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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 796 Documents

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ISOLASI DAN UJI PENANGKAPAN RADIKAL BEBAS DPPH OLEH ISOLAT-1, FRAKSI ETIL ASETAT, DAN EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia Jack) Nurani, Laela Hayu
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The free radical was produced when undertaking processes metabolit or opposedinfection and when the body dissolved food. The unstable free radical could beneutralised with antioxidant. The root of the pasak bumi (Eurycoma longifolia Jack)was known contained the compound flavonoid, that it was known had the activity asantioxidant. This research aimed at knowing the activity capacity of the capture of thefree radical the water fraction and the faction ethyl acetate fraction the extract ethanolof the root of the pasak bumi by using the DPPH method.The root of the pasak bumi was extracted with ethanol 70% used maceration. Theethanolic extract was dissolved in ethyl acetate, fractination with ethyl acetate so as tobe received by the fraction ethyl acetate. The concentration of the ethanolic extract andthe fraction of ethyl acetate that was used were 2; 4; 8; 16 ug/mL and isolat-1 that is:0.8; 1.6; 3.2; and 6.4 ug/mL.Results of the research showed that all the treatments had the activity asscavenging the free radical. Results of the analysis statistika with the Kruskal Wallismethod in the level of the confident 95% that was followed by the test Mann Whitneyshowed the existence of the difference of the activity of the capture of the free radicalwho was significant between respectively the treatment group. The conclusion from thisresearch was the value ES50 ethanalic extract (15.64 ug/mL) bigger than the factionethyl acetate fraction and higher (13.948 ug/mL) value of ethanalic extract was thanisolat 1 (3.961 g/mL).

EKSTRAKSI ANDROGRAFOLID DARI Andrographis paniculata (Burm.f.) Nees MENGGUNAKAN EKSTRAKTOR SOXHLET Rais, Ichwan Ridwan
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Chemical component extraction from plant herbal influenced by various aspect, such asextraction technique or chemical component character from the plant. Extraction method and solventpolarity exteremly influence chemical component transfer from the cell of plant to solvent solution.Soxhlet is extraction system instrument with frequently same solvent extraction based on liquid-steamcirculation process of the solvent. Solvent polarity to extract chemical component of the plant herbaldepend on chemical component character it self and ability to penetrate cell membrane.Andrographolide, an active chemical component of Andrographis paniculata has been suggested themost active constituent that responsible to activity of Andrographis paniculata in herbal medication.This chemical constituen has solubility character in solvent with middle polarity that indicates solventelection to extract it. This study shows that chemical component extraction of herbal plant influencedby solvent polarity. Thin Layer Chromatography qualitative analyses indicate that absolute polar andAndrographis paniculatanonpolar solvent could not extract andrographolide, different from middle polarity. Andrographolideextraction with similar solvent and correct method offer extract yield with 16,6% andrographolide.

PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL SARANG SEMUT (Myrmecodia tuberosa (non Jack) Bl.) SECARA IN VITRO Ernawati, Ernawati; Susanti, Hari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Uric acid is the end product of purine metabolism that can settle in the joints and form smallcrystals, causing inflammation known as gout. Gout is a disease caused by high levels of uric acid inthe blood (hyperuricemia). One of the drugs used to treat gout was allopurinol to inhibite the activityof xanthine oxidase mechanism. Myrmecodia tuberosa (non Jack) Bl. known to contain flavonoids andempirically proven to treat rheumatic complaints and gout. Therefore, research needs to examinewhether the ethanol extract of the sarang semut to inhibite xanthine oxidase activity. Allopurinol isused as a comparison. The active substances of the Myrmecodia tuberosa (non Jack) Bl. was extractedwith ethanol using maceration method after soaked with petroleum ether. The xanthine oxidaseinhibitor activity of the Myrmecodia tuberosa (non Jack) Bl production ethanol extract wasspectrophotometrically determined by monitoring the reducing of uric acid at a wavelength(Î») 295 nm with xanthine as substrate. Rate values obtained subsequently used to calculate the valueof the activity. Then determined the concentration of the ethanol extract can inhibit the activity ofof xanthine oxidase by 50% (IC50). The results of the research showed that the ethanol extracts of sarang semut inhibited xanthine oxidase activity with IC50 112.40 Âµg/ml, while allopurinol was3.16 Âµg/ml.

