 men) were hospitalized with SARS-CoV-2-related akut respiratory failure, of whom 41 (61%) received HFNCO and 26 (39%) did not. Age and comorbidities did not significantly differ in the two groups, whereas clinical presentation was more severe in the HFNCO group (NEW2 score: 8 (5–11) vs. 7 (5–8), p = 0.02, and Sp02/Fi02: 88 (98–120) vs. 117 (114–148), p = 0.03). Seven (17%) vs. two (5%) patients survived at 30 days in the HFNCO and HCM group, respectively. Overall, HFNCO was significantly associated with greater survival (adjusted hazard ratio (AHR) 0.57, 95% CI 0.33–0.99; p = 0.04). HFNCO use was associated with a lower need for morphine (AHR 0.39, 95% CI 0.21–0.71; p = 0.005), but not for midazolam (AHR 0.66, 95% CI 0.37–1.19; p = 0.17). In conclusion, HFNCO use in non-intensive care units may reduce mortality and discomfort in older inpatients with SARS-CoV-2-related akut respiratory failure.  
A Tumor Ampulla Vater pada Pasien Dewasa Muda Aleya Yostha Kaban; Risal Wintoko; Anggi Setiorini
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.315

Abstract

Ampullary tumors are known as tumors that grow at the end of the common bile duct that passes through the duodenal wall of the papilla ampullaris of the pancreatic duct and the common bile duct which then coalesces and exits through the duodenal ampulla. The most common symptoms of this tumor are signs of biliary obstruction. Tumors in the gallbladder and bile ducts are generally asymptomatic early in the course of the disease and only manifest when the tumor is at an advanced stage so that the possibility of curative resection decreases. Malignancy of the ampulla of vater often manifests at an early stage so the prognosis is likely to be better. Etiological factors include smoking and previous partial gastrectomy. There is no established association between tumors of the ampulla of Vater and drinking coffee or alcohol. This case was found in a male patient, aged 33 years who came to Dr. H. Abdoel Moelok with complaints of abdominal pain on the right side accompanied by thick tea-colored urine, enlarged stomach, shortness of breath. The results of examination and support in the form of abdominal ultrasound led to the diagnosis of an ampulla of Vater tumor. The treatment given to the patient was supportive treatment in the form of a blood transfusion of three kolf to increase the hemoglobin level before being carried out in the form of a whipple operation procedure.
Kurkumin dan Inflammatory Bowel Disease Stevani Febeline; Winda Trijayanthi Utama; Waluyo Rudiyanto
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflammatory Bowel Disease (IBD) is an inflammatory disease of the gastrointestinal tract. The exact cause of Inflammatory Bowel Disease is not yet known clearly. The diagnosis of inflammatory bowel disease is often delayed due to non-specific and intermittent symptoms. There are 2 types of IBD, namely Ulcerative Colitis and Crohn's Disease. Management of IBD can be done with drug therapy, surgery, or a combination of both. This therapy aims to reduce symptoms, improve quality of life, prevent disease recurrence and avoid complications. IBD treatment can occur over a long period of time, during which time it costs quite a bit and can cause various side effects that can be experienced by patients. Therefore, experts began to consider other alternative therapies that could be used, for example the use of curcumin compounds. Curcumin is the active pigment that gives turmeric its yellow color, a plant that belongs to the ginger family or Zingiberaceae and contains anti-inflammatory substances. The mechanism of action of curcumin is by suppressing activity of Nuclear Factor-Kappa B (NF-KB) and also plays a role in suppressing Interleukin-1 (IL-1), IL-6, IL-12, IL-17, and Tumor Necrosis Factor Alpha (TNF). -α), two major cytokines that play an important role in the regulation of the inflammatory response. Management of IBD can be done through the administration of drugs so that curcumin can be considered as one of the treatments for IBD.
Pemanfaatan Gerakan Salat Sebagai Upaya Mencegah dan Mengatasi Hipertensi Rr Astri Nur Azizah Utama Utama; Rasmi Zakiah Oktarlina; Oktafany
Medula Vol 12 No 1 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i1.320

