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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
ISSN : -     EISSN : -     DOI : -
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Articles 105 Documents
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FOXID-EGG: PENGEMBANGAN INDUSTRI NUTRACEUTICAL BERBASIS TELUR ITIK LOKAL KAYA OMEGA-3 Andri, Faizal; Sukoco, Aji; Hilman, Taufich; Susilo, Hadi; Sibawi, Sibawi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cardiovascular disease is the number one cause of death and disability worldwide. The purpose of this experiment was to create local ducks egg enriched with omega-3 as a candidate of nutraceutical to prevent cardiovascular disease. Sixty local ducks were randomly distributed to six treatment with three levels of fish oil (0 ppm, 1500 ppm, and 3000 ppm) and two levels of tomato meal (0 ppm and 150 ppm) in a 3x2 factorial arrangement. Data of local ducks performances were analyzed using two-way Anova, data of egg yolk omega-3 fatty acid content was analyzed descriptively. There was an interaction (p<0.05) of fish oil and tomato meal supplementation on egg weight. Supplementation of 3000 ppm fish oil +150 ppm tomato meal tend to increase DHA content of egg yolk with 0,43% compare than control treatment with 0,18%. The conclusion of this research supplementation of 3000 ppm fish oil +150 ppm tomato meal could produce egg yolk of local ducks egg with 0,04% ALA and 0,43% DHA.Keywords:  cardiovascular disease, DHA, local ducks egg, fish oil, tomato meal
DOKSISIKLIN SEBAGAI INHIBITOR MMP-2 dan MMP-9 PADA DERMATITIS PAEDERUS DENGAN METODE GELATIN ZIMOGRAFI Romadhon, Brenda Desy; Kusuma, Bagus Indra; Chasya, Silvi Ahmada; Kusumaningarum, Putri Erlinda; Prasetya, Rovian Cahya
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Tomcat (Paederus sp.) venom can bring a condition called dermaconecrosis. Initially, paederin toxins was thought that come from the body of Tomcat (Paederus sp.). However, based on Piel’s research, the genes come from biosynthesis of tomcat (Paederus sp.) venom is more approach to Pseudomonas aeruginosa genes than body itself. In other fact, Pseudomonas aeruginosa can secrete enzymes metalloprotease (MMP), especially extracellular MMP-2 and MMP-9. MMP-2 and MMP-9 are gelatinase that can destroy the gelatin on human skin. There has been no previous report about the treatment of dermatitis paederus based on the mechanism of action except for the use of corticosteroids as symptomatic drugs. Because of that, researcher hypotheses that MMP-2 and MMP-9 have a role on dermatitis paederus and doxycycline can inhibit that process as MMP inhibitor and antibiotics component. The research design is quasi-experimental research, in vitro with a post-test only control group design. The research steps are Tomcat (Paederus sp.) venom extraction, doxycycline solution preparation, and electrophoresis of gelatin zymografi. The independent variables are induction of Tomcat (paederin sp.) venom and the doses of doxycycline, while the dependent variable is the density of the gel. Gel density was measured using densitometry software ImageJ and calibrated as optical density. This study describes the first time the mechanism Paederus dermatitis caused by MMP-2 and MMP-9, so that the first line of therapy that can be used is doxycycline with an effective dose of 10 mM in vitro.Keywords:  paederus dermatitis, doxycycline, gelatin zimografi, MMP
FAKTOR PENGARUH GADGET TERHADAP KECERDASAN MOTORIK SISWA SD MELALUI REGRESI LOGISTIK ORDINAL Octaviana, Fanny Ayu; Pertiwi, Tutut Januar; Purnama, Giyanti Linda; Hapsery, Alfisyahrina; Yoshinta, Andriana
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Gadget is an electronic device that has a specific function and widely used by all people, without exception for kid. Use of gadgets positively has helpful children for homework and as entertaiment. However, without realizing that overusing gadgets have a negative effect.Therefore, the research will be conducted to determine the factors affecting of using gadgets early on the development of motoric intelligence elementary students using ordinal logistic regression.  Source of data used are primary data obtained from the survey, the sampling unit are all mothers who have children in grade 1 SDN Klampis Ngasem I Surabaya. The response variable (Y) is the level of intelligence of the childs motor development (1 = poor, 2 = fair, 3 = good). The results of the analysis, can be concluded that the factors that influence the development of motor 120 students of SDN Klampis Ngasem I Surabaya is long child recognize and use of gadgets every day. Keywords:  Gadgets, Intelligence motoric skills, Logistik Ordinal Regression, Elementary Students. 
