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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 796 Documents

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EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN Febrianti, Ririt Vita; Wahyuningsih, Iis
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ibuprofen is an anti inflammatory, analgesic, and antipyretic agent. It has low solubility and bioavailability.The administration of ibuprofen in a long time and high dose can increased of side effect at gastrointestinal (pepticulcer). This study was aimed to determine the influence its solid dispersions formation on ulcerogenic effect ofibuprofen buprofenis compared with ibuprofen alone and physical mixture. Solid dispersion of Ibuprofen-PVP(1:1) was prepared by solvent method. The ulcerogenic test was conducted by observing is white rat, dividedrandomly into 5 groups are healthy group (aquadest), suspending agent control (PVP 1%), drug (ibuprofen) at adose of 360 mg/kg body weight, group solid dispersion (ibuprofen-PVP) and group physical mixture(ibuprofen-PVP). Rats gastric was observed of formation ulcer and evaluated by scoring then followed thecalculation by the index ulcer. The results showed that the number of ulcer index of ibuprofen is 6,67. Number ofulcer index of solid dispersion was 4,00 and physical mixture was 3,34. The ulcerogenic effect of solid dispersionand physical mixture difference was significant (p<0,05) compared with ibuprofen alone. Ulcerogenic effectadministration of solid dispersion was smaller than ibuprofen alone and statistically no different (p>0,05)compared with physical mixture.

DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL Damayanti, Resty Annisa; Yuwono, Tedjo
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. Thissubstance is used as a medicine and solve. It can also be used as an absorptionenhancer of various drugs, either synthetical or herbal medicines. This study conductedwith DMSO as transdermal absorption enhancer of theophylline, which often used asan anti-cellulite dosage forms. The experiments studied in vitro transdermalabsorption of theophylline in gel dosage forms, containing 7% theophylline danvarious concentration of DMSO i.e. 0% , 3%, 5% and 7% DMSO respectively. Thesestudies used skin membrane of Wistar strain male rats in a vertical type diffusion Cell.The results indicated that DMSO was very potential as a permeation enhancertheophylline, the formula containing 7% DMSO increased the theophylline transportfrom 17,9 Âµg to 139,1 Âµg.

ANALISIS KEPUASAN MAHASISWA TERHADAP KUALITAS PELAYANAN TENAGA ADMINISTRATIF DI FAKULTAS FARMASI UNIVERSITAS AHMAD DAHLAN YOGYAKARTA Hidayati, Ana; Fudholi, Achmad; Sumarni, Sumarni
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Student satisfaction measurement has been done with populatif observation and data collectedprospectively at the fourth level students of the Faculty of Pharmacy Ahmad Dahlan University. Thepurpose this study to describe and determine student satisfaction ratings gap that arises from servqual.The results obtained indicate generally that the service element in the Faculty of Pharmacy is namelyemployees has not given in accordance with the expectations of student performance is characterizedby a range of values of each gap there is nothing close to the ideal of zero (0). Gap values ofemployees in the education ministry on Tangible dimensions with a gap value -0,90, Reliability withthe gap value -0,90, Assurance gap value -0,90, Empathy with the gap value -1,10 andResponsiveness to the value gap -1,10 . While the reliability of the employee dimension into the first rank and dimensions of responsiveness on the faculty is considered the most excellent service tostudents.

PENGARUH KONSENTRASI ETANOL SEBAGAI PELARUT PENGEKSTRAKSI TERHADAP KADAR NAFTOKINON DALAM EKSTRAK DAUN PACAR KUKU (Lawsonia inermis L.) Zainab, Zainab
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The extract quality can be affected by the components and concentration of chemical compounds containedin the extract.Type and quantities of chemical compounds that are dissolved in the extraction process is stronglyinfluenced by the solvent extraction. The aim of this study is to determine the effect of concentration of ethanol assolvent extraction on naphthoquinone content in Henna leaves extract. The extraction method was done bymaceration for one hours with water, ethanol 50% , 70% , 90% and 95% v/v solvens of the dried Henna leavespowder. Each macerate was made 5 % w/v concentration and than was spotted 5 ÂµL on plate of silica gel F 254 andeluted with mixture of chloroform - methanol (17:3 v/v) as mobile phase. The spots on chromathogram werescanning and measured the area under curve with TLC densitometer at maximum wave lenght. The results showedthat spot at Rf 0.31 had similar spectra with naphthoquinone standard and same maximum wavelength at 279 nm.The result of solvent optimization indicated that the best solvent extraction for Henna leaves was ethanol 50% v/vwith the highest naphthoquinone contentat 1.43 Â± 0.1942% w/v.

