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Kota semarang,
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INDONESIA
Jurnal Kesehatan Masyarakat
Published by Universitas Negeri Semarang
ISSN : 18581196     EISSN : 23553596     DOI : -
Core Subject : Health,
Public Health
KEMAS Journal: Research Study in Public Health publishes the article based on research or equivalent to research results in public health or other disciplines related to public health that has not been loaded/published by other media. The journal contains articles about epidemiology and biostatistics, health policy and administration, public health nutrition, environmental health, occupational health and safety, health promotion, reproductive health, maternal and child health, and other related articles in public health. The journal can be used by health practitioners, health caregivers, teachers, medical students, and people who are interested in public health issues. The journal was first published in July 2005 and subsequently published twice a year, in July and January. KEMAS Journal is a peer review journal and can be accessed in http://journal.unnes.ac.id/nju/index.php/kemas. Semarang State University (Unnes) is a leading university in Indonesia with the vision to become a world-class conservation university. The conservation vision is closely related to the study of public health sciences. Unnes also published high quality e-journal from various disciplines, integrated, and managed through Open Access Journals that can be accessed in http://journal.unnes.ac.id. The IAKMI (Ikatan Ahli Kesehatan Masyarakat Indonesia/The Association of Indonesian Public Health Expert) is a non-profit membership association dedicated to advance public health as a scientific discipline and profession that serves public good for Indonesia and humanity.
Arjuna Subject : -
Articles 1,403 Documents
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Occupational Respiratory Symptoms Caused by Chemical Hazard on Hairdresser Workers in Palembang Andarini, Desheila; Camelia, Anita; Listianti, Ani Nidia
KEMAS: Jurnal Kesehatan Masyarakat Vol 15, No 1 (2019)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v15i1.12111

Abstract

Respiratory Disease is the leading cause of death in the majority of people and is among the top 10 causes of death in the world. Factors causing respiratory disease are occupational exposure, smoking and lung infections. According to WHO, 65 million people have respiratory illnesses ranging from moderate to severe. Nearly 90% of deaths from respiratory illness occur in low- and middle-income countries. Hairdressers are exposed to many chemicals in the use of many hair products such as shampoos, curling products, hair dyes, and hair sprays. This study aims to obtain risk factor related to occupational respiratory symptoms on hairdresser workers in Palembang. Cross sectional study design was chosen with a sample size of 150 respondents. The result showed that the prevalence of Occupational Respiratory Symptoms was 40%, female hairdresser were 85.3%, 64.7% were less than 35 years old, those with contact duration of eight hours a day was 78.7%, and those with contact frequency of more than three times a day was 86.6%.There were no significant relationship between sex, age and duration of contact with Occupational Respiratory Symptoms. There was a significant relationship between frequency of contact with Occupational Respiratory Symptoms.
HUBUNGAN ANTARA PENGETAHUAN, MOTIVASI, DAN DUKUNGAN KELUARGA DENGAN KEPATUHAN TERAPI ARV ODHA Mahardining, Anggipita Budi
KEMAS: Jurnal Kesehatan Masyarakat Vol 5, No 2 (2010)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v5i2.1871

