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All Journal JBIO: jurnal biosains (the journal of biosciences) Current Biochemistry Jurnal Pedagogik Olahraga AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh The Journal of Society Medicine (JSOCMED)
Priawan, Indra
Master Program In Biomedical Sciences, Faculty Of Medicine, Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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IDENTIFIKASI EKTOPARASIT PADA IKAN KOI (Cyprinus caprio) Indra Priawan; Endang Sulistyarini Gultom; Ahmad Shafwan S. Pulungan
JBIO: jurnal biosains (the journal of biosciences) Vol 3, No 1 (2017): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v3i1.7368

Abstract

Penelitian ini bertujuan untuk mengetahui ektoparasit yang terdapat pada ikan koi yang dijual di Jalan Bintang Medan. Ektoprarasit diketahui dapat menyebabkan penyakit pada ikan. Hal ini akan berdampak pada ikan lainnya. Kerusakan yang diakibatkan oleh ektoparasit ini akan meningkatkan intensitas penyakit pada ikan. Luka yang ditimbulkan oleh adanya ektoparasit pada ikan menjadi jalan masuk bagi kuman lain untuk menyerang ikan. Sampel yang digunakan ialah tiga ekor ikan koi yang mana ektoparasit yang menginfeksi ikan di amati lendir pada tubuh dan sirip ikan mas koki. Identifikasi ektoparasit dilakukan dengan menggunakan literatur. Ektoparasit yang teridentifikasi ialah Ichthyophthirius sp., Oodinium sp., Costia Sp. Dengan jumlah parasit terbanyak ialah spesies Oodinium sp.Kata Kunci : Ektoparasit, ikan koi, identifikasi.
GCMS ANALYSIS OF BIOACTIVE COMPOUNDS OF CHINESE BEAT LEAVES (Peperromia pellucida) WITH EXTRACTION APPLICATION USING SOXHLET ATION METHOD Armansyah Maulana Harahap; Nila Zusmita Wasni; Indra Priawan M
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 3 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i3.33512

Abstract

Chinese betel leaf (Perperomia pellucida) is generally widely used as a medicinal plant. Many people use Chinese betel leaf as a traditional medicine based on natural ingredients which are believed to be able to treat various diseases with fewer side effects than synthetic drugs. In general, China betel leaf has several secondary metabolites, generally flavonoids, steroids, alkaloids and terpenoids. However, in testing for secondary metabolites, there is still no clear description of the plant parts taken. So this study aims to determine the secondary metabolites in the young leaves of Chinese betel (Peperromia pellucida) by gas chromatography. The results obtained based on the GCMS analysis contained 18 secondary metabolites. Phytol, 2,3-BIS (4-(CA RBOXYMETHYL) PHENYL) BENZO [B] FURAN, and 6-ALLYL-4,5 -DIMETHOXY- 1,3-BENZOD IOXOLE are the 3 highest bioactive com pounds based on the percentage of content.
EFFECT OF ETHANOLIC EXTRACT OF MELINJO PEEL (Gnetum gnemon) ON SERUM MALONDIALDEHYDE (MDA) LEVELS IN HYPERURISEMIA WISTAR STRAIN RATS Indra Priawan; Yetty Machrina; Ririe Fachrina Malisie
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 3 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i3.43187

