Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

4 5 6 7 8

AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL BUAH PAPRIKA HIJAU (Capsicum annum L.) Guntarti, Any; warsi, warsi
PHARMACIANA Vol 3, No 1: Mei 2013
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Paprika hijau (Capsicum annum L.) banyak mengandung âkaroten(provitamin A), vitamin E serta vitamin C yang berkhasiat sebagai antioksidan. Tujuanpenelitian ini ialah untuk mengetahui daya antioksidan dari buah paprika hijau(Capsicum annum L). Analisis aktivitas antioksidan dalam penelitian ini digunakanmetode penangkap radikal DPPH (1,1âdifenilâ2âpikrilhidrazil). Sampel dipreparasidengan cara maserasi selama 4 hari menggunakan metanol. Ekstrak kental yangdiperoleh dilakukan analisis secara kualitatif dengan pereaksi DPPH 0,4 mM. Hasilanalisis tersebut menunjukkan bahwa buah paprika hijau mempunyai dayaantioksidan. Absorbansinya kemudian dilakukan pengukuran menggunakanspektrofotometer UVâVis pada panjang gelombang 517 nm. Hasil analisis aktivitasantioksidan ekstrak metanol paprika hijau diperoleh nilai EC50 sebesar 0,3399 Â±0,01408 mg/ml.

KERAGAMAN ISOLAT ACTINOMYCETES BERDASARKAN ANALISIS RFLP TERHADAP GEN NRPS Sulistyani, Nanik
PHARMACIANA Vol 3, No 1: Mei 2013
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Actinomycetes merupakan salah satu jenis mikroorganisme yang sangat pentingsebagai penghasil senyawa aktif, salah satunya adalah antibiotika. IsolasiActinomycetes dari rizosfer tanaman padi (Oryza sativa L) dan tanaman tin (Ficuscarica L.) telah menghasilkan 13 isolat Actinomycetes penghasil antibiotik. Penelitianini bertujuan mengetahui keragaman isolat berdasarkan analisis RFLP (LestrictionFragment Length Polymorphism) terhadap gen NRPS (Non Ribosomal PeptideSynthetase). Penelitian dilakukan dengan mengisolasi DNA isolat Actinomycetes dandilakukan PCR terhadap gen 16SrRNA dan gen NRPS. Produk PCR terhadap genNRPS selanjutnya dilakukan analisis RFLP menggunakan enzim HaeIII. Identifikasikeberadaan DNA, hasil PCR dan hasil RFLP dilakukan dengan elektroforesis gelagarose. Keragaman isolat dianalisis dengan analisis multivariate. Hasil penelitianmenunjukkan bahwa dari keragaman 13 isolat Actinomycetes dapat dikelompokkanmenjadi 5 kelompok yaitu isolat 5 (kelompok 1), isolat 8 (kelompok 2), isolat 11(kelompok 3), isolat 6,7,9 (kelompok 4) dan isolat 1,2,3,4,10,12,13 (kelompok 5).

GAMBARAN PASIEN GERIATRI MELAKUKAN SWAMEDIKASI DI KABUPATEN SLEMAN Supadmi, Woro
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The increase in life expectancy caused geriatric population is also increasing. Geriatric patient is identicalto the decline in physiological function that can lead to various diseases. Self medication in geriatric requirespecial attention from the pharmacist. The purpose of this study was to determine the description of geriatric thatdoes self medication and assosation factors in geriatric patients doing the self medication in Sleman. This researchwas conducted using a survey to determine the presence of pharmacy in Sleman. Determination of pharmaciesconducted with a purposive sampling technique and determination of areas of research subjects or respondentswith accidental sampling. Subjects were geriatric patients with age> 60 years who did self medication inpharmacies. The data were analyzed by using chi-square statistic to determine which are the most influentialassociation factors. The research subjects in this study was 38 respondents. The pattern of disease that occur ingeriatric patients who performs a self-medication is a chronic 12 respondens, non-respondens and 16 non chronicrespondens ten respondens is unknown. Factors that association geriatric patients that is doing self medication isown of health insurance. The results of the chi square test showed that the sex factor with OR 1,11 ( p >0,05),ownership asurance (OR = 1,841,p < 0,05,CI : 1,184 â 2,184) is a factor of self association with geriatric patientsmedications at the pharmacy of district Sleman.