Abstract

Hypertension is defined as systolic blood pressure> 140 mm Hg and diastolic blood pressure> 90 mm Hg. Hypertension is a major risk factor for cardiovascular disease and metabolic syndrome, which is influenced by aging, but hypertension is a preventable disease. One of the preventions of hypertension is lifestyle modification such as physical activity, diet, and emotional management. In another study also mentioned that the combination of physical activity and meditation has the same effectiveness in reducing and preventing increased blood pressure compared to only low-salt food diets. Salat is a kind of meditation that involves physical movements consisting of standing, bowing, prostration, and sitting. During salat, parasympathetic activity is increased which is marked by a decrease in heart rate, especially when the prostration position (69 bpm) and a decreased of systolic blood pressure by 2.5% and diastolic by 2.8%. It shows that salat has a positive effect on the cardiovascular system. Another study showed that salat also effects on musculoskeletal so salat can be used as physical therapy in geriatric rehabilitation. Study about the benefit of salat in the cardiovascular system is still limited, so further research is needed to prove the effectiveness of the use of salat as an alternative method in reducing the prevalence of hypertension in Indonesia.
The management of hypertension : penatalaksaan hipertensi dan gout artritis Aldi Setia; Azelia Nusadewiarti
Medula Vol 12 No 1 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i1.323

Abstract

The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide with millions of people at risk in a growing number of countries. Though there are no clinically approved antiviral drugs and vaccines for COVID-19, attempts are ongoing for clinical trials of several known antiviral drugs, their combination, as well as development of vaccines in patients with confirmed COVID-19. This review focuses on the latest approaches to diagnostics and therapy of COVID-19. We have summarized recent progress on the conventional therapeutics such as antiviral drugs, vaccines, anti-SARS-CoV-2 antibody treatments, and convalescent plasma therapy which are currently under extensive research and clinical trials for the treatment of COVID-19. The developments of nanoparticle-based therapeutic and diagnostic approaches have been also discussed for COVID-19. We have assessed recent literature data on this topic and made a summary of current development and future perspectives.
Hubungan Tingkat Pengetahuan Wanita Usia Subur (WUS) dan Dukungan Suami dengan Pemeriksaan Inspeksi Visual Asam Asetat (IVA) sebagai Metode Deteksi Lesi Prakanker Serviks di Puskesmas Kalibalangan Kabupaten Lampung Utara Tahun 2019 M. Rizky Fathurrohim; Rasmi Zakiah Oktarlina; Nurul Islamy4
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.260

Abstract

Cervical cancer is the fourth most common cancer in women with an estimated 530,000 new cases, representing 7.9% of all female cancers. Cervical cancer events can be detected by the Visual Inspection Method of Acetic Acid (IVA). The relationship between the level of knowledge of women of childbearing age and husband's support to the visual inspection of acetic acid as an early detection of cervical pre-cancerous lesions. This type of quantitative research with cross sectional design. This research has been carried out at the Kalibalangan Main Health Center. The target of this study is all women of childbearing age who have been married, a sample of 196 people with convenience sampling technique. The object taken is the husband's knowledge and support with data collection by questionnaire. Data analysis used univariate and bivariate (chi square). As many as 151 (77.0%) respondents had never had an IVA examination. Based on the results of the study, most of the respondents with poor knowledge were 121 (61.7%) and there were no husband's support around 144 (73.5%). There is a correlation between knowledge of women of childbearing age and husband's support to the Acetic Acid Visual Inspection Examination as an early detection of cervical pre-cancerous lesions in Induk Health Center, Kalibalangan Village, North Lampung Regency in 2019 (p-value 0,000 and OR 13,707).
Pendekatan Diagnosis Berbasis Molekuler pada Pasien Talasemia Bagus Pratama; Intanri Kurniati
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.280

Abstract

Thalassemia is a red blood disorder which is one of the causes of death and illness in Indonesia. This disease occurs due to genetic disorder that affect the inability of a person to synthesize globin chains. A globin chain is one of the constituents of hemoglobin so that abnormality of composition of hemoglobin will cause abnormality of elasticity and lysis of the erythrocytes. This disorder has various clinical manifestations ranging from anemia, pale, fatigue, pain, abnormalities in the bone (thalassemic facie) to jaundice and hepatosplenomegaly. Generally, the diagnosis of thalassemia uses a complete blood count including calculating the number of erythrocytes, hemoglobin levels, hematocrit levels, MCV and MCH, blood smear examination and hemoglobin electrophoresis. The genetic examination on molecular-based diagnostic approach is an examination to get a result of changes in gene sequences or genetic mutations that will affect the difference of clinical manifestation and severity of thalassemia patients. Molecular diagnosis can be made in an effort to improve the effective management and the quality of life of patients.
Hubungan antara Penggunaan Kateter Tenchkoff , Status Gizi, Pembedahan, dan Komplikasi pada Anak Dengan CAPD di RSUP dr. Mohammad Hoesin, Palembang Tinton Ardiyan; Eka I Fitriana; Shalita Dastamuar; Ziske Maritska
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i4.321

