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Journal of Mathematical and Fundamental Sciences
Published by Institut Teknologi Bandung
ISSN : 23375760     EISSN : 23385510     DOI : https://doi.org/10.5614/j.math.fund.sci.
Core Subject : Science, Education,
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics
Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health, Medical, Pharmacy), Mathematics, Physics, and Statistics.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 689 Documents
 64   65   66   67   68 
Role of Hypoxia on Growth and Differentiation of Human Adipose Derived Stem Cells Grown on Silk Fibroin Scaffold Induced by Platelet Rich Plasma Anggraini Barlian; Marselina Irasonia Tan; Ergha Widya Sarjana; Noviana Vanawati
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 3 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.3.6

Abstract

Previous research has proven that 10% platelet-rich plasma (PRP) can enhance growth and differentiation of human adipose derived stem cells (hADSC) grown on silk fibroin scaffold into chondrocytes. A low oxygen concentration (hypoxia) condition is an important factor that potentially affects the ability of hADSC to grow and differentiate. The objective of this research was to analyze the difference in growth and differentiation capacity of hADSC grown on salt leached silk fibroin scaffold supplemented by 10% PRP under normoxic and hypoxic conditions. The growth capacity of the hADSC was determined by MTT assay and differentiation was tested using glycosaminoglycan (GAG) content analysis, while chondrocyte markers were visualized with the immunocytochemistry (ICC) method. This research observed hADSC proliferation under normoxic and hypoxic conditions for 21 days. Visualization of type 2 collagen showed that it was more abundant under hypoxia compared to normoxia.  HIF-1α was only detected in the hADSC cultured in hypoxic conditions. In conclusion, culture under hypoxic conditions increases the capacity of hADSC to grow and differentiate into chondrocytes. This is the first study that has shown that hypoxia is able to enhance the proliferation and differentiation of hADSC grown on 3D salt leached silk fibroin scaffold supplemented by 10% PRP.
Properties of the Environment of Galaxies in Clusters of Galaxies CL 0024+1654 and RX J0152.7−1357 Premana Wardayanti Premadi; Dading Hadi Nugroho; Anton Timur Jaelani
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 3 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.3.7

Abstract

We report the results of combined analyses of X-ray and optical data of two galaxy clusters, CL 0024+1654 and RX J0152.7−1357 at redshift z = 0.395 and z = 0.830, respectively, offering a holistic physical description of the two clusters. Our X-ray analysis yielded temperature and density profiles of the gas in the intra-cluster medium (ICM). Using optical photometric and spectroscopic data, complemented with mass distribution from a gravitational lensing study, we investigated any possible correlation between the physical properties of the galaxy members, i.e. their color, morphology, and star formation rate (SFR), and their environments. We quantified the properties of the environment around each galaxy by galaxy number density, ICM temperature, and mass density. Although our results show that the two clusters exhibit a weaker correlation compared to relaxed clusters, it still confirms the significant effect of the ICM on the SFR in the galaxies. The close relation between the physical properties of galaxies and the condition of their immediate environment found in this work indicates the locality of galaxy evolution, even within a larger bound system such as a cluster. Various physical mechanisms are suggested to explain the relation between the properties of galaxies and their environment.
Pharmacophore Modeling, Docking, and Molecular Dynamics Simulation of Flavonoids as Inhibitors of Urokinase-type Plasminogen Activator Bina Lohita Sari; Slamet Ibrahim; Daryono Hadi Tjahjono
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 3 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.3.8

Abstract

The urokinase-type plasminogen activator (uPA) system plays a significant role in the invasion and metastasis of cancer cells. The present study was conducted to investigate natural product compounds as inhibitors and hit molecules of uPA using in-silico analysis. A pharmacophore model was built to screen the Indonesian Herbal Database (HerbalDB) to obtain inhibitors of different scaffolds. Based on the molecular docking score, four ligands were selected as potential uPA inhibitors. Subsequently, the stability of the ligand-uPA complex was analyzed using molecular dynamics (MD) simulation. An RMSD graph of the backbone protein and the RMSF values of the amino acid residues were also determined. In addition, the MM-PBSA method was applied to calculate the free binding energy. According to the results, Model_3, characterized by aromatic rings 23 (F1 and F2), cationic H-bond donor (F3), and metal ligator (F4) features, had an adequate goodness-of-hit score (GH). The four top-ranked ligands, isorhamnetin, rhamnetin, quercetin, and kaempferol, showed higher docking scores compared to the others. This study confirmed that isorhamnetin, rhamnetin, and kaempferol build stable complexes with uPA with lower binding energy than quercetin.
Vulnerability of Primary Productivity and Its Carbon Use Efficiency to Unfavorable Climatic Conditions in Jambi Province, Indonesia Ummu Ma'rufah; Tania June; Ashehad Ashween Ali; Akhmad Faqih; Yonny Koesmaryono; Christian Stiegler; Alexander Knohl
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 1 (2022)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2022.54.1.4

Abstract

Climatic conditions and land cover play crucial roles in influencing the process of carbon uptake through vegetation. This study aimed to analyze the effect of climate variability on carbon uptake of four different land covers in Jambi Province, Indonesia. The four land cover types studied were: forest, shrub, grass, and irrigated soybean, based on Community Land Model version 5. Forest was found to have the highest net primary production (NPP) compared to the other land covers. Seasonal climate variability showed no major effect on NPP and gross primary production (GPP). However, GPP and NPP experienced significant declines during El Niño Southern Oscillation (ENSO), particularly in 2015. Carbon use efficiency (CUE = NPP/GPP) was also affected by ENSO, where CUE decreased during El Niño, particularly in October and November with an increased number of days without rainfall. In addition, the difference between latent (LE) and sensible heat (H) flux, denoted as (LE-H), decreased from August to November. This difference was highly correlated with NPP. This result indicates that when water supply is low, stomata will close, thereby reducing photosynthesis and transpiration, and allocating more of the available energy to sensible heat flux rather than latent heat flux.
Metagenomic Analysis of Bacterial Community in the Gut of Blister Beetle Mylabris pustulata Thunberg Achmad Dinoto; Zahra Noviana; Oscar Efendy; Heddy Julistiono
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 1 (2022)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2022.54.1.10

Abstract

Blister beetles are an important object of study in the field of agriculture and health. Despite being known to be important for the host animal, the gut bacteria of blister beetles have not been investigated deeply. This study aimed to provide the first initial description of the gut bacterial community of Mylabris pustulata as one species of blister beetles, based on a culture-independent technique. Adult blister beetles of the same colony were sampled and confirmed as Mylabris pustulata Thunberg. The gut content was used in high throughput sequencing, targeting the V3-V4 regions of 16S rRNA gene, and in the cultivation of resident bacteria. The results showed that higher bacterial richness was present in the gut communities when compared to the grown bacterial culture. Proteobacteria was confirmed as the most abundant phylum in the gut of M. pustulata, whereby most reads belonged to the class of Gammaproteobacteria. The dominant bacterial genera were determined as Enterobacter, Acinetobacter, Enterococcus, Klebsiella, and Pseudomonas. In addition, our cultivation attempts led to successful isolation of members of Klebsiella and Enterococcus. The subject of this study could be explored further to find the potential roles of these microbiota in the gut of the specific beetles and their bioprospects.
Mathematical Analysis of Two Strains Covid-19 Disease Using SEIR Model Adetayo Samuel Eegunjobi; Oluwole Daniel MAKINDE
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 2 (2022)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2022.54.2.1

Abstract

The biggest public health problem facing the whole world today is the COVID-19 pandemic. From the time COVID-19 came into the limelight, people have been losing their loved ones and relatives as a direct result of this disease. Here, we present a six-compartment epidemiological model that is deterministic in nature for the emergence and spread of two strains of the COVID-19 disease in a given community, with quarantine and recovery due to treatment. Employing the stability theory of differential equations, the model was qualitatively analyzed. We derived the basic reproduction number  for both strains and investigated the sensitivity index of the parameters. In addition to this, we probed the global stability of the disease-free equilibrium. The disease-free equilibrium was revealed to be globally stable, provided and the model exhibited forward bifurcation. A numerical simulation was performed, and pertinent results are displayed graphically and discussed.
Oxygen Reduction Reaction Mechanism on the Square Paddle-Wheel Cage Site of TM-BTC (TM=Mn, Fe, Cu) Metal-Organic Framework Ahmad Nuruddin; Adhitya Gandaryus Saputro; Syauqi Abdurrahman Abrori; Arifin Luthfi Maulana; Virgiawan Listanto Rahagung; Mohammad Kemal Agusta; Fadjar Fathurrahman; Amrina Mustaqim; Hermawan Kresno Dipojono
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 2 (2022)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2022.54.2.2

Abstract

Our study examined the mechanism of oxygen reduction reactions (ORR) at the square paddle-wheel cage active site of TM-BTC metal-organic frameworks (MOFs), where TM is a transition metal, Mn, Fe, or Cu. We used a combination of density functional theory (DFT) and microkinetic calculations to investigate this mechanism. By using a small cluster for modeling the TM-BTC active site structure, we successfully reproduced the experimental trend of ORR activity in the TM-BTC systems: Mn-BTC > Fe-BTC > Cu-BTC. We also found that the unusual ORR activity trend in experiments for Mn and Fe systems originates from the strength of OH adsorption on these systems. The Mn-BTC system exhibits higher ORR activity than the Fe-BTC system due to its weaker adsorption of OH groups. A very strong OH adsorption makes the final OH reduction step sluggish, hence hindering the ORR process.
Antibacterial Activity of Gyrinops versteegii Fruit Extracts against Staphylococcus aureus and Escherichia coli and GC-MS Analysis Ernin Hidayati; Yuli Handayani; I Made Sudarma
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 2 (2022)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2022.54.2.3

Abstract

Gyrinops versteegii is widely used in the perfume, incense, and cosmetic industries as a raw material. Other potential uses of the plant are being explored, including in food and medicine. Therefore, this study carried out antibacterial assay and gas chromatography-mass spectroscopy of G. versteegii fruit extracts in three solvents with different polarities, i.e., n-hexane, dichloromethane, and methanol. The agar well diffusion method was then used to test the extracts against Staphylococcus aureus and Escherichia coli. The dichloromethane extract showed the most effective antibacterial activity against S. aureus at a concentration of 40%, with a zone of inhibition of 13.17 mm compared to E. coli, for which it was 7 mm. Furthermore, the bacterial species showed different responses to the extracts. Total and partial inhibition was shown by the G. versteegii fruit extracts against S. aureus and E. coli, respectively. Furthermore, GC-MS identified the following compounds in G. versteegii fruit extract: palmitic, oleic, and stearic acid, as well as bis-(2-ethylhexyl) phthalate, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl octadec-9-enoate, squalene, and 2-monopalmitin derivates. The results showed antibacterial potency of G. versteegii fruit extract against pathogenic bacteria. Additionally, the antibacterial activity of the extract was stronger against S. aureus compared to E. coli.
Synthesis of Human Antibodies Against HBsAg in Newly Established Chinese Hamster Lung (CHL-YN) Cell Line Meutia Diva Hakim; Noriko Yamano- Adachi; Takeshi Omasa; Marselina Irasonia Tan; Lia Dewi Juliawaty; Ernawati Arifin Giri-Rachman
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 3 (2023)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2023.54.3.1

Abstract

Hepatitis B immunoglobulin (HBIG) is an effective treatment for hepatitis B, including postexposure prophylaxis of HBV infection, prevention of HBV reinfection in liver transplant patients, and reducing sexual transmission. This study investigated the synthesis of human IgG antibodies that specifically target HBsAg subtype adr in CHL-YN cells, a newly established cell line that grows faster than CHO-K1. To achieve the synthesis of human IgG antibodies, a plasmid vector encoding DNA sequences for human IgG antibodies against HBsAg was constructed and then transiently transfected into CHL-YN cells. The expression and antigen-binding capacity of the recombinant human IgG antibodies were analyzed using western blot and ELISA. The results showed successful expression and secretion of human IgG antibodies that recognize HBsAg subtype adr in CHL-YN cells. The ELISA test confirmed the specificity of the human IgG antibodies towards HBsAg subtype adr. Thus, this study concluded that human IgG antibodies that target HBsAg subtype adr were transiently expressed in CHL-YN cells.
Evaluation NO2 Detection Using Low-Cost Folded-Path Photometer Januar Arif Fatkhurrahman; Puji Lestari
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 3 (2023)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2023.54.3.5

Abstract

The measurement of nitrogen dioxide (NO2) in industrial and residential areas needs comprehensive and reliable instrumentation providing long-interference-free operation and minimum maintenance and recalibration. Differential optical absorption spectroscopy can be used as a direct measurement technique based on the specific absorption characteristics of NO2 following the Berr-Lambert law. This paper proposes a low-cost folded-path photometer to measure NO2 in the air. Cheap tubular acrylic was used as a detection cell with a 3D printed framework, making it compact, modular, and flexible. Evaluation of this differential optical absorption spectroscope (DOAS) was conducted by instrument test responses using NO2 gas. The estimated LOD was ~1263 ppb using a 2-nm resolution of the spectrometer and a 6-meter detection cell length. Deviation of the DOAS was estimated to be 0.8% at high concentration and 2.85% at low concentration based on the calibrated DOAS. Intercomparison of the results was conducted using two different instruments to evaluate the DOAS’s performance by measuring NO2 from motorcycle emissions, which indicated that there was a good correlation between the results. The coefficient correlation (R) was 0.649 for the DOAS- ASTM D1607 Griesz Saltzmann method pairing and 0.846 for the DOAS- electrochemical gas analyzer pairing.

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