Abstract

Kota Semarang adalah kota dengan jumlah kasus penderita HIV/AIDS terbesar di Jawa Tengah yaitu sampai dengan 31 Desember 2008 ditemukan sejumlah 175 kasus HIV/AIDS. Salah satu langkah penting menanggulangi HIV/AIDS adalah dengan meningkatkan jumlah ODHA yang minum obat ARV. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan, motivasi, dan dukungan keluarga dengan kepatuhan dalam terapi ARV pada ODHA (Bimbingan LSM Graha Mitra Semarang). Jenis dan rancangan penelitian ini adalah survei analitik dengan pendekatan belah lintang. Populasinysa adalah keseluruhan orang dengan HIV/AIDS (ODHA) yang menjalani terapi ARV bimbingan LSM Graha Mitra Semarang. Pengambilan sampel dengan menggunakan teknik total yaitu berjumlah 22 orang. Analisis data dilakukan secara univariat dan bivariat menggunakan uji fisher’s exact. Hasil dari penelitian ini adalah ada hubungan antara pengetahuan motivasi serta dukungan keluarga dengan kepatuhan terapi ARV pada ODHA di bawah bimbingan LSM Graha Mitra Semarang. AbstractSemarang is a city with the biggest of HIV / AIDS cases in Central Java. Until December 31, 2008 it is found a number of 175 cases of HIV / AIDS. One important step tackling HIV / AIDS is to improve people living with HIV who take antiretroviral drugs. The purpose of this study was to determine the relationship between knowledge, motivation, and family support with adherence to antiretroviral therapy in the treatment of PLWHA (NGOs Guidance Graha Mitra Semarang). The type and design of this study is a survey cross sectional analytic approach. Population is the whole people living with HIV / AIDS (PLWHA) who underwent antiretroviral therapy guidance of NGOs Graha Mitra Semarang. Samples were collected totaly up to 22 peoples. Data analysis was performed using univariate and bivariate fisher’s exact test. The results show that there is a relationship between motivation and knowledge of family support with antiretroviral therapy adherence in people living under the guidance of NGOs Graha Mitra Semarang.Keywords: HIV / AIDSComplianceARV therapyPeople living with HIV
PENGETAHUAN, SIKAP DAN MOTIVASI TERHADAP KEAKTIFAN KADER DALAM PENGENDALIAN TUBERKULOSIS Kusuma Wijaya, I Made
KEMAS: Jurnal Kesehatan Masyarakat Vol 8, No 2 (2013)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v8i2.2637

Abstract

Masalah penelitian adalah bagaimana hubungan antara pengetahuan, sikap, dan motivasi kader kesehatan dalam pengendalian kasus tuberkulosis. Tujuan penelitian untuk menganalisis hubungan antara pengetahuan, sikap, dan motivasi kader kesehatan dalam pengendalian kasus tuberkulosis di Kabupaten Buleleng. Metode penelitian menggunakan desain studi analitik observasional dengan pendekatan cross-sectional. Randomisasi dilakukan untuk mendapatkan sampel penelitian. Instrumen menggunakan kuesioner dan analisis menggunakan multivariat dengan regresi logistik ganda. Hasil penelitian menunjukkan terdapat hubungan antara variabel pengetahuan dengan keaktifan kader (p=0,012; OR=18.44), antara sikap dengan keaktifan kader (p=0,011; OR=8.08), dan antara motivasi dengan keaktifan kader (p=0,018; OR=15.01). Kader kesehatan dengan pengetahuan tinggi memiliki kemungkinan untuk aktif 18 kali lebih besar daripada pengetahuan rendah. Kader kesehatan dengan sikap baik memiliki kemungkinan untuk aktif 8 kali lebih besar daripada sikap kurang. Kader kesehatan dengan motivasi tinggi memiliki kemungkinan untuk aktif 15 kali lebih besar daripada motivasi rendah. Simpulan penelitian terdapat hubungan yang signifikan antara pengetahuan, sikap, dan motivasi dengan keaktifan kader kesehatan dalam pengendalian kasus tuberkulosis. Research problem was how the relationship between knowledge, attitudes, and motivation of health cadres in tuberculosis control. Research purpose was to analyze the relationship between knowledge, attitudes, and motivation of health cadres in tuberculosis control in Buleleng regency. The research method used analytic observational study by cross - sectional approach. Samples obtained by randomization. Instruments used questionnaires and multivariate analyzes used multiple logistic regression. The results showed there were association between knowledge and cadre activity (p=0.012 ; OR =18.44), between the attitude and cadres activity (p=0.011; OR=8.08), between motivation and cadre activity (p=0.018; OR=15.01) . Health cadres with high knowledge tended to be 18 times more active than the low knowledge. Health cadres with a good attitude tended to be 8 times more active than the fewer attitudes. Likewise, health cadres with high motivation were 15 times more active than the low motivation. Conclusion, knowledge, attitudes, and motivations related with activeness of health cadres in tuberculosis control.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU MENYISAKAN MAKANAN PASIEN DIIT DIABETES MELLITUS Puspita, Devi Karina; Ratna Rahayu, Rr. Sri
KEMAS: Jurnal Kesehatan Masyarakat Vol 6, No 2 (2011)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v6i2.1762