KLASIFIKASI RUMAH TANGGA MISKIN DI KABUPATEN JOMBANG DENGAN PENDEKATAN RANDOM FOREST CART Seftiana, Dian; Arleina, Oktiva Dhani; S., Giriesa Kinanti; Dewi S., Rizka Amalia; Fachrunisah, Fachrunisah
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Poverty is a major cause of a number of social problems, political, economic and particularly in developing countries. Poverty reduction is the key factor that must be done to achieve the targets in the Millennium Development Goals (MDGs) by 2015 government assistance program for the reduction of poverty that exist today have not been able to reduce the number of poor households in Jombang, whereas Jombang have a positive economic growth rate from year to year. Thus, in order to support effective and efficient government then carried out a classification based on the household assistance package that is expected by the poor households in Jombang. Poor households as the object of observation is divided into two according to their poverty status, namely Poor Households (RTM) and Chronically Poor Households (RTSM). Classification is done by using the CART approach is then combined with the method of the Random Forest to obtain a more accurate and stable classification. Classification results using Random Forest CART stated that the expected assistance package by RTSM determined by income per month, place of dispocing of fecal water, type of floor building, and source of drink water. While, the most important characteristic of RTM classification income per month, place of dispocing of fecal water, source of drink water, and large of house building. The classification result from Random Forest CART method produces a total accuracy rate of 99.50 percent for RTSM and 98.33 percent for RTM. The mapping of households in Jombang stated that cash money, cattle, and modal were the most expexted assistance package. Keywords: CART, Chronically Poor Households, Poor Households, Random Forests, Total Accuracy Rate.
YLS-THERAPY: POTENSI SUPERNATAN YOGURT LBA–ST SEBAGAI ANTIKANKER SERVIKS BERBASIS BIOMOLEKULER Permata Sari, Desie Suci; Ridho, Wildan Mochamad; Lizziyyannida, Lizziyyannida; Sholihah, Zurniatus; Putra Pratama, Satya Hanggara; Rahmani, Erita; Riawan, Wibi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cervical cancer is the third most diagnosed cancer and the fourth leading cause of cancer death in females in the world. Zebrafish have been used as experimental animals in human tumors because of similar gene expression (70%) than other experimental animals. Yogurt LBA-ST produces SCFA metabolites (acetate, lactate, and butyrate) that can provide anticarcinogenic effects. There has been a vast growth of related research focusing on proliferation and apoptosis without clear mechanism. However, Important concern need to considered in the development of tumors is protein-coding invasion, migration, and adhesion (IMA) of tumor cells. This study aims at investigating (1) Antiproliferation activities of supernatan yogurt LBA-ST (SY LBA-ST) on zebrafish embryos and HeLa cells, and (2) anti-IMA’s pathway on HeLa cells. The anti-cancer property of SY LBA-ST was evaluated by MTT assay for viability and imunositochemistry of MMP-2, Laminin5-y2, Hsp27, and TGF-β for anti-IMA mechanism. The data is collected and analyzed using One-Way ANOVA.This study could be concluded that (1) SY LBA-ST increase mortality rate and decreased the hatching rate in zebrafish embryos, LC50 ≈ 20% (v/v),  (2) supernatant, pellet, and whole yogurt shows antiproliferation activity on HeLa cells, (3) IC50 SY LBA-ST ≈ 30% (v/v) and the ED = 10% (v/v), and (4) the anti-IMA’s pathway was via decrease MMP-2, Laminin5-y2, Hsp27, and TGF-β expression (p<0.05 ± 0.005).Keywords:  lactobacillus bulgaricus-acidophilus, streptococcus thermophillus, cancer, HeLa, zebrafish

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