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Current Biochemistry
Published by Institut Pertanian Bogor
ISSN : 23557877     EISSN : 23557931     DOI : -
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Education
Current Biochemistry (CB) publishes the results of original research that contribute significantly to the understanding of the chemical compound and reaction that occur within living organism. Preference will be accorded to manuscripts that develop new concepts or experimantal approaches, particularly in the advancing areas of biochemistry science. Manuscripts that are primarily theoretical in nature or in the field of bioinformatics must be directed toward explaining important results previously not understood, making important predictions that can be experimentally tested, or developing segnificant advances in theory of general interest to biochemists. Submission of manuscripts in emerging areas in biochemistry, chemical biology, biophysics, proteomics, model studies and structures, cellular and molecular biology, computational biochemistry, biotechnology, and new methods development is encouraged especially if they address basic biochemical mechanisms.
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Articles 3 Documents
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Search results for , issue "Vol. 12 No. 1 (2025)" : 3 Documents clear
IN SILICO STUDY OF ACTIVE COMPOUNDS IN Halosi (Bidens pilosa) AS ANDROGEN INHIBITORS IN PROSTATE CANCER Harahap, Armansyah Maulana; Priawan, Indra; Siregar, Sarah Rahmayani
Current Biochemistry Vol. 12 No. 1 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.1.1

Abstract

Prostate cancer is a disease that affects men's prostate gland cells and can spread to other parts of the body, mostly bones and lymph nodes. It is the third most common type of cancer in men in Indonesia and the second most common type of cancer in men worldwide. Ini adalah studi in silico tentang aktivitas chemical compounds in the leaves of the halosi plant (Bidens pilosa) to inhibit the Androgen receptor (1E3G) in the treatment of prostate cancer. Androgen receptor (AR) is a receptor protein that plays an important role in the development of prostate cancer cells. Molecular docking method using Chemdraw 3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, and Ligandscout were used to conduct tests. Hasil menunjukkan bahwa bahan Bidens pilosa memiliki rendahnya ∆G free bond energy sebesar -10.26 KKal/mol and interaction with with several amino acid residues similar to Oxymetholone, a natural ligand. Therefore, it can be concluded that andrographolid compounds from halosi plant are the most able to inhibit Andorgen receptors
INOVASI PRODUKSI BIOETANOL BERBASIS LIGNOSELULOSA LIMBAH KULIT KOPI (COFFEA SP.) DENGAN KONSEP BIOREFINERY MENGGUNAKAN SACCHAROMYCES CEREVISIAE Azmi, Haikal; Octaviani, Nazla Fauziyah; Musa'adah, Musa'adah
Current Biochemistry Vol. 12 No. 1 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.1.2

Abstract

Indonesia is the fourth largest coffee exporter in the world, with a market share of around 11%. In 2021, Indonesia's coffee production reached 765,415 tons, generating 382,000 tons of coffee husk waste. However, only about 2% of this amount is utilized, coffee skins contain 20-50% cellulose which hasthepotential to used as a substrate for bioethanol production, a renewable energy source. This study aims to explore innovations in bioethanol production from lignocellulosic coffee pulp waste, particularly through a biorefinery method using Saccharomyces cerevisiae as fermentation agent. The research employs an exploratory descriptive approach, by reviewing relevant scientific articles. The process of converting lignocellulosic substrates into ethanol consists of four main stages in bioethanol production, namely: (1) pretreatment, which can be done physically, chemically, or biologically; (2) hydrolysis of polymers such as cellulose and hemicellulose into simple sugars such as hexose and silose; (3) fermentation of sugars by microorganisms to produce ethanol; and (4) separation and purification of the produced ethanol. The utilization of the biorefinery concept in bioethanol production not only facilitates the conversion of biomass into bioethanol, but also enables the production of other high-value products, such as biohydrogen (environmentally friendly fuel), furfural (resin and composite industry), HMF (bioplastic precursor and furan fuel), xylitol (sweetener in food and pharmaceutical industries), vinasse (organic fertilizer and biomass fuel), organic acids (chemical and pharmaceutical industries), and microbial biomass (high-protein animal feed). Keywords: bioethanol, biorefinery, coffee skin, lignocellulosic waste, saccharomyces cerevisiae
Pengembangan Beras Putih Tinggi Protein Rendah Glikemik (RASPUTIN) untuk Penderita Diabetes Berbasis CRISPR/Cas9 Abhinaya, Danendra Daryl; Fitria, Lutfiah Rahmadini; Asgasatya, Syahid Fattah; Budiharjo, Anto
Current Biochemistry Vol. 12 No. 1 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.1.3

Abstract

Diabetes merupakan salah satu penyakit mematikan yang banyak menjangkit masyarakat Indonesia dengan jumlah penderita yang terus meningkat setiap tahunnya. Salah satu faktor yang menjadi pemicunya adalah konsumsi beras putih yang bernilai indeks glikemik tinggi sebagai makanan pokok sehari-hari. Salah satu alternatif untuk mengatasi masalah tersebut adalah dengan memproduksi beras RASPUTIN, yakni beras terekayasa genetik dengan indeks glikemik rendah. Penelitian ini bertujuan untuk mengetahui potensi beras RASPUTIN dalam menurunkan risiko diabetes serta cara memproduksi beras RASPUTIN secara efektif menggunakan CRISPR/Cas9. Penelitian ini menggunakan metode studi literatur yang bersumber dari artikel ilmiah dan jurnal penelitian. Gen OsSPL16 diisolasi dengan menggunakan bulir padi sebagai sampel. Sel dilisiskan dengan manual grinding dan diekstraksi menggunakan metode CTAB. Plasmid direkonstruksi dengan melibatkan promoter U6 dan CAG yang secara berturut-turut mampu mengekspresikan sgRNA dan SpCas9. Agrobacterium-delivered CRISPR/Cas9 digunakan sebagai model sel kompeten yang akan ditransfer ke dalam kecambah padi setelah dikloning pada media lysogeny broth (LB). Kecambah RASPUTIN dikultivasi dan tanaman dewasa diaklimatisasi. Analisis dilakukan secara kualitatif dan kuantitatif. Hasil yang diperoleh, yaitu diperoleh rancangan rekonstruksi plasmid serta desain sgRNA yang kompatibel untuk memproduksi beras putih termodifikasi secara genetik. Beras RASPUTIN diproduksi melalui teknologi rekayasa genetika CRISPR/Cas9 dapat menjadi solusi alternatif untuk menurunkan risiko terjadinya diabetes melitus.

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