Abstract

Chronic kidney disease is a detrimental health problem in children with increasing morbidity and mortality rates. CAPD as an option for renal replacement therapy provides superior benefits over conventional hemodialysis in children with terminal kidney disease. However, the effectiveness of CAPD in long term needs to be anticipated because of the risk of infectious and non-infectious complications. Cross-sectional study was conducted in the Medical Record Department of RSMH. The samples were pediatric patients with CAPD in June (2016-2021) with complete medical records. The Sample study was analyzed by univariate and bivariate. The relationship between risk factors and complications was analyzed using the Chi-square test. The subjects were 14 people, male, >5 years old, normal nutritional status (42.9%), had abnormality anatomy kidney (57.1%), and surgery by laparoscopy (71.4%). The most infectious complication is peritonitis (50%) and the non-infectious complication is poor drainage ( 42.9 %). There was no meaningful relationship among risk factors to complications in patients children with CAPD in RSMH (p>0.05). By the descriptive analysis, every factor plays a role in the incident of complications. However, no there is a meaningful relationship among factor risk of complications infectious and non-infectious.
Malassezia Furfur Pada Pitriasis Versikolor Dan Malassezia Folikulitis HENDRA TARIGAN
Medula Vol 12 No 1 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i1.444

Abstract

The skin is one of the largest organs of the body that hosts various communities including organisms that are harmless but can also be potential pathogens. Malassezia is part of the normal skin flora (microbiome). Malassezia also has a potential pathogen which under suitable conditions can invade the stratum corneum and manifest in various diseases including pityriasis versicolor and Malassezia folliculitis. Pityriasis versicolor (PV) is a chronic infectious disease of the skin caused by the fungus Malassezia furfur, is characterized by hypopigmented or depigmented patches with scaling. Malassezia folliculitis is an inflammatory condition caused by Malassezia involving the deeper unit, the pilo-sebaceous. Pityriaris versicolor and malassezia folliculitis are global skin diseases. Pityriasis versicolor and malassezia folliculitis often occur in tropical and hot climates and have high humidity and temperature, such as in Indonesia. In Indonesia, it is estimated that 50% of the population suffers from PV. This disease can affect all groups ranging from children to the elderly. With the high incidence of PV and malacezia folliculitis in Indonesia, the authors are interested in making this reference. The purpose of writing this report is to make the authors and readers better understand the characteristics of these two diseases, to be able to diagnose and treat them appropriately and to take preventive measures so as to reduce the incidence of PV and folliculitis malassezia in Indonesia.
DIAGNOSIS DAN PENATALAKSANAAN KUSTA hendra T
Medula Vol 11 No 2 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i2.445

Abstract

Leprosy or Morbus Hansen or lepra is a chronic infectious disease caused by the bacillus Mycobacterium leprae. Leprosy attacks the peripheral nerves, skin, and other body tissues except the central nervous system. Mycobacterium leprae reproduces slowly and the average disease incubation period is 5 years. Symptoms can occur within 1 year but can also last for 20 years or even more. This disease can be cured with multidrug therapy. Kusta is likely transmitted by droplets, from the nose and mouth, during close and frequent contact with untreated cases. Diagnosis of leprosy is based on clinical, bacterioscopic, histopathological, and serological features. Of the three, clinical diagnosis is the most important and the simplest. Determination of the type of leprosy needs to be done in order to determine the appropriate therapy. In several provinces in Indonesia, the prevalence of Leprosy is still above 1 per 10,000 population where this figure cannot be declared free of Morbus Hansen and occurs in 10 provinces in Indonesia. Kusta sufferers not only suffer because of their illness but also suffer psychological impacts because people think that Leprosy is a hereditary disease. Based on the description, it is necessary to explore and know about the definition, etiology, pathogenesis, clinical manifestations, investigations, complications, management, and prognosis of Leprosy.

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