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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
Arjuna Subject : -
Articles 1,068 Documents
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Antiplatelet Drugs and Its Gastrointestinal Side Effects among Ischemic Stroke Patients in Dr. Hasan Sadikin General Hospital 2011 Ananthakrishnan A/L Rajendram; Ike Rostikawati Husen; Andi Basuki
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

 Background: Antiplatelet drugs with known side effects are given in long term therapies to prevent secondary ischemic stroke. Gastrointestinal side effect is the most prevalent issue. The aim of this study was to identify which antiplatelet drugs have the most gastrointestinal side effects and the duration of administration. Methods: Seven hundred twenty six medical records were obtained from the Medical Record Department of Dr.Hasan Sadikin General Hospital Bandung from August to December 2011. Inclusion criteria were >18 years old and treated by long term antiplatelet drugs with complete medical records. Data analyzed descriptively consist of antiplatelet type, gastrointestinal effects, and drug administration duration. Results: Of 726 medical records only 246 were enrolled this study. Aspirin 80 mg was the most frequent drug given to ischemic stroke patients (65.9%). GI bleeding and nausea were the two side effects mostly found in aspirin >80 mg group (90%; 95% respectively). The side effects was found after less than 3 months in the aspirin >80 mg group, while it took longer to appear in clopidogrel 75 mg group. Conclusions: Aspirin (>80 mg) presents the most frequent gastrointestinal side effect compared to low dose aspirin 80 mg , clopidogrel, and combination of clopidogrel and aspirin.Keywords: Antiplatelet, ischemic stroke, side effects DOI: 10.15850/amj.v2n1.425  
Pseudoexfoliation Glaucoma in the National Eye Center, Cicendo Eye Hospital, January–October 2012 Rizki Fasa Ramdhani; Elsa Gustianty; Fenny Dwiyatnaningrum
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

  Background: Pseudoexfoliation syndrome is characterized by the deposition of a distinctive fibrillar material in the anterior segment of the eye. This condition is a major risk factor for development of glaucoma, termed pseudoexfoliation glaucoma (PEXG). The aim of this study was to describe the characteristic and management of PEXG in the National Eye Center Cicendo Eye Hospital.Methods: A descriptive retrospective study was conducted in October–November 2012 using medical records of PEXG patients in the National Eye Center Cicendo Eye Hospital during January–October 2012. Results: There were 32 patients (43 eyes) diagnosed as PEXG, most of them were male (78.1%), age 70–74 years old (34.4%) and followed by those in the range of age 65–69 years old (21.9%). Most of the cases were unilateral (65.6%) decrease of visual acuity less than 3/60 (76.7%), increase of intraocular pressure (IOP) with majority in the range of 31–40 mmHg (32.6%) and 41–50 mmHg (32.6%), Cup/Disc Ratio 0.9–1.0 (46.51%) and followed by those classified as majority which were hard to assess because of the presence of opaque media (34.89%). The type of glaucoma was open angle glaucoma (88.4%). The treatment received was a combination of two types of antiglaucoma medication and surgery IOPConclusion: PEXG is mostly found in elderly patients. While most of the patients come with high IOP and late stage of the disease IOPKeywords: Characteristics, glaucoma, pseudoexfoliation DOI: 10.15850/amj.v2n1.446 
Vegetables contamination by Parasitic Helminth Eggs in Malaysia and Indonesia Reashnaa Loganathan; Ridad Agoes; Insi Farisa Desy Arya
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Soil-transmitted helminth infection is known to be a serious issue in South East Asia when the farmers use night soil and contaminated water for their plants. In Indonesia, some of the farmers still use human feces and sometimes also mixed it with urine from the latrines as fertilizers. On the contrary, in Malaysia these contamination occured at a lower rate due to strict rules by the authorities.The objective of this study was to identify the helminth eggs in vegetables from traditional markets in Indonesia and Malaysia.Methods: Three traditional markets were selected by non-random sampling, namely Pasar Ampang in Malaysia and 2 traditional markets in Indonesia, i.e Pasar Tanjungsari and Jatinangor. Cabbages and lettuce were bought from 15 different vegetable sellers per market. The samples were examined at the laboratory of the Medical Faculty, Universitas Padjadjaran. The method to obtain the specimen was in accordance with Khairul Anwar and Ramachandran. This study was carried out from July to October 2014. The collected data was analyzed by percentage and frequency tabulation.Result: Most of the samples are contaminated by helminth eggs. In Pasar Ampang, 13.3% in cabbage and 6.7% in lettuce. In Pasar Tanjung Sari, 46.7% in cabbage and 40% in lettuce. Moreover, in Pasar Jatinangor, 33.3% in cabbage and 26.7% in lettuce. Most of the helmint eggs were Ascaris lumbricoides.Conclusions: The helminthes eggs contamination is higher in Indonesian traditional markets compared to in Malaysia. [AMJ.2016;3(2):190–4]DOI: 10.15850/amj.v3n2.796