RESIDU PESTISIDA ALDRIN DAN DIELDRIN PADA SAMPEL TANAH DAN AIR DI DESA SRIGADING KECAMATAN SANDEN KABUPATEN BANTUL Narwanti, Iin; Sugiharto, Eko; Anwar, Chairil
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aldrin and dieldrin pesticide residue in soil and water samples from Srigading Village, Sanden District,Bantul Regency has been investigated. The purpose of this study were to analyze, identificate and evaluatepyrethroid pesticide residues in soil and water samples. Soil sample was extracted using shaker with acetonesolvent. Water samples was extracted using separator funnel with 15% (v/v) dichloromethane/n-hexanesolvent.Clean-up was couducted using chromatography column using florisil and determination of pesticideresidue in the samples was carried out by gas chromatography apparatus equipped with electron capture detector(GC-ECD). The result showed that pesticide residues in soil sample in the range level: aldrin (4,8-64,8 ppb) anddieldrin (not detected-6,0 ppb). In water sample pesticide residues in the range level: aldrin (not detected-1,0 ppb)dan dieldrin (-not detected1,2 ppb). The quality or water sample taken from onion field is laid under the standardof water that has been settled.

BIOAVAILABILITAS TABLET IBUPROFEN PADA PEMBERIAN BERSAMAAN DENGAN EKSTRAK AIR HERBA PEGAGAN (Centella asiatica (L) Urban) PADA KELINCI JANTAN Sutanti, Depprelia Wahyu; Wahyuningsih, Iis
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The tendency to use herbal drug simultaneously with synthetic drug may result inan interaction. Based on research, aqueous extract of Centella asiatica (L) Urbancontains saponin (asiaticoside and madecassoside) compounds that inhibit CYP450and is a safe herbal alternative that is used for anti-inflammatory treatment. The aim ofthis study was to investigate the effect of aqueous extract of Centella asiatica (L) Urbanto the ibuprofen tablet bioavailability in male rabbits. Both compounds are metabolizedby CYP450 enzymes in the same way with different mechanism. The cross over designwith the same subject was used in this study. The samples consisted of 400 mg ibuprofenwith 0%b/v, 25%b/v, 50%b/v dan 100%b/v aqueous extract of Centella asiatica (L)Urban respectively. The blood were taken after 0; 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10hours after samples treatment, then the ibuprofen plasma concentration weredetermined spectrophotometrically. The results then were used to evaluat thebioavailability parameters: tmaks, Cpmaks, and AUC and were analyzed using ANOVAtest in the same way as well as the 95% trust standart. The results showed, the use ofibuprofen tablet stimultaneously with aqueous extract of Centella asiatica (L) Urbanincreased Cpmaks dan AUC, but there were no influence to the tmaks value. The use ofibuprofen tablet stimultaneously with 50 %b/v and 100 %b/v aqueous extract ofCentella asiatica (L) Urban had a significant influence to the bioavailability ofibuprofen.

UJI TOKSISITAS SUBKRONIS EKSTRAK CURCUMA BEBAS MINYAK ATSIRI (ECBA) DITINJAU DARI PARAMETER PROFIL LEUKOSIT PADA TIKUS PUTIH GALUR WISTAR Farida, Verda; Ikawati, Zullies; Pramono, Suwidjiyo
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The effect of Volatil Oil of Curcuma Extraxt or Curcumin extract withcentration of essential oil in reducing the levels of cholesterol in the blood has beenECBA as antihyperlipidemic agent is given for a long - term therapeutic purpose. Thisexperiment was performed to investigate the subchronic toxicity of ECBA on leukocytes profile ofWistar rats. ECBA was investigated at dose 15 mg, 120 mg, and 960 mg/200 g body weight for 90days in 40 male Wistar rats. CMC-Na was used for control. The blood was examined for theleukocytes profile on day 0, 45, and 90. The rats were still maintained under experimental conditionswithout giving ECBA until day 105 for the reversibility test. The result showed that the administrationof ECBA for 90 days did not affect leukocytes profile of Wistar rats.

EFEK EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) TERHADAP MEMORI SPASIAL TIKUS MODEL DEMENSIA YANG DIINDUKSI TRIMETHYLTIN Aspamufita, Nuroh; Yuliani, Sapto
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb is one of the plants containing curcumin. Curcumin has anti-amyloidogenic,antioxidant, and anti-inflammatory activity that can prevent dementia. The aim of the research was to know theeffect of Curcuma xanthorrhiza Roxb rhizome ethanol extract (CREE) to spatial memory on dementia model ratinduced by trimethyltin (TMT). This research use 30 rats, divided into 6 groups, each group consisted of 5 rats. Allgroupswere given trimethyltin intraperitoneal lyexcep tgroup I.Group I (healthy controls) and group II (TMT/illness control) were given a solution of 1% CMC-Na orally. Group III (drug control) were given citicoline 200mg/kgBW orally. Group IV, V, and VI were given CREE orally dose 50 mg/kgBW, 100 mg/kgBW, and 150mg/kgBW respectively. Data of spatial memory were obtained by Morris water maze test consisted of acquisitiontrial, and a probe trial. Data from the test then statistically analyzed by one-way repeated measure ANOVA.Morris water maze test showed that there were significant differences (p<0,05) between TMT group comparedwith CREE dose 50 mg/kgBW, 100 mg/kgBW, and 150 mg/kgBW group. But there was no significant difference(p>0,05) between CREE dose100 mg/kgBW group anddrug control group.Based on the research results can beconcluded that ethanol extract Curcuma xanthorrhiza Roxb rhizome at dose of 100 mg/kgBW can improvespatial memory on dementia model rat induced by trimethyltin.

IMPACT OF LIMITED ORAL ANTITUBERCULOSIS INFORMATION TO THE TUBERCULOSIS PATIENTSâ COMPLIANCE AND THEIR QUALITY OF LIFE Handayani, Dian; Perwitasari, Diah Aryani
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The study about impact of limited oral antituberculosis information delivered bypharmacist to patient compliance and their quality of life in two public health centers inYogyakarta has been carried out. This study was performed using cohort eventmonitoring design, with 14 pulmonary TB patients and positive Acid Resistant Basilwere treated with oral antituberculosis (OAT) for at least 1 month and were older than15 years old. We observed the compliance of one group of patients using oralantituberculosis who were serviced with OAT information and the other group withoutOAT information service. The patientsâ compliance was checked by counting theremaining OAT and by interviewing the patients, meanwhile patientâs quality of lifewere measured by SF-36 instrument. The correlation between limited OAT informationservice and patient compliance were analysed using Chi Square and quality of patientâslife were analysed using Independent t-Test with 95% confidence level. It was shownthat characteristics of patients such as age, gender, education, duration of illness, andDirectly Observed Treatment involvement did not influence patient compliance. Therewas no significant correlation between limited OAT information service to patientcompliance and patientsâ quality of life (P>0.05). There is no impact of limited OATinformation service to the TB patientsâ compliance and their quality of life. Wesuggested that the further and deeply information service delivered by pharmacists inthe public helath centers in Yogyakarta should be carried out.

SINTESIS SILIKA MCM-41 DAN UJI KAPASITAS ADSORPSI TERHADAP METILEN BIRU ahda, Mustofa; Sutarno, Sutarno; Kunarti, Eko Sri
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Synthesis of MCM-41 with hydrothermal time variation 18, 24, 36, 48 hoursusing templating agent cetiltrimetilammonium bromide (CTAB) has been done. Theresults showed that the time of hydrothermal influence the intensity and the index field(ao). Synthesis of MCM-41 with a time of hydrothermal 24 hours produce the highestintensity which indicates that MCM-41 has the best crystallinity. While testing theadsorption capacity of MCM-41 has 37,037 mg/g for adsorption of the methylene blue.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urb) DENGAN METODE FOSFOMOLIBDAT Salamah, Nina; Farahana, Liani
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antioxidant compound extends widely used to prevent degenerative disease. Centella asiatica(L.) Urb or known as pegagan is a plant which grown in Indonesia and itâs leaves contain somecompounds reported to have antioxidant activities. The research aimed to know antioxidant activity ofethanolic extract of pegagan herbs by mechanism of reducing power. The antioxidant activity analyzedusing visible spectrophotometric with phosphomolybdate method. Antioxidant activity of ethanolicextract of pegagan was expressed as mg quercetin equivalence/gram extract). The result showed thatusing this method the ethanolic extract of pegagan activity had antioxidant activity which is43.198 Â± 2.048 mg mgQE/gram extract.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Kota yogyakarta,

Daerah istimewa yogyakarta

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