Abstract

Hyperuricemia is a state of uric acid in the body that is higher than the body's tolerance limit. The formation of uric acid will be accompanied by the formation of Reactive Oxygen Species (ROS) by the changes of Xanthine Dehydrogenase to Xanthine Oxide with the help of NAD+ and Oxygen, which can trigger oxidative stress, causing cell damage and apoptotic cell, one of which is through lipid peroxidation followed by the release of Malondialdehyde (MDA) into the extracellular space. This study aims to analyze the effect of giving melinjo peel ethanol extract (Gnetum gnemon) on serum MDA levels in hyperuricemic Wistar strain rats. Rats were grouped into 4 treatment groups, namely K0 (without treatment), Kneg (hyperuricemia and CMC), Kpos (hyperuricemia and allopurinol), and P (hyperuricemia and ethanol extract of melinjo peel). Manufacture a hyperuricemic rat model by giving a high-fructose diet and then measuring uric acid levels to ensure that the rat is already in hyperuricemia. The high-fructose diet was continued until the rats were executed. Serum MDA was measured using the Thiobarbituric acid (TBA) method. The results showed differences in MDA levels between groups of hyperuricemic rats. Based on the examination of lower MDA levels after administration of melinjo peel ethanol extract compared to the CMC group and the allopurinol group, statistically significant differences were obtained (p = 0.001). Based on the analysis results, it was concluded that the ethanolic extract of melinjo peel (Gnetum gnemon) could reduce serum MDA levels in hyperuricemic Wistar rats.
MEKANISME AKTIVITAS FISIK Fast Interval Training SEBAGAI PENATALAKSANAAN PENURUNAN KADAR ASAM URAT PADA PENDERITA HIPERURISEMIA: META ANALISIS- REVIEW Armansyah Maulana Harahap; Farah dhiba; Indra Priawan; Nila Zusmita Wasnia
Jurnal Pedagogik Olahraga Vol 9, No 1 (2023): Jurnal Pedagogik Olahraga
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpor.v9i1.46587

Abstract

Hiperurisemia dapat disebabkan oleh keadaan sindrom metabolik. Penyakit yang melibatkan kelainan metabolisme dari metabolisme purin atau nukleotida meliputi banyak ragam jenis kelainan namun pada umumnya meliputi Hiperurisemia dan juga Gout. Dalam kasus konsumsi purin yang berlebih akan memberikan efek gangguan eksresi produk metabolik akhir metabolisme purine atau asam urat. aktivitas fisik seperti olahraga teratur  dapat mencegah terhadap banyaknya produksi dan penimbunan asam urat, dan tidak menentukan lamanya pelaksanaan aktivitas fisik berupa olahraga yang diberian untuk penderita Hiperurisemia. Artikel ini membuktikan analisa pengaruh aktivitas fisik FIT (Fast Interval Training) menyebabkan penurunan kadar asam urat melalui mekanisme perubahan molekuler dengan menggunakan artikel dari 10 tahun belakangan. Metode penulisan artikel ini menggunakan Technical Expert Panel (TEP) dari 4 orang yang memiliki ahli dibidang kesehatan, hasil review di tulis dengan desaign (PRISMA-ScR) Reviews and Meta Analyses Extension for scoping Reviews model. Menggunakan pencarian kata kunci pencarian “Aktivitas fisik” dan “Asam urat” . Hasil penelitian diperoleh dari 90 artikel yang di analisa, diperoleh 10 penelitian yang sesuai dan fokus dengan kajian mencakup hasil penelitian, review, maupun case report. Sehingga hasil akhir meyimpulkan bahwa diperoleh hubungan aktivitas fisik tipe Fast Interval Training terhadap penurunan kadar asam urat.
The Effect of Bidens pilosa Extract on Vancomycin-Induced Acute Kidney Injury in Prepubertal Rats Priawan, Indra; Harahap, Armansyah Maulana; Siregar, Sarah Rahmayani
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.19225

Abstract

The long-term use of Vancomycin and its administration at inappropriate doses still cause uncontrolled physiological side effects, particularly in terms of kidney development and metabolism. This study aims to investigate the effects of Bidens pilosa extract (BPE) on vancomycin-induced acute kidney injury in prepubertal rats. This study employed an experimental research method, randomly dividing 40 female Wistar rats into five equal groups: control/adult (C), prepubertal (P), prepubertal + Bidens pilosa (PB), prepubertal + vancomycin (PV), and prepubertal + vancomycin + Bidens pilosa (PVB). Gentamicin caused kidney damage in both PG and PVB groups. We treated PB and PVB with a single dose of BPE. At necropsy, we collected blood, serum, and kidney tissue for evaluation. The research results showed that the total leukocyte count was higher in PB compared to the others (P = 0.002). Serum urea, creatinine, aspartate aminotransferase, and total protein levels significantly increased in PB, PV, and PVB compared to C and P. Glutathione levels were low in the serum and kidney tissue of PV, and malondialdehyde levels were high compared to the others (P<0.05). Using BPE in vancomycin-induced acute kidney injury in ovariectomized rats resulted in a decrease in serum creatinine, urea, and malondialdehyde levels in PVB compared to PV, an increase in glutathione levels, and a milder severity of histopathological findings. The conclusion of this study shows that a single dose of BPE partially reduces kidney damage in rats with gentamicin-induced acute kidney injury
IN SILICO STUDY OF ACTIVE COMPOUNDS IN Halosi (Bidens pilosa) AS ANDROGEN INHIBITORS IN PROSTATE CANCER Harahap, Armansyah Maulana; Priawan, Indra; Siregar, Sarah Rahmayani
Current Biochemistry Vol. 12 No. 1 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.1.1

Abstract

Prostate cancer is a disease that affects men's prostate gland cells and can spread to other parts of the body, mostly bones and lymph nodes. It is the third most common type of cancer in men in Indonesia and the second most common type of cancer in men worldwide. Ini adalah studi in silico tentang aktivitas chemical compounds in the leaves of the halosi plant (Bidens pilosa) to inhibit the Androgen receptor (1E3G) in the treatment of prostate cancer. Androgen receptor (AR) is a receptor protein that plays an important role in the development of prostate cancer cells. Molecular docking method using Chemdraw 3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, and Ligandscout were used to conduct tests. Hasil menunjukkan bahwa bahan Bidens pilosa memiliki rendahnya ∆G free bond energy sebesar -10.26 KKal/mol and interaction with with several amino acid residues similar to Oxymetholone, a natural ligand. Therefore, it can be concluded that andrographolid compounds from halosi plant are the most able to inhibit Andorgen receptors
Antidiabetic Effects of Moringa oleifera Leaf Extract on Blood Glucose Levels in Alloxan-Induced Diabetic Rats (Rattus norvegicus): A Systematic Literature Review Harahap , Armansyah Maulana; Ginting, Muhammad Aldi Rivai; Putri, Yulia; Sari, Herviani; Priawan, Indra
Journal of Society Medicine Vol. 4 No. 12 (2025): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i12.267

Abstract

Introduction: This systematic literature review, guided by PRISMA guidelines, evaluates the effectiveness of Moringa oleifera leaf extracts in reducing blood glucose levels in alloxan-induced diabetic rats. Method: Literature was searched in PubMed and Google Scholar using keywords including “Moringa oleifera,” “leaf extract,” “alloxan-induced diabetes,” and “blood glucose.” From 472 identified articles, 9 studies met inclusion criteria and were analyzed. Results: Nearly all studies reported significant reductions in blood glucose levels following administration of Moringa oleifera leaf extracts at effective doses ranging from 200–800 mg/kg body weight over 14–28 days. Key mechanisms include protection of pancreatic β-cells from oxidative stress, enhanced insulin secretion, and improved insulin sensitivity. Both aqueous and ethanolic extracts exhibited antihyperglycemic effects, with aqueous extracts demonstrating faster onset and ethanolic extracts providing more sustained outcomes. Conclusion: These findings support the potential of Moringa oleifera leaf extracts as a natural antidiabetic agent in preclinical models. However, further research is required to standardize extraction methods, dosages, and molecular mechanisms to facilitate clinical translation in humans.
Co-Authors Ahmad Shafwan S. Pulungan Endang Sulistyarini Gultom Farah dhiba Ginting, Muhammad Aldi Rivai Harahap, Armansyah Maulana Lingga, Rahmad Maruf, Rosalin Yuniarti Nila Zusmita Wasni Nila Zusmita Wasnia Ririe Fachrina Malisie Roshuna, Ghaida Sarah Rahmayani Siregar Sari, Herviani Septiadi, Abdurrohman Syach Putra, Marthin Yetty Machrina Yulia Putri