Diagnostic Value of Narrow Band Imaging in Diagnosing Nasopharyngeal Carcinoma Debbi Yuniserani; Bethy S. Hernowo; Agung Dinasti Permana
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Carcinoma is the most common tumor in nasopharynx. Endoscopy is used to determine the presence of lesions suspected of malignancy. Narrow Band Imaging is an endoscopic technique that uses narrow–band spectrum as a filter to determine any mucosal vascular changes in carcinoma. Narrow Band Imaging can early detect superficial mucosal lesions that are difficult to detect with conventional endoscopy, so that diagnosing is more accurate and occurrence of unnecessary biopsies can be reduced. This study aimed to determine diagnostic value of Narrow Band Imaging in diagnosing nasopharyngeal carcinoma.Methods: This diagnostic test study was conducted at Department of Otorhinolaryngology-Head and Neck Surgery Dr. Hasan Sadikin General Hospital, Bandung from September to October 2014. Twenty four patients with clinical signs and symptoms of nasopharyngeal carcinoma that fulfilled the study criteria were assigned using consecutive sampling to examine with Narrow Band Imaging and histopathology examination. The data were then analyzed with 2x2 table to determine sensitivity, specificity, positive predictive value, negative predictive value, and accuracy.Results: In this study, the results of sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in diagnosing nasopharyngeal carcinoma using Narrow Band Imaging were 93.75%, 62.5%, 83.3%, 83.3%, and 83.3%, respectively. Conclusions: Sensitivity of Narrow Band Imaging is 93.75%. [AMJ.2017;4(1):133–7] DOI: 10.15850/amj.v4n1.1034
Factors Related with Knowledge of Basic Life Support among Members of Student Body Volunteer Organizations at Universitas Padjadjaran Nur Fadilla; Irvan Afriandi; Rudi Herman Sitanggang; Elsa Pudji Setiawati
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Mortality caused by accidents remains a public health challenge. Prompt response during first aid accident may prevent disability or death. At Universitas Padjadjaran three student body volunteer organizations provide training in Basic Life Support as the component of first aid. They are Korps Sukarela Palang Merah Indonesia (KSR PMI), Perhimpunan Mahasiswa Pecinta Alam (PMPA) Palawa, and Unit Search and Rescue (SAR). This study aims to assess the level of Basic Life Support knowledge of the members inthree organizations and the factors related with their knowledge.Methods: The method used was a descriptive study carried out on subjects diagnosed with PSS at the National EThis was a cross sectional study that included 59 members of three student body volunteer organizations of Universitas Padjadjaran that have received training in Basic Life Support. A questionnaireabout respondent’s characteristics, Basic Life Support-related experiences, and Basic Life Support’s knowledge was administered to the participants during October 2012Results: The total mean for the three student body volunteer organizations on questionnaire was 64.12±19.40 with minimum score was 25 and maximum score was 100. The interval of last period of training and Basic Life Support-related experiences did not show statistically significant (p=0.647) and(p=0.357) however educational background related to Basic Life Support knowledge showed statistically significant (p<0.01).Conclusions: The level of Basic Life Support knowledge in three student body volunteer organizations was moderate and that educational background has relation with the knowledge. The increase in number of effective training and application in the field may increase the knowledge on Basic Life Support. [AMJ.2015;2(1):186–90]
Relation between Risk Factors of Pyoderma and Pyoderma Incidence Lila Indria Depari; Unwati Sugiri; Lola Ilona Fuad Abdul Hamied
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Pyoderma is a purulent bacterial infection of the skin. In developing countries, pyoderma is the most common skin disease in children. Pyoderma attacks male more often than female. Factors influencing pyoderma are low socioeconomic level, low education, low personal hygiene and unhygienic house. This study was conducted to assess the relation between risk factors of pyoderma and pyoderma incidence.Methods: This study used cross-sectional study design and was conducted from August–November 2013. The sample collection was done with multistage random sampling, where 196 primary school children in Jatinangor subdistrict were randomly taken to be admitted into this study. The data collection procedure consisted of physical examination and questionnaire filling. The data were statistically analyzed using independent T and chi-square test.Results: Upon examining 196 subjects, four were found with pyoderma. As such, the prevalence of pyoderma on primary school children in Jatinangor in 2013 was 2%. There was relation between personal hygiene and pyoderma incidence (p=0.041). Sex (p=0.623), healthy housing (p=0.097), socioeconomic level (p=0.742) and education level of parents (p=0.989) were not related with pyoderma.Conclusions: Personal hygiene is the risk factor that had relation with incidence of pyoderma. [AMJ.2016;3(3):434–39] DOI: 10.15850/amj.v3n3.867
Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion Rizda Nurul Zartiana; Samsudin Surialaga; Hikmat Permana
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease. This study aimed to analyse the effect of Psidium guajava leaf to inhibit glucose absorption in intestine epithelial membrane of wistar rats.Methods: This laboratory experimental study used 5 wistar rats as subjects in the Laboratory of Biochemistry at Padjadjaran University from 10−26 October 2012. All rats were given three solutions by in situ perfusionmethod. The first was 25 ml 3.0 X 10-3 M glucose solution, the second was 25 ml 3.0 X 10-3 M glucose solution with 1 ml Psidium guajava infusion added, and the third was 25 ml 3.0 X 10-3 M glucose solution.The sample from each solution was taken five times at 0, 15, 30, 45, and 60 minutes after the solutions were given. The spectrophotometer was to quantify the concentration of glucose from the samples. Data were analyzed using Friedman and Wilcoxon test.Results:The means of glucose concentration for each solution from the first solution to the third were 6.126 mg/dl, 2.447 mg/dl, and 5.345 mg/dl. The probability value showed significant difference between the first and second solutions (p ≤ 0.05).Conclusions: Psidium guajava leaf infusion can inhibit glucose absorption in wistar rat intestine and the effect is reversible. [AMJ.2015;2(4):546–9] DOI: 10.15850/amj.v2n4.508
Gestational Age Conformity between New Ballard Score and Last Menstrual Period in Newborn with Respiratory Distress Syndrome Wulan Dwi Sakinah; Aris Primadi; Ihrul Prianza Prajitno
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Gestational age is required to determine diagnosis and optimal management of newborns. The gold standard for gestational age determination is the first day of last menstrual period (LMP). However, not all mothers remember their LMP. Another method for gestational age determination after birth is the New Ballard Score (NBS). This method measures gestational age using two main components, namely neorumuscular and physical maturity. In premature infants, surfactant deficiency leads to hypoxia which eventually leads to neuromuscular disorders. This situation may cause younger gestational age estimation when using NBS. The objective of this study was to analyze the conformity between NBS and LMP in determining gestational age in newborns with respiratory distress syndrome (RDS).Methods: A cross-sectional study was conducted on 35 newborns with RDS that were recorded in 2012 database in Dr. Hasan Sadikin General Hospital Bandung. Data on the date of birth, LMP, NBS soon after birth, sex, birth weight, type of delivery and diagnosis were collected and analyzed statistically using Wilcoxon test.Results: The study showed that there was a significant difference (p<0.05) between gestational age determination done using NBS soon after birth and LMP in newborns with RDS.Conclusions: Gestational age determination based on NBS soon after birth does not conform the LMP in newborns with RDS. [AMJ.2016;3(3):401–4]DOI: 10.15850/amj.v3n3.888
Larvacidal Effect of Imperata Cylindrical Root Decoction against Culex sp. Larvae Afini Tiara Resi; Diah Dhianawaty; Neneng Syarifah
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Filariasis is one of the neglected tropical diseases. About 337 of 401 districts in Indonesia are endemic areas for filariasis, especially in Sumatera,  Kalimantan, and Papua. Culex sp. is one of the lymphatic filariasis vectors which can be controlled by insecticide, including larvacide. This study was conducted to determine the larvacidal effect of Imperata cylindrical root decoction against Culex sp. larvae.Methods: This study was conducted at the Laboratory of Parasitology, Faculty of Medicine, Universitas Padjadjaran during the period of September to November 2012. The study object was Culex sp. larvae III/IV instars. The design of this study was experimental laboratory using true experimental approach. The larvae were divided into three groups: negative control (distilled water), reference (Abate®), and decoction. The number of larvae in each group was 25 larvae, and the effects were evaluated by the total number of dead larvae in 48 hours under observation. The data were then analyzed by Mann-Whitney test and Probit test.Results: The result of the Mann-Whitney test to compare Imperata cylindrica root decoction treatment to distilled water as control  was significant (p<0.05). However, Abate® gave a better result. The Probit test resultwas LC50:  63% and LC90: 489%.Conclusions: Imperata cylindrical root decoction has a larvacidal effect against Culex sp. larvae.Keywords: Culex sp., Filariasis, Imperata cylindrica (L.) Beauv., Larvacidal, LC50  Pengaruh Larvasida Rebusan akar alang-alang (Imperata Cylindrical) terhadap Larva Nyamuk (Culex sp.) AbstrakLatar Belakang: Filariasis merupakan salah satu penyakit tropis yang terabaikan. Sekitar 337 dari 401 kabupaten di Indonesia adalah daerah endemik untuk filariasis terutama di Sumatera, Kalimantan, dan Papua.  Nyamuk (Culex Sp.) adalah salah satu vektor filariasis limfatik yang dapat dikendalikan oleh insektisida, termasuk larvasida. Penelitian ini dilakukan untuk mengetahui pengaruh larvasida dari rebusan  akar alang-alang terhadap larva nyamuk (Culex sp.)Metode: Penelitian ini dilakukan di Laboratorium Parasitologi, Fakultas Kedokteran, Universitas Padjadjaran selama periode September-November 2012. Objek penelitian adalah larva nyamuk (Culex sp.) instar III / IV.. Desain penelitian ini adalah eksperimental laboratoris dengan menggunakan pendekatan eksperimental yang benar. Larva dibagi menjadi tiga kelompok: kontrol negatif (air suling), referensi (Abate®), dan rebusan. Jumlah larva dalam setiap kelompok adalah 25 larva, dan efek dievaluasi dengan jumlah total larva mati dalam 48 jam di bawah pengawasan. Data kemudian dianalisis dengan uji Mann-Whitney dan uji Probit. Hasil: Hasil uji Mann-Whitney untuk membandingkan pemberian rebusan akar alang-alang (Imperata cylindrica) terhadap air suling sebagai kontrol adalah signifikan (p <0,05). Namun, Abate® memberikan hasil yang lebih baik. Hasil tes Probit adalah LC50: 63% dan LC90: 489%.Simpulan: Rebusan akar alang-alang (Imperata cylindrical) memiliki efek larvsidal terhadap larva nyamuk (Culex sp.) Kata kunci: Nyamuk (Culex sp.), Filariasis, Alang-alang (Imperata cylindrica (L.) Beauv), Larvasida, LC50 DOI: 10.15850/amj.v1n2.349
Durian Consumption Effect on the Plasma Malondialdehyde Level as Biomarker of Stress Oxidative in Rats Anugrah Aulia Ulil Amri; Ani Melani Maskoen; Syarief Hidayat
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Excessive consumption of durian (Durio zibethinus Murray) in Indonesia is often connected with its effect on health. This study aims to understand the effect of durian consumption to malondialdehyde (MDA) in plasma as oxidative stress biomarker.Methods: The study used an experimental research design on animal models, in the Biochemistry and Molecular Biology Department, Faculty of Medicine, Universitas Indonesia, July–August 2012. Thirty two Sprague-Dawley rats were used, divided into four groups: control, treatment week 1, 2, and 3. Each treatment group was given 20 gram durian fruit diluted with water until 20 ml volume per oral, divided into two doses (10 ml each) with 4 hours interlude between doses for 1 week, 2 weeks, and 3 weeks. All groups got normal diet and water ad libitum. Plasma MDA level was measured by TBARS method, then analyzed using Kurskal-Wallis and Mann-Whitney tests.Results: Seventeen samples were successfully decapitated (5 for control; 6 for week 1; 3 for week 2; 3 for week 3). Average plasma MDA level for control treatment week 1, 2 and 3 groups were 0.707 nmol/ml, 0.432 nmol/ml, 0.312 nmol/ml, and 0.746 nmol/ml respectively. Data was significant (p<0.05) with p=0.02. Compared with control group, a significant increase occurred in week 1 and 2 groups with p=0.028 and p=0.025 respectively.Conclusions: Results of durian consumption show MDA level significantly decreases in week 1 and 2. However, MDA level dramatically increases exceeding control group level in week 3. [AMJ.2016;3(1):22–8] DOI: 10.15850/amj.v3n1.695

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