EFEK SITOTOKSIK DAN PEMACUAN APOPTOSIS FRAKSI PETROLEUM ETER EKSTRAK ETANOL DAUN TAPAK LIMAN (Elephantopus scaber Linn) TERHADAP SEL HELA Listyowati, Yeni; Nurkhasanah, Nurkhasanah
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Elephantopus scaber Linn. has been reported to have cytotoxic effects on breast cancer cells and thepotential to be developed as anticancer agent. This study aims was to determine the cytotoxic activity andapoptosis induction effect of petroleum ether fractions of ethanolic extract of (Elephantopus scaber Linn) leavesagainst cervical cancer cells (HeLa). Petroleum ether fraction was obtained by dissolving eyhanolic extract inpetroleum ether, and the soluble fraction was as petroleum ether fraction. The method used for cytotoxic activitytest was MTT test. The concentration series used were 2000; 1500; 1000; 800; 400; 200; 100; 50; 25; 12.5; 6.25and 3.125 mg/ml. The IC50 used as cytotoxic parameters. The apoptotic observations was conducted usingacridine orange and ethidium bromide. The study showed the IC50 of petroleum ether fraction of (Elephantopusscaber Linn) ethanolic extract was 185 ug/ml. The study also showed the potency to stimulate apoptosis in HeLacells.

AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL BUAH PAPRIKA HIJAU (Capsicum annum L.) Warsi, Warsi; Guntarti, Any
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Green paprica (Capsicum annum L.) is one of fruits which have containâcarotene, vitamin E and vitamin C, which have antioxidant activity. The aim of thisresearch is to know an antioxidant capacity of green paprica. An analysis of theantioxidant activity of this research used radical scavenging DPPH(1,1âdifenilâ2âpikrilhidrazil) method. The sample was preparated with maceration for4 days using methanol as the solvent. Crude extract was evaluated qualitatively using0,4 mM DPPH reagent. This result of qualitative analysis showed that green papricahave an antioxidant activity. Then, absorbance was measured using UVâVisspectrophotometer at wavelength of 517 nm. The result of this analysis obtained EC50value of green paprica was 0,3399 Â± 0,01408 mg/ml.

PENGEMBANGAN SENYAWA TURUNAN BENZALASETON SEBAGAI SENYAWA TABIR SURYA Prabawati, Susy Yunita; Wijayanto, A; Wirahadi, Aria
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The goal of this research was to synthesize benzalaceton derivative i.e. 4-dimethyl-aminodibenzalacetonto increase the potency as sunscreen agent. The synthesis was carried out through aldolcondensation reaction with 4- dimetilamino-benzaldehida as a starting material and NaOH as catalystat various reaction times i.e. 3 , 4 and 6 hours. The characterizations of the product was observed bymelting point, FTIR and 1H NMR spectrometers. The product was obtained as a yellowish orangesolid with a melting point between 62-640C. The activity assay as sunscreen agent showed that the 4 âdimethylamino-dibenzalaseton have a maximum wavelength at 340 nm, so its can be active as asunscreen in the UV - A rays. The SPF value at 15 ppm was 17.409 with ultra protection type.

FORMULASI COLD CREAM PROPRANOLOL UNTUK PENGHANTARAN TRANSDERMAL DENGAN BASIS EMULSI YANG MENGANDUNG VCO (VIRGIN COCONUT OIL) Lestari, Muji; Binarjo, Annas
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Propanolol is a non-selective beta-blocker that is used widely to overcome cardiovascular disorder.Development of propranolol in transdermal delivery is necessary to avoid the first pass metabolism that reducesthe active metabolite up to 15-23% left. This study was objected to determine the effect of VCO (Virgin CoconutOil) concentration as a base and penetration enhancer of propranolol in the cold cream preparation through rat skinmembrane in vitro. Variation concentration of VCO (0%, 14%, 28%, and 42%) was added to propanolol coldcream. Transdermal in vitro study was performed using vertical type diffusion cell with PBS pH 7,4 as receptormedia. The temperature was maintained at 35ÂºC with a constant stirring rate at 300 rpm. The transport wasconducted for 8 hours. Flux, efficiency, and lag time were calculated as responses. The results showed that flux atvarious concentration of VCO (0%, 14%, 28%, 42%) were 12,30; 14,13; 14,52; and 23,06 -1 cm-2respectively. The transport efficiency were 6,5x10-4; 7,5x10-4; 8,1x10-4; and 1,22x10-3 % cm-2 respectively. Thelag time were 1,13; 1,26; 1,11; and 0,92 hours respectively. It can be concluded that the VCO can be used mainlyas a base in the preparation of cold cream and can increase percutaneous permeation of propranolol significantly(p <0.05). VCO concentration of 42% has the highest performance.