Abstract

Permasalahan penelitian ini adalah mengetahui faktor-faktor yang menyebabkan pasien diit diabetes mellitus menyisakan makanannya? Tujuannya untuk mengetahui faktor-faktor yang berhubungan dengan perilaku menyisakan  makanan pada pasien penderita diit diabetes mellitus di RSUD Dr. M. Ashari Pemalang. Jenis dan rancangan penelitian yang digunakan adalah penjelasan, dengan menggunakan pendekatan belah lintang. Jumlah sampel penelitian sebanyak 14 pasien. Teknik pemilihan sampel dilakukan dengan cara total. Data dianalisis menggunakan uji fisher dengan tingkat kebermaknaan < 0,05. Ins-trumen yang digunakan adalah kuesioner, timbangan makanan dan formulir pengamatan sisa makanan. Hasil penelitian dapat disimpulkan bahwa faktor yang berhubungan dengan sisa makanan diit DM yaitu jadwal makan (nilai p = 0,005), makanan luar RS (nilai p = 0,015), cita rasa makanan (nilai p = 0,005), dan kebiasaan makan (nilai p = 0,003). AbstractProblem in this study was how to identify factors that cause diabetes mellitus patients leaving his food? Purpose of this study was to determine the factors associated with food leaving behavior of patients who received diabetes mellitus in Dr. M. Ashari Pemalang Hospital. The type and design of the study was explanatory, using cross-sectional approach. The number of samples were as many as 14 patients. Sample selection technique was using the total sampling. The data analyzed using fisher test with significance level <0.05. The instruments used were questionnaires, food scales and observation form. In conclusion, the factors associated with DM diet leftovers are meal schedule (p value = 0.005), outside the hospital food (p value = 0.015), the taste of food obtained (p value = 0.005), and eating habits (p value = 0.003).Keywords: Diet of DM; Leftovers; Glouse
SOCIAL CAPITAL AND NUTRITIONAL STATUS OF CHILD UNDER 5 YEARS IN RURAL INDONESIA AND THAILAND Kasmini H, Oktia Woro; Rahayu, Tandyo; Budiono, Irwan; Hunnirun, Pornsuk; Tornee, Songpol; Hansakul, Anong
KEMAS: Jurnal Kesehatan Masyarakat Vol 10, No 1 (2014)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v10i1.3074

Abstract

Prevalensi gizi kurang balita di pedesaan pada satu dasawarsa terakhir terdapat kecenderungan penurunan, yaitu di Thailand (0.3%) lebih cepat secara signifikan dibanding di Indonesia (3,5%). Diduga ada perbedaan pola pemanfaatan modal sosial dalam upaya perbaikan gizi balita. Permasalahan dalam penelitian ini adalah apakah ada perbedaan pengaruh modal sosial yang berhubungan dengan status gizi balita pada urban area di Indonesia dan Thailand. Penelitian ini menggunakan pendekatan kualitatif, dengan strategi penelitian lapangan studi kasus di wilayah kerja Puskesmas Kajen 1, Kabupaten Pekalongan, Indonesia dan di Ongkharak Thailand. Fokus penelitian berupa aspek modal sosial yang terdiri dari: (1) citizenship, (2) asosiasi/organisasi sosial, (3) sosial suport yang mempengaruhi status gizi balita di masyarakat. Teknik penentuan informan dengan cara purposive sampling dan snowball sampling. Hasil penelitian modal sosial yang berkaitan dengan status gizi balita di desa di Indonesia dan Thailand mempunyai corak sejenis. Dimana unsur-unsur modal sosial yang mempengaruhi berupa: 1) cytizenship, dalam bentuk partisipasi aktif dan kreatif terutama dari para kader atau relawan, 2) organisasi sosial berupa Posyandu dan Pusat Pengembangan Balita. Sedangkan perbedaan yang tergambar adalah: 1) Organisasi sosial di Thailand merupakan program yang lebih pro aktif, 2) Di Indonesia aspek cytiznship yang berkaitan dengan unsur resiprocyti atau semangat untuk membantu sangat menonjol, dan 3) Program pemerintah Thailand yang sangat menentukan status gizi balita diperlemah dengan banyaknya masalah bencana alam dan situasi politik. In Indonesia and Thailand, the prevalence trend of malnutrition of children under five in rural area in the last decade has declined, in Thailand (0.3%) was significantly faster than in Indonesia (3.5%). So the problem in this study is whether the different effect of social capital associated with nutritional status of children in rural area in Indonesia and Thailand.This study used a qualitative approach, in Kajen 1 health center, Pekalongan, Indonesia and in Ongkharak, Thailand. The focus of this study was the form of social capital aspect which consists of: (1) citizenship, (2) the association/social organization, (3) social support that affect the nutritional status of children in society. Informants consisted of village heads, heads of health center, village midwives, IHC cadres, community leaders and children’s families. The technique of determining the informant by purposive sampling and snowball sampling.Based on result, social capital related to the nutritional status of children in rural area in Indonesia and Thailand had similar patterns. The elements of social capital that influence as follows: 1) citizenship, in the form of active and creative participation, especially from the cadre or volunteers, 2) social organizations such as IHC and Children Development Center. While the differences were illustrated: 1) social organization in Thailand was a more pro-active programs, 2) In Indonesia, citizenship aspects related to the elements reciprocity or passion to help each other was very prominent, and 3) The Thailand government programs that determine the nutritional status of children had been weakened with the many problems of natural disasters and political situation.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KESEMBUHAN PENDERITA TUBERKULOSIS PARU -, Murtantiningsih; Wahyono, Bambang
KEMAS: Jurnal Kesehatan Masyarakat Vol 6, No 1 (2010)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v6i1.1751

