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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 5 Documents
 1 
Search results for , issue "Vol. 22 No. 1: March 2025" : 5 Documents clear
Formulation of Body Lotion Ethanol Extract of Kepundung Bark (Baccaurea Macrocarpa (Miq.) Mull Arg.) and Antioxidant Activity Test Putri, Noni Rahayu; Sari, Tisa Mandala; Rahma Z, Sri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.25872

Abstract

The bark of kepundung (Baccaurea macrocarpa (Miq.) Mull Arg.) contains secondary metabolite compounds from polyphenols such as flavonoids, phenolic, terpenoids, and alkaloids, which have the potential for natural antioxidants. This research aims to evaluate of ethanol extract from kepundung bark and formulate the body lotion to test its antioxidant activity using the DPPH method. Body lotion formulas were made with variations in the concentration 0.4, 1.0, and 1.6% of ethanol extract of kepundung bark as active ingredients. The evaluation of body lotion included organoleptic, pH, homogeneity, type of body lotion, stability, viscosity, irritation, and antioxidant activity tests. The results of the physical evaluation of the body lotion meet the requirements. Namely, all formulas are homogeneous, according to skin pH, the viscosity of the preparation ranges from 2500 cP, stable, and does not irritate. The value IC50 antioxidant activity of ethanol extract of kepundung bark was 4.04 ppm. The value IC50 antioxidant activity body lotion at F1, F2, and F3 respect 41.91, 36.98, and 33.13 ppm. The result showed the best formula is F3 with a value IC50 33.13 ppm. Based on the study, the ethanol extract of depending bark and the body lotion has very strong antioxidant activity.
Physical Stability and Antioxidant Peel-Off Kefir Mask Arachi (Arachis Hypogaea L) Khairunnisa, Amalia; Kartinah, Nani; Viogenta, Pratika; Mulia, Mulia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.28501

Abstract

The fermented product sector can produce kefir for use in cosmetic preparations. Kefir has weak storage stability and strong antioxidant properties, making it a suitable raw material for cosmetic formulations. The purpose of this study is to determine the best concentration of peanut kefir in Peel-off mask Arachi through antioxidant activity and physical stability during seven cycles of room temperature storage and freeze-thaw (4±2ºC and 40±2ºC). Using the DPPH method based on the IC50 value, the antioxidant activity test was conducted. It was retested after 7 cycles or 28 days. At ambient temperature and freeze-thaw temperature, organoleptic tests, pH, adhesion, and spreadability were conducted in cycles ranging from 0 to 7. The peel-off kefir mask preparations with F1 (0.5%), F2 (1%), and F3 (2%), concentrations created a homogeneous, viscous preparation that was stable at room temperature and freeze-thaw stable for seven cycles, according to the results. In terms of the pH test, the sample showed a drop in pH following storage, stable adhesion for up to seven cycles. However, for F1, the adhesion was not stable in either scenario. With a significant activity category, the formula's antioxidant activity also declines in IC50 values. Therefore, it can be said that even though the peel-off mask preparation changed after storage in a few different ways, it still falls short of the threshold in terms of the physical characteristics of the cosmetic preparation.
Prescription Patterns in the Outpatient Unit of XYZ Hospital, Pekanbaru: A Study from 2022 Iskandar, Benni; Tiara Tri Agustini; Mira Febrina; Rahmadhani; Rickha Octavia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30388