KERAGAMAN ISOLAT ACTINOMYCETES BERDASARKAN ANALISIS RFLP TERHADAP GEN NRPS Sulistyani, Nanik
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Actinomycetes is one of the types of microorganisms that is essential forproducing the active compounds, one of which is an antibiotic. Isolation ofActinomycetes from the rhizosphere of rice plant (Oryza sativa L.) and tin plant (Ficuscarica L.) has yielded 13 isolates of antibiotic-producing Actinomycetes. This studyaims to determine the diversity of isolates by RFLP analysis (Restriction FragmentLength Polymorphism) of the NRPS (Non Ribosomal Peptide Synthetase) gene. Thestudy was carried out by isolating Actinomycetes isolate DNA and performed PCR onthe 16SrRNA and NRPS genes. The RFLP analysis of the NRPS gene PCR products isthen performed using the enzyme HaeIII. Identify the presence of DNA, the PCRproduct and RFLP results was performed by agarose gel electrophoresis. The diversityof isolates was analyzed by multivariate analysis. The results showed that the diversityof 13 isolates of Actinomycetes can be grouped into 5 groups: isolates 5 (group 1),isolates 8 (group 2), isolates 11 (group 3), isolates 6,7,9 (group 4) and isolates1,2,3,4,10,12,13 (group 5).

PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 Âµg DAN 100 Âµg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA Dania, Haafizah; Wahyono, Djoko; Retnowati, Sulistiari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripeningat pregnancy and labor induction. However, until now misoprostol dosage and administration route forinduction are various. There is no fix guide on administration and dosage of misoprostol. This researchwas intended to identify profile of misoprostol usage and effectiveness of misoprostol administrationat dosage of 50 Âµg and 100 Âµg on labor process progress of patient hospitalized in Yogyakarta PKUMuhammadiyah Hospital based on induction success. This research was non experimental research with historical cohort design. Limitation of this method was not all desired data exist in medical recordand capability of physician was not same. Subject was pregnant mothers giving birth with misoprostolinduction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptivelyanalytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administrationat 50 Âµg and 100 Âµg dosage on labor process progress. Research subjects who meet the inclusioncriteria in this research was 109 mothers, where 69 women (63,30%) got 50 Âµg misoprostol and 40women (36,70%) got 100 Âµg misoprostol. The results of this study indicate that the success ofinduction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR= 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%),while the success induction at 100 ug misoprostol group as many as 39 people from 40 people(97.50%). The difference was statistically significant with p = 0.014 (p <0.05).

EFEK FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia, Jack) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG SECARA IN VITRO Arifah, Aminda Nur; Nurkhasanah, Nurkhasanah
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Eurycoma longifolia has been used as a remedy for detoxification, aphrodisiaca, anticancer andimmunistimulant. The quassinoids of pasak bumi root extract, have antioxidant activity andimmunomodulatory activity by increasing IL-12. This study aims to determine the effect of the ethylacetate fraction of ethanolic extract of pasak bumi root on macrophages phagocytic activity in vitro.Macrophages were isolated from peritoneal fluid of male Balb/Cmice, and thenwere cultured for 24hours in 24 well plate. The ethyl actetate fraction ethanolic extract of pasak bumi root withconcentration of 10, 50, and 100 Âµg/ml, lipopolysaccharides and dimethyl sulfoxide were added, andincubated for 1.5 hours. The phagocytosis tests was carried out by adding latex with density5x104/well and incubated for 1.5 hours at incubator (5% CO2,37oC). Macrophage were then stained byGiemsa. The results showed that the percentage of active phagocytic cells treated with ethyl actetatefraction of ethanolic extract of pasak bumi root of 10, 50 and 100 Âµg/ml, lipopolysaccharides, anddimethyl sulfoxide were 95.4%, 90%, 85.4%, 83.4%, and 79% respectively. Phagocytic capacity attreatment levels of 10, 50, and 100 Âµg/ml, lipopolysaccharides,and dimethyl sulfoxide were 469; 439.8; 360.8; 204.6; and 147.6 respectively. The result showed thatreatment of ethyl acetate fractionof ethanolic extract of pasak bumi root can increase the phagocytic activity of macrophages in vitro.

KINETIKA ADSORPSI-REDUKSI ION Au(III) PADA ASAM HUMAT HASIL ISOLASI DARI TANAH GAMBUT RAWA PENING Prasasti, Dian; Juari, Sri; Sudiono, Sri
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Isolation of peat soil humic acid and its application for adsorption reduction of Au(III) have beenconducted. Humic acid was isolated from peat soil that was collected from Rawa Pening, Central Java. Isolation ofhumic acid from peat soil was based on conventional alkaline extraction method. Humic acid was extracted frompeat soil with NaOH 0.1 M, then precipitated with 0.1 M HCl, and purified with 0.1 M HCl/0.3 M HF 1/1. Theisolated humic acid was characterized by FTIR spectroscopy, then applied for adsorption and reduction process ofAu (III).Adsorption kinetics on adsorption reduction process of Au (III) also were studied. The gold metal formedwas confirmed by XRD diffractogram, and photo optical microscope. The adsorption rate constant (k) withSantosa kinetics model for humic acid is 0.0065 min-1.Peaks of gold particles in the difractogram are 2 = 38, 44,and 64.