PENGARUH NATTOKINASE TERHADAP DAYA KERJA Metformin HCl DALAM MENURUNKAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR Okta, M Sandila; Sofia, Vivi
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Interaction of modern drug and traditional drug is an issue that needs to beexamined, not least in the treatment of diabetes mellitus. Nattokinase is a nutraceuticalproduct that can be used in conjunction with antidiabetic oral drugs that allows theinteraction. This study aims to determine the effect of Nattokinase against their powerMetformin HCl in decreasing of blood glucose levels male white rats (Rattusnorvegicus) Wistar. This study uses an oral glucose tolerance test with glucose loadingdose of 4.5 g/kg. Animals test used were white male Wistar rats aged 2-3 monthsweighing 150-200 g, 20 rats were divided into 4 groups, each group consisted of 5 rats.Group I as a negative control group was given tween 80 - span 80, group II as a positivecontrol group was given metformin HCl doses of 45 mg/kg, group III was givenNattokinase dose 300 mg/kgBB, group IV given nattokinase 300 mg/kgBB 1 hour thenwere given metformin HCl. 30 minutes later all treatment of groups were given glucose.When treatment is considered as a time at-0. The given of glucose is considered as thetime at-30. Blood sampling via the tail at 0, 30, 60, 120, and 180. Blood glucose levelswas measured with the Easy Touch. The effect of decreasing blood glucose levelsindicated by the value of LDDK0-180 (Regional Area Under the Curve minute 0 tominute 180 of the graph time vs blood glucose levels). The data can be testedstatistically by Kruskal-Wallis and Mann Whitney with a level of 95%. The resultsshowed that administration of Metformin HCl after 1 hour administration Nattokinasecan be decreased 52.22% of Metformin HCl.

EFEK HIPOGLIKEMIK EKSTRAK ETANOL UMBI KETELA RAMBAT (Ipomoea batatas P) (EEUKR) PADA MENCIT SWISS YANG DIINDUKSI ALOKSAN Akrom, Akrom; D, Harjanti P; T, Armansyah
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sweet potatos rood contain lots of beta-carotene, polyphenols and flavonoids. Alloxan provenpancreatic cell damage through oxidative stress mechanisms. The compound beta-carotene,polyphenols and flavonoids are thought to antioxidative and cytoprotective, inhibit cell damage causedby alloxan exposure. This study aimed to determine the effect of ethanolic extract of sweet potatos(Ipomoea batatas P) (EEUKR) on blood glucose levels and pancreatic histopathology on alloxaninducedSwiss mice. Used 15 test animals, Swiss mice, with an average weight of 20-30 grams. Testanimals were divided into 5 groups, with each group consisting of 3 mice. Group I was the negativecontrol group who were given distilled water (akua group), and group II, III, IV and V are thetreatment group were given ethanolic extract of sweet potatos rood (EEUKR) at a dose of 2.5, 7.5,22.5 and 67.5 mg/KgBW/day orally for 10 days, 7 days before and 3 days after the alloxan induced.Alloxan induction performed on the 7th day intraperitoneally at a dose of 120 mg/kgBW. Examinationof blood glucose levels conducted on 4th and day 10th day of treatment. On the 10th day of the testanimals were sacrificed for isolated pancreas and histopathologic examination. Analysis of varianceconducted to determine the significance difference in average blood glucose levels between groupsduring the test and ANOVA followed by LSD test at 95% confidence level. Pancreatic histopathologydata were analyzed qualitatively. The results showed that the EEUKR dose of 22.5 and 67.5mg/kgBW/day had the effect of hypoglycemia in Swiss mice. Blood glucose levels of Swiss micebefore alloxan induced in treatment group with EEUKR dose of 67,5 mg/Kg BW were lower thanblood glucose levels of akua groups, statistically significant (p <0,05). Blood glucose levels of alloxaninduced swiss mice of treatment groups with EEUKR dose of 22.5 and 67.5 mg/KgBW were lowerthan blood glucose level of akua group and statistically significant (p <0.05). The percentage ofpancreatic necrosis of alloxan-induced Swiss mice of treatment groups with EEUKR dose of 22.5 and67.5 mg/kg BW were lower than the percentage of necrosis of akua group. Based on these results itcan be concluded that the EEUKR doses of 22.5 and 67.5 mg/KgBW are found to be hypoglycemic inSwiss mice both before and after alloxan induced. The EEUR also shown to decrease the incidence ofpancreatic necrosis in alloxan-induced Swiss mice.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Kota yogyakarta,

Daerah istimewa yogyakarta

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