Abstract

Tuberkulosis paru masih menjadi masalah utama kesehatan masyarakat. Angka kesembuhan tuberculosis (TB) Paru di Puskesmas Purwodadi 1 masih rendah. Tujuan penelitian ini adalah mempelajari faktor-faktor yang berhubungan de-ngan kesembuhan penderita TB Paru di Puskesmas Purwodadi I. Penelitian ini menggunakan desain kendali kasus. Populasi kasusnya adalah penderita TB paru BTA positif yang dinyatakan tidak sembuh. Populasi kendali yaitu pen-derita TB paru BTA positif. Sampel kasus dan kendali berjumlah 25 orang yang diperoleh dengan teknik acak sederhana. Hasil menunjukkan bahwa faktor yang berhubungan dengan kesembuhan penderita TB paru yaitu status gizi, pendapatan, keteraturan berobat dan faktor yang tidak berhubungan yaitu  penyuluhan oleh petugas kesehatan, jenis kelamin, pendidikan dan dukungan PM. AbstractPulmonary tuberculosis (TB) becomes a major public health problem. Pulmonary TB cure rate in the health center Purwodadi 1 is still low. The purpose of this study is to identify the factors associated with cure of TB patients at health centers Pulmonary Purwodadi I. This study used a case-control design. Population case is smear positive pulmonary TB patients who otherwise recover. The control population are patients with smear-positive pulmonary TB. Samples of cases and controls amount of 25 peoples are obtained by simple random sampling technique. The results show that factors related to the healing of pulmonary tuberculosis patients are nutritional status, income, regularity of treatment and factors not related to are the counseling by health, sex, education and PM support.Keyword: Recover risk factor; Pulmonary TB; Positive BTA
SARUNG TANGAN LATEX SEBAGAI UPAYA PENCEGAHAN DERMATITIS KONTAK Ningtiyas, Ardhinka Fitri
KEMAS: Jurnal Kesehatan Masyarakat Vol 9, No 1 (2013)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v9i1.2835