STUDI PENETAPAN KADAR LOSARTAN DENGAN METODE SPEKTROFOTOMETRI DAN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) SERTA APLIKASINYA PADA TRANSPOR TRANSDERMAL in vitro Binarjo, Annas; Nugroho, Achmad Kharis
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The development of drug delivery system needs a usefull determination method ofdrug in many kind of samples. This research was purposed to develop a determinationmethod of losartan, an angiotension receptor antagonist II, from the sample of in vitrotransdermal transport. Three methods were studied, i.e. normal spectrophotometric, 1stderivative spectrophotometric, and HPLC. The spectrophotometric method wasconducted using Spectrophotometer Shimadzu tipe UV 1700 controlled by UV Probesoftware (Shimadzu), while HPLC method was performanced by Shimadzu HPLCcontrolled by LC Solution software (Shimadzu). Lichrospher RP 18 250-4 (5 Âµm) wasused as stationary phase and acetonitril-acetic buffer 0,01 M pH 4 (60:40) was used asmobile phase. Chromatogram was recorded using UV 223 nm and 254 nm as adetector. Some parameters of determination method performance were calculated, i.e.LOD, LOQ, recovery, systemic error, and random error. The results shown thatspectrofotometric methods did not have an enough performance parameters to use intransdermal transport of losartan, while HPLC method had LOD and LOQ 27,329 and91,098 ng/ml using UV 223 nm as detector and 36,178 and 120,590 ng/ml using UV 254nm as detector. Detector UV 223 nm was selected. This HPLC method had recovery106,405% and random error 3,71%, and could be used to determine the losartanconcentration in sample from transdermal transport in vitro.

PENGEMBANGAN FORMULASI MASKER EKSTRAK AIR DAUN ALPUKAT (Persea americana Mill) SEBAGAI ANTIBAKTERI Staphylococcus aureus UNTUK PENGOBATAN JERAWAT Lestari, Tri; Ismiyati, Nur
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Skin problems are often on the spotlight, one of them is acne. Inflammation of acne can betriggered by the bacteria Propionibacterium acne, Staphylococcus epidermidis and Staphylococcusaureus. One of the herbs that can be used for acne treatment is the leaves of avocado (Perseaamericana). This study aims to determine the potential antibacterial activity of avocado leafwater extract on the growth of Staphylococcus aureus bacteria that causes acne and mask-makingformulation preparation. Antibacterial activity test was carried out by the diffusion method and theobserved inhibition zone that occured in a series of concentrations of avocado leaf water extract (15%, 17.5% , 35% , 50% , 75%). Antibacterial activity test was also conducted on some avocado leafwater extract mask formula (17.5% , 35% , 50% , 75%) was evaluated the physical properties of themask and irritation test was done. The results showed that the avocado leaf water extract mask formulahad antibacterial activity greater than the extract form. The physical condition evaluation and irritationtest showed that the best mask formulation was concentration of 35%.

POLA PENGGUNAAN ANTIBIOTIK POST OPERASI PADA PASIEN YANG MENJALANI OPERASI GASTROINTESTINAL Faridah, Imaniar Noor
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gastrointestinal surgery is a surgery that has a high risk of the incidence of surgical wound infection (ILO).Surgical wound infection is the result of bacterial contamination when the operation happens. The purpose of thisstudy was to determine the pattern of post operative antibiotics usage in patients undergone gastrointestinalsurgery at PKU Muhammadiyah Hospital in Bantul. The result of this study was expected to be useful as a sourceof information on patterns of post operative antibiotics that used, as well as for a base for next studies. This studywas a descriptive non-experimental research that prospectively held at PKU Muhammadiyah Bantul YogyakartaHospital. Subjects for this study were all patients who had undergone gastrointestinal surgery, which hospitalizedat PKU Muhammadiyah Bantul Yogyakarta Hospital and met the inclusion criteria. As for the inclusion criteria inthis study i.e., patients who have undergone gastrointestinal surgery, patients undergo hospitalization, as well aspatients that use antibiotics for ILOs prevention. The data analyzed was data of patterns on antibiotics usage thatused to prevent ILO incident. Based on this study showed that the usage of the most widely used post operativeantibiotics is a combination of Ceftriaxon and Cefadroxil as many as 28 patients (47,46%). Intravenous antibioticsthat mostly used is Ceftriaxon as many as 43 patients (6,29%), whereas for the most of oral antibiotics isCefradoxil as many as 45 patients (76,27%).

Page 6 of 81 | Total Record : 808

4 5 6 7 8

Filter by Year

2011 2025

Filter By Issues

All Issue Vol. 15 No. 3 (2025): Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 3, No 1 (2013): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1: Mei 2011 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA