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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
Arjuna Subject : -
Articles 339 Documents
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Rosmarinic Acid from Orthosiphon aristatus Potentially Targets Estrogen Receptor-Alpha in Breast Cancer: In-silico Study Qurrotaayun, Ghina Alya Putri; Sitompul, Joy Elizabeth Nauli; Fadhilah, Naya; Pramudita, Fransisca Widi; Putri, Nazwa Septiriana; Muljono, Fajar Oktavian; Fardhan, Firghi Muhammad; Novitasari, Dhania
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp150-161

Abstract

Breast cancer is the most common cancer among women. Tamoxifen, a widely used estrogen receptor-alpha (ER-α) inhibitor, is effective but often causes side effects, necessitating the search for alternative inhibitors from natural sources. Ortosiphon aristatus, also known as cat's whiskers, is a medicinal plant traditionally valued for its anti-inflammatory and antioxidant properties. Recent studies suggest its bioactive compounds may exhibit anticancer activity by inducing apoptosis in cancer cell lines. This study explores the potential of O. aristatus metabolites as ER-α inhibitors using computational approaches. Nine metabolites were assessed for their physicochemical properties based on Lipinski’s rule of five and ADMET predictions, followed by pharmacophore-based virtual screening with LigandScout and molecular docking with AutoDock. The results showed that all tested compounds complied with Lipinski’s rule, and most met ADMET criteria. Among these, rosmarinic acid was identified as one of the hit compounds based on pharmacophore screening, exhibiting binding interactions comparable to 4-hydroxytamoxifen with the ER-α amino acid residues HIS524 and GLY521. It also demonstrated a binding energy of -8.02 kcal/mol and a low inhibition constant (Ki) of 1.31 μM. These findings highlight the potential of O. aristatus and rosmarinic acid for further evaluation as candidates against ER-α in breast cancer cells.Keywords: breast cancer, estrogen receptor-alpha, Orthosiphon aristatus, in silico.
Molecular Insights into Breast Cancer Treatment: An Integrated Approach of Network Pharmacology and Component Analysis for Lansium parasiticum Bark Extract Mutiah, Roihatul; Annisa, Rahmi; Zahiro, Syayida Roisatus
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp96-107

Abstract

Medicinal plants containing multi-components have the potential for multi-target genes, multi-pathways, and various effects on diverse diseases. With the increasing technological advancements, understanding the complex interactions between multi-component substances and biological systems is becoming more crucial. In this context, conventional experimental research might have limitations as it typically focuses on the impact of one component on one gene. The objective of this research is to identify compounds in the bark extract of Lansium parasiticum and elucidate the molecular mechanisms of these compounds in inhibiting the progression of breast cancer cells using a network pharmacology approach. Compound identification in Lansium parasiticum bark extract (LPBE) has been conducted using Liquid Chromatography Tandem Mass Spectrophotometry (LC-MS/MS) technique. ADMET predictions were utilized to determine the absorption and bioavailability profiles. A network pharmacology approach employing Cytoscape 3.9.1, GeneCards, Disgenet, STRING 2.0.0, SRplot, and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to predict the anti-cancer molecular mechanisms of these compounds. Seventeen active compounds have been successfully identified via LC-MS/MS. Among these, the compounds Moronic Acid, 4-Morpholineacetic Acid, and Ursolic Aldehyde were found in the highest concentrations. The results of the network pharmacology analysis indicate that the compounds in LPBE are involved in three potential pathways for breast cancer treatment: the NF-κß signaling pathway (hsa 04064), microRNA in cancer (hsa05206), and apoptosis (hsa04210). Target genes implicated in these pathways include BAX, BCL2, TNF-α, PARP1, STAT3, NOTCH1, and NF-κß1. It can be concluded that LPBE contains compounds with potential for treating breast cancer, as they are predicted to interact with relevant target pathways and genes. Therefore, further research is highly recommended, particularly in the development of drugs for breast cancer.Keywords: apoptosis, microRNA, NF-κß, TNF-α, STAT3.
Nanotechnology in Cancer Treatment: Innovative Approaches to Overcoming Drug Resistance in Tumors Eskandar, Kirolos
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp162-174

Abstract

Nanotechnology has emerged as a groundbreaking approach in oncology, offering innovative solutions to one of the most significant challenges in cancer treatment: drug resistance. This literature review explores the role of nanotechnology in overcoming multidrug resistance (MDR) in tumors, focusing on the use of nanoparticles for targeted drug delivery, gene therapy, and immunotherapy. By penetrating biological barriers and modulating the tumor microenvironment, nanocarriers enhance the efficacy of anticancer agents while minimizing side effects. Additionally, this review provides a comprehensive analysis of recent clinical trials, offering insights into the real-world effectiveness of nanotechnology-based treatments. Ethical, regulatory challenges, and nanotoxicity are discussed to ensure the safe translation of nanomedicine to clinical practice. The review concludes with future directions in personalized nanomedicine, highlighting nanotechnology’s transformative potential in revolutionizing cancer treatment and improving patient outcomes by addressing the pervasive issue of drug resistance.Keywords: nanotechnology, drug resistance, nanoparticles, targeted drug delivery, cancer therapy.
Structure-based Virtual Screening, and Design of Some Lead Compounds as Inhibitors of Kras-G12D of Pancreatic Cancer Ovaku, Idris Momohjimoh; Abechi, Stephen Eyije; Shallangwa, Gideon Adamu; Umar, Abdullahi Bello; Uzairu, Adamu
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp108-126

Abstract

Pancreatic cancer is an abnormal cell growth in the pancreas. In 2021, approximately 60,430 individuals were diagnosed in the USA, with the annual increasing incidence rates. Pancreatic cancer is anticipated to become the second leading cause of cancer mortality by 2030. This escalating challenge has prompted a search for innovative therapeutic agents. Virtual screening, a computational technique, was employed to discover novel drug-like compounds from a diverse set of 30 chemical compounds, sourced from the PubChem database. These compounds were evaluated based on some important properties, including pharmacokinetics, lipophilicity, drug-likeness, water-solubility, and physicochemical characteristics. Seventeen compounds emerged as promising candidates for pancreatic cancer treatment. Subsequent molecular docking studies focused on the Kras-G12D protein target and identified Ligand 18 as the leading candidate, exhibiting a binding energy (BE) of -10.5 kcal mol-1 and extensive interactions with the target protein. Additionally, a newly designed compound, D4, displayed an even higher BE of -10.8 kcal mol-1, fitting more effectively into the protein's binding site than existing drugs like Gemcitabine and Irinotecan. All newly designed compounds met the five scientists' rule, indicating favorable drug-likeness and bioavailability. These findings pave the way for developing a new generation of less toxic therapeutic compounds for pancreatic cancer treatment.Keywords: virtual screening, binding energy, kras-G12D, pancreatic cancer, designed compounds.
Network Pharmacology and In Vitro Validation of Brazilin as a Potential Apoptosis-Inducing Agent in HBV-Related Hepatocellular Carcinoma Hanifa, Mila; Utomo, Rohmad Yudi; Jenie, Riris Istighfari
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp210-223

Abstract

Hepatitis B virus (HBV) reactivation-related hepatocellular carcinoma (HCC) presents a significant threat due to its potential to cause liver failure and mortality. Consequently, the discovery of novel treatments that offer anticancer efficacy and liver protection is urgently needed. Brazilin, a natural compound, has previously been reported to possess cytotoxic and liver-protective properties. This research aimed to investigate the potency of brazilin in suppressing the growth of HCC cells through in silico and in vitro approaches. Hep3B cells, which harbor integrated HBV DNA, were selected as the HCC model, with PGV- 1 utilized as a positive control. The in silico study used network pharmacology to predict brazilin’s potential gene targets. Cytotoxicity was evaluated using the CCK-8 assay, and apoptosis detection was carried out using Annexin V/PI staining followed by flow cytometry. The analysis predicted that brazilin targets key genes such as SRC, EGFR, AKT1, GRB2, IGF1, ESR1, STAT1, MMP9, JAK2, and PPARG involved in cancer proliferation and metastasis. Proteins such as SRC, GRB2, and MMP9 are overexpressed in TP53-mutated HCC and linked to low survival. Brazilin showed moderate cytotoxicity with an IC50 value of 17 μM at 72 h and significantly induced apoptosis in Hep3B cells. These findings suggest that brazilin is a promising apoptosis-inducing agent for HBV-related HCC.Keywords: brazilin, Hep3B cell lines, network pharmacology, cytotoxic, apoptosis.
In Silico Analysis of Cucurbitacin IIa and Cucurbitacin IIb as Potential Modulators of Oxidative Stress Regulatory Proteins Sarmoko, Sarmoko; Suprahman, Nisa Yulianti; Putri, Refsya Azanti; Hakim, Ahmad Zammi Autadan; Cahyadi, Dzaky Raihan; Saputra, Muhammad Yogi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp224-236

Abstract

Oxidative stress, resulting from imbalance between rective oxygen species (ROS) production and antioxidant defenses, contributes significantly to numerous pathological conditions, including inflammation, cancer and neurodegeneration. Natural compounds with antioxidant properties offer promising therapeutic potential. This study aims to investigate the potential of Cucurbitacin IIa and IIb to modulate oxidative stress regulatory proteins (NOS2, Lipoxygenase, KEAP1, and Xanthine oxidase) using molecular docking approaches. Target protein structures were retrieved from the RSCB Protein Data Bank. Ligand geometries were constructed and optimized using density functional theory. Molecular docking was performed using AutoDock 1.5.6 with a validated docking protocol (RPMS<2Å). Our results demonstrated favorable binding energies for both compounds with NOS2 (-9.75 and -9.57 kcal/mol) and KEAP1 (-8.52 and -9.34 kcal/mol), approaching the affinities of their respective native ligands. Moderate binding was observed with Lipoxygenase (-6.14 and -5.54 kcal/mol), while both compounds showed incompatibility with Xanthine oxidase, as evidenced by highly positive binding energies. The interaction between Cucurbitacins with NOS2, KEAP1 and Lipoxygenase was mediated through hydrogen and hydrophobic interaction. These findings provide mechanistic insight into their bioactivity and support further experimental studies for therapeutic development in oxidative stress-related disorders.Keywords: Cucurbitacin, Molecular docking, Oxidative stress, NOS2, KEAP1.
Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Abstract

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.
Neoadjuvant and Adjuvant Surgical Interventions in Oncology: Optimizing Treatment Pathways Eskandar, Kirolos
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp237-250

Abstract

The advancement of cancer treatment has seen significant progress through the integration of neoadjuvant and adjuvant therapies, particularly within the realm of surgical oncology. This literature review follows a systematic approach using PRISMA guidelines, analyzing studies from databases such as PubMed, Google Scholar, Scopus, and Web of Science. The review examines the historical progression, current practices, and future directions of multimodal approaches, focusing on the synergistic benefits of surgery, drug development, targeted therapies, and technological innovations. Neoadjuvant interventions, designed to shrink tumors preoperatively, enhance surgical outcomes by improving resectability, while adjuvant therapies, administered postoperatively, aim to eliminate residual disease and reduce recurrence risk. Findings from clinical trials and case studies highlight improved survival rates, increased tumor resectability, and enhanced patient outcomes through the combination of these therapies. Additionally, the review emphasizes the crucial role of personalized medicine, molecular profiling, and emerging surgical technologies in refining treatment pathways. As the landscape of cancer care evolves, optimizing treatment sequencing and tailoring therapies to individual tumor profiles will be essential for maximizing therapeutic efficacy and improving patient prognosis.Keywords: Neoadjuvant Therapy, Adjuvant Surgical Intervention, Surgical Oncology, Multimodal Cancer Treatment, Targeted Cancer Therapy.
Cytotoxic Effects of Cinnamon Powder and Lemongrass Oil-Enriched Roselle Tea on T47D Breast Cancer Cells Aisyah, Sabila; Cahyono, Edy; WH, Nugrahaningsih; Alighiri, Dante; Alauhdin, Mohammad; Zaky, Adrian Maulana; Handayani, Tri; Permatasari, Bella
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp186-197

Abstract

Breast cancer is the most prevalent cancer among women and is the leading cause of cancer-related mortality worldwide. This underlines the importance of preventive strategies to reduce the risk. Harnessing natural products like tea could be an alternative preventive strategy. In this study, the chemopreventive potential of roselle flower tea (Hibiscus sabdariffa L.) enriched with cinnamon oil (Cinnamomum burmannii) and lemongrass (Cymbopogon citratus) was evaluated. The tea was formulated using a stirred boiler tank and tested for its cytotoxicity against T47D cells using the MTT method. The cytotoxicity test showed that with the addition of cinnamon oil and lemongrass, roselle tea had more significant cytotoxic activity against T47D cancer cells than pristine roselle tea. Adding 5 g of cinnamon and lemongrass oil vapor for 15 seconds into the tea showed the highest cytotoxicity, with an IC50 of 730 μg/mL. This value is almost three times higher than without adding cinnamon oil and lemongrass. In conclusion, adding cinnamon oil and lemongrass to the roselle tea formulation can increase cytotoxic activity against T47D cancer cells, indicating its potential as a natural anti-cancer agent.Keywords: Chemopreventive, Cinnamon, Lemongrass, Roselle Tea, T47D Cells.

Page 34 of 34 | Total Record : 339

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