Abstract

Berdasarkan survei pendahuluan di CV. Yuasa Food Wonosobo, ditemukan 3 dari 7pekerja pengupas Karika Dieng merasakan gatal dibagian pergelangan tangan dan sekitarkuku walaupun memakai sarung tangan. Penelitian ini bertujuan untuk mengetahuikemampuan sarung tangan latex untuk mencegah dermatitis kontak pada pekerja bagianpengupasan Karika Dieng di CV. Yuasa Food Wonosobo. Jenis penelitian ini adalaheksperimen semu dengan pendekatan Pre-test Post-test Control Group Design yangdilakukan pada tahun 2012. Pengambilan sampel dilakukan dengan random sampling.Populasi dalam penelitian ini adalah 30 pekerja, sedangkan sampel dalam penelitian iniberjumlah 8 pekerja. Hasil uji wilcoxon diperoleh hasil signifi kansi 1,000 berarti tidakterdapat perbedaan yang bermakna antara hasil pre-test dan post-test. Berdasarkan hasilpenelitian dapat disimpulkan bahwa sarung tangan latex dapat digunakan sebagai upayapencegahan dermatitis kontak pada pekerja bagian pengupasan Karika Dieng di CV.Yuasa Food Wonosobo. Based on a pre-study in CV. Yuasa Food Wonosobo, there were 3 from 7 workers who peelKarika Dieng felt itchy in their wrist and around the nails even wore gloves. Th e purposeof the study was to fi nd out the ability latex gloves for preventing the contact dermatitis inworkers parer Karika Dieng in CV. Yuasa Food Wonosobo. Th e study was quasi experimentwith approaches pre-test post-test control group design conducted in 2012. Sampling wasconducted with a random sampling. Population in this study were 30 workers, the sampleswere 8 workers. Wilcoxon test result obtained 1,000 signifi cant results that means therewas no signifi cant diff erences in value between pretest and posttest. Based on the result ofthis study concluded that the latex gloves can be used for preventing dermatitis contact inworkers who peel Karika Dieng in CV. Yuasa Food Wonosobo.
KEMATIAN LARVA AEDES AEGYPTI SETELAH PEMBERIAN ABATE DIBANDINGKAN DENGAN PEMBERIAN SERBUK SERAI Nugroho, Arif Dwi
KEMAS: Jurnal Kesehatan Masyarakat Vol 7, No 1 (2011)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v7i1.2802

Abstract

Penggunaan larvasida sintesis sangat merugikan masyarakat, seperti pencemaran lingkungan dan menyebabkan resistensi. Alternatif untuk mengurangi dampak negatif tersebut adalah dengan menggunakan larvasida nabati yang berasal dari tanaman yaitu serai. Tujuan dari penelitian ini adalah untuk mengetahui untuk mengetahui perbedaan jumlah kematian larva Aedes aegypti setelah pemberian abate dibandingkan pemberian serbuk serai. Jenis penelitian ini adalah eksperimen yang dilakukan pada tahun 2011, menggunakan rancangan penelitian post test only with control group design. Dengan populasi seluruh larva Aedes aegypti instar III dan IV yang berada di B2P2VRP Salatiga. Sampel berjumlah 400 ekor larva. Analisis data yang dilakukan secara univariat dan bivariat (menggunakan uji independent t-test dengan α= 0,05). Kesimpulan dari penelitian ini adalah ada perbedaan yang signifikan jumlah kematian larva Aedes aegypti setelah pemberian abate dibandingkan dengan pemberian serbuk serai, dapat dilihat dari hasil uji independent t-test, dimana nilai p=0,002 (p<0,05).The usage of sintesis larvacide harmed the society, such as contamination of enviroment, and resistense. Some alternatives to reduce the negative impact were use vegatation larvacide from flora such as lemongrass. The purpose of this research was to investigate the differences on the number of Aedes aegypti larvae mortality after giving abate compared with giving lemongrass powder. The study was experiment research in 2011, used post test only with control group design plan research. The population were all of Aedes aegypti larvae instars III and IV in B2P2VRP Salatiga. Sample were 400 larvaes. The data analysis used univariate and bivariate (used independent t-test with α = 0,05). The conclusion is that there is a significant difference in the number of Aedes aegypti larvae mortality after giving abate compared with giving lemongrass powder, can be seen from the test results of independent t-test, where the p value = 0,002 (p < 0,05).
PENGARUH INTENSITAS PENCAHAYAAN LOKAL Widowati, Evi
KEMAS: Jurnal Kesehatan Masyarakat Vol 5, No 1 (2009)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v5i1.1862

Abstract

Tujuan penelitian ini adalah untuk mengetahui pengaruh intensitas pencahayaan lokal terhadap kelelahan mata operator bagian loom weaving V denim perusahaan tekstil di Semarang. Metode penelitian ini bersifat penjelasan de-ngan menggunakan pendekatan belah lintang. Variabel dalam penelitian ini adalah intensitas pencahayaan lokal dan kelelahan mata. Populasi berjumlah 33 yang bekerja sebagai operator mesin loom weaving V denim. Sampel dipilih de-ngan teknik purposif berdasarkan kriteria inklusi sehingga diperoleh sebanyak 13 orang. Hasil penelitian menunjukkan ada pengaruh antara intensitas pencahayaan terhadap kelelahan mata yaitu meningkatnya intensitas pencahayaan 1 lux akan diikuti dengan menurunnya kelelahan mata responden sebesar 1.782 milidetik. AbstractThe purpose of this study was to determine the effect of local illumination intensity with the operator eyestrain, in loom weaving V denim of textile company in Semarang. The method of this research was explanatory research using cross sectional approach. The variable in this study was the intensity of local lighting and eyestrain. Population are 33 operators who worked as machine operators of weaving looms V denim. The samples were selected by purposive sampling technique based on inclusion criteria as many as 13 peoples. The results show influence between the intensity of illumination with the eyestrain that is the increasing intensity of illumination 1 lux will be followed by a decrease eyestrain respondents for 1782 milliseconds.Keywords: Local lighting; Eyestrain
THE EFFECT OF ALL-TRANS RETINOIC ACID (ATRA) AND ZINC SULPHATE SUPPLEMENTATION ON PERIODONTITIS Hanafi, Praptiwi
KEMAS: Jurnal Kesehatan Masyarakat Vol 11, No 1 (2015)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v11i1.3512

Abstract

The study executed to know the effect of ATRA and Zn supplementations to periodontitis rat collagen treated with tetracycline.The experimental study with factorial design used 54 Wistar adult male rat. Periodontitis was resulted from porphyromonas gingivalis inoculation. Tetracycline 90 mg/kg and the supplementations were given for 7 days. Nine groups sample were randomly allocated. The independent variables were supplementation of ATRA 10; 5 mg/kg, Zn 2.5; 1 mg/kg, and their combinations. Dependent variable was collagen status i.e degradation and synthesis, consecutively measured by mRNA MMP-2 and mRNA P1CP, using reverse transcriptase polymerase chain reaction. Control was periodontitis group receiving tetracycline. T-test, ANOVA, Post Hoc Duncan and least significant differences (LSD) were used. High dose ATRA 10 mg/kg and Zn 2.5 mg/kg supplementations consecutivetly degraded (0.25 x of control) and increased collagen synthesis (4 x of control). High dose ATRA and Zn combined supplementation gave no effect to collagen degradation, but increased synthesis (3 x of control). The effect of high dose ATRA and Zn combined supplementation on collagen synthesis was the nearest to healthy condition.Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi ATRA dan Zinc pada kolagen jaringan periodontium tikus periodontitis yang mendapat tetrasiklin. Studi eksperimental dengan desain faktorial dilakukan pada 54 tikus Wistar jantan dewasa. Periodontitis dihasilkan melalui inokulasi porphyromonas gingivalis. Tetrasiklin 90 mg/kg dan suplementasi diberikan selama 7 hari. Sembilan kelompok sampel terpilih secara alokasi acak. Variabel bebas adalah suplementasi ATRA 10; 5 mg/kg; Zn 2,5; 1 mg/kg; dan kombinasinya. Variabel tergantung adalah status kolagen meliputi degradasi dan sintesis, indikator mRNA MMP-2 dan mRNA P1CP, terukur dengan reverse transcriptase polymerizing chain reaction. Kontrol adalah kelompok periodontitis dan mendapat tetrasiklin. Analisis data menggunakan uji t, ANOVA, Post Hoc Duncan, dan LSD.  Suplementasi dosis tinggi ATRA 10 mg/kg dan Zn 2,5 mg/kg berturut-turut mendegradasi (0,25 x kontrol) dan meningkatkan sintesis kolagen (4 x kontrol). Kombinasi suplementasi dosis tinggi ATRA dan Zn tidak berefek pada degradasi kolagen, tetapi meningkatkan sintesisnya (3 x kontrol). Suplementasi kombinasi dosis tinggi ATRA dan Zn memberikan sintesis kolagen paling dekat dengan keadaan sehat.

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