Abstract

This study aims to assess the rationality of drug prescribing practices in the Outpatient Department of XYZ Hospital Pekanbaru using the World Health Organization (WHO) prescribing indicators. The research is an observational study with a descriptive nature, employing systematic random sampling to analyze data extracted from prescription records in the pharmacy department of XYZ Hospital Pekanbaru. A total of 660 prescription samples were evaluated, revealing an average of 2.91 drugs prescribed per prescription sheet, indicating a lack of adherence to diagnostic considerations. The findings show that the percentage of generic drug prescriptions was 64.04%, while antibiotic prescriptions accounted for 32.57%. Additionally, prescriptions for injectable forms constituted 1.36%, and adherence to the national formulary was at 72.27%. Out of the five prescribing indicators assessed, only the prescribing of injectable forms met the WHO’s prescribing indicators standard. These results highlight the necessity for improved adherence to rational prescribing practices to enhance treatment efficacy, minimize adverse drug reactions, and ensure cost-effectiveness in patient care. Regular monitoring and education of healthcare providers regarding rational drug use principles are essential for improving healthcare service quality.
A Design and Evaluation of a SNEDDS-Based System for Temu Ireng (Curcuma aeruginosa Roxb.) Extract: Enhancing Antioxidant Efficacy Using the SLD Technique Waznah , Urmatul; Oktaviani, Riska Kurnia Oktaviani; Ainin, Shabrina; Khafid, M. Iskandar; Mugiyanto, Eko
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30268

Abstract

Temu Ireng (Curcuma aeruginosa Roxb.) is known for its strong antioxidant properties, primarily due to its bioactive compounds such as curcumin. However, these chemicals' lipophilia and instability in traditional formulations frequently limit their bioavailability. To address these challenges, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) was developed using the Simple Lattice Design (SLD) method to improve the chemical and physical properties of Temu Ireng extract by forming a stable nanoemulsion that is uniformly distributed in the digestive system. This study aimed to formulate and evaluate a SNEDDS of Temu Ireng extract using the SLD approach, with a focus on enhancing its antioxidant activity. The formulation involved selecting suitable oils, surfactants, and cosurfactants, followed by optimization based on solubility studies, phase diagrams, and thermodynamic stability tests. The SNEDDS was characterized for physical properties such as emulsification time, transmittance, particle size, zeta potential, and polydispersity index. The optimized SNEDDS formulation exhibited excellent characteristics, including an emulsification time of less than 1 minute, near 100% transmittance, a particle size of 9.77 ± 1.33 nm, zeta potential of 0.9 ± 0.1 mV, and a polydispersity index of 0.302 ± 0.033. Antioxidant testing using the DPPH method showed that the 0.1% SNEDDS formulation of Temu Ireng extract had an inhibition concentration (IC50) value of 58.482 mg/L, indicating strong antioxidant activity. The results suggest that the SNEDDS formulation using the SLD method could be an effective strategy to enhance the bioavailability and therapeutic efficacy of Temu Ireng extract as an antioxidant agent.
Cost Effectiveness Analysis (CEA) of Antihypertensives Use in Inpatient Hemodialysis Patients at Abdoel Wahab Sjahranie Hospital Samarinda Sri Setianingsih, Diah; Nur Chairin Hanifa, Deasy
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30730

Abstract

Hypertension is the first comorbid disease that can occur in patients with damaged kidney function. Apart from that, hypertension is a complicating disease that often occurs during the hemodialysis process.  The large variations in the use of antihypertensives in patients with chronic renal failure on hemodialysis therapy can affect the cost incurred by these patients. The purpose of this study was to optimize the use of the most cost-effective and pharmacological antihypertensive drugs in patients undergoing hemodialysis therapy. This research is a descriptive study with a pharmacoeconomic approach using the Cost Effectiveness Analysis (CEA) method. The measurement indices used to analyze the data are ACER and ICER. Data collection was conducted retrospectively, taken from the medical records of inpatient hemodialysis patients by reviewing the inclusion data of patients who were eligible to be research objects. Direct medical costs were taken from the average cost of hemodialysis, other procedures, room costs and drug costs. The effectiveness of drug therapy was determined based on the Mean Arterial Pressure (MAP) value that met the normal value. Research data is grouped based on therapy patterns and then analyzed to obtain cost – effective therapy. The results of the study showed that the percentage effectiveness of antihypertensive therapy with Furosemide was 46%, the combination of Amlodipine and Candesartan was 69% and the combination of Furosemide, Amlodipine, and Candesartan was 56%. Based on the ACER value of Rp. 1,726,133.4, the combination of antihypertensive Amlodipine and Candesartan is the most cost-effective therapy option and based on the ICER value of Rp. -6,697,330.3, the combination of antihypertensive Amlodipine and Candesartan is also the most cost-effective therapy option.

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