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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 796 Documents

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UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETER HASIL HIDROLISIS INFUSA DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN METODE DPPH (1,1-DIPHENIL-2-PICRYLHYDRAZYL) Ardianti, Agustina; Guntarti, Any; Zainab, Zainab
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antioxidant is compounds which have abilities to inhibit oxidation rate. Anredera cordifoliafolium consist of flavonoid which have activities as antioxidant. The purpose of this research was toknow antioxidant activity at ether fraction of hydrolysed aquous extract of Binahong folium (Anrederacordifolia). Ether fraction was obtained by hydrolysing the infuse Binahong folium (Anrederacordifolia) with HCl 2N then fractionated with ether and then evaporated. The antioxidant activity wasmeasured by DPPH method using spectrophotometer. The maximum wavelength and operating timequercetin and samples were 515,0 nm (quersetin) and 514,0 nm (ether fraction), 19-30 minute(quersetin) and 19-29 minute (ether fraction). Scavenging activity test done with the DPPH method(1,1- dyphenyl-2-picrylhydrazyl). The decreasing of DPPH radical solution decreased the absorbantintensity. The percentage of radical scavenging activity was performed as EC50 (EffectiveConcentration). The results indicated that both samples showed free radical scavenging activity withEC50 value for quercetin (2,702Â±0,15) Âµg/ml, and ether fraction of (249,31Â±9,26) Âµg/ml. Statisticalanalysis using Kruskall Wallis method with 95% of confident level followed by Mann Whitney testgiving evidence the results between samples and positive control (quercetin) are significantlydifference.

PENETAPAN KADAR Pb PADA SHAMPOO BERBAGAI MERK DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Jaya, Farida; Guntarti, Any; Kamal, Zainul
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The source of lead pollution (Pb) can come from cosmetic product including shampoo. The purpose of thisresearch are to know wether there is Pb in the shampoo cosmetic based on different brands and colours of theshampoo. The sample of the shampoos that used in this research are A, B, C, and D. Each of the samples replicated5 times, then analyzed with atomic absorbtion specktrophotometry. Then, one of the sample are taken from onebrand with different colour and replicated 5 times. The result of this research shows that from the different brandof shampoos contain Pb. The average level of Pb that obtained from analysis are, brand A (0,4838 ppm 0,0538ppm), brand B (0,6935 ppm 0,3131 ppm), brand C (0,8354 ppm 0,0405 ppm), and brand D ( 0,9517 ppm0,0811 ppm). Whereas for the same shampoo brand but different in colour had average level of Pb: shampoo I (redcolour)= (0,5428 0,0192) ppm, Shampoo II (yellow colour) = (0,3606 0,0255) ppm, Shampoo III (blue colour)= (0,4385 0,0062) ppm, and Shampoo IV (green colour) = (0,1427 0,0133) ppm.

STANDARISASI PARAMETER NON SPESIFIK DAN PERBANDINGAN KADAR KURKUMIN EKSTRAK ETANOL DAN EKSTRAK TERPURIFIKASI RIMPANG KUNYIT Azizah, Barokati; Salamah, Nina
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Turmeric (Curcuma domestica Val.) is one of the plants that contain curcumincompounds with various activity. Use of curcumin from turmeric is widely used in theform of ethanolic extract, but there are ballast substances that cause low levels ofcurcumin. This can be pursued with the manufacture of a purified of ethanolic extract.Ethanolic extract of turmeric was made by maceration using ethanolic 96%. Ethanolicextract soaked with hexane until the hexane phase is clear and purified extract obtainedis insoluble hexane phase. Curcumin levels determined using Thin LayerChromatography (TLC) method with the stationary phase silica gel 60 F and mobilephase of chloroform: ethanolic: glacial acetic acid (94: 5:1) and be analyzedquantitatively using densitometry with a maximum wavelength of 426 nm . The watercontent of the extract determined using toluene distillation method, ash and acidinsoluble ash content determined using gravimetric method. The statistic analysis withLSD showed significant differences of curcumin content and analysis of non-specificparameter values on ethanolic extract and purified extract.

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

High Performance Liquid Chromatography (HPLC) was one of analytical methods commonlyto determine the concentration of epigallocatechin gallate (EGCG) on green tea extract. The methodmust be validated in order to fit to its purpose. The aim of this research was to prove that the usedmethod has selectifity, liniearity, precise, accurate and know limit of detection (LOD) and limit ofquantification (LOQ) is acceptable. The selectifity of analytical method was determined bycalculating the resolution value between two peak. Data from 10 ug/ml and 100 ug/ml with 5replicates would give precition and accuration. Precition was known from CV value and accurationwas known from recovery value in each concentration. Liniearity was known from regression linearbetween concentration and wide area of peak. From regresion linear could calculate LOD and LOQ.Research show that method of analyse have selectificity with Rs= 2,27>1,5; liniearity with r= 0,99;precision with CV 8,74% at concentration 200 Âµg/ml and 3,74% at concentration 500 Âµg/ml;accuration with recovery 99,76% at concentration 200 Âµg/ml and 100,52% at concentration 500 Âµg/mland the value of LOD is 33,28 ug/ml and LOQ is 110,93 ug/ml.

EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0Â±5.099 U/L; 113.6Â±5.508 U/L; 60.5Â±2.887 U/L; and 129.0Â±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4Â±11.165;263.0Â±1.803; 194.5Â±7.448; and 451.5Â±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.

SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT Noor Pratiwi, Artie; Mahfudh, Nurkhasanah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized bynucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantrolinemonohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determinedbased on the melting range data and TLC. Identification of the structure of the compoundssynthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is acolorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with anoptimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount ofyield product, there is an optimal yield in the mole ratio of 1:1.

RESIDU PESTISIDA PIRETROID PADA BAWANG MERAH DI DESA SRIGADING KECAMATAN SANDEN KABUPATEN BANTUL Narwanti, Iin; Sugiharto, Eko; Anwar, Chairil
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pyrethroid pesticide residue in onion from Srigading Village, Sanden District,Bantul Regency has been investigated. The purpose of this study were to analyze,identificate and evaluate pyrethroid pesticide residues in onion. Onion sample wasextracted using homogenizer with acetone solvent. Clean-up was done usingchromatography column using florisil and determination of pesticide residue in thesamples was carried out by gas chromatography apparatus equipped with electroncapture detector (GC-ECD). The result showed that pesticide residues in onion samplein the range level: -cypermethrin (98.8-245.6 ppb) and -cyhalothrin (14.4-120.0ppb). The following pesticides have been detected in some of samples of onion analysed,but they have been detected above the Maximum Residue Limit (MRL).

OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (DC) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN Nurlaela, Endah; Sugihartini, Nining; Ikhsanudin, Azis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The disease of Dengue hemorrhagic fever (DHF) is caused by the bite of femaleAedes aegypti mosquito. Cream of repelan sere leaf essential oils can be used to preventmosquito bites. The cream of volatile oil sere (Cymbopogon citratus (DC) Stapf)required emulsifier to maintain the stability of cream. Tween 80 and Span 80 is a widelyused emulsifier in a cream formula. Aims of this study is to determine the optimumcomposition of Tween 80 and Span 80 as emulsifier in a cream repelan of sere leafessential oils in the basis Vanishing Cream with Simplex Lattice Design methode. ThreeFormula cream is designed based on the Simplex Lattice Design methode with a ratio ofTween 80: Span 80 as follows: FI (100%-0%), F II (50%-50%), F III (0%-100%).Cream was then tested repelan activity and physical properties that includespreadibility, adhesivity and irritation. Data of physical properties and repellantactivity was calculate to get the optimum formula. The validity of optimization methodswas evaluated by comparing experimental results with predicted results in optimumcream formula with t test at 95% level of confidence. The results of study showed that theoptimum composition of Tween 80: Span 80 was 60%:40%. Cream with optimumemulsifier composition was predicted has spreadibility 29.24 cm2; adhesivity 3.512seconds; irritation 0.608; power repelan 41.469 minutes. T test results showed nosignificant differences between the experimental results and predicted results (p<0.05).

EVALUASI KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK KOTA YOGYAKARTA Baroroh, Faridah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Customer satisfaction with pharmaceutical care in pharmacy can be measured bycomparing the expectations of consumers on the quality of pharmacy services desired by thefact that it received. This study was aimed to identify the dimensions of the expected quality ofpharmaceutical care, is considered important, and which has a good performance with a modelof quality pharmaceutical care to costumer at pharmacy in Yogyakarta. This study wasobservational descriptive method and the results are presented with quadrant diagram. Theresults showed that the costumer at pharmacy in Yogyakarta satisfied with pharmaceutical carein Tangible and Empathy dimension. The Tangible and Empathy dimensions are in quadrant IIof the diagram. Howefer, the Assurance, Responsiveness and Reliability dimension, costumersless satisfied because the assume of patients if the pharmacy performance is still lower than theexpectations of consumers. That showed the Assurance, Responsiveness and Reliabilitydimensions are in quadrant III of the diagram.

FORMULASI VANISHING CREAM MINYAK ATSIRI RIMPANG JAHE (Zingiber officinale Roxb) DAN UJI AKTIVITAS REPELAN TERHADAP NYAMUK Aedes aegypti BETINA Ikhsanudin, Azis
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The essential oil of Ginger rhizome is a natural subtance which has been provedto have a repellent effect to the mosquito. The aim of this study was to know the effect ofthis subtance/these substances in vanishing cream dosage forms as repellant to thefemale Aedes aegypti mosquito. The essential oil of Ginger rhizome was isolated withaqueous vapor destillation. Then the result was determined for its physical properties,these were: viscosity, adhesivity, spreadibility and its repellant effect to mosquito aswell. The vanishing cream formulation, containing variation of the essential oilconcentration were prepared, these were: FI (formulation I), FII, FIII, FIV and FV,containing 6,25%, 12,5%, 15%, 20% and 25% of the essential oil respectivity. Eachformulas were tested for their physical properties were viscosity, adhesivity,spreadibility and its repellant effect to mosquito as well. The datas were analyzed.Statistically using SPSS version 16 with Kolmogorov-Smirnov and continued with thet-test (Mann-Whitney) (=0,05). The result showed that the duration of the adhesivityof FI was the longest than the others (1,37Â±0,15 minutes); the spreadibility of the FIwas widest (71,69Â±1,76 mm2), and the viscosity was the largert than others (27Â±0 cps).The repellant capasity of the FV was the longest than the others (47,3Â±1,80